利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

462 条记录 (耗时 0.024 秒)

    Thin-layered endovascular silk-covered stent device and method of manufacture thereof
    61.
    发明申请
    Thin-layered endovascular silk-covered stent device and method of manufacture thereof 审中-公开
    薄层血管内真丝覆膜支架装置及其制造方法

    公开(公告)号：US20060030927A1

    公开(公告)日：2006-02-09

    申请号：US11246338

    申请日：2005-10-06

    申请人： Kathy Hess ,  Barbara Kelley

    发明人： Kathy Hess ,  Barbara Kelley

    IPC分类号： A61F2/06

    CPC分类号： A61F2/07 ,  A61F2/89 ,  A61F2002/072 ,  A61F2002/075 ,  A61F2220/0075 ,  A61L27/22 ,  A61L31/043

    摘要： A stent-graft composite intraluminal prosthesis comprises an elongate radially adjustable tubular stent, defining opposed exterior and luminal stent surfaces and a polymeric stent sheath covering at least the exterior surface thereof. The stent can include a plurality of open spaces extending between the opposed exterior and interior surfaces so as to permit said radial adjustability. The stent has a polymeric material on its exterior surface, its interior surface, in interstitial relationship with the stent or any combination of the above. The polymer is preferably selected from the group of polymeric materials consisting of biological or genetically engineered spider silks, such as those derived from Nephila clavipes. The silk includes bioengineered spider silks as well as silk-like polymers manufactured using human proteins and blends of such silks with commonly used polymeric graft materials. If separate sheaths are placed on both the exterior and interior surfaces of the stent, the sheaths are secured to one another through said open spaces, such as by lamination, suturing or adhesion.

    摘要翻译： 支架 - 移植物复合管腔内假体包括细长的可径向调节的管状支架，限定相对的外部和内腔支架表面以及至少覆盖至少其外表面的聚合物支架护套。 支架可以包括在相对的外表面和内表面之间延伸的多个开放空间，以允许所述径向可调节性。 支架在其外表面上具有聚合材料，其内表面与支架间隔关系或上述的任何组合。 聚合物优选选自由生物或基因工程的蜘蛛丝组成的聚合物材料，例如衍生自Nephila clavipes的那些。 丝绸包括生物工程蜘蛛丝以及使用人类蛋白质制造的丝状聚合物以及这种丝与常用聚合物接枝材料的混合物。 如果将单独的护套放置在支架的外表面和内表面上，则护套通过所述开放空间彼此固定，例如通过层压，缝合或粘合。

    High strength and lubricious materials for vascular grafts
    65.
    发明申请
    High strength and lubricious materials for vascular grafts 审中-公开
    血管移植物的高强度和光滑材料

    公开(公告)号：US20050085894A1

    公开(公告)日：2005-04-21

    申请号：US10686833

    申请日：2003-10-16

    申请人： James Kershner

    发明人： James Kershner

    IPC分类号： A61L27/00 ,  A61F2/00 ,  A61F2/06 ,  A61F2/84 ,  A61F2/90 ,  A61L27/22 ,  A61L31/00 ,  A61L31/04 ,  C07K14/435

    CPC分类号： A61F2/07 ,  A61F2/89 ,  A61F2/91 ,  A61F2002/075 ,  A61F2250/0039 ,  A61L27/22 ,  A61L31/043

    摘要： A stent-graft fabricated from a high strength and lubricious material provides for a more durable and lower profile endoprosthesis. The stent-graft comprises one or more stent segments covered with a fabric formed by the weaving, knitting or braiding of a biocompatible, high tensile strength, abrasion resistant, highly durable fiber such as spider dragline silk. The one or more stent segments may be balloon expandable or self-expanding. The fabric may be attached to the stent segments utilizing any number of known materials and techniques.

    摘要翻译： 由高强度和光滑的材料制成的支架移植物提供更耐用和更低轮廓的内置假体。 支架移植物包括一个或多个支架段，其覆盖有织物，编织或编织生物相容性，高拉伸强度，耐磨，耐久性高的纤维如蜘蛛丝线丝所形成的织物。 一个或多个支架段可以是气囊扩张的或自膨胀的。 织物可以利用任何数量的已知材料和技术附接到支架段上。

    Collagen/polysaccharide bilayer matrix
    68.
    发明授权
    Collagen/polysaccharide bilayer matrix 失效
    胶原/多糖双层基质

    公开(公告)号：US06773723B1

    公开(公告)日：2004-08-10

    申请号：US09652604

    申请日：2000-08-30

    申请人： Robert C. Spiro ,  Lin Shu Liu

    发明人： Robert C. Spiro ,  Lin Shu Liu

    IPC分类号： A61K31715

    CPC分类号： A61L27/24 ,  A61L27/22 ,  Y10T428/249981 ,  C08L5/08

    摘要： Disclosed are bilayer matrices of a polysaccharide such as collagen (COL) and another polysaccharide such as hyaluronic acid (HA) with various COL/HA ratios. Each layer has a porous structure. These materials are useful for tissue regeneration, particularly when used with orthopedic implants and drug delivery.

    摘要翻译： 公开了具有各种COL / HA比例的多糖例如胶原（COL）和另一种多糖如透明质酸（HA）的双层基质。 每层具有多孔结构。 这些材料可用于组织再生，特别是当与矫形植入物和药物递送一起使用时。

    Soybean-based thermoplastic as biomaterials
    70.
    发明申请
    Soybean-based thermoplastic as biomaterials 审中-公开
    大豆基热塑性塑料作为生物材料

    公开(公告)号：US20040081698A1

    公开(公告)日：2004-04-29

    申请号：US10343555

    申请日：2003-06-09

    发明人： Matteo Santin ,  Luigi Nicolais ,  Luigi Ambrosio

    IPC分类号： A61K007/28 ,  A61K009/14 ,  A61K038/16

    CPC分类号： A61L27/3691 ,  A61L27/22 ,  A61L27/3637 ,  A61L27/3687 ,  A61L31/005 ,  A61L31/043 ,  C08H1/00

    摘要： The invention provides thermoplastic materials for biomedical applications through the processing of soybean de-fatted Tofu cheese. The material films show a relatively high degree of water uptake from the dry state as well as good tensile strength and elastic modulus when tested in wet conditions. The materials minimise in vitro the humoral and cell-mediated inflammatory response, promote the formation of calcium phosphate crystals and undergo a slow degradation in buffer systems. Adhesion and proliferation of tissue cells are favoured by this natural composite material.

    摘要翻译： 本发明通过加工大豆脱脂豆腐干酪提供用于生物医学应用的热塑性材料。 当在湿条件下测试时，材料膜显示出相对较高的干燥状态下的吸水率以及良好的拉伸强度和弹性模量。 这些材料在体外使体液和细胞介导的炎症反应最小化，促进磷酸钙晶体的形成并在缓冲体系中缓慢降解。 这种天然复合材料有利于组织细胞的粘附和增殖。