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公开(公告)号：US20170328924A1
公开(公告)日：2017-11-16
申请号：US14947971
申请日：2015-11-20
申请人： Ronald Jones , Adrian Gropper , Robert Hagopian , Charles Rogers , Thomas Vitella , Tyler Cote , Donald Barry , Dirk Osterloh , Chen Yi
发明人： Ronald Jones , Adrian Gropper , Robert Hagopian , Charles Rogers , Thomas Vitella , Tyler Cote , Donald Barry , Dirk Osterloh , Chen Yi
IPC分类号： G01N35/00 , B01L3/00 , G02B21/16 , G01N1/31 , G01N35/10 , G02B21/34 , G01N15/14 , G01N15/00 , G01N15/10
CPC分类号： G02B21/16 , B01L3/502715 , B01L9/527 , B01L2200/04 , B01L2200/0605 , B01L2200/0684 , B01L2200/0689 , B01L2200/16 , B01L2300/021 , B01L2300/0654 , B01L2300/0867 , B01L2300/0883 , B01L2300/123 , B01L2300/161 , B01L2400/049 , B01L2400/0622 , B01L2400/0644 , B01L2400/0694 , G01N1/312 , G01N1/38 , G01N15/1463 , G01N35/00069 , G01N2015/0073 , G01N2015/008 , G01N2015/1006 , G01N2015/1486 , G01N2035/00138 , G02B21/34
摘要： Disclosed in one aspect is a method for performing a complete blood count (CBC) on a sample of whole blood by metering a predetermined amount of the whole blood and mixing it with a predetermined amount of diluent and stain and transferring a portion thereof to an imaging chamber of fixed dimensions and utilizing an automated microscope with digital camera and cell counting and recognition software to count every white blood cell and red blood corpuscle and platelet in the sample diluent/stain mixture to determine the number of red cells, white cells, and platelets per unit volume, and analyzing the white cells with cell recognition software to classify them.
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公开(公告)号：US20170326549A1
公开(公告)日：2017-11-16
申请号：US15017498
申请日：2016-02-05
申请人： Ronald Jones , Adrian Gropper , Charles Rogers , Thomas Vitella , Donald Barry , Dirk Osterloh , Chen Yi , Tyler Cote
发明人： Ronald Jones , Adrian Gropper , Charles Rogers , Thomas Vitella , Donald Barry , Dirk Osterloh , Chen Yi , Tyler Cote
CPC分类号： G06K9/00134 , B01L3/502715 , B01L3/502738 , B01L2200/027 , B01L2200/0605 , B01L2200/0647 , B01L2200/16 , B01L2300/0627 , B01L2400/0633 , B01L2400/0644 , G01N1/10 , G01N1/30 , G01N15/1434 , G01N15/1463 , G01N15/1484 , G01N21/05 , G01N33/487 , G01N33/49 , G01N33/4915 , G01N33/5094 , G01N33/80 , G01N2015/0065 , G01N2015/008 , G01N2015/0084 , G01N2015/1006 , G01N2015/1486 , G01N2035/00148 , G06K9/00147 , Y10T436/101666
摘要： This disclosure describes single-use test cartridges, cell analyzer apparatus, and methods for automatically performing microscopic cell analysis tasks, such as counting blood cells in biological samples. A small unmeasured quantity of a biological sample such as whole blood is placed in the disposable test cartridge which is then inserted into the cell analyzer. The analyzer isolates a precise volume of the biological sample, mixes it with self-contained reagents and transfers the entire volume to an imaging chamber. The geometry of the imaging chamber is chosen to maintain the uniformity of the mixture, and to prevent cells from crowding or clumping, when it is transferred into the imaging chamber. Images of essentially all of the cellular components within the imaging chamber are analyzed to obtain counts per unit volume. The devices, apparatus and methods described may be used to analyze a small quantity of whole blood to obtain counts per unit volume of red blood cells, white blood cells, including sub-groups of white cells, platelets and measurements related to these bodies.
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公开(公告)号：US20160097749A1
公开(公告)日：2016-04-07
申请号：US14927586
申请日：2015-10-30
CPC分类号： G01N33/6848 , B82Y15/00 , C07K2/00 , G01N30/7233 , G01N30/8665 , G01N30/8675 , G01N33/532 , G01N33/68 , G01N2458/15 , H01J49/0009 , H01J49/0031 , H01J49/0036 , Y10T436/25 , Y10T436/25125
摘要： Quantitation of analytes, including but not limited to peptides, polypeptides, and proteins, in mass spectrometry using a labeled peptide coupled to a reporter, and a universal reporter.
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4.发明授权Methods for isotopically labeling biomolecules using mammalian cell-free extracts 有权使用哺乳动物无细胞提取物同位素标记生物分子的方法公开(公告)号：US08945861B2
公开(公告)日：2015-02-03
申请号：US13565135
申请日：2012-08-02
申请人： Ryan D. Bomgarden , Eric Leigh Hommema , John Charles Rogers , Penny JoAnn Jensen , Derek Karl Baerenwald
发明人： Ryan D. Bomgarden , Eric Leigh Hommema , John Charles Rogers , Penny JoAnn Jensen , Derek Karl Baerenwald
IPC分类号： C12P21/00 , G01N33/566 , G01N25/00 , G01N33/68 , C12P21/02
CPC分类号： G01N33/6848 , C12P21/02 , G01N33/58 , G01N2458/15 , G01N2560/00
摘要： Methods for producing an isotope-labeled mammalian, including a human, biomolecule, such as polypeptides and proteins, in a cell-free protein synthesis system. A biomolecule standard is produced having at least one isotope different in abundance than that of the naturally occurring isotopes in the biomolecule. Methods for quantifying biomolecules standards expressed using mammalian cell-free extracts are disclosed. Methods for producing such standards, kits, systems and reagents, relating to the use of isotope-labeled biomolecule as quantification standards in mass spectrometric and nuclear magnetic resonance analysis.
摘要翻译： 在无细胞蛋白质合成系统中生产同位素标记的哺乳动物，包括人类，生物分子，如多肽和蛋白质的方法。 产生具有与生物分子中的天然存在的同位素丰度不同的至少一种同位素的生物分子标准。 公开了使用哺乳动物无细胞提取物表达的生物分子标准物质的方法。 生产与使用同位素标记的生物分子作为质谱和核磁共振分析中的定量标准相关的标准，试剂盒，系统和试剂的方法。
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公开(公告)号：US08661572B2
公开(公告)日：2014-03-04
申请号：US12205323
申请日：2008-09-05
申请人： David Charles Rogers
发明人： David Charles Rogers
摘要： An improved edge band for a protective helmet includes a flexible woven-fiber elongate band applied to the edge of a helmet shell. The elongate band is positioned such that side edges of the elongate band extend in intimately conforming contact along a surface contour of the helmet shell. The edge band includes a matrix material in contact with fibers of the elongate band.
摘要翻译： 用于防护头盔的改进的边缘带包括施加到头盔壳的边缘的柔性编织纤维细长带。 细长带被定位成使得细长带的侧边缘沿着头盔壳体的表面轮廓在紧密配合的接触部中延伸。 边缘带包括与细长带的纤维接触的基体材料。
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公开(公告)号：US08580266B2
公开(公告)日：2013-11-12
申请号：US12669940
申请日：2008-07-21
申请人： David Sancho-Madrid , Oliver Schulz , Neil Charles Rogers , Caetano Reis E Sousa , Olivier Pierre Joffre , Daniel Pennington
发明人： David Sancho-Madrid , Oliver Schulz , Neil Charles Rogers , Caetano Reis E Sousa , Olivier Pierre Joffre , Daniel Pennington
IPC分类号： A61K39/395 , A61K39/00
CPC分类号： A61K47/48415 , A61K39/0005 , A61K39/0011 , A61K47/6811 , A61K2039/507 , A61K2039/57 , A61K2039/6056 , C07K16/2851 , C07K16/2878 , C07K2317/55 , C07K2317/74 , C07K2317/75 , C07K2317/76 , C07K2319/33
摘要： The invention relates to the regulation of the immune system, and in particular to the finding that the CLEC9a molecule is a marker for dendritic cells which are capable of cross-presenting extracellular antigens via the MHC class I pathway. This makes them particularly suitable for generation of cytotoxic T lymphocyte responses. Materials and methods are provided both for the induction of immune responses against target antigens, and for the inhibition or suppression of undesirable immune responses in which these cells are involved.
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公开(公告)号：US20130034867A1
公开(公告)日：2013-02-07
申请号：US13565135
申请日：2012-08-02
申请人： Ryan D. Bomgarden , Eric Leigh Hommema , John Charles Rogers , Penny JoAnn Jensen , Derek Karl Baerenwald
发明人： Ryan D. Bomgarden , Eric Leigh Hommema , John Charles Rogers , Penny JoAnn Jensen , Derek Karl Baerenwald
CPC分类号： G01N33/6848 , C12P21/02 , G01N33/58 , G01N2458/15 , G01N2560/00
摘要： Methods for producing an isotope-labeled mammalian, including a human, biomolecule, such as polypeptides and proteins, in a cell-free protein synthesis system. A biomolecule standard is produced having at least one isotope different in abundance than that of the naturally occurring isotopes in the biomolecule. Methods for quantifying biomolecules standards expressed using mammalian cell-free extracts are disclosed. Methods for producing such standards, kits, systems and reagents, relating to the use of isotope-labeled biomolecule as quantification standards in mass spectrometric and nuclear magnetic resonance analysis.
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公开(公告)号：US20100221265A1
公开(公告)日：2010-09-02
申请号：US12669940
申请日：2008-07-21
申请人： David Sancho-Madrid , Oliver Schulz , Neil Charles Rogers , Caetano Reis E. Sousa , Olivier Pierre Joffre , Daniel Pennington
发明人： David Sancho-Madrid , Oliver Schulz , Neil Charles Rogers , Caetano Reis E. Sousa , Olivier Pierre Joffre , Daniel Pennington
IPC分类号： A61K39/395 , C12N5/0784 , A61K39/00 , C07K14/00 , C07K16/00 , A61K31/7052 , A61K38/43 , C12N9/00 , G01N33/53 , C12N5/0783 , A61K35/12 , A61P37/00
CPC分类号： A61K47/48415 , A61K39/0005 , A61K39/0011 , A61K47/6811 , A61K2039/507 , A61K2039/57 , A61K2039/6056 , C07K16/2851 , C07K16/2878 , C07K2317/55 , C07K2317/74 , C07K2317/75 , C07K2317/76 , C07K2319/33
摘要： The invention relates to the regulation of the immune system, and in particular to the finding that the CLEC9a molecule is a marker for dendritic cells which are capable of cross-presenting extracellular antigens via the MHC class I pathway. This makes them particularly suitable for generation of cytotoxic T lymphocyte responses. Materials and methods are provided both for the induction of immune responses against target antigens, and for the inhibition or suppression of undesirable immune responses in which these cells are involved.
摘要翻译： 本发明涉及免疫系统的调节，特别是关于CLEC9a分子是能够通过MHC I类途径交叉呈递细胞外抗原的树突状细胞的标记的发现。 这使得它们特别适合于产生细胞毒性T淋巴细胞应答。 提供材料和方法用于诱导针对靶抗原的免疫应答，以及用于抑制或抑制其中涉及这些细胞的不期望的免疫应答。
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公开(公告)号：US07537730B2
公开(公告)日：2009-05-26
申请号：US10362873
申请日：2001-08-27
申请人： Bruno Colin , Cécile Paris , Bernard Limon , Patrick Broyer , Charles Rogers
发明人： Bruno Colin , Cécile Paris , Bernard Limon , Patrick Broyer , Charles Rogers
CPC分类号： B01L3/502738 , B01L2200/10 , B01L2300/0816 , B01L2300/087 , B01L2400/0638 , B01L2400/0655 , G01N2035/00247 , G01N2035/00257 , Y10T137/0396
摘要： A reaction card (1) having a body, a front surface (62) and a rear surface (63) defined by an edge (68), at least one inlet (2, 3, 4 and/or 5) and at least one outlet (7and/or 8), connected by a network of channels (64) constituting at least one reaction path for at least one fluid which is directed via valves (11to 36 and/or 61); each valve includes a flexible film (67) which can be deformed to allow fluid passage, the film being fixed on the card's rear surface at a peripheral indentation of an assembly of channels associated with the valve; the card includes channels flush with at least one of its surfaces, the channels being of two different cross-sections, a small cross-section serving as a reaction compartment; each front or rear surface is delimited by at least one film (48, 49, 65, 66 and/or 67).
摘要翻译： 具有主体的反应卡（1），由边缘（68）限定的前表面（62）和后表面（63），至少一个入口（2,3,4和/或5）和至少一个 出口（7和/或8）通过构成用于至少一个通过阀（11至36和/或61）的流体的至少一个反应路径的通道网络（64）连接; 每个阀包括柔性膜（67），其可以变形以允许流体通过，所述膜被固定在卡的后表面上与阀相关联的通道组件的周边凹陷处; 卡包括与其表面中的至少一个平齐的通道，通道具有两个不同的横截面，小的横截面用作反应室; 每个前表面或后表面由至少一个膜（48,49,65,66和/或67）限定。
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公开(公告)号：US20070169251A1
公开(公告)日：2007-07-26
申请号：US11335934
申请日：2006-01-20
申请人： David Rogers , Charles Rogers , Peter Stokes
发明人： David Rogers , Charles Rogers , Peter Stokes
IPC分类号： A42B1/22
CPC分类号： A42B3/324
摘要： An adjustment mechanism for a helmet. A first sliding surface is defined in a first portion of the helmet and includes an opening. A second sliding surface is defined in a second portion of the helmet. Two spaced apart arms extend from the second sliding surface. The first and second sliding surfaces are in sliding engagement with one another with the arms sliding within the opening. A lever is pivotally connected to the first portion in proximity of the opening and pivotable between a locked position and an unlocked position. The lever has a series of regularly spaced apart parallel teeth which in the locked position protrude through the opening with at least a selected one of the teeth being engageable between the two spaced apart arms to prevent the first and second sliding surfaces from sliding relative to one another.
摘要翻译： 头盔调整机构。 第一滑动面限定在头盔的第一部分中，并且包括开口。 第二滑动表面限定在头盔的第二部分中。 两个间隔开的臂从第二滑动表面延伸。 第一和第二滑动表面彼此滑动接合，同时臂在开口内滑动。 杠杆在开口附近枢转地连接到第一部分并且可在锁定位置和解锁位置之间枢转。 所述杠杆具有一系列规则间隔开的平行齿，所述平行齿在所述锁定位置突出穿过所述开口，所述齿中的至少一个齿可接合在所述两个间隔开的臂之间，以防止所述第一和第二滑动面相对于一个滑动 另一个。
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