公开(公告)号：US20180333863A1

公开(公告)日：2018-11-22

申请号：US16052374

申请日：2018-08-01

Applicant: TECAN TRADING AG

Inventor： STEFAN BUCHLOH ,  Thomas ITEN ,  Sara FERDI ,  Nico BIRKNER

IPC: B25J15/00 ,  G01N35/00 ,  G01N35/10 ,  B25J15/06

CPC classification number: B25J15/0047 ,  B25J15/0052 ,  B25J15/008 ,  B25J15/0608 ,  G01N35/0099 ,  G01N35/10 ,  G01N2035/103 ,  G01N2035/1051

Abstract: A transport tool for transporting a laboratory article using a pipette of a pipetting system and having a plug-in sleeve at a top end, an article holder at a bottom end, and a connecting part which connects the plug-in sleeve to the article holder. The plug-in sleeve has a side sleeve wall and a bottom which surround an interior space of the plug-in sleeve having a cylindrical and conically tapering shape. The plug-in sleeve further has an upward-facing opening for receiving an end of a pipette of an automated pipetting system. The connecting part has a top surface which defines the bottom of the plug-in sleeve, is positioned between the interior space of the plug-in sleeve and the article holder. The article holder has a holding plate which is flat and faces downward away from the plug-in sleeve, and further has a flatly acting magnet on the holding plate.

公开(公告)号：US20180313683A1

公开(公告)日：2018-11-01

申请号：US15768711

申请日：2016-09-22

Applicant: TECAN TRADING AG

Inventor： WERNER HINN ,  Lars KAMM ,  David KRESS

IPC: G01F23/26

CPC classification number: G01F23/26 ,  G01F23/266 ,  G01N35/1009 ,  G01N2035/1025

Abstract: The invention relates to a device (100) having multiple capacitively working channels, wherein the device (100) comprises a advancable sensor (3.1, 3.2) and a fluid container per channel. The device (100) also comprises a generator (G) for providing a periodic input signal (s,in(t)). In addition, the device (100) comprises one compensation circuit (CT.1, CT.2) per channel, which can be supplied with the periodic input signal (Sin(t)) and which is designed to provide an input signal (Sin1(t), Sin2(t)) at a first output (A.1, A.2) for applying to the sensor (3.1, 3.2) of the channel, wherein the compensation circuit (CT.1, CT.2) comprises a further output (6.1, 6.2) which is designed to provide a signal (s1(t), s2(t)) that can be evaluated to detect a phase boundary.

公开(公告)号：US20180214862A1

公开(公告)日：2018-08-02

申请号：US15420693

申请日：2017-01-31

Applicant: TECAN Trading AG

Inventor： Michael HORSLEY ,  Kevin TRUEMPI ,  Sukesh GOPINATHAN

IPC: B01L3/02 ,  G01N35/00 ,  G01N1/14

CPC classification number: B01L3/0237 ,  B01L2200/143 ,  B01L2300/0627 ,  G01N1/14 ,  G01N11/08 ,  G01N35/00623 ,  G01N35/1016 ,  G01N2001/1418

Abstract: Aspiration of a pipette arrangement is initiated. A sensor arrangement senses a least one prevailing first parameter that is dependent from the effect in the pipette arrangement during initiating and upholding the suctioning action. This at least one parameter is analyzed in an analyzing stage. From a result of this analysis and in a determining stage at least one test criterium TC for at least one further parameter as sensed by the sensor arrangement is determined. In a checking stage there is checked whether this further parameter fulfills the at least one test criterium.

公开(公告)号：US09964556B2

公开(公告)日：2018-05-08

申请号：US14654382

申请日：2014-10-30

Applicant: TECAN TRADING AG

Inventor： Gyoergy Wenczel ,  Harald Gebetsroither ,  Friedrich Menges

IPC: G01N35/02 ,  C12M1/34 ,  B01L9/00 ,  C12M1/32 ,  C12M1/00 ,  G01N35/04 ,  G01N35/00

CPC classification number: G01N35/028 ,  B01L9/523 ,  B01L2200/142 ,  B01L2300/041 ,  B01L2300/0829 ,  C12M23/12 ,  C12M23/38 ,  G01N35/04 ,  G01N2035/00356 ,  G01N2035/0403 ,  G01N2035/0477

Abstract: Microplate reader has measuring space, action source, measuring device for biological structure signals of microplate wells, transport support for positioning wells in relation to an optical axis of the device and controller for the action source, the measuring device and the transport support. An incubation apparatus with a frame accommodates a microplate with wells having bottoms for reducing liquid evaporation. The frame has a first opening surrounded by an inner wall for the microplate and an outer wall parallel to the inner wall and connected thereto by an intermediate bottom so that a channel is formed and the intermediate bottom for accommodating a liquid adjusted to the content of the microplate wells. The incubation apparatus has a support surface with a second opening for a microplate and, as a result, at least a portion of the well bottoms is freely accessible by the second opening.

公开(公告)号：US09784711B2

公开(公告)日：2017-10-10

申请号：US14402717

申请日：2014-01-06

Applicant: TECAN TRADING AG

Inventor： Daniel Hoffmeyer ,  Tiffany Lay ,  Travis Lee ,  Marc N. Feiglin ,  Werner Halg ,  Anne R. Kopf-Sill

IPC: G01N27/447 ,  B01L3/00 ,  B81B1/00

CPC classification number: G01N27/44791 ,  B01L3/502715 ,  B01L3/502792 ,  B01L3/505 ,  B01L2200/027 ,  B01L2200/04 ,  B01L2300/044 ,  B01L2300/123 ,  B01L2400/0427 ,  B81B1/00 ,  G01N27/44756

Abstract: A disposable cartridge used in a digital microfluidics system has a bottom layer with first hydrophobic surface, a rigid cover plate with second hydrophobic surface, and a gap there-between. The bottom layer is a flexible film on an uppermost surface of a cartridge accommodation site of a system, attracted to and spread over the uppermost surface by an underpressure. A lower surface of the plate and the flexible bottom layer are sealed to each other. The assembled cartridge is removed from the cartridge accommodation site in one piece and potentially includes samples and processing fluids. The system has a base unit and a cartridge accommodation site with an electrode array of individual electrodes and a central control unit for controlling selection of individual electrodes and for providing these electrodes with individual voltage pulses for manipulating liquid droplets within the gap by electrowetting.

公开(公告)号：US20170113224A1

公开(公告)日：2017-04-27

申请号：US15398518

申请日：2017-01-04

Applicant: TECAN TRADING AG

Inventor： Marc N. FEIGLIN

IPC: B01L3/00 ,  G01N27/447 ,  C12Q1/68 ,  B01F13/00 ,  B01L3/02 ,  B01L7/00

CPC classification number: B01L3/502792 ,  B01F13/0071 ,  B01F13/0076 ,  B01F2215/0037 ,  B01L3/0268 ,  B01L3/502715 ,  B01L3/527 ,  B01L7/525 ,  B01L2200/027 ,  B01L2200/0605 ,  B01L2200/10 ,  B01L2200/16 ,  B01L2300/0636 ,  B01L2300/0819 ,  B01L2300/1822 ,  B01L2300/1883 ,  B01L2400/0409 ,  B01L2400/0415 ,  B01L2400/0427 ,  B01L2400/0475 ,  C12Q1/686 ,  G01N27/447 ,  G01N27/44756 ,  G01N27/453 ,  C12Q2563/143 ,  C12Q2563/149 ,  C12Q2563/159

Abstract: A cartridge has a container with at least one well, protrusions distributed on the container base side, and a flat polymer film having a lower surface and a hydrophobic upper surface kept at a distance (d) to the container base side by the protrusions. The container and the film are reversibly attachable to a liquid droplet manipulation instrument so that the lower surface of the film abuts at least one electrode array of the instrument. The container enables displacement of at least one liquid droplet from a well onto the hydrophobic upper surface of the flat polymer film and above the electrode array. The liquid droplet manipulation instrument comprises a control unit with a voltage control and an electrode selector for individually selecting each electrode of the electrode array and for providing the selected electrode with a voltage and thus controlling a guided movement of a liquid droplet on the hydrophobic upper surface of the flat polymer film by electrowetting. Also disclosed are a corresponding kit and method.

公开(公告)号：US09578959B2

公开(公告)日：2017-02-28

申请号：US14739745

申请日：2015-06-15

Applicant: TECAN Trading AG

Inventor： Claudio Isgrò ,  Theo Meier ,  Dominic Erb ,  Beat Bolli

IPC: A47B13/00 ,  A47B13/08 ,  F16B1/00 ,  B01L9/02 ,  A47B37/00 ,  G01N35/00

CPC classification number: A47B13/088 ,  A47B2037/005 ,  B01L9/02 ,  B01L2200/025 ,  B01L2200/028 ,  B01L2300/0829 ,  F16B1/00 ,  F16B2001/0035 ,  G01N2035/00306

Abstract: Laboratory table with front and opposite rear frame parts, has replaceable tabletop elements positionable thereon. In a first variant, the laboratory table further has detent openings at regular distances on the front and/or rear frame parts, defining a modular grid. Each opening can receive a detent bolt of a modular tabletop element, each element having at least two detent bolts for the insertion into one of the detent openings. In a second variant, each tabletop element has at least one detent opening on a front and/or rear side of the tabletop element, for insertion of a detent bolt. The front and/or rear frame part of the laboratory table have detent bolts arranged at a regular distance defining a modular grid, each one of the detent bolts being for insertion into one of the detent openings of the tabletop elements positioned on these front and rear frame parts.

Abstract translation: 具有前后相框部件的实验台，具有可置换的桌面元件。 在第一种变型中，实验台在前部和/或后部框架部分进一步具有规则距离的定位开口，限定了模块化网格。 每个开口可以容纳模块化桌面元件的止动螺栓，每个元件具有至少两个用于插入其中一个止动开口的止动螺栓。 在第二种变型中，每个桌面元件在桌面元件的前侧和/或后侧具有至少一个止动开口，用于插入止动螺栓。 实验台的前部和/或后部框架部分具有以规定距离布置的定位螺栓，限定了模块化格栅，每个止动螺栓用于插入位于这些前后的桌面元件的止动开口之一 框架部件。

公开(公告)号：US09488576B2

公开(公告)日：2016-11-08

申请号：US14794394

申请日：2015-07-08

Applicant: TECAN TRADING AG

Inventor： Torleif Ove Bjornson ,  Thomas Geiges

IPC: G01N21/17 ,  G01N21/03 ,  G01N21/13 ,  G01N21/64 ,  G01N21/59 ,  G01N35/00 ,  C12Q1/68 ,  G01N21/33 ,  G01N21/01 ,  B01L3/02 ,  G01N21/85 ,  G01N35/10

CPC classification number: G01N21/59 ,  B01L3/021 ,  B01L3/0241 ,  G01N21/01 ,  G01N21/17 ,  G01N21/33 ,  G01N21/64 ,  G01N21/645 ,  G01N21/6486 ,  G01N35/1009 ,  G01N2021/0162 ,  G01N2021/0314 ,  G01N2021/035 ,  G01N2021/8564 ,  G01N2035/1046 ,  G01N2035/1062 ,  G01N2201/0612 ,  G01N2201/062 ,  G01N2201/08 ,  Y10T436/11 ,  Y10T436/119163 ,  Y10T436/143333 ,  Y10T436/2575

Abstract: Optical measuring apparatus for analysis of samples contained in liquid drops includes a liquid handling system with at least one liquid handling tip. The apparatus has a light source for irradiating the drop, a detector for measuring sample light, an optics system with first optical elements for transmitting irradiation light, and a processor for processing measurement signals. The drop is suspended at the liquid handling orifice of the tip in a position where the drop is penetrated by a first optical axis defined by the light source and the first optical elements. The drop is physically touched only by the liquid handling tip and the liquid sample inside the tip. The tip is attached to a robot arm which adjusts the position of the liquid drop with respect to at least one optical element of the optics system.

Abstract translation: 用于分析包含在液滴中的样品的光学测量装置包括具有至少一个液体处理尖端的液体处理系统。 该装置具有用于照射液滴的光源，用于测量样品光的检测器，具有用于发射照射光的第一光学元件的光学系统和用于处理测量信号的处理器。 液滴悬挂在尖端的液体处理孔处，其中液滴被由光源和第一光学元件限定的第一光轴穿透。 该液滴仅由液体处理尖端和尖端内部的液体样品物理接触。 尖端附接到机器人臂，其相对于光学系统的至少一个光学元件调节液滴的位置。

公开(公告)号：US20160023210A1

公开(公告)日：2016-01-28

申请号：US14842339

申请日：2015-09-01

Applicant: TECAN TRADING AG

Inventor： Nico Birkner ,  Thomas Iten ,  Marina Knoppke ,  Markus Wiggli

IPC: B01L3/00 ,  F16K1/32 ,  F16K21/04

CPC classification number: B01L3/523 ,  B01L3/502 ,  B01L3/502738 ,  B01L3/508 ,  B01L3/50825 ,  B01L2300/04 ,  B01L2300/044 ,  B01L2300/049 ,  F16K1/32 ,  F16K21/04

Abstract: An inlet valve charges an inner chamber with liquid and has a first axis and an inlet opening with a tool that automatically recloses. The inlet valve has a valve body with a blocking element, and a pressing part; a valve space enclosing the valve body at least partly; a spring mechanism and a sealing element. An open passage region opens into the liquid passage of the pressing part and into the valve space. The spring mechanism presses a sealing surface of the blocking element against the sealing element in a closed position of the valve body. The valve body of the inlet valve can be brought to an open position by pressing the pressing part against the resistance of the spring mechanism. Chamber systems and sample containers with such inlet valves are also disclosed.

Abstract translation: 入口阀用液体对内腔充电，并且具有第一轴线和具有自动重合闸的工具的入口开口。 入口阀具有带有阻塞元件的阀体和按压部分; 至少部分地封闭阀体的阀门空间; 弹簧机构和密封元件。 开放的通道区域通向按压部分的液体通道并进入阀门空间。 弹簧机构在阀体的关闭位置将阻塞元件的密封表面压靠密封元件。 通过按压按压部件抵抗弹簧机构的阻力，可以使进气阀的阀体进入打开位置。 还公开了具有这种入口阀的室系统和样品容器。

公开(公告)号：US20160018429A1

公开(公告)日：2016-01-21

申请号：US14870673

申请日：2015-09-30

Applicant: TECAN Trading AG

Inventor： Florian REINER ,  Harald GEBETHSROITHER ,  Josef GRASSL

IPC: G01N35/02 ,  G01N21/25 ,  G01N21/64

CPC classification number: G01N35/028 ,  B01L9/52 ,  C12M1/04 ,  C12M41/14 ,  C12M41/16 ,  C12Q1/02 ,  G01J3/12 ,  G01N21/253 ,  G01N21/6452 ,  G01N33/5005 ,  G01N2035/00356 ,  G01N2201/023 ,  G01N2201/0231 ,  G01N2201/0238 ,  G01N2201/0446 ,  G01N2201/06113

Abstract: The invention relates to a microplate reader and a respective method, wherein the microplate reader comprises at least one measuring device and a holding device for accommodating at least one microplate and for positioning the samples-containing wells of this(these) microplate(s) in relation to the at least one measuring device. The at least one measuring device is used for detecting light which is emitted by samples in wells of a microplate inserted in this microplate reader and/or which is influenced by samples transilluminated by light in wells of a microplate inserted in this microplate reader. The microplate reader comprises a control unit for controlling the temperature of a gas atmosphere surrounding the wells containing the samples of microplates used in this microplate reader.

Abstract translation: 本发明涉及一种酶标仪和相应的方法，其中该酶标仪包括至少一个测量装置和用于容纳至少一个微孔板的保持装置，并将该（微）微孔板的含样品的孔定位在 与至少一个测量装置的关系。 所述至少一个测量装置用于检测由插入该酶标板读数器中的微孔板的孔中的样品发出的光，和/或由插入该酶标板读数器中的微板的孔中的光透过的样品影响。 酶标仪包括用于控制包含在该酶标板读数器中使用的微孔板样品的孔周围的气体气氛的温度的控制单元。