公开(公告)号：US10071375B2

公开(公告)日：2018-09-11

申请号：US15277889

申请日：2016-09-27

Applicant: International Business Machines Corporation

Inventor： Jaione Tirapu Azpiroz ,  Peter William Bryant ,  Rodrigo Neumann Barros Ferreira ,  Ronaldo Giro ,  Ricardo Luis Ohta

IPC: B01L3/00 ,  B81B1/00 ,  B81C1/00 ,  B81B7/04 ,  F16B1/00

CPC classification number: B01L3/502746 ,  B01L3/502707 ,  B01L3/502715 ,  B01L3/502761 ,  B01L2200/06 ,  B01L2200/0652 ,  B01L2200/0668 ,  B01L2200/12 ,  B01L2300/0645 ,  B01L2300/123 ,  B01L2400/0661 ,  B01L2400/082 ,  B01L2400/086 ,  B81B1/006 ,  B81B2201/058 ,  B81B2203/0361 ,  B81C1/00111 ,  F16B1/0014

Abstract: A microfluidic device, including a substrate including a microchannel, an activation setup disposed in the microchannel, and a matrix array of controllable shape-changing micropillars connected to the activation setup. A shape of the controllable shape-changing micropillars changes based on an activation of the activation setup.

公开(公告)号：US20180250686A2

公开(公告)日：2018-09-06

申请号：US14914917

申请日：2014-08-28

Applicant: University of Washington through its Center for Commercialization

Inventor： Daniel T CHIU ,  Robbyn K. PERDUE ,  Eleanor S. JOHNSON

IPC: B03C5/00 ,  C12N13/00 ,  B01L3/00 ,  G01N27/447 ,  G01N27/27 ,  B03C5/02

CPC classification number: B03C5/005 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502761 ,  B01L2200/06 ,  B01L2200/0647 ,  B01L2200/0668 ,  B01L2300/0816 ,  B01L2300/0861 ,  B01L2300/0864 ,  B01L2300/161 ,  B01L2300/165 ,  B01L2400/0424 ,  B01L2400/0487 ,  B03C5/026 ,  B03C2201/26 ,  C12M33/00 ,  C12M47/04 ,  C12N13/00 ,  G01N15/0612 ,  G01N15/1459 ,  G01N15/1463 ,  G01N27/27 ,  G01N27/44756 ,  G01N35/08 ,  G01N2015/1006 ,  G01N2015/149

Abstract: Methods, systems, and devices for manipulating objects are provided. In certain aspects, the methods, systems, and devices can be used for dielectrophoretic manipulation of objects using bipolar electrodes. Some aspects of the methods, systems, and devices of the present disclosure can be used for encapsulation and amplification of samples.

公开(公告)号：US09975117B2

公开(公告)日：2018-05-22

申请号：US15147132

申请日：2016-05-05

Applicant: Industry-Academic Cooperation Foundation, Yonsei University

Inventor： Taeyoon Lee ,  Jonghyun Ahn ,  Jungmok Seo ,  Seoung Ki Lee

IPC: B01L3/00

CPC classification number: B01L3/502 ,  B01L3/50273 ,  B01L3/502792 ,  B01L3/5088 ,  B01L2200/06 ,  B01L2200/0642 ,  B01L2200/10 ,  B01L2300/123 ,  B01L2400/0457 ,  B01L2400/0475

Abstract: Provided is an apparatus and method for controlling a droplet. The apparatus for controlling the droplet does not contaminate/damage a sample, has a high degree of freedom in droplet control, and is capable of being repeatedly used for a long time. An apparatus (100) for controlling a droplet according to an embodiment includes a flexible substrate (120) having a hydrophobic or oleophobic surface, a dimple formation unit (140), which locally deforms a bottom surface of the flexible substrate (120) to form a dimple, and a driving unit (160), which moves the dimple formation unit (140) at a lower side of the flexible substrate.

公开(公告)号：US20180133714A1

公开(公告)日：2018-05-17

申请号：US15323105

申请日：2015-07-02

Applicant: National Taiwan University

Inventor： Andrew Man Chung Wo ,  Chen-Lin Chen ,  Cheng-Wei Yang ,  Wei-Fan Hsu

IPC: B01L3/00 ,  G01N33/49 ,  G01N1/40

CPC classification number: B01L3/502753 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/567 ,  B01L2200/025 ,  B01L2200/027 ,  B01L2200/04 ,  B01L2200/06 ,  B01L2300/0803 ,  B01L2300/0816 ,  B01L2300/0858 ,  B01L2300/0864 ,  B01L2400/0409 ,  B01L2400/0487 ,  B01L2400/0655 ,  G01N1/4077 ,  G01N33/491 ,  G01N35/00069 ,  G01N2001/4083

Abstract: A sample processing kit including a centrifugal microfluidic component and a collection component detachably fitted into the microfluidic component is provided. Upon the application of the sample processing kit, target molecules or cells may be separated and collected by the collection component for further experimentation.

公开(公告)号：US09968930B2

公开(公告)日：2018-05-15

申请号：US14780262

申请日：2014-03-26

Applicant: SURNETICS, LLC

Inventor： Brian David Babcock

IPC: B01L3/00 ,  G01N3/00 ,  B81C1/00

CPC classification number: B01L3/50273 ,  B01L3/502707 ,  B01L3/502715 ,  B01L3/502746 ,  B01L2200/06 ,  B01L2300/0627 ,  B01L2300/0816 ,  B01L2300/16 ,  B01L2300/161 ,  B01L2400/0406 ,  B01L2400/0493 ,  B01L2400/088 ,  B81B2201/058 ,  B81C1/00206

Abstract: A microfluidic product utilizing gradient surface energy coatings for fluid control comprising a plurality of fluid passages wherein at least one fluid passage comprises a coating configured to control liquid flow wherein the coating configured to control liquid flow comprises a gradient surface energy coating from a proximal location to a distal location on a surface of the fluid passage. The product can include uniform regions and surface gradient regions in the same passage. Coating compositions and product dimensions can be selected to provide control over different flow properties including fluid velocity, reduction and acceleration of fluid flow, and starting and stopping fluid flow.

公开(公告)号：US20180126374A1

公开(公告)日：2018-05-10

申请号：US15572577

申请日：2016-05-06

Applicant: ALPHA DIAGNOSTIC INTERNATIONAL, INC.

Inventor： Masarrat ALI

IPC: B01L3/00 ,  G01N1/40 ,  G01N33/52

CPC classification number: B01L3/5023 ,  B01L2200/06 ,  B01L2200/141 ,  B01L2300/021 ,  B01L2300/069 ,  B01L2300/0825 ,  B01L2400/0406 ,  G01N1/405 ,  G01N21/8483 ,  G01N33/521

Abstract: Provided herein are devices and methods for facile, reliable, quantitative collection and transfer of liquid samples. In particular, the disclosure relates to strip-based systems for the quantitative collection and transfer of biological samples such as proteins, antibodies, DNA, bioanalytical reagents, and chemicals.

公开(公告)号：US20180085755A1

公开(公告)日：2018-03-29

申请号：US15277889

申请日：2016-09-27

Applicant: International Business Machines Corporation

Inventor： Jaione Tirapu Azpiroz ,  Peter William Bryant ,  Rodrigo Neumann Barros Ferreira ,  Ronaldo Giro ,  Ricardo Luis Ohta

IPC: B01L3/00 ,  B81B1/00 ,  B81C1/00

CPC classification number: B01L3/502746 ,  B01L3/502707 ,  B01L3/502715 ,  B01L3/502761 ,  B01L2200/06 ,  B01L2200/0652 ,  B01L2200/0668 ,  B01L2200/12 ,  B01L2300/0645 ,  B01L2300/123 ,  B01L2400/0661 ,  B01L2400/082 ,  B01L2400/086 ,  B81B1/006 ,  B81B2201/058 ,  B81B2203/0361 ,  B81C1/00111 ,  F16B1/0014

Abstract: A microfluidic device, including a substrate including a microchannel, an activation setup disposed in the microchannel, and a matrix array of controllable shape-changing micropillars connected to the activation setup. A shape of the controllable shape-changing micropillars changes based on an activation of the activation setup.

公开(公告)号：US20180021773A1

公开(公告)日：2018-01-25

申请号：US15329069

申请日：2014-07-22

Applicant: Loughborough University

Inventor： Alexander Daniel Edwards ,  Nuno Miguel Fernandes Reis

IPC: B01L3/00 ,  B01L9/00

CPC classification number: B01L3/50273 ,  B01L3/502707 ,  B01L3/502715 ,  B01L9/527 ,  B01L2200/027 ,  B01L2200/06 ,  B01L2200/12 ,  B01L2200/16 ,  B01L2300/0825 ,  B01L2300/0861 ,  B01L2300/161 ,  B01L2300/168 ,  B01L2400/0406 ,  B01L2400/0457 ,  G01N33/552

Abstract: The present invention provides assay devices having a unitary body with an exterior surface, the unitary body being substantially transparent to visible light and formed from a material having a refractive index in the range 1.26 to 1.40, the refractive index being measured at 20° C. with light of wavelength 589 nm, and wherein the unitary body is formed from a hydrophobic material, and at least two capillary bores extending internally along the unitary body, wherein at least a portion of the surface of each capillary bore includes a hydrophilic layer for retaining an assay reagent, and wherein the hydrophilic layer is also substantially transparent to visible light to allow optical interrogation of the capillary bores through the capillary wall. The present invention also provides assay systems including such assay devices, methods of performing an assay using such assay devices and method of method for manufacturing such assay devices.

公开(公告)号：US20170338079A1

公开(公告)日：2017-11-23

申请号：US15600470

申请日：2017-05-19

Applicant: Plasmotica, LLC

Inventor： Nedal Saleh ,  Waqas Khalid ,  Faisal Saleh

IPC: H01J37/32

CPC classification number: H01J37/3233 ,  B01F13/0064 ,  B01J19/0093 ,  B01J2219/00781 ,  B01J2219/00869 ,  B01L3/5023 ,  B01L3/5027 ,  B01L3/502715 ,  B01L3/502753 ,  B01L2200/06 ,  B01L2300/0645 ,  B01L2300/0654 ,  B01L2300/0681 ,  B01L2300/1827 ,  B01L2400/0688 ,  C12Q1/6837 ,  G01N1/38 ,  H01J37/32366 ,  H01J37/3244 ,  H01J37/32733 ,  H01J37/3299 ,  H01J2237/327 ,  H01J2237/334

Abstract: A spatially selective surface functionalization device configured to generate a pattern of micro plasmas and functionalize a substrate surface may include: a pattern management system, a patterning head, and a gas delivery system, wherein the gas delivery system provides a primed gas mixture for forming a plasma between the patterning head and a target substrate below the patterning head. A patterning head may generate a distribution of micro plasmas from individual directed beams of electrons with spatial separation. A pattern management system may store and manipulate information about a pattern of surface functionalization and generate instructions for regulating a distribution of micro plasmas that functionalize a substrate surface.

公开(公告)号：US20170307487A1

公开(公告)日：2017-10-26

申请号：US15196049

申请日：2016-06-29

Applicant: LITE-ON ELECTRONICS (GUANGZHOU) LIMITED ,  Lite-On Technology Corporation

Inventor： Chia-Chun Wei ,  Hung-Wei Chen

IPC: G01N1/38 ,  B01F7/26 ,  B01F15/00 ,  B01L3/00

CPC classification number: G01N1/38 ,  B01F7/26 ,  B01F9/00 ,  B01F9/0018 ,  B01F15/00435 ,  B01F2015/00629 ,  B01F2215/0037 ,  B01L3/502 ,  B01L2200/06 ,  B01L2300/0609 ,  B01L2300/0803 ,  B01L2300/123 ,  B01L2400/0409 ,  B04B5/0407 ,  F16H19/003 ,  F16H35/18 ,  G01N33/49 ,  G01N35/00 ,  G01N2001/386 ,  G01N2035/00495 ,  G01N2035/00524

Abstract: A liquid analyzing device includes a carrier, a driving unit, a rotating plate and a transmission mechanism. The driving unit is adapted to drive the carrier to rotate. The rotating plate is rotatably disposed on the carrier and adapted to support an analyzing cassette. The transmission mechanism is connected between the carrier and the rotating plate. When the driving unit drives the carrier to rotate to enable a rotation speed of the carrier to be changed and cross a predetermined rotation speed, the rotating plate rotates relatively to the carrier.