公开(公告)号：US08889844B2

公开(公告)日：2014-11-18

申请号：US12064185

申请日：2006-08-10

申请人： Hideto Chono ,  Kazuya Matsumoto ,  Junichi Mineno ,  Ikunoshin Kato

发明人： Hideto Chono ,  Kazuya Matsumoto ,  Junichi Mineno ,  Ikunoshin Kato

IPC分类号： C07H21/00 ,  C12N15/00 ,  C12N15/86 ,  C12N15/867 ,  A61K31/7088 ,  C12N9/22 ,  C12N15/85 ,  C12N5/0783 ,  C07K14/47 ,  A61K48/00 ,  A61K38/00

CPC分类号： C12N15/86 ,  A61K31/7088 ,  A61K35/17 ,  A61K38/00 ,  A61K38/465 ,  A61K48/00 ,  C07K14/4702 ,  C12N5/0636 ,  C12N9/22 ,  C12N15/85 ,  C12N2510/00 ,  C12N2830/002 ,  Y02A50/473

摘要： A nucleic acid comprising a transcription regulation sequence whose transcription is induced by a trans-acting factor of a human immunodeficiency virus and a gene encoding a polypeptide having an endoribonuclease activity specific to single-stranded RNA, wherein the gene is located in such a position that the expression of the gene can be regulated by the transcription regulation sequence; a method for production of a cell showing an inhibited replication of a human immunodeficiency virus therein, the method comprising the step of introducing the nucleic acid into a cell; and a method for treatment or prevention of a human immunodeficiency virus infection.

摘要翻译： 一种核酸，其包含其转录由人免疫缺陷病毒的反式作用因子诱导的转录调控序列和编码具有对单链RNA特异性的内切核糖核酸酶活性的多肽的基因，其中所述基因位于 该基因的表达可以通过转录调控序列来调节; 一种在其中显示抑制人体免疫缺陷病毒复制的细胞的制备方法，所述方法包括将核酸引入细胞的步骤; 以及用于治疗或预防人类免疫缺陷病毒感染的方法。

公开(公告)号：US08649836B2

公开(公告)日：2014-02-11

申请号：US13271732

申请日：2011-10-12

申请人： Etsuro Shimizu ,  Kazuya Matsumoto ,  Ryo Ota ,  Atsushi Matsumoto

发明人： Etsuro Shimizu ,  Kazuya Matsumoto ,  Ryo Ota ,  Atsushi Matsumoto

IPC分类号： A61B5/1455

CPC分类号： G01N21/77 ,  A61B5/14532 ,  A61B5/1459 ,  G01N2021/7753 ,  G01N2021/7786

摘要： A needle-type fluorescence sensor that measures glucose based on fluorescence produced by excitation light is provided. The needle-type fluorescence sensor includes a needle body section including a sensor portion disposed in a needle distal end portion and metal lines disposed from the sensor portion to a needle proximal end portion, and a connector which is integrated with the needle body section and in which the metal lines extend. The sensor portion includes a silicon substrate having first and second principal surfaces, a PD device that converts fluorescence into an electric signal, an LED device that transmits fluorescence and emits excitation light, and an indicator layer that interacts with an analyte under the excitation light to produce fluorescence. The PD device, the LED device, and the indicator layer overlap with each other above the first principal surface of the silicon substrate.

摘要翻译： 提供了一种根据由激发光产生的荧光测量葡萄糖的针型荧光传感器。 针型荧光传感器包括：针体部，其包括设置在针前端部的传感器部和从传感器部到针基端部的金属线;以及连接器，其与针体部一体化， 金属线延伸。 传感器部分包括具有第一和第二主表面的硅衬底，将荧光转换为电信号的PD器件，透射荧光并发射激发光的LED器件，以及在激发光下与分析物相互作用的指示器层 产生荧光。 PD器件，LED器件和指示层在硅衬底的第一主表面之上彼此重叠。

公开(公告)号：US20110236905A1

公开(公告)日：2011-09-29

申请号：US12936569

申请日：2009-03-04

申请人： Kazuya Matsumoto ,  Kouichi Morimoto ,  Haruka Ikegami ,  Kouhei Nagai

发明人： Kazuya Matsumoto ,  Kouichi Morimoto ,  Haruka Ikegami ,  Kouhei Nagai

IPC分类号： G01N33/566 ,  C12Q1/02

CPC分类号： C07K16/18 ,  G01N33/68 ,  G01N2333/4718

摘要： There are provided a method for screening individual cattle having useful economic traits in which proteins related to the economic traits of beef cattle are identified by proteomics and are used as biomarkers, and a cattle screening kit for use in the method.The method for screening individual cattle according to the present invention includes the steps of (1) harvesting body tissue from the cattle, (2) extracting the full complement of proteins from the body tissue harvested, (3) detecting a wild-type annexin A5 protein, an isoform of the wild-type annexin A5 protein, or a modified protein of the wild-type annexin A5 protein or the isoform thereof in the full complement of proteins extracted, and (4) determining whether or not the cattle will have a high average carcass weight on the basis of the type of annexin A5 detected. The wild-type annexin A5 protein, the isoform thereof, and the modified protein thereof are detected by two-dimensional electrophoresis or an antigen-antibody reaction.

摘要翻译： 提供了一种筛选具有有用的经济性状的个体牛的方法，其中通过蛋白质组学鉴定与牛的经济性状相关的蛋白质并用作生物标志物，以及用于该方法的牛筛选试剂盒。 根据本发明的用于筛选个体牛的方法包括以下步骤：（1）从牛收获身体组织，（2）从收获的身体组织中提取全部蛋白质，（3）检测野生型膜联蛋白A5 蛋白质，野生型膜联蛋白A5蛋白的同种型，或野生型膜联蛋白A5蛋白的修饰蛋白或其同源物在提取的全部蛋白质中，以及（4）确定牛是否具有 基于检测到膜联蛋白A5的类型的高平均胴体重。 通过二维电泳或抗原 - 抗体反应检测野生型膜联蛋白A5蛋白及其同种型及其修饰蛋白。

公开(公告)号：US07952256B2

公开(公告)日：2011-05-31

申请号：US11870786

申请日：2007-10-11

申请人： Kazuya Matsumoto ,  Ryo Ohta ,  Mamoru Hasegawa ,  Hideo Adachi ,  Katsuhiro Wakabayashi

发明人： Kazuya Matsumoto ,  Ryo Ohta ,  Mamoru Hasegawa ,  Hideo Adachi ,  Katsuhiro Wakabayashi

IPC分类号： H01L41/08

CPC分类号： A61B8/4488 ,  A61B8/12 ,  A61B8/445 ,  B06B1/0292 ,  Y10T29/42 ,  Y10T29/49005 ,  Y10T29/49155

摘要： An ultrasonic transducer according to the present invention includes: two or more ultrasonic transducer cells, each of which has a lower electrode, a first insulating layer placed on the lower electrode, a cavity placed on the first insulating layer, a second insulating layer placed on the cavity, and an upper electrode placed above the second insulating layer; channels which communicate the cavities with each other; the second insulating layer placed on the channels; holes formed in the second insulating layer placed on the channels; and sealing portions which seal the holes, where that part of the sealing portions which enters the channels is the same in cross-sectional shape as the holes.

摘要翻译： 根据本发明的超声波换能器包括：两个或更多个超声波换能器单元，每个超声换能器单元具有下电极，设置在下电极上的第一绝缘层，放置在第一绝缘层上的空腔，放置在第二绝缘层上的第二绝缘层 所述空腔和位于所述第二绝缘层上方的上电极; 将空腔相互通信的通道; 第二绝缘层放置在通道上; 形成在通道上的第二绝缘层中的孔; 以及密封孔的密封部分，其中进入通道的密封部分的那部分与孔的横截面形状相同。

公开(公告)号：US07589455B2

公开(公告)日：2009-09-15

申请号：US11942364

申请日：2007-11-19

申请人： Hideo Adachi ,  Katsuhiro Wakabayashi ,  Kazuya Matsumoto ,  Ryo Ota ,  Masaaki Amikura ,  Hiroshi Ito ,  Mamoru Hasegawa

发明人： Hideo Adachi ,  Katsuhiro Wakabayashi ,  Kazuya Matsumoto ,  Ryo Ota ,  Masaaki Amikura ,  Hiroshi Ito ,  Mamoru Hasegawa

IPC分类号： H01L41/09

CPC分类号： A61B8/12 ,  A61B8/445 ,  A61B8/4483 ,  A61B2562/028 ,  B06B1/0292

摘要： A capacitive micromachined ultrasonic transducer (cMUT) is constituted by a plurality of transducer elements comprising plural transducer cells that are mutually connected in parallel and comprises: a silicon substrate; a bottom electrode placed on the top surface of the silicon substrate; an upper electrode placed opposite to the bottom electrode and apart therefrom by a prescribed air or vacuum; a membrane for supporting the bottom electrode; and a membrane supporting part for supporting the membrane, wherein the cMUT comprises a third electrode which has an electrical continuity to the bottom electrode and which corresponds to either one of the transducer cells of a prescribed number of the transducer subelement or of the transducer elements, and a fourth electrode which is a ground electrode electrically connected to the bottom electrode.

摘要翻译： 电容微加工超声换能器（cMUT）由多个换能器元件构成，多个换能器元件包括并联的多个换能器单元，包括：硅基底; 放置在硅衬底的顶表面上的底电极; 上电极通过规定的空气或真空与底电极相对设置并与其分离; 用于支撑底部电极的膜; 以及用于支撑所述膜的膜支撑部分，其中所述cMUT包括与所述底部电极具有电连续性并且对应于规定数量的所述换能器子元件或所述换能器元件中的任一个换能器单元的第三电极， 以及第四电极，其是与所述底部电极电连接的接地电极。

公开(公告)号：US20080158033A1

公开(公告)日：2008-07-03

申请号：US11965279

申请日：2007-12-27

申请人： Yasuyuki Doi ,  Makoto Hattori ,  Hisao Kunitani ,  Atsuhisa Kageyama ,  Tetsuro Oomori ,  Osamu Sarai ,  Tooru Suyama ,  Kurumi Nakayama ,  Kazuya Matsumoto

发明人： Yasuyuki Doi ,  Makoto Hattori ,  Hisao Kunitani ,  Atsuhisa Kageyama ,  Tetsuro Oomori ,  Osamu Sarai ,  Tooru Suyama ,  Kurumi Nakayama ,  Kazuya Matsumoto

IPC分类号： G09G3/36

CPC分类号： G09G3/3685 ,  G09G3/2059 ,  G09G3/3696 ,  G09G2310/027 ,  G09G2340/0428

摘要： A driving device for driving an image display system, which sequentially receives input image data corresponding to gradation of each pixel of a display image and outputs a driving voltage signal includes: an operation section for obtaining output image data of which a bit number is smaller than a bit number of the input image data based on input image data of a target pixel to be processed and input image data of a pixel in vicinity of the target pixel; a reference voltage generation section for generating a plurality of reference voltages of different levels; and a reference voltage selection section for selecting one of the plurality of reference voltages. The operation section is configured to obtain output image data of the target pixel so that a difference between the input image data and output image data of the target pixel and a difference between the input image data and output image data of the pixel in vicinity of the target pixel cancel out each other.

摘要翻译： 一种用于驱动图像显示系统的驱动装置，其顺序地接收与显示图像的每个像素的灰度对应的输入图像数据并输出驱动电压信号，包括：操作部，用于获得位数小于 基于要处理的目标像素的输入图像数据的输入图像数据的位数，并输入目标像素附近的像素的图像数据; 用于产生不同电平的多个参考电压的参考电压产生部分; 以及用于选择多个参考电压中的一个的参考电压选择部分。 操作部被配置为获得目标像素的输出图像数据，使得输入图像数据和目标像素的输出图像数据之间的差异以及输入图像数据与输入图像数据之间的像素的输出图像数据之间的差异 目标像素相互抵消。

公开(公告)号：US07180149B2

公开(公告)日：2007-02-20

申请号：US10924205

申请日：2004-08-24

申请人： Satoshi Yamamoto ,  Tatsuo Suemasu ,  Sayaka Hirafune ,  Toshihiko Isokawa ,  Koichi Shiotani ,  Kazuya Matsumoto

发明人： Satoshi Yamamoto ,  Tatsuo Suemasu ,  Sayaka Hirafune ,  Toshihiko Isokawa ,  Koichi Shiotani ,  Kazuya Matsumoto

IPC分类号： H01L31/0203

CPC分类号： H01L24/94 ,  H01L21/76898 ,  H01L23/481 ,  H01L23/5389 ,  H01L24/48 ,  H01L25/0652 ,  H01L25/0657 ,  H01L27/14618 ,  H01L27/14632 ,  H01L27/14687 ,  H01L2224/02372 ,  H01L2224/0401 ,  H01L2224/13024 ,  H01L2224/451 ,  H01L2224/48091 ,  H01L2224/48227 ,  H01L2225/06524 ,  H01L2225/06541 ,  H01L2924/00014 ,  H01L2924/01004 ,  H01L2924/01005 ,  H01L2924/01006 ,  H01L2924/01013 ,  H01L2924/01015 ,  H01L2924/01019 ,  H01L2924/01023 ,  H01L2924/01029 ,  H01L2924/01033 ,  H01L2924/01057 ,  H01L2924/01067 ,  H01L2924/01078 ,  H01L2924/01079 ,  H01L2924/01082 ,  H01L2924/01322 ,  H01L2924/014 ,  H01L2924/04953 ,  H01L2924/10253 ,  H01L2924/14 ,  H01L2924/15153 ,  H01L2924/15165 ,  H01L2924/15788 ,  H01L2924/16195 ,  H01L2924/3025 ,  H01L2924/00 ,  H01L2224/45099

摘要： A semiconductor package of the invention comprises: a semiconductor element provided with a circuit element on one surface of a semiconductor substrate; an external wiring region provided on an other surface of the semiconductor substrate; a support substrate disposed on the one surface of the semiconductor substrate; an electrode pad disposed on the one surface of the semiconductor substrate; and a through-electrode which extends from the electrode pad through to the other surface of the semiconductor substrate.

摘要翻译： 本发明的半导体封装包括：在半导体衬底的一个表面上设置有电路元件的半导体元件; 设置在所述半导体衬底的另一个表面上的外部布线区域; 支撑基板，设置在所述半导体基板的一个表面上; 设置在所述半导体衬底的一个表面上的电极焊盘; 以及从电极焊盘延伸到半导体衬底的另一个表面的贯通电极。

公开(公告)号：US07109834B2

公开(公告)日：2006-09-19

申请号：US10791438

申请日：2004-03-02

申请人： Kazuya Matsumoto

发明人： Kazuya Matsumoto

IPC分类号： H01H51/22

CPC分类号： H02K41/0354 ,  H01F2007/068 ,  H02K2201/18

摘要： An electromagnetic drive type actuator comprises a movable plate having a flat surface, a support positioned around the movable plate, an elastic member connecting the movable plate with the support, wirings extending through the support, the movable plate and the elastic member, and a magnetic field generator. The elastic member is elastically deformable and supports the movable plate so as to allow the movable plate to move in directions parallel to the flat surface of the movable plate. The wirings pass currents. The magnetic field generator generates a magnetic field in a space around the movable plate. The magnetic field has a direction orthogonal to the flat surface of the movable plate. The movable plate is moved in the directions parallel to the flat surface of the movable plate by an interaction between the currents flowing through the wirings and the magnetic field generated by magnetic field generator.

摘要翻译： 电磁驱动型致动器包括具有平坦表面的可移动板，围绕可动板的支撑件，将可移动板与支撑件连接的弹性元件，延伸穿过支撑件，可动板和弹性元件的布线，以及磁 场发生器。 弹性构件是可弹性变形的并且支撑可移动板，以允许可动板在平行于可动板的平坦表面的方向上移动。 接线通过电流。 磁场发生器在可动板周围的空间中产生磁场。 磁场具有与可动板的平坦表面正交的方向。 可移动板通过流过布线的电流和由磁场发生器产生的磁场之间的相互作用在平行于可动板的平坦表面的方向上移动。

公开(公告)号：US20050220773A1

公开(公告)日：2005-10-06

申请号：US10504969

申请日：2002-10-21

申请人： Toshimasa Uemura ,  Tetsuya Tateishi ,  Kazuya Matsumoto ,  Hiroko Kojima

发明人： Toshimasa Uemura ,  Tetsuya Tateishi ,  Kazuya Matsumoto ,  Hiroko Kojima

IPC分类号： A61K35/12 ,  A61K38/19 ,  A61L27/22 ,  A61L27/38 ,  A61K48/00 ,  C12N5/08

CPC分类号： A61L27/3821 ,  A61K35/32 ,  A61K38/1866 ,  A61L27/227 ,  A61L27/3847 ,  A61L27/3895 ,  A61L2430/02 ,  A61K2300/00

摘要： This invention provides alternative bone implants that have high bioadaptability and enable rapid bone regeneration. Specifically, this invention relates to implants consisting of a bioadaptable material comprising cells transfected with growth factor genes. Such implants are produced by inoculating bone-marrow-derived cells transfected with the genes of vascular endothelial growth factors (VEGF) into a bioadaptable material, such as porous ceramics, and culturing them.

摘要翻译： 本发明提供了具有高生物适应性并能够快速骨再生的替代性骨植入物。 具体地，本发明涉及由包含用生长因子基因转染的细胞的生物适应材料组成的植入物。 通过将由血管内皮生长因子（VEGF）的基因转染的骨髓来源的细胞接种到诸如多孔陶瓷的生物适应材料中并进行培养来产生这种植入物。

公开(公告)号：US06436674B1

公开(公告)日：2002-08-20

申请号：US09699684

申请日：2000-10-31

申请人： Masaru Honjo ,  Naokazu Naitoh ,  Hiroshi Uchida ,  Daisuke Mochizuki ,  Kazuya Matsumoto

发明人： Masaru Honjo ,  Naokazu Naitoh ,  Hiroshi Uchida ,  Daisuke Mochizuki ,  Kazuya Matsumoto

IPC分类号： C12N1509

CPC分类号： C12N1/20 ,  C07K14/245 ,  C07K14/265 ,  C07K14/61 ,  C07K2319/02 ,  C07K2319/75 ,  C12N9/48 ,  C12N9/52 ,  C12N15/62 ,  C12N15/70 ,  C12P21/02 ,  C12R1/19

摘要： A DNA encoding 20K hGH is connected directly to a gene encoding Escherichia coli OppA protein secretion signal, or a modified form thereof, and a DNA encoding signal peptidase 1 to construct a recombinant plasmid, E. coli is transformed by the plasmid and cells of the resulting E. coli transformant strain are cultured for secretory production of the 20K hGH in the E. coli periplasm. This method enables efficient secretory production of 20K hGH and easy isolation and purification of 20K hGH from the periplasm fraction because the level of impure proteins in the E. coli periplasm is low.

摘要翻译： 将编码20KhGH的DNA直接连接到编码大肠杆菌OppA蛋白分泌信号的基因或其修饰形式，以及编码信号肽酶1的DNA构建重组质粒，通过质粒和 培养得到的大肠杆菌转化体菌株用于在大肠杆菌周质中分泌生产20KhGH。 这种方法可以有效的分泌生产20K hGH，并且容易地从周质部分分离和纯化20KhGH，因为大肠杆菌周质中不纯的蛋白质水平低。