利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

158 条记录 (耗时 0.03 秒)

    Retinal prosthesis
    81.
    发明申请
    Retinal prosthesis 有权
    视网膜假体

    公开(公告)号：US20070270919A1

    公开(公告)日：2007-11-22

    申请号：US11880009

    申请日：2007-07-19

    申请人： Robert Greenberg ,  Neil Talbot ,  Brian Mech ,  James Little

    发明人： Robert Greenberg ,  Neil Talbot ,  Brian Mech ,  James Little

    IPC分类号： A61N1/05

    CPC分类号： A61N1/0543 ,  A61N1/36046

    摘要： The invention is a retinal prosthesis with an improved configuration mounting necessary components within and surrounding the eye. The present invention better allows for the implantation of electronics within the delicate eye structure. The invention further limits the necessary width of a thin film conductor passing through the sclera by use of a multiplexer external to the sclera and a demultiplexer internal to the sclera.

    摘要翻译： 本发明是具有改进的构造的视网膜假体，其将眼睛内部和周围的必要部件安装。 本发明更好地允许在精细的眼睛结构内植入电子装置。 本发明通过使用巩膜外部的多路复用器和巩膜内部的解复用器进一步限制穿过巩膜的薄膜导体的必要宽度。

    Surgical tool for electrode implantation
    84.
    发明申请
    Surgical tool for electrode implantation 有权
    电极植入手术工具

    公开(公告)号：US20070093852A1

    公开(公告)日：2007-04-26

    申请号：US10627260

    申请日：2003-07-24

    申请人： Robert Greenberg ,  Da-Yu Chang

    发明人： Robert Greenberg ,  Da-Yu Chang

    IPC分类号： A61B19/00

    CPC分类号： A61F9/08

    摘要： The present invention is a surgical tool for implanting an electrode array and its connected cable within an orbital socket. The insertion tool is used to aid the surgeon in pulling the electrode wire and array through the scull, four-rectus muscles of the eye, and the sclera. The insertion tool consists of a medical grade ABS material that is commonly used in various medical products.

    摘要翻译： 本发明是用于将电极阵列及其连接的电缆注入轨道插座内的手术工具。 插入工具用于帮助外科医生拉动电极线和阵列穿过杓状物，眼睛的四直肌和巩膜。 插入工具由通常用于各种医疗产品的医疗级ABS材料组成。

    Sub-threshold stimulation to precondition neurons for supra-threshold stimulation
    85.
    发明申请
    Sub-threshold stimulation to precondition neurons for supra-threshold stimulation 有权
    用于超临界刺激的预处理神经元的亚阈值刺激

    公开(公告)号：US20070078496A1

    公开(公告)日：2007-04-05

    申请号：US11523897

    申请日：2006-09-19

    申请人： Robert Greenberg ,  Matthew McMahon

    发明人： Robert Greenberg ,  Matthew McMahon

    IPC分类号： A61N1/00

    CPC分类号： A61N1/36046 ,  A61N1/0543

    摘要： In order to generate the smallest phosphenes possible, it is advantageous to selectively stimulate smaller cells. By hyperpolarizing the somas of the large cells selectively with sub-threshold anodic ‘pre-pulse’ stimuli (making them more difficult to stimulate) and then selectively depolarize the smaller cells one can selectively stimulate smaller cells. Alternatively, one can hyperpolarize the dendrites of the cells with larger dendritic fields by applying sub-threshold anodic currents on surrounding electrodes and then depolarizing the smaller cells in the center. Further, one can manipulate the phases of an individual biphasic wave to affect selective stimulation resulting in more focal responses. It is possible to increase resolution with the ‘pre-pulse’ described above. One can also effect resolution by modifying the pulse order of the cathodic and anodic phases. Further, one can isolate the effect of the phases by separating them in time (long inter-phase interval) or by making one of the phases long and low amplitude—always keeping equal total charge for the two phases. As an example, one can preferentially stimulate smaller ganglion cells by providing a longer sub-threshold anodic pulse balanced with a shorter supra-threshold cathodic pulse. Preferentially stimulating the smaller ganglion cells will allow stimulation of different brightness levels while maintaining high spatial resolution.

    摘要翻译： 为了产生可能的最小磷光体，有利的是选择性地刺激较小的细胞。 通过使用亚阈值阳极“预脉冲”刺激（使它们更难刺激）选择性地超极化大细胞的体细胞，然后选择性去极化较小的细胞，可以选择性地刺激较小的细胞。 或者，可以通过在周围电极上施加亚阈值阳极电流然后使中心的较小细胞去极化来超极化具有较大树枝状场的细胞的树突。 此外，人们可以操纵单个双相波的相位以影响选择性刺激，导致更多的局部反应。 可以用上述'预脉冲'来提高分辨率。 也可以通过改变阴极和阳极相的脉冲顺序来影响分辨率。 此外，可以通过在时间上（长的相间间隔）将它们分离，或者通过使相位中的一个长和低振幅 - 总是保持两相的总电荷来隔离相的影响。 作为示例，可以通过提供用较短的超阈值阴极脉冲平衡的较长的亚阈值阳极脉冲来优先地刺激较小的神经节细胞。 优先刺激较小的神经节细胞将允许刺激不同的亮度水平，同时保持高的空间分辨率。

    Trans-retinal flexible circuit electrode array
    87.
    发明申请
    Trans-retinal flexible circuit electrode array 有权
    视网膜软电路电极阵列

    公开(公告)号：US20070049987A1

    公开(公告)日：2007-03-01

    申请号：US11521281

    申请日：2006-09-13

    申请人： Robert Greenberg ,  Mark Humayun

    发明人： Robert Greenberg ,  Mark Humayun

    IPC分类号： A61N1/36

    CPC分类号： A61N1/36046 ,  A61F9/08 ,  A61N1/0543 ,  H05K1/028 ,  H05K1/0281 ,  H05K1/118 ,  H05K3/28 ,  H05K2201/0133

    摘要： Applicant has proposed a combination of the subretinal and epiretinal methods by placing the electronics external to the eye, entering the eye through the pars plana and the piercing the retina (retinotomy) from inside the eye to stimulate subreintally. The present invention is an improved electrode array for subretinal stimulation. A hard polymer such as polyimide is biocompatible and strong for supporting an electrode array and supporting traces in a thin flex circuit array. In the present invention applicant takes advantage of the sharp nature of thin polyimide making a point on the end of the electrode array. This allows the flexible circuit electrode array to be both electrode array and surgical tool to cut the retinal and slide the array under the retina in a single action.

    摘要翻译： 申请人提出了通过将眼睛外部电子放置在眼睛的外部并通过平面进入眼睛并从眼睛刺穿视网膜（视网膜切开术）以刺激眼底的方式来组合视网膜下和视网膜的方法。 本发明是用于视网膜下刺激的改进的电极阵列。 诸如聚酰亚胺之类的硬聚合物是生物相容性强的，用于支撑电极阵列和支撑在薄柔性电路阵列中的迹线。 在本发明中，申请人利用薄聚酰亚胺的尖锐特性，在电极阵列的末端形成点。 这使得柔性电路电极阵列既可以是电极阵列，也可以是手术工具，以切割视网膜，并在阵列下方以单一动作滑动阵列。

    Pixel re-mapping for visual prosthesis
    88.
    发明申请
    Pixel re-mapping for visual prosthesis 有权

    公开(公告)号：US20070027503A1

    公开(公告)日：2007-02-01

    申请号：US11493471

    申请日：2006-07-25

    申请人： Robert Greenberg ,  Richard Williamson

    发明人： Robert Greenberg ,  Richard Williamson

    IPC分类号： A61F2/16

    CPC分类号： A61N1/36046

    摘要： A method and apparatus for adjusting a visual image provided to a patient. In one embodiment, an image may be presented to the patient to obtain the patient's subjective perception of the image, and the patient may either manipulate the image to obtain a desired adjustment, or guide a clinician performing the adjustment. In another embodiment, the clinician may make objective observations of, for example, the position of an electrode array on the patient's retina, and make adjustments accordingly. The adjustment may be a spatial adjustment comprising a re-mapping performed to decreases image distortion resulting from differences in the patient's perception of stimulation of different areas of the retina. Such distortion may result from differences between the patient's perception of stimulation falling within the macula, and stimulation falling within the periphery surrounding the macula. The adjustment may also compensate for translations or rotations of the electrode array on the retina.

    Flexible circuit electrode array
    90.
    发明申请
    Flexible circuit electrode array 有权

    公开(公告)号：US20060247754A1

    公开(公告)日：2006-11-02

    申请号：US11207644

    申请日：2005-08-19

    申请人： Robert Greenberg ,  Neil Talbot ,  Jordan Neysmith ,  Dilek Guven ,  James Little ,  Brian Mech ,  Mark Humayun

    发明人： Robert Greenberg ,  Neil Talbot ,  Jordan Neysmith ,  Dilek Guven ,  James Little ,  Brian Mech ,  Mark Humayun

    IPC分类号： A61N1/05

    CPC分类号： H05K3/0011 ,  A61N1/0541 ,  A61N1/0543 ,  A61N1/36036 ,  A61N1/36046 ,  Y10T29/49124

    摘要： Polymer materials are useful as electrode array bodies for neural stimulation. They are particularly useful for retinal stimulation to create artificial vision, cochlear stimulation to create artificial hearing, or cortical stimulation many purposes. The pressure applied against the retina, or other neural tissue, by an electrode array is critical. Too little pressure causes increased electrical resistance, along with electric field dispersion. Too much pressure may block blood flow. Common flexible circuit fabrication techniques generally require that a flexible circuit electrode array be made flat. Since neural tissue is almost never flat, a flat array will necessarily apply uneven pressure. Further, the edges of a flexible circuit polymer array may be sharp and cut the delicate neural tissue. By applying the right amount of heat to a completed array, a curve can be induced. With a thermoplastic polymer it may be further advantageous to repeatedly heat the flexible circuit in multiple molds, each with a decreasing radius. Further, it is advantageous to add material along the edges. It is further advantageous to provide a fold or twist in the flexible circuit array. Additional material may be added inside and outside the fold to promote a good seal with tissue.