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    Gas control in a reactor
    2.
    发明申请
    Gas control in a reactor 审中-公开
    反应堆中的气体控制

    公开(公告)号：US20050271560A1

    公开(公告)日：2005-12-08

    申请号：US11147415

    申请日：2005-06-07

    Applicant: Seth Rodgers ,  A. Russo ,  Timothy Johnston ,  Sean LeBlanc

    Inventor： Seth Rodgers ,  A. Russo ,  Timothy Johnston ,  Sean LeBlanc

    IPC: B01J19/00 ,  B01L3/00 ,  C12M20060101

    CPC classification number: B01J19/0093 ,  B01J2219/00837 ,  B01J2219/00862 ,  B01J2219/00869 ,  B01J2219/00907 ,  B01J2219/00952 ,  B01J2219/00963 ,  B01J2219/0097 ,  B01L3/5025 ,  B01L3/502715 ,  B01L3/502746 ,  B01L2200/027 ,  B01L2200/0668 ,  B01L2200/0684 ,  B01L2300/0816 ,  B01L2300/0825 ,  B01L2300/0877 ,  B01L2300/0887 ,  B01L2300/10 ,  B01L2400/0457 ,  B01L2400/0688 ,  B01L2400/086

    Abstract: Chemical, biological, and/or biochemical reaction systems, including chips or reactors, may be configured so as to restrain immiscible materials such as gas bubbles from interfering with the determination of environmental factors associated with the chip according to one aspect of the invention. In another aspect, a chip or other reaction system may be configured to maintain a gas headspace in the chip or other reaction system. In certain embodiments, impediments such as physical barriers may be used to contain gas bubbles within a gas containing region, or otherwise away from a detection region. In other embodiments, surface tension properties may be used to control the location of gas bubbles. The chip or other reaction systems may include reaction site containers that can be very small, for example, having a volume of less than about 2 ml. In certain embodiments, chips or other reaction systems of the invention include one or more reaction sites, which, in some cases, may be defined by reaction site containers. According to another aspect of the invention, a reaction site container may be shaped to limit the formation of gas bubbles during the filling of the reaction site container with liquid by providing reaction site container shapes that do not include sharp angles or abrupt changes in reaction site container width.

    Abstract translation: 包括芯片或反应器的化学，生物和/或生物化学反应系统可以被配置为根据本发明的一个方面来抑制诸如气泡的不混溶材料干扰与芯片相关的环境因素的确定。 在另一方面，芯片或其它反应系统可以被配置为在芯片或其他反应系统中保持气体顶部空间。 在某些实施方案中，阻挡物例如物理屏障可以用于在含气体区域内或以其他方式远离检测区域容纳气泡。 在其它实施例中，可以使用表面张力特性来控制气泡的位置。 芯片或其他反应系统可以包括可以非常小的反应位点容器，例如具有小于约2ml的体积。 在某些实施方案中，本发明的芯片或其它反应体系包括一个或多个反应位点，其在一些情况下可由反应位点容器限定。 根据本发明的另一方面，反应部位容器可以成形为通过提供不包括尖锐角度的反应部位容器形状或反应部位的突然变化来限制在用液体填充反应部位容器期间产生气泡的形成 容器宽度。

    Methods and devices for storing and dispensing liquids
    3.
    发明申请
    Methods and devices for storing and dispensing liquids 审中-公开
    用于储存和分配液体的方法和装置

    公开(公告)号：US20050118074A1

    公开(公告)日：2005-06-02

    申请号：US11024158

    申请日：2004-12-28

    Applicant: Allyn Hubbard ,  Samesh Kale ,  Scott Rollins ,  Jeremy Springhorn ,  Stephen Squinto ,  Prasad Akkapeddi

    Inventor： Allyn Hubbard ,  Samesh Kale ,  Scott Rollins ,  Jeremy Springhorn ,  Stephen Squinto ,  Prasad Akkapeddi

    IPC: B01J19/00 ,  B81B3/00 ,  C40B60/14 ,  C40B70/00 ,  G01N35/10 ,  B01L3/02

    CPC classification number: G01N35/1074 ,  B01J19/0046 ,  B01J2219/00369 ,  B01J2219/00378 ,  B01J2219/00547 ,  C40B60/14 ,  C40B70/00 ,  G01N2035/1039 ,  Y10T436/2575

    Abstract: In a liquid handling system including a liquid handling substrate having a plurality of channels for conducting a liquid sample in said substrate, where the channels terminate in a plurality of exit ports in an outer surface of the substrate for transfer of a quantity of the liquid sample. The handling system also includes a liquid storage and dispensing substrate having a plurality of separable cartridges corresponding to the channels, with each cartridge terminating at a microelectro mechanical system (MEMS) comprising a laminate of glass, silicon and a piezoelectric substance. The handling system further includes a liquid detecting system comprising a light emitting diode and a photo-detector, where each channel includes a reservoir in communication with a corresponding cartridge creating an interface therebetween. The handling system enables a method for storing and dispensing liquids including drawing a liquid sample into the channels either by capillary action, vacuum, electoosmotic flow, a minipump or any combination thereof, storing the liquid sample into the cartridge, and dispensing the liquid sample.

    Abstract translation: 在液体处理系统中，该液体处理系统包括液体处理基板，该液体处理基板具有用于在所述基板中传导液体样品的多个通道，其中所述通道终止于所述基板的外表面中的多个出口，用于转移一定数量的液体样品 。 处理系统还包括具有对应于通道的多个可分离盒的液体存储和分配基板，每个盒终止于包括玻璃，硅和压电物质的层叠体的微电子机械系统（MEMS）。 处理系统还包括液体检测系统，其包括发光二极管和光检测器，其中每个通道包括与相应的墨盒连通的储存器，其在其间形成界面。 处理系统实现了一种用于存储和分配液体的方法，包括通过毛细管作用，真空，电渗流，微型泵或其任何组合将液体样品拉入通道，将液体样品储存在盒中并分配液体样品。

    Method for performing fed-batch operations in small volume reactors
    4.
    发明申请
    Method for performing fed-batch operations in small volume reactors 审中-公开
    在小容量反应堆中进行补料分批操作的方法

    公开(公告)号：US20070178023A1

    公开(公告)日：2007-08-02

    申请号：US11603950

    申请日：2006-11-22

    Applicant: A. Russo ,  Phil Bergman ,  Matthew Stebulis ,  James Hope ,  Timothy Johnson ,  Howard Schreyer

    Inventor： A. Russo ,  Phil Bergman ,  Matthew Stebulis ,  James Hope ,  Timothy Johnson ,  Howard Schreyer

    IPC: B01J19/00

    CPC classification number: C12P7/40 ,  B01J19/0093 ,  B01J2219/00038 ,  B01L3/5027 ,  C12M23/16 ,  C12M23/58 ,  C12M41/32 ,  C12M41/44 ,  C12P7/6463 ,  C12P13/04 ,  C12P19/34 ,  C12P33/00

    Abstract: Methods for forming chemical and/or biological products in reactors, and/or analyzing chemical and/or biological interactions in reactors are provided. The methods relate, more specifically, to forming such products and/or carrying out such analyses in small volume reactors with control over overall fluid volume in the reactors. The methods can be used to mimic processes in large scale reactors and/or to obtain reaction or interaction information relevant to large scale reactors (e.g., to adjust/optimize large-scale reactor processes). Advantageously, the methods can allow parameters of small scale reactors to be correlated with those of large scale reactors, where desired.

    Abstract translation: 提供了在反应器中形成化学和/或生物产物和/或分析反应器中的化学和/或生物相互作用的方法。 所述方法更具体地涉及在具有对反应器中的总流体体积的控制的小体积反应器中形成这种产物和/或进行这种分析。 该方法可用于模拟大规模反应器中的工艺和/或获得与大规模反应器相关的反应或相互作用信息（例如，调整/优化大规模反应器工艺）。 有利地，如果需要，这些方法可以允许小规模反应器的参数与大规模反应器的参数相关。

    Microfermentor device and cell based screening
    5.
    发明申请
    Microfermentor device and cell based screening 审中-公开
    微型发酵设备和基于细胞的筛选

    公开(公告)号：US20060270025A1

    公开(公告)日：2006-11-30

    申请号：US11500573

    申请日：2006-08-07

    Applicant: Andrey Zarur ,  H. Schreyer ,  Lawrence Fama ,  Anne Heibel

    Inventor： Andrey Zarur ,  H. Schreyer ,  Lawrence Fama ,  Anne Heibel

    IPC: C12M1/34 ,  C12M1/12

    CPC classification number: C12M23/16 ,  C12M41/12 ,  C12M41/26 ,  C12M41/32 ,  C12M41/36 ,  C12M41/40

    Abstract: A microfermentor device that can be used for a wide variety of purposes is described. The microfermentor device includes one or more cell growth chambers having a volume of less than 1 ml. The microfermentor device can be used to grow cells used for the production of useful compounds, e.g., therapeutic proteins, antibodies or small molecule drugs. The microfermentor device can also be used in various high-throughput screening assays. For example, the microfermentor device can be used to screen compounds to assess their effect on cell growth and/or a normal or abnormal biological function of a cell and/or their effect on the expression of a protein expressed by the cell. The device can also be used to investigate the effect of various environmental factors on cell growth, biological function or production of a cell product. The device, including various controlling components and sensing components can be microfabricated on a support material.

    Abstract translation: 描述了可用于各种目的的微发光装置。 微发酵器装置包括一个或多个体积小于1ml的细胞生长室。 微发酵器装置可用于生长用于生产有用化合物的细胞，例如治疗性蛋白质，抗体或小分子药物。 微发酵装置也可用于各种高通量筛选试验。 例如，微发光器件可用于筛选化合物以评估其对细胞生长和/或细胞的正常或异常生物学功能的影响和/或其对细胞表达的蛋白质表达的影响。 该装置还可用于研究各种环境因素对细胞生长，生物功能或细胞产物生产的影响。 包括各种控制部件和传感部件在内的装置可以在支撑材料上进行微制造。

    Systems and methods for control of pH and other reactor environment conditions
    7.
    发明申请
    Systems and methods for control of pH and other reactor environment conditions 审中-公开
    用于控制pH和其他反应器环境条件的系统和方法

    公开(公告)号：US20050026134A1

    公开(公告)日：2005-02-03

    申请号：US10664068

    申请日：2003-09-16

    Applicant: Scott Miller ,  Gennady Malin ,  Howard Schreyer ,  Seth Rodgers ,  Andrey Zarur

    Inventor： Scott Miller ,  Gennady Malin ,  Howard Schreyer ,  Seth Rodgers ,  Andrey Zarur

    IPC: C12M3/00

    CPC classification number: B01L3/502746 ,  B01L3/5025 ,  B01L3/502715 ,  B01L2200/0668 ,  B01L2200/12 ,  B01L2300/0654 ,  B01L2300/0819 ,  B01L2300/0822 ,  B01L2300/0867 ,  B01L2300/0874 ,  B01L2300/0883 ,  B01L2300/0887 ,  B01L2300/1838 ,  B01L2400/046 ,  B01L2400/0487 ,  B01L2400/086 ,  C12M23/16 ,  C12M29/04 ,  C12M41/26

    Abstract: The present invention generally relates to chemical, biological, and/or biochemical reactor chips and other reaction systems such as microreactor systems, as well as systems and methods for constructing and using such devices. In one aspect, a chip or other reaction system may be constructed so as to promote cell growth within it. In certain embodiments, the chips or other reaction systems of the invention include one or more reaction sites. The reaction sites can be very small, for example, with a volume of less than about 1 ml. In one aspect of the invention, a chip is able to detect, measure and/or control an environmental factor such as the temperature, pressure, CO2 concentration, O2 concentration, relative humidity, pH, etc. associated with one or more reaction sites, by using one or more sensors, actuators, processors, and/or control systems. In another aspect, the present invention is directed to materials and systems having humidity and/or gas control, for example, for use with a chip. Such materials may have high oxygen permeability and/or low water vapor permeability. The present invention, in still another aspect, generally relates to light-interacting components suitable for use in chips and other reactor systems. These components may include waveguides, optical fibers, light sources, photodetectors, optical elements, and the like.

    Abstract translation: 本发明一般涉及化学，生物和/或生化反应堆芯片和其他反应系统，例如微反应器系统，以及用于构建和使用这些装置的系统和方法。 在一个方面，可以构建芯片或其它反应系统，以促进细胞内的细胞生长。 在某些实施方案中，本发明的芯片或其它反应体系包括一个或多个反应位点。 反应位点可以非常小，例如，体积小于约1ml。 在本发明的一个方面，芯片能够检测，测量和/或控制与一个或多个反应位点相关联的环境因素例如温度，压力，CO 2浓度，O 2浓度，相对湿度，pH等， 通过使用一个或多个传感器，致动器，处理器和/或控制系统。 在另一方面，本发明涉及具有例如用于芯片的湿度和/或气体控制的材料和系统。 这样的材料可以具有高氧渗透性和/或低水蒸汽渗透性。 在另一方面，本发明通常涉及适用于芯片和其它反应器系统的光相互作用组分。 这些组件可以包括波导，光纤，光源，光电检测器，光学元件等。

    Materials and reactor systems having humidity and gas control
    10.
    发明申请
    Materials and reactor systems having humidity and gas control 审中-公开
    具有湿度和气体控制的材料和反应堆系统

    公开(公告)号：US20070037244A1

    公开(公告)日：2007-02-15

    申请号：US11584149

    申请日：2006-10-20

    Applicant: Seth Rodgers ,  A. Russo ,  Howard Schreyer ,  Andrey Zarur

    Inventor： Seth Rodgers ,  A. Russo ,  Howard Schreyer ,  Andrey Zarur

    IPC: C12Q1/02

    CPC classification number: C12M25/02 ,  C12M23/12 ,  C12M23/24 ,  C12M29/04 ,  C12M41/34

    Abstract: The present invention is directed to materials and reactor systems having humidity and/or gas control. The material may have high oxygen permeability and/or low water vapor permeability. In some cases, the material may have sufficient permeance and/or permeability to allow cell culture to occur in a chip or other reactor system using the material. In certain embodiments, the material may be positioned adjacent to or abut a reaction site within a chip or reactor; in other embodiments, the material may be positioned such that it is in fluidic communication with the reaction site. The material may also be porous and/or transparent in some cases. In one set of embodiments, the material include a polymer that is branched, and/or contains bulky side groups that allow the polymer to have a more open structure. In some cases, the material may include two or more layers. Each layer may have a desired property, which may include, for example, permeability, transparency, cytophilicity, biophilicity, hydrophilicity, or a structural feature. In some embodiments, the material may be chosen so as to promote cell growth within the chip or reactor.

    Abstract translation: 本发明涉及具有湿气和/或气体控制的材料和反应器系统。 该材料可能具有高的透氧性和/或低水蒸气渗透性。 在一些情况下，该材料可具有足够的渗透性和/或渗透性，以允许细胞培养在使用该材料的芯片或其它反应器系统中发生。 在某些实施方案中，材料可以位于与芯片或反应器内的反应位置相邻或邻接的位置; 在其它实施方案中，材料可以被定位成使其与反应部位流体连通。 在某些情况下，材料也可以是多孔的和/或透明的。 在一组实施方案中，材料包括分支的聚合物和/或包含允许聚合物具有更开放结构的庞大的侧基。 在一些情况下，材料可以包括两层或更多层。 每个层可以具有期望的性质，其可以包括例如渗透性，透明度，细胞毒性，生物亲和力，亲水性或结构特征。 在一些实施方案中，可以选择材料以促进芯片或反应器内的细胞生长。

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