公开(公告)号：US20140322287A1

公开(公告)日：2014-10-30

申请号：US14263387

申请日：2014-04-28

Applicant: BioInteractions Ltd.

Inventor： Simon Onis ,  Fanny Burrows ,  Krishan Kapoor ,  Alan Rhodes ,  Ajay Luthra

IPC: A61K31/728 ,  A61K47/32 ,  A61K31/131 ,  A61K9/00 ,  A61K31/727 ,  A61K31/14

CPC classification number: A61K31/728 ,  A61K9/0012 ,  A61K31/131 ,  A61K31/14 ,  A61K31/727 ,  A61K47/32 ,  A61L27/16 ,  A61L27/26 ,  A61L27/34 ,  A61L27/54 ,  A61L29/041 ,  A61L29/049 ,  A61L29/085 ,  A61L29/16 ,  A61L31/041 ,  A61L31/048 ,  A61L31/10 ,  A61L31/16 ,  A61L33/0011 ,  A61L33/064 ,  A61L2300/206 ,  A61L2300/208 ,  A61L2300/236 ,  A61L2300/404 ,  A61L2300/42 ,  A61L2300/44 ,  A61L2300/45

Abstract: Antimicrobial and antithrombogenic polymer or polymeric blend, compounds, coatings, and materials containing the same, as well as articles made with, or coated with the same, and methods of making the same exhibiting improved antimicrobial properties and reduced platelet adhesion. Embodiments include polymers with antimicrobial and antithrombogenic groups bound to a single polymer backbone, an antimicrobial polymer blended with an antithrombogenic polymer, and medical devices coated with the antimicrobial and antithrombogenic polymer or polymeric blend.

Abstract translation: 抗微生物和抗血栓形成聚合物或聚合物共混物，化合物，涂料和含有它们的材料，以及用其制备或涂覆的制品以及制备该抗体的方法显示改进的抗微生物性能和降低的血小板粘附。 实施方案包括具有结合单个聚合物主链的抗微生物和抗血栓形成基团的聚合物，与抗血栓形成聚合物共混的抗微生物聚合物，以及用抗微生物剂和抗血栓形成聚合物或聚合物共混物涂覆的医疗器械。

公开(公告)号：US20140290732A1

公开(公告)日：2014-10-02

申请号：US14140391

申请日：2013-12-24

Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE

Inventor： Joanna AIZENBERG ,  Michael AIZENBERG ,  Sung Hoon KANG ,  Tak Sing WONG ,  Philseok KIM

IPC: H01L31/0236 ,  F01D25/18 ,  F28F13/18 ,  B05D3/00

CPC classification number: C09D5/00 ,  A61L15/24 ,  A61L15/34 ,  A61L15/42 ,  A61L15/46 ,  A61L27/28 ,  A61L27/34 ,  A61L27/50 ,  A61L33/0094 ,  A61L33/064 ,  A61L2400/12 ,  B01D69/02 ,  B01D2325/06 ,  B01L3/5027 ,  B01L2300/16 ,  B05D3/002 ,  B05D5/00 ,  B05D5/083 ,  B63B59/04 ,  B64D15/00 ,  B65D25/14 ,  C02F1/44 ,  C09D5/16 ,  C09D5/1656 ,  C09D5/1681 ,  C09D5/1693 ,  C10M105/54 ,  C10M105/56 ,  D06M13/00 ,  E04B1/92 ,  F01D25/02 ,  F01D25/18 ,  F15D1/02 ,  F15D1/10 ,  F16L57/00 ,  F28F13/185 ,  F28F19/02 ,  F28F2245/04 ,  G02B1/14 ,  H01L31/02167 ,  H01L31/0236 ,  Y10T428/24355 ,  Y10T428/24364 ,  C08L27/12

Abstract: The present disclosure describes a strategy to create self-healing, slippery liquid-infused porous surfaces (SLIPS). Roughened (e.g., porous) surfaces can be utilized to lock in place a lubricating fluid, referred to herein as Liquid B to repel a wide range of materials, referred to herein as Object A (Solid A or Liquid A). SLIPS outperforms other conventional surfaces in its capability to repel various simple and complex liquids (water, hydrocarbons, crude oil and blood), maintain low-contact-angle hysteresis (

公开(公告)号：US20140235748A1

公开(公告)日：2014-08-21

申请号：US14237664

申请日：2012-08-10

Applicant: Kazutoshi Haraguchi ,  Kazuomi Kubota ,  Tooru Takehisa ,  Tetsuo Takada ,  Noriko Santou

Inventor： Kazutoshi Haraguchi ,  Kazuomi Kubota ,  Tooru Takehisa ,  Tetsuo Takada ,  Noriko Santou

IPC: A61L33/06

CPC classification number: A61L33/064 ,  A61L33/06 ,  C08F220/56 ,  C08F293/005 ,  C08F2438/03 ,  C09D133/26 ,  C09D153/00 ,  C08F2220/281 ,  C08F220/58

Abstract: The object of the present invention is achieved by providing a copolymer, in particular, a block copolymer which has excellent coating formation ability, adhesive properties to a substrate, and does not adsorb protein; an antithrombotic coating agent which has superior antithrombotic properties and adhesive properties to a substrate to those of the conventional antithrombotic coating agent; and a medical instrument which is obtained by coating the antithrombotic coating agent, and the block copolymer includes a polymer (A) containing a (meth)acrylic ester monomer and a polymer (B) containing a (meth)acrylamide monomer and has excellent coating formation ability and high adhesive properties to a substrate.

Abstract translation: 本发明的目的是通过提供共聚物，特别是具有优异的涂层形成能力，对基材的粘合性能并且不吸附蛋白质的嵌段共聚物来实现的; 一种抗血栓形成剂，其具有优异的抗血栓形成性能和对基质的粘合性能，与常规抗凝血剂的抗凝血性能和粘合性能相当; 以及通过涂布抗血栓形成剂而得到的医疗器械，嵌段共聚物包含含有（甲基）丙烯酸酯单体的聚合物（A）和含有（甲基）丙烯酰胺单体的聚合物（B），并且具有优异的涂布形成 能力和高粘合性能。

公开(公告)号：US20140187666A1

公开(公告)日：2014-07-03

申请号：US13980858

申请日：2012-01-19

Applicant: Joanna Aizenberg ,  Benjamin Hatton ,  Donald Ingber ,  Michael Super ,  Tak Sing Wong

Inventor： Joanna Aizenberg ,  Benjamin Hatton ,  Donald Ingber ,  Michael Super ,  Tak Sing Wong

IPC: C09D5/16

CPC classification number: C09D5/1693 ,  A61L15/24 ,  A61L15/34 ,  A61L15/42 ,  A61L15/46 ,  A61L27/28 ,  A61L27/34 ,  A61L27/50 ,  A61L33/0094 ,  A61L33/064 ,  A61L2400/12 ,  B05D5/083 ,  C09D5/1656 ,  C09D5/1681 ,  F15D1/02 ,  F15D1/10 ,  C08L27/12

Abstract: A self-healing, scratch resistant slippery surface that is manufactured by wicking a chemically-inert, high-density liquid coating over a roughened solid surface featuring micro and nanoscale topographies is described. Such a slippery surface shows anti-wetting properties, as well as exhibits significant reduction of adhesion of a broad range of biological materials, including particles in suspension or solution. Specifically, the slippery surfaces can be applied to medical devices and equipment to effectively repel biological materials such as blood, and prevent, reduce, or delay coagulation and surface-mediated clot formation. Moreover, the slippery surfaces can be used to prevent fouling by microorganisms such as bacteria.

Abstract translation: 描述了通过在具有微观和纳米尺度形貌的粗糙化固体表面上吸收化学惰性，高密度液体涂层制造的自愈合，耐刮擦的光滑表面。 这种光滑表面显示出抗湿润性，并且显示出广泛范围的生物材料（包括悬浮液或溶液中的颗粒）的粘附性的显着降低。 具体地说，滑动表面可以应用于医疗装置和设备以有效地排斥诸如血液的生物材料，并且防止，减少或延迟凝血和表面介导的凝块形成。 此外，光滑表面可用于防止微生物如细菌的结垢。

公开(公告)号：US20130158518A1

公开(公告)日：2013-06-20

申请号：US13715095

申请日：2012-12-14

Applicant: SEMPRUS BIOSCIENCES CORP.

Inventor： Jun LI ,  Zheng ZHANG ,  Douglas WEAVER ,  Eric W. MARCHESE ,  Abby N. DELEAULT ,  Phu C. NGUYEN ,  Kobe ELIAS ,  Chad HUVAL ,  Christopher R. LOOSE

IPC: A61M25/00

CPC classification number: A61M25/0045 ,  A61L29/049 ,  A61L29/085 ,  A61L29/14 ,  A61L29/18 ,  A61L33/0023 ,  A61L33/064 ,  A61L2400/12 ,  A61M25/00 ,  A61M25/0012 ,  A61M2025/0019 ,  A61M2025/0042 ,  A61M2025/0046 ,  A61M2025/0047 ,  A61M2025/0062 ,  Y10T428/1393 ,  C08L75/04 ,  C08L33/04 ,  C08L33/14

Abstract: Catheters and a method for preparation thereof, the catheter comprising as component parts thereof a catheter body, a juncture hub, at least one extension line and at least one connector, each of said component parts comprising an exterior surface, at least one lumen having an intraluminal surface and a bulk polymer, wherein the intraluminal or external surface of a first of said component parts and the exterior or intraluminal surface of a second of said component parts comprise a hydrophilic polymer layer thereon having an Average Dry Thickness of at least about 50 nanometers and the first and second component parts comprise bulk polymers having different chemical compositions

Abstract translation: 导管及其制备方法，所述导管包括导管主体，接合毂，至少一个延伸线和至少一个连接器的组成部分，每个所述部件包括外表面，至少一个内腔具有 腔内表面和体积聚合物，其中所述组分部分中的第一个的管腔内或外表面以及所述组分第二部分的外部或管腔内表面包含其上具有至少约50纳米的平均干燥厚度的亲水性聚合物层 并且第一和第二组分部分包括具有不同化学组成的本体聚合物

公开(公告)号：US20090286435A1

公开(公告)日：2009-11-19

申请号：US11918390

申请日：2006-04-12

Applicant: Jas Pal S. Badyal ,  Declan Oliver H. Teare ,  Wayne C. Schofield

Inventor： Jas Pal S. Badyal ,  Declan Oliver H. Teare ,  Wayne C. Schofield

IPC: B32B9/04 ,  C23C14/34 ,  B05D1/00 ,  B32B27/06 ,  B32B17/06 ,  B32B15/04 ,  B32B29/00 ,  B32B21/04

CPC classification number: A61L33/064 ,  B05D1/62 ,  D06M10/025 ,  D06M10/08 ,  D06M13/224 ,  D06M13/342 ,  D06M14/18 ,  D06M15/233 ,  D06M15/263 ,  D06M15/285 ,  Y10T428/31544 ,  Y10T428/31678 ,  Y10T428/31855 ,  Y10T428/31971 ,  Y10T428/31989 ,  Y10T428/31993 ,  Y10T442/20

Abstract: The invention relates to a method of rendering the surface of a substrate, or at least part of the substrate, to have increased protein resistance. This is achieved by applying an n-substituted glyconic derivative onto the surface of the substrate, or areas or domains of the substrate surface, to allow the pattern resistance to be changed in those areas where the material is applied. In one embodiment the deposition is performed in or in conjunction with a plasma.

Abstract translation: 本发明涉及使底物表面或至少部分底物呈现增加的蛋白质抗性的方法。 这通过将n-取代的glyconic衍生物施加到基底的表面或基底表面的区域或域上来实现，以允许在施加材料的那些区域中改变图案电阻。 在一个实施例中，沉积在等离子体中或结合等离子体进行。

公开(公告)号：US06590054B2

公开(公告)日：2003-07-08

申请号：US09962591

申请日：2001-09-26

Applicant: Masaru Tanaka ,  Shoji Ochiai ,  Norifumi Tokunaga ,  Yukiko Irie

Inventor： Masaru Tanaka ,  Shoji Ochiai ,  Norifumi Tokunaga ,  Yukiko Irie

IPC: C08F22010

CPC classification number: C08F220/28 ,  A61L33/064 ,  C08F2220/281 ,  C08L33/14 ,  C08F220/60 ,  C08F220/34

Abstract: A copolymer comprising a monomer of formula (1) below and a monomer having a basic functional group copolymerizable with the monomer as monomer components, wherein molar ratio of the monomer of formula (1) to the monomer having a basic functional group is 85/15 to 99.9/0.1 and wherein the copolymer has a number based mean molecular weight of 5,000 to 500,000. The copolymer is excellent in antithrombotic activity and further in biocompatibility and can be used as a medial material having high hydrophilicity. It also can serve as an antithrombotic surface treating agent. (wherein R1 is an alkylene group having 1 to 4 carbon atoms, R2 is an alkyl group having 1 to 4 carbon atoms, and R3 represents hydrogen or a methyl group).

Abstract translation: 包含下述式（1）的单体和具有可与单体共聚的碱性官能团的单体作为单体组分的共聚物，其中式（1）的单体与具有碱性官能团的单体的摩尔比为85/15 至99.9 / 0.1，并且其中所述共聚物的数均分子量为5,000至500,000。 该共聚物的抗血栓活性优异，生物相容性更好，可以作为具有高亲水性的内侧材料使用。 也可以作为抗血栓表面处理剂（其中，R 1为碳原子数为1〜4的亚烷基，R 2为碳原子数1〜4的烷基，R 3表示氢或甲基）。

公开(公告)号：US06551267B1

公开(公告)日：2003-04-22

申请号：US09691423

申请日：2000-10-18

Applicant: Richmond R. Cohen ,  Preston Keusch

Inventor： Richmond R. Cohen ,  Preston Keusch

IPC: A61L3300

CPC classification number: B01L3/5082 ,  A61B5/15003 ,  A61B5/150351 ,  A61B5/150389 ,  A61B5/150503 ,  A61B5/150755 ,  A61L33/0064 ,  A61L33/064 ,  C08L39/06

Abstract: A plastic medical article, such as a catheter or blood collection tube, is coated with a crosslinked hydrogel permanently bound to the inside wall of the tube. The hydrophilic surface provided by the hydrogel prevents adherence of blood components to the surface, and the permanent adherence of the hydrogel prevents its removal by blood.

Abstract translation: 诸如导管或采血管的塑料医疗制品涂覆有永久地结合到管的内壁的交联水凝胶。 由水凝胶提供的亲水表面防止血液成分粘附到表面，并且水凝胶的永久粘附防止其被血液除去。

公开(公告)号：US06379368B1

公开(公告)日：2002-04-30

申请号：US09311508

申请日：1999-05-13

Applicant: Michael P. Corcoran ,  Peter M. Buonomo ,  Joseph A. Marino

Inventor： Michael P. Corcoran ,  Peter M. Buonomo ,  Joseph A. Marino

IPC: A61B1700

CPC classification number: A61L31/129 ,  A61B17/0057 ,  A61B17/12122 ,  A61B17/12172 ,  A61B2017/00575 ,  A61B2017/00592 ,  A61B2017/00606 ,  A61B2017/1205 ,  A61L31/146 ,  A61L33/0029 ,  A61L33/007 ,  A61L33/064 ,  A61L2430/36 ,  C08L29/04

Abstract: An occlusion device for the closure of atrial or ventricular septal defects, for the closure of patent ductus arteriosus, patent foramen ovale, or other vascular defects. The occlusion device comprises a center section extending in an axial direction, with upper and lower stranded wire fixation devices emanating from the center section. The stranded wire fixation devices have been heat treated and formed with a shape memory. The stranded wire fixation devices are formed of multiple wire strands and have atraumatic tips. Attached to the fixation devices are heparin treated sheets, which serve to occlude the opening and significantly reduce the occurrence of thrombosis at the device.

Abstract translation: 用于闭合心房或室间隔缺损的闭塞装置，用于闭合动脉导管未闭，卵圆孔卵孔或其他血管缺损。 闭塞装置包括沿轴向方向延伸的中心部分，具有从中心部分发出的上部和下部绞线固定装置。 绞线固定装置已经被热处理并形成形状记忆。 绞线固定装置由多根线股形成，具有无创伤的尖端。 附着于固定装置的是肝素处理片，其用于阻塞开口并显着减少装置处血栓形成的发生。

公开(公告)号：US06294614B1

公开(公告)日：2001-09-25

申请号：US09230535

申请日：1999-01-27

Applicant: Kazunori Kataoka ,  Masao Kato ,  Yukio Nagasaki ,  Hotaka Ito ,  Teiji Tsuruta ,  Yasuhisa Sakurai ,  Teruo Okano ,  Ken Suzuki

Inventor： Kazunori Kataoka ,  Masao Kato ,  Yukio Nagasaki ,  Hotaka Ito ,  Teiji Tsuruta ,  Yasuhisa Sakurai ,  Teruo Okano ,  Ken Suzuki

IPC: C08F2012

CPC classification number: C08F297/026 ,  A61L27/16 ,  A61L27/34 ,  A61L29/085 ,  A61L33/064 ,  C08F265/04 ,  C08F290/06 ,  C08F290/061 ,  C08F291/00 ,  C08F297/02 ,  C08L33/14 ,  C08L51/00

Abstract: Modified polymers containing a poly(2-hydroxyethyl(meth)acrylate) chain as the hydrophilic polymer segment in which a hydrophobic polymer chain or a lipid residue of a sterol is bound to either end of the poly(2-hydroxyethyl(meth)acrylate) chain through a covalent bond or in which the poly(2-hydroxyethyl(meth)acrylate) chain is grafted onto the backbone chain at either end thereof. These modified polymers are excellent in compatibility with liquid or a living body, thus being advantageously usable particularly in medical fields.

Abstract translation: 含有聚（2-羟乙基（甲基）丙烯酸酯）链的改性聚合物作为亲水性聚合物链段，其中疏水性聚合物链或固醇的脂质残基与聚（（甲基）丙烯酸2-羟基乙酯）的任一端结合， 通过共价键或其中聚（2-羟乙基（甲基）丙烯酸酯）链在其任一端接枝到主链上。 这些改性聚合物与液体或活体的相容性优异，因此特别适用于医疗领域。