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    Attenuated FNR deficient enterobacteria
    71.
    发明授权
    Attenuated FNR deficient enterobacteria 有权
    减少FNR缺陷型肠细菌

    公开(公告)号：US08101168B2

    公开(公告)日：2012-01-24

    申请号：US12500366

    申请日：2009-07-09

    申请人： Hosni M. Hassan ,  Ryan C. Fink ,  Matthew R. Evans

    发明人： Hosni M. Hassan ,  Ryan C. Fink ,  Matthew R. Evans

    IPC分类号： A01N63/00 ,  A61K39/112 ,  C12N1/36

    CPC分类号： A61K39/0258 ,  A61K39/0275 ,  A61K2039/522 ,  Y02A50/474 ,  Y02A50/482

    摘要： The invention provides an attenuated enterobacterium comprising an attenuating mutation in the fnr gene, and optionally further comprising a heterologous nucleic acid encoding a foreign antigen. Also provided are pharmaceutical formulations comprising the attenuated enterobacteria of the invention. Further disclosed are methods of inducing an immune response in a subject by administration of an immunogenically effective amount of an attenuated enterobacterium or pharmaceutical formulation of the invention.

    摘要翻译： 本发明提供了一种减毒的肠杆菌，其包含fn基因中的减毒突变，并任选地还包含编码外源抗原的异源核酸。 还提供了包含本发明的减毒肠杆菌的药物制剂。 进一步公开的是通过施用免疫原性有效量的本发明的减毒的肠杆菌或药物制剂在受试者中诱导免疫应答的方法。

    Edible Vaccines Expressed in Soybeans
    74.
    发明申请
    Edible Vaccines Expressed in Soybeans 审中-公开
    在大豆中表达的食用疫苗

    公开(公告)号：US20110135685A1

    公开(公告)日：2011-06-09

    申请号：US12692722

    申请日：2010-01-25

    申请人： Kenneth John Piller ,  Kenneth Lee Bost

    发明人： Kenneth John Piller ,  Kenneth Lee Bost

    IPC分类号： A61K39/108 ,  A61K39/07 ,  A61K39/08 ,  A61K39/245 ,  A61K39/285 ,  A61K39/12 ,  A61K39/21 ,  A61K39/215 ,  A61P31/04 ,  A61P31/18 ,  A61P31/22 ,  A61P31/14

    CPC分类号： C12N15/8258 ,  A61K39/0005 ,  A61K39/02 ,  A61K39/0258 ,  A61K39/35 ,  A61K2039/517 ,  A61K2039/55544 ,  C12N2710/00088 ,  Y02A50/469 ,  Y02A50/474

    摘要： The present invention relates to vaccines that are made in transgenic soybeans for use in humans, animals of agricultural importance, pets, and wildlife. These vaccines are used as vaccines against viral, bacterial, fungal, parasitic or prion related diseases, cancer antigens, toxins, and autologous or self proteins. The transgenic soybeans of the instant invention also can be used for inducing tolerance to allergens or tolerance to autoimmune antigens, wherein an individual shows hypersensitivity to said allergen or has developed autoimmunity to autologous or self proteins, respectively. The invention also relates to prophylactically treating individuals and/or populations prior to showing hypersensitivity to allergens. Other aspects of the invention include using the transgenic soybeans as an oral contraceptive, and the expression of protein adjuvants in transgenic soybeans.

    摘要翻译： 本发明涉及用于人类的转基因大豆，具有农业重要性的动物，宠物和野生动物的疫苗。 这些疫苗用作抗病毒，细菌，真菌，寄生或朊病毒相关疾病，癌症抗原，毒素和自体或自身蛋白的疫苗。 本发明的转基因大豆还可用于诱导对变应原的耐受性或对自身免疫抗原的耐受性，其中个体对所述变应原显示过敏反应或分别对自体或自身蛋白产生自身免疫性。 本发明还涉及在对过敏原显示过敏之前预防性地治疗个体和/或群体。 本发明的其它方面包括使用转基因大豆作为口服避孕药，以及在转基因大豆中表达蛋白佐剂。

    COMPOSITIONS PRODUCED USING ENTERIC PATHOGENS AND METHODS OF USE
    80.
    发明申请
    COMPOSITIONS PRODUCED USING ENTERIC PATHOGENS AND METHODS OF USE 有权
    使用Enteric PATHOGENS生产的组合物和使用方法

    公开(公告)号：US20100111903A1

    公开(公告)日：2010-05-06

    申请号：US12269636

    申请日：2008-11-12

    申请人： Daryll A. Emery ,  Darren E. Straub ,  Laura Wonderling

    发明人： Daryll A. Emery ,  Darren E. Straub ,  Laura Wonderling

    IPC分类号： A61K35/66 ,  A61K38/00

    CPC分类号： A61K39/0258 ,  A61K39/0275 ,  A61K39/105 ,  A61K2039/54 ,  A61K2039/542 ,  A61K2039/545 ,  A61K2039/55 ,  A61K2039/552 ,  C07K14/205 ,  C07K14/245 ,  C07K14/255 ,  Y10S530/825

    摘要： The present invention provides compositions including polypeptides having the characteristics of polypeptides expressed by a reference microbe such E coli or Salmonella. Examples of Salmonella strains that can be used include, for instance, S. enterica serovar Newport, S. enterica serovar Enteritidis, S. enterica serovar Typhimurium, and S. enterica serovar Dublin. Also provided are compositions including polypeptides having a particular molecular weight and a mass fingerprint that includes polypeptide fragments having a particular set of masses, or polypeptides having an amino acid sequence with at least about 95% identity with an amino acid sequence, wherein the polypeptide has seroreactive activity. The present invention also provides methods of making and methods of using such compositions.

    摘要翻译： 本发明提供包含具有由参考微生物如大肠杆菌或沙门氏菌表达的多肽特征的多肽的组合物。 可以使用的沙门氏菌属菌株的实例包括例如肠杆菌血清型Newport，肠杆菌肠炎沙门氏菌，肠炎沙门氏菌血清型鼠伤寒沙门氏菌和肠溶肠炎血清型都柏林。 还提供了包括具有特定分子量的多肽和包括具有特定质量组的多肽片段的质量指纹的组合物，或具有与氨基酸序列具有至少约95％同一性的氨基酸序列的多肽，其中所述多肽具有 血清活性。 本发明还提供了制备方法和使用这些组合物的方法。