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    OPTICAL GLUCOSE SENSOR CHIP AND METHOD OF MANUFACTURING THE SAME
    1.
    发明申请
    OPTICAL GLUCOSE SENSOR CHIP AND METHOD OF MANUFACTURING THE SAME 审中-公开
    光学葡萄糖传感器芯片及其制造方法

    公开(公告)号：US20080020454A1

    公开(公告)日：2008-01-24

    申请号：US11780033

    申请日：2007-07-19

    申请人： Ikuo Uematsu ,  Masaaki Hirakawa ,  Kayoko Oomiya

    发明人： Ikuo Uematsu ,  Masaaki Hirakawa ,  Kayoko Oomiya

    IPC分类号： C12M1/00

    CPC分类号： C12Q1/002 ,  C12Q1/006 ,  G01N21/552 ,  G01N21/78

    摘要： An optical glucose sensor chip includes a substrate, a pair of optical elements formed on a surface of the substrate for introducing light into the substrate and for emitting the light from the substrate, and a glucose sensing membrane formed on the surface of the substrate at a position between the optical elements. The sensing membrane includes a color reagent substrate, a first enzyme which oxidizes or reduces glucose, a second enzyme that generates a material which makes the color reagent substrate exhibit color by a reaction with a product obtained by oxidation or reduction of glucose, a nonionic cellulose derivative, and an ionic polymer into which a buffer is incorporated. At least one of the first and second enzymes is coated with the ionic polymer, and the color reagent substrate. The first and second enzymes, the buffer and the ionic polymer are supported by the nonionic cellulose derivative.

    摘要翻译： 光学葡萄糖传感器芯片包括：基板，形成在基板的表面上的一对光学元件，用于将光引入基板并从基板发射光;以及葡萄糖感测膜，其形成在基板的表面上 光学元件之间的位置。 检测膜包括着色试剂底物，氧化或降低葡萄糖的第一种酶，产生通过与通过氧化或还原葡萄糖获得的产物的反应而使着色试剂底物显色的第二种酶，非离子型纤维素 衍生物和其中加入缓冲剂的离子聚合物。 第一和第二酶中的至少一种用离子聚合物和着色剂底物涂覆。 第一和第二酶，缓冲液和离子聚合物由非离子纤维素衍生物负载。

    OPTICAL GLUCOSE SENSOR CHIP AND METHOD OF MANUFACTURING THE SAME
    2.
    发明申请
    OPTICAL GLUCOSE SENSOR CHIP AND METHOD OF MANUFACTURING THE SAME 失效
    光学葡萄糖传感器芯片及其制造方法

    公开(公告)号：US20100221408A1

    公开(公告)日：2010-09-02

    申请号：US12771343

    申请日：2010-04-30

    申请人： Ikuo UEMATSU ,  Masaaki Hirakawa ,  Kayoko Oomiya

    发明人： Ikuo UEMATSU ,  Masaaki Hirakawa ,  Kayoko Oomiya

    IPC分类号： B05D3/00

    CPC分类号： C12Q1/002 ,  C12Q1/006 ,  G01N21/552 ,  G01N21/78

    摘要： An optical glucose sensor chip includes a substrate, a pair of optical elements formed on a surface of the substrate for introducing light into the substrate and for emitting the light from the substrate, and a glucose sensing membrane formed on the surface of the substrate at a position between the optical elements. The sensing membrane includes a color reagent substrate, a first enzyme which oxidizes or reduces glucose, a second enzyme that generates a material which makes the color reagent substrate exhibit color by a reaction with a product obtained by oxidation or reduction of glucose, a nonionic cellulose derivative, and an ionic polymer into which a buffer is incorporated. At least one of the first and second enzymes is coated with the ionic polymer, and the color reagent substrate. The first and second enzymes, the buffer and the ionic polymer are supported by the nonionic cellulose derivative.

    摘要翻译： 光学葡萄糖传感器芯片包括：基板，形成在基板的表面上的一对光学元件，用于将光引入基板并从基板发射光;以及葡萄糖感测膜，其形成在基板的表面上 光学元件之间的位置。 检测膜包括着色试剂底物，氧化或降低葡萄糖的第一种酶，产生通过与通过氧化或还原葡萄糖获得的产物的反应而使着色试剂底物显色的第二种酶，非离子型纤维素 衍生物和其中加入缓冲剂的离子聚合物。 第一和第二酶中的至少一种用离子聚合物和着色剂底物涂覆。 第一和第二酶，缓冲液和离子聚合物由非离子纤维素衍生物负载。

    Optical glucose sensor chip and method of manufacturing the same
    3.
    发明授权
    Optical glucose sensor chip and method of manufacturing the same 失效
    光学葡萄糖传感器芯片及其制造方法

    公开(公告)号：US08372630B2

    公开(公告)日：2013-02-12

    申请号：US12771343

    申请日：2010-04-30

    申请人： Ikuo Uematsu ,  Masaaki Hirakawa ,  Kayoko Oomiya

    发明人： Ikuo Uematsu ,  Masaaki Hirakawa ,  Kayoko Oomiya

    IPC分类号： C12M1/34 ,  C12Q1/54 ,  G01N21/78

    CPC分类号： C12Q1/002 ,  C12Q1/006 ,  G01N21/552 ,  G01N21/78

    摘要： An optical glucose sensor chip includes a substrate, a pair of optical elements formed on a surface of the substrate for introducing light into the substrate and for emitting the light from the substrate, and a glucose sensing membrane formed on the surface of the substrate at a position between the optical elements. The sensing membrane includes a color reagent substrate, a first enzyme which oxidizes or reduces glucose, a second enzyme that generates a material which makes the color reagent substrate exhibit color by a reaction with a product obtained by oxidation or reduction of glucose, a nonionic cellulose derivative, and an ionic polymer into which a buffer is incorporated. At least one of the first and second enzymes is coated with the ionic polymer, and the color reagent substrate. The first and second enzymes, the buffer and the ionic polymer are supported by the nonionic cellulose derivative.

    摘要翻译： 光学葡萄糖传感器芯片包括：基板，形成在基板的表面上的一对光学元件，用于将光引入基板并从基板发射光;以及葡萄糖感测膜，其形成在基板的表面上 光学元件之间的位置。 检测膜包括着色试剂底物，氧化或降低葡萄糖的第一种酶，产生通过与通过氧化或还原葡萄糖获得的产物的反应而使着色试剂底物显色的第二种酶，非离子型纤维素 衍生物和其中加入缓冲剂的离子聚合物。 第一和第二酶中的至少一种用离子聚合物和着色剂底物涂覆。 第一和第二酶，缓冲液和离子聚合物由非离子纤维素衍生物负载。

    TEST ELEMENT, TEST KIT, TEST DEVICE, AND TEST METHOD
    5.
    发明申请
    TEST ELEMENT, TEST KIT, TEST DEVICE, AND TEST METHOD 审中-公开
    测试元件，测试套件，测试设备和测试方法

    公开(公告)号：US20120064559A1

    公开(公告)日：2012-03-15

    申请号：US13207690

    申请日：2011-08-11

    申请人： Ichiro TONO ,  Takaaki Wada ,  Kayoko Oomiya ,  Shingo Kasai ,  Masaaki Hirakawa

    发明人： Ichiro TONO ,  Takaaki Wada ,  Kayoko Oomiya ,  Shingo Kasai ,  Masaaki Hirakawa

    IPC分类号： C12Q1/28 ,  C12Q1/26 ,  C12M1/34

    CPC分类号： C12Q1/28 ,  C12Q1/26 ,  G01N21/7703 ,  G01N21/78

    摘要： According to one embodiment, a test element includes a base, a pair of optical element units, an optical waveguide unit, a detection unit and a holding unit. The base has transparency. The pair of optical element units are arranged away from each other on a major surface of the base. The optical waveguide unit is provided on the major surface of the base. The detection unit is provided on a major surface of the optical waveguide unit of between the optical element units. The major surface of the optical waveguide unit is an opposite side which touches the base. The holding unit is in a frame shape, and one end of the holding unit being is provided to protrude from a major surface of the detection unit. The detection unit includes a color former and a film-formed body holding the color former.

    摘要翻译： 根据一个实施例，测试元件包括基座，一对光学元件单元，光波导单元，检测单元和保持单元。 基地有透明度。 一对光学元件单元在基座的主表面上彼此远离布置。 光波导单元设置在基座的主表面上。 检测单元设置在光学元件单元之间的光波导单元的主表面上。 光波导单元的主表面是与基座接触的相对侧。 保持单元是框架形状，并且保持单元的一端设置成从检测单元的主表面突出。 检测单元包括着色剂和保持着色剂的成膜体。

    COLOR REACTION DETECTING DEVICE AND METHOD FOR MANUFACTURING SAME
    8.
    发明申请
    COLOR REACTION DETECTING DEVICE AND METHOD FOR MANUFACTURING SAME 审中-公开
    颜色反应检测装置及其制造方法

    公开(公告)号：US20080131315A1

    公开(公告)日：2008-06-05

    申请号：US11771533

    申请日：2007-06-29

    申请人： Tomohiro Takase ,  Isao Nawata ,  Ikuo Uematsu ,  Masaaki Hirakawa

    发明人： Tomohiro Takase ,  Isao Nawata ,  Ikuo Uematsu ,  Masaaki Hirakawa

    IPC分类号： G01N21/76 ,  G11B7/00 ,  G11B20/18

    CPC分类号： G01N21/78 ,  G01N21/7703

    摘要： A color reaction detecting device includes: a support configured to support a sensor chip, the sensor chip including a thin film which causes a color reaction by a substance released from an object under inspection; a light source configured to introduce light into the sensor chip supported by the support; a photodetector configured to sense light emitted from the sensor chip; a temperature sensor configured to measure temperature; and a control unit. The control unit computes an amount of color reaction in the sensor chip using a result of the sensing by the photodetector and a result of the measurement by the temperature sensor.

    摘要翻译： 一种颜色反应检测装置，包括：支撑体，其被配置为支撑传感器芯片，所述传感器芯片包括由检查对象物质释放的物质引起着色反应的薄膜; 光源，被配置为将光引入由所述支撑件支撑的所述传感器芯片中; 光检测器，被配置为感测从所述传感器芯片发射的光; 配置成测量温度的温度传感器; 和控制单元。 控制单元使用光检测器的感测结果和温度传感器的测量结果来计算传感器芯片中的颜色反应量。

    Method for preparing porous SOG film
    9.
    发明授权
    Method for preparing porous SOG film 有权
    多孔SOG薄膜的制备方法

    公开(公告)号：US06919106B2

    公开(公告)日：2005-07-19

    申请号：US09926671

    申请日：2001-04-03

    申请人： Hirohiko Murakami ,  Chiaki Tanaka ,  Masaaki Hirakawa

    发明人： Hirohiko Murakami ,  Chiaki Tanaka ,  Masaaki Hirakawa

    IPC分类号： H01L21/316 ,  H01L21/768 ,  H05H1/00

    CPC分类号： H01L21/02126 ,  H01L21/02203 ,  H01L21/02216 ,  H01L21/02282 ,  H01L21/0234 ,  H01L21/02359 ,  H01L21/02362 ,  H01L21/31695 ,  H01L21/7682 ,  H01L2221/1047

    摘要： A porous SOG film is formed by preparing an organic silane solution containing an organic silane, water and an alcohol, subjecting the organic silane to acid hydrolysis or alkali hydrolysis and then heat-treating the resulting reaction system in the presence of a surfactant to thus form a porous SiO2 film to use for an interlayer insulating film. Alternatively, a porous SOG film is formed by repeating the foregoing step at least one time; or by forming a hydrophobic film on the porous SiO2 film prepared by the foregoing step by the CVD or sputtering technique to thus cap the surface of the porous film; or repeating the porous film-forming and capping steps at least one time. Moreover, after the preparation of the foregoing porous SiO2 film, it is subjected to either of the oxygen plasma-treatment, electron beam-irradiation treatment and UV light-irradiation treatment to remove the unreacted OH groups remaining on the porous film and to thus form a porous SOG film. Further, the foregoing heat-treatment is carried out in the following two stages: in the first stage, the porous film is treated at a temperature capable of mainly removing the water and the alcohol through evaporation thereof; and in the second stage, the porous SiO2 film is treated at a temperature (350 to 450° C.) sufficient for covering at least the inner walls of the holes with the hydrophobic moieties of the surfactant.

    摘要翻译： 通过制备含有有机硅烷，水和醇的有机硅烷溶液，使有机硅烷进行酸水解或碱水解，然后在表面活性剂存在下对所得反应体系进行热处理，从而形成多孔SOG膜 用于层间绝缘膜的多孔SiO 2膜。 或者，通过至少一次重复上述步骤形成多孔SOG膜; 或者通过CVD或溅射技术在上述步骤制备的多孔SiO 2膜上形成疏水膜，从而覆盖多孔膜的表面; 或至少一次重复多孔成膜和封盖步骤。 此外，在制备上述多孔SiO 2膜之后，对其进行氧等离子体处理，电子束照射处理和UV光照射处理，以除去未反应的OH基团 并在多孔膜上形成多孔的SOG膜。 此外，上述热处理在以下两个阶段进行：在第一阶段中，多孔膜在能够主要通过蒸发除去水和醇的温度下进行处理; 并且在第二阶段中，多孔SiO 2膜在足以用表面活性剂的疏水部分覆盖孔的至少内壁的温度（350-450℃）下进行处理。

    Cathode substrate and its manufacturing method
    10.
    发明申请
    Cathode substrate and its manufacturing method 审中-公开
    阴极基板及其制造方法

    公开(公告)号：US20050230750A1

    公开(公告)日：2005-10-20

    申请号：US11066562

    申请日：2005-02-28

    申请人： Haruhisa Nakano ,  Masaaki Hirakawa ,  Osamu Miura ,  Hirohiko Murakami ,  Kensuke Okasaka ,  Tomoaki Kojima

    发明人： Haruhisa Nakano ,  Masaaki Hirakawa ,  Osamu Miura ,  Hirohiko Murakami ,  Kensuke Okasaka ,  Tomoaki Kojima

    IPC分类号： H01J9/02 ,  H01J1/304 ,  H01J3/02 ,  H01J29/48 ,  H01J31/12 ,  H01L29/76

    CPC分类号： H01J29/481 ,  H01J3/021 ,  H01J9/025 ,  H01J31/127

    摘要： A cathode substrate according to the present invention comprises a cathode electrode layer(12), insulator layer(14) and gate electrode layer(15) formed sequentially on a substrate to be processed (11). The insulator layer includes a hole (14a) formed there through. A gate aperture (16) is formed through the gate electrode layer. An emitter (E) is then provided at the bottom of the hole (14a). In this case, the gate aperture comprises a plurality of openings (16a), the total area of which is smaller than the area of top opening of the hole in the insulator layer. The openings are arranged densely at a position opposite to the emitter and just above the hole of the insulator layer.

    摘要翻译： 根据本发明的阴极基板包括依次形成在待处理基板（11）上的阴极电极层（12），绝缘体层（14）和栅电极层（15）。 绝缘体层包括形成在其上的孔（14a）。 通过栅电极层形成栅极孔（16）。 然后在孔（14a）的底部设置发射器（E）。 在这种情况下，栅极孔包括多个开口（16a），其总面积小于绝缘体层中孔的顶部开口面积。 这些开口密集地布置在与发射极相对的位置，并刚好在绝缘体层的孔的正上方。