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    Method of forming a structure having multiple cell layers
    1.
    发明授权
    Method of forming a structure having multiple cell layers 失效
    形成具有多个单元层的结构的方法

    公开(公告)号：US06821107B1

    公开(公告)日：2004-11-23

    申请号：US09699133

    申请日：2000-10-27

    申请人： Masayuki Hara ,  Jun Miyake ,  Ayako Yamaki

    发明人： Masayuki Hara ,  Jun Miyake ,  Ayako Yamaki

    IPC分类号： C12N506

    CPC分类号： C12N5/0062 ,  C12N5/0068 ,  C12N2533/54 ,  C12N2533/74

    摘要： Multiple cell layers are formed with one cell layer formed on another cell layer. A carrier is provided having an alginate gel layer formed on a porous membrane. An extracellular matrix component gel layer or extracellular matrix component sponge layer may be formed on the alginate gel layer. A cell layer is formed on the alginate gel layer, or the extracellular matrix component gel layer or extracellular matrix component sponge layer. The alginate gel layer is solubilized such as with a chelating agent to exfoliate the cell layer from the porous membrane, and the exfoliated cell layer is placed on another cell layer on a carrier. The number of cell layers formed on each other may be 1-10, preferably 1-5, and more preferably 1-3.

    摘要翻译： 形成多个单元层，其中一个单元层形成在另一个单元层上。 提供了在多孔膜上形成藻酸盐凝胶层的载体。 可以在藻酸盐凝胶层上形成细胞外基质组分凝胶层或细胞外基质组分海绵层。 在藻酸盐凝胶层或细胞外基质组分凝胶层或细胞外基质组分海绵层上形成细胞层。 藻酸盐凝胶层例如用螯合剂溶解以从多孔膜剥离细胞层，并将剥离的细胞层置于载体上的另一个细胞层上。 彼此形成的电池层的数量可以为1-10，优选为1-5，更优选为1-3。

    Methods and systems for analyzing a network of biological functions
    4.
    发明申请
    Methods and systems for analyzing a network of biological functions 审中-公开
    分析生物功能网络的方法和系统

    公开(公告)号：US20070174009A1

    公开(公告)日：2007-07-26

    申请号：US11262554

    申请日：2005-10-28

    申请人： Masato Miyake ,  Tomohiro Yoshikawa ,  Takanori Ueda ,  Jun Miyake

    发明人： Masato Miyake ,  Tomohiro Yoshikawa ,  Takanori Ueda ,  Jun Miyake

    IPC分类号： G06F19/00

    CPC分类号： G16B5/00 ,  G16B20/00

    摘要： The present invention provides a method and system for analyzing a network of biological functions, such as transcriptional factors, structural genes, cellular markers, cell surface markers, cell shapes, organelle shapes, cell mobility, enzyme activities, metabolite concentrations, and localization of cellular components, in a biological entity such as a cell. Particularly, an object of the present invention is to provide a system and method for presenting biological information in a global manner without modification where the cell is considered a complex system.

    摘要翻译： 本发明提供了用于分析转录因子，结构基因，细胞标志物，细胞表面标志物，细胞形状，细胞器形状，细胞迁移率，酶活性，代谢物浓度和细胞定位的生物学功能网络的方法和系统 组分，在诸如细胞的生物实体中。 特别地，本发明的目的是提供一种用于以全局方式呈现生物信息的系统和方法，而不改变该细胞被认为是复杂的系统。

    Semiconductor memory device
    6.
    发明授权
    Semiconductor memory device 失效

    公开(公告)号：US5444665A

    公开(公告)日：1995-08-22

    申请号：US254416

    申请日：1994-06-06

    申请人： Yasunori Yamaguchi ,  Jun Miyake

    发明人： Yasunori Yamaguchi ,  Jun Miyake

    IPC分类号： G11C7/00 ,  G11C7/10 ,  H04N5/907 ,  G11C8/00

    CPC分类号： H04N5/907 ,  G11C7/00 ,  G11C7/1006

    摘要： A semiconductor memory device is provided with a memory portion, a logical operation circuit which receives the data signal read out from such memory portion and the input data signal to form data to be offered to such memory portion, and a gate circuit. In case a data input operation is required which eliminates the logical operation, the input data signal is fed not via the logical operation circuit, but via the gate circuit directly to the memory portion. The semiconductor memory device constructed as above permits a high speed operation and is suited for use as the memory for image processing.

    Chemical sensor system
    7.
    发明申请
    Chemical sensor system 审中-公开
    化学传感器系统

    公开(公告)号：US20070054266A1

    公开(公告)日：2007-03-08

    申请号：US10516210

    申请日：2003-05-28

    申请人： Takaaki Sato ,  Junzo Hirono ,  Hiroshi Hamana ,  Masato Miyake ,  Tomohiro Yoshikawa ,  Jun Miyake

    发明人： Takaaki Sato ,  Junzo Hirono ,  Hiroshi Hamana ,  Masato Miyake ,  Tomohiro Yoshikawa ,  Jun Miyake

    IPC分类号： C12Q1/68 ,  C12M1/34

    CPC分类号： G01N33/502 ,  G01N33/02 ,  G01N33/5008 ,  G01N33/5438

    摘要： A chemical sensor utilizing a chemical receptor (for example, one stimulating the sense of taste or smell) is provided. More specifically speaking, such a receptor is introduced into cells and the cells are immobilized on a support to form a chip. This chip is then employed as a component of a sensor. This sensor shows a reaction almost the same as the body's perception of the taste or smell or sense, thereby enabling analysis. Thus, it is also usable as an artificial sensory organ. Moreover, this sensor is usable in diagnosis, which imparts a high industrial usefulness to it.

    摘要翻译： 提供了利用化学受体（例如刺激味觉或嗅觉的化学受体）的化学传感器。 更具体地说，将这种受体引入细胞中，将细胞固定在载体上以形成芯片。 然后将该芯片用作传感器的组件。 该传感器显示与身体对味道或气味或感觉的感觉几乎相同的反应，从而能够进行分析。 因此，它也可用作人造感觉器官。 此外，该传感器可用于诊断，赋予其高的工业用途。

    Novel nerve stem cell marker
    8.
    发明申请
    Novel nerve stem cell marker 审中-公开
    新型神经干细胞标记

    公开(公告)号：US20070031894A1

    公开(公告)日：2007-02-08

    申请号：US10571268

    申请日：2004-09-10

    申请人： Tomoko Syofuda ,  Yonehiro Kanemura ,  Jun Miyake ,  Hideo Niwa ,  Kenji Yamashita

    发明人： Tomoko Syofuda ,  Yonehiro Kanemura ,  Jun Miyake ,  Hideo Niwa ,  Kenji Yamashita

    IPC分类号： G01N33/567 ,  C07K14/475 ,  C07K16/22 ,  C07H21/04

    CPC分类号： G01N33/5058 ,  C12Q1/6876 ,  G01N33/5008 ,  G01N33/5023 ,  G01N33/5073 ,  G01N2500/00

    摘要： It is an object of the present invention to provide a method for detecting nerve stem cells/progenitor cells among a tissue or a mass of cells as constituted of a plurality of cell species, and a method for screening for a drug functioning as a nerve differentiation factor or the like by using the above-mentioned detection method. It was found in this invention that the expression of the NC1 gene was high in undifferentiated nerve stem cells and said expression decreased with an advance of differentiation. Furthermore in this invention, by using the NC1 gene, the product thereof (NC1 protein) and the base sequences or the amino acid sequences thereof, antibodies or the like, it became possible to detect nerve stem cells/progenitor cells by way of various methods, so that a novel method for screening for a drug functioning as a nerve differentiation factor or the like was provided.

    摘要翻译： 本发明的目的是提供一种由多种细胞种组成的组织或大量细胞中的神经干细胞/祖细胞的检测方法，以及筛选作为神经分化的药物的方法 因子等通过使用上述检测方法。 在本发明中发现NC1基因的表达在未分化神经干细胞中高，并且所述表达随着分化的进展而降低。 此外，在本发明中，通过使用NC1基因，其产物（NC1蛋白）及其碱基序列或其氨基酸序列，抗体等，可以通过各种方法检测神经干细胞/祖细胞 ，因此提供了筛选用作神经分化因子等的药物的新方法。

    Semiconductor memory device
    10.
    发明授权
    Semiconductor memory device 失效
    半导体存储器件

    公开(公告)号：US5206832A

    公开(公告)日：1993-04-27

    申请号：US729337

    申请日：1991-07-12

    申请人： Yasunori Yamaguchi ,  Jun Miyake

    发明人： Yasunori Yamaguchi ,  Jun Miyake

    IPC分类号： G11C7/00 ,  G11C7/10 ,  H04N5/907

    CPC分类号： G11C7/1006 ,  G11C7/00 ,  H04N5/907

    摘要： A semiconductor memory device is provided with a memory portion, a logical operation circuit which receives the data signal read out from such memory portion and the input data signal to form data to be offered to such memory portion, and a gate circuit. In case a data input operation is required which eliminates the logical operation, the input data signal is fed not via the logical operation circuit, but via the gate circuit directly to the memory portion. The semiconductor memory device constructed as above permits a high speed operation and is suited for use as the memory for image processing.

    摘要翻译： 半导体存储器件具有存储器部分，逻辑运算电路，其接收从这种存储器部分读出的数据信号和输入数据信号，以形成要提供给这种存储器部分的数据;以及门电路。 在需要消除逻辑运算的数据输入操作的情况下，输入数据信号不是通过逻辑运算电路而是经由门电路直接馈送到存储器部分。 如上构造的半导体存储器件允许高速操作，并且适合用作用于图像处理的存储器。