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1.发明申请公开(公告)号：US20090305437A1
公开(公告)日：2009-12-10
申请号：US12282160
申请日：2007-03-08
CPC分类号： G03F7/265 , B82Y10/00 , B82Y30/00 , G01N33/54353 , G03F7/165 , H01L21/0237 , H01L21/02439 , H01L21/02521 , H01L21/02639 , H01L21/02645 , H01L21/02647
摘要： A method of forming an integrated circuit layer material is described, comprising depositing a layer of templates on a substrate, said template including a first binding site having an affinity for the substrate, a second binding site having an affinity for a target integrated circuit material and a protecting material coupled to the second binding site via a labile linkage to prevent the binding site from binding to the target integrated circuit material; exposing the template to an external stimulus to degrade the labile linkage; removing the protecting material; and binding the integrated circuit material to the second binding site.
摘要翻译： 描述了形成集成电路层材料的方法，包括在衬底上沉积模板层，所述模板包括对衬底具有亲和性的第一结合位点，对目标集成电路材料具有亲和力的第二结合位点，以及 经由不稳定连接物耦合到第二结合位点的保护材料以防止结合位点结合到靶集成电路材料; 将模板暴露于外部刺激以降低不稳定性联系; 去除保护材料; 并将集成电路材料结合到第二结合位点。
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公开(公告)号：US20110043797A1
公开(公告)日：2011-02-24
申请号：US12545042
申请日：2009-08-20
IPC分类号： G01N21/88
CPC分类号： G01N21/956
摘要： An inspection system for creating images of a substrate. A light source directs an incident light onto the substrate, and a light source timing control controls a pulse timing of the incident light. A stage holds the substrate and moves the substrate under the incident light, so that the substrate reflects the incident light as a reflected light. A stage position sensor reports a position of the stage, and a stage position control controls the position of the stage. A time domain integration sensor receives the reflected light, and a time domain integration sensor timing control controls a line shift of the time domain integration sensor. A control system is in communication with the light source timing control, the stage position control, and the time delay integration sensor timing control, and sets the pulse timing of the incident light, the position of the stage, and the line shift of the time delay integration sensor, such that a single line of the time domain integration sensor integrates reflected light from more than one pulse of the incident light from the light source.
摘要翻译： 一种用于创建基板的图像的检查系统。 光源将入射光引导到基板上，并且光源定时控制器控制入射光的脉冲定时。 台阶保持基板并在入射光下移动基板，使得基板作为反射光反射入射光。 舞台位置传感器报告舞台的位置，舞台位置控制控制舞台的位置。 时域积分传感器接收反射光，时域积分传感器定时控制控制时域积分传感器的线偏移。 控制系统与光源定时控制，平台位置控制和时间延迟积分传感器定时控制通信，并且设置入射光的脉冲定时，平台的位置和时间的线偏移 延迟积分传感器，使得单行的时域积分传感器集成来自光源的入射光的多于一个脉冲的反射光。
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公开(公告)号：US06921660B2
公开(公告)日：2005-07-26
申请号：US10097351
申请日：2002-03-15
申请人： Gregory L. Kirk , Matthew Brown , Emanuele Ostuni , Enoch Kim , Bernardo D. Aumond , Olivier Schueller , Paul Sweetnam , Brian Benoit
发明人： Gregory L. Kirk , Matthew Brown , Emanuele Ostuni , Enoch Kim , Bernardo D. Aumond , Olivier Schueller , Paul Sweetnam , Brian Benoit
CPC分类号： B82Y30/00 , B01L3/5025 , B01L3/5027 , B01L3/502746 , B01L2300/0681 , B01L2300/0829 , B01L2400/0406 , Y10S435/809
摘要： The present invention discloses a device for monitoring chemotaxis or chemoinvasion including a housing comprising: a support member and a top member, the top member mounted to the support member by being placed in substantially fluid-tight conformal contact with the support member. The support member and the top member are configured such that they together define a discrete chamber adapted to allow a monitoring of chemotaxis or chemoinvasion therein. The discrete chamber includes a first well region including at least one first well, the at least one first well configured to received a test agent therein; a second well region including at least one second well, the at least one second well configured to receive a sample comprising cells therein; and a channel region including at least one channel connecting the first well region and the second well region with one another. The second well region is preferably horizontally offset with respect to the first well region in a test orientation of the device.
摘要翻译： 本发明公开了一种用于监测趋化性或化学侵蚀的装置，包括：壳体，包括：支撑构件和顶部构件，顶部构件通过与支撑构件基本上不流体密封地共形接触而安装到支撑构件。 支撑构件和顶部构件被构造成使得它们一起限定适于允许监测其中的趋化性或化学侵蚀的离散室。 离散室包括包括至少一个第一井的第一井区，所述至少一个第一井构造成在其中接收测试剂; 包括至少一个第二阱的第二阱区，所述至少一个第二阱被配置为在其中接收包含电池的样品; 以及沟道区域，其包括将第一阱区域和第二阱区域彼此连接的至少一个沟道。 在设备的测试方向上，第二阱区域优选地相对于第一阱区域水平偏移。
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4.发明授权Method for arraying biomolecules and for monitoring cell motility in real-time 失效排列生物分子和实时监测细胞运动的方法公开(公告)号：US06893851B2
公开(公告)日：2005-05-17
申请号：US10206112
申请日：2002-07-29
申请人： Enoch Kim , Gregory L. Kirk , Olivier Schueller , Emanuele Ostuni
发明人： Enoch Kim , Gregory L. Kirk , Olivier Schueller , Emanuele Ostuni
CPC分类号： C12M25/06 , B01D2325/08 , B01J2219/00317 , B01J2219/00662 , B01J2219/00722 , B01J2219/00725 , B01J2219/00743 , B01L3/5025 , B01L3/5027 , B01L3/5085 , B01L2200/0647 , B01L2200/12 , B01L2300/0636 , B01L2300/0829 , B01L2300/0887 , B82Y30/00 , C12M23/12 , C12M41/46 , C12Q1/025 , C40B40/06 , C40B40/10 , C40B60/14 , G01N15/1468 , G01N33/54366 , G01N2015/1497 , G06K9/0014 , G06T7/0012 , G06T7/70 , G06T2207/10056 , G06T2207/10064 , G06T2207/30072
摘要： The invention relates to devices, devices for arraying biomolecules, including cells, methods for arraying biomolecules, assays for monitoring cellular movement, and systems for monitoring cellular movement. The devices include a support; a first layer configured to be placed in fluid-tight contact with the support, the first layer having an upper surface and defining a pattern of micro-orifices, each micro-orifice of the pattern of micro-orifices having walls and defining a micro-region on the support when the first layer is placed in fluid-tight contact with the support such that the walls of said each micro-orifice and the micro-region on the support together define a micro-well; and a second layer configured to be placed in fluid-tight contact with the upper surface of the first layer, the second layer defining a pattern of macro-orifices, each macro-orifice of the pattern of macro-orifices having walls and defining a macro-region when the first layer is placed in fluid-tight contact with the support and the second layer is placed in fluid-tight contact with the first layer such that the walls of the macro-orifice and the macro-region together define a macro-well.
摘要翻译： 本发明涉及用于排列生物分子的装置，包括细胞，用于排列生物分子的方法，用于监测细胞运动的测定法和用于监测细胞运动的系统。 这些装置包括一个支架; 第一层，其被配置为与所述支撑件流体密封接触，所述第一层具有上表面并限定微孔图案，所述微孔图案的每个微口具有壁并限定微孔， 当第一层与支撑件流体密封地接触时，支撑件上的区域在支撑件上，使得所述每个微孔的壁和支撑件上的微区域一起限定微孔; 以及第二层，其被配置为与所述第一层的上表面流体密封接触，所述第二层限定宏观孔的图案，所述宏观孔的图案的每个宏观孔口具有壁并且限定宏观 当所述第一层与所述支撑件流体密封接触时，所述第二层与所述第一层流体密封接触，使得所述宏观孔和所述宏观区域的壁一起限定宏观尺寸， 好。
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公开(公告)号：US06864065B2
公开(公告)日：2005-03-08
申请号：US10206374
申请日：2002-07-29
申请人： Enoch Kim , Gregory L. Kirk , Olivier Schueller , Emanuele Ostuni
发明人： Enoch Kim , Gregory L. Kirk , Olivier Schueller , Emanuele Ostuni
CPC分类号： C12M25/06 , B01D2325/08 , B01J2219/00317 , B01J2219/00662 , B01J2219/00722 , B01J2219/00725 , B01J2219/00743 , B01L3/5025 , B01L3/5027 , B01L3/5085 , B01L2200/0647 , B01L2200/12 , B01L2300/0636 , B01L2300/0829 , B01L2300/0887 , B82Y30/00 , C12M23/12 , C12M23/20 , C12M33/00 , C12M41/46 , C12Q1/025 , C40B40/06 , C40B40/10 , C40B60/14 , G01N15/1468 , G01N33/54366 , G01N2015/1497 , G06K9/0014 , G06T7/0012 , G06T7/70 , G06T2207/10056 , G06T2207/10064 , G06T2207/30072
摘要： The invention relates to devices, devices for arraying biomolecules, including cells, methods for arraying biomolecules, assays for monitoring cellular movement, and systems for monitoring cellular movement. The devices include a support; a first layer configured to be placed in fluid-tight contact with the support, the first layer having an upper surface and defining a pattern of micro-orifices, each micro-orifice of the pattern of micro-orifices having walls and defining a micro-region on the support when the first layer is placed in fluid-tight contact with the support such that the walls of said each micro-orifice and the micro-region on the support together define a micro-well; and a second layer configured to be placed in fluid-tight contact with the upper surface of the first layer, the second layer defining a pattern of macro-orifices, each macro-orifice of the pattern of macro-orifices having walls and defining a macro-region when the first layer is placed in fluid-tight contact with the support and the second layer is placed in fluid-tight contact with the first layer such that the walls of the macro-orifice and the macro-region together define a macro-well.
摘要翻译： 本发明涉及用于排列生物分子的装置，包括细胞，用于排列生物分子的方法，用于监测细胞运动的测定法和用于监测细胞运动的系统。 这些装置包括一个支架; 第一层，其被配置为与所述支撑件流体密封接触，所述第一层具有上表面并限定微孔图案，所述微孔图案的每个微孔具有壁并限定微孔， 当第一层与支撑件流体密封地接触时，支撑件上的区域在支撑件上，使得所述每个微孔的壁和支撑件上的微区域一起限定微孔; 以及第二层，其被配置为与所述第一层的上表面流体密封接触，所述第二层限定宏观孔的图案，所述宏观孔的图案的每个宏观孔口具有壁并且限定宏观 当所述第一层与所述支撑件流体密封接触时，所述第二层与所述第一层流体密封接触，使得所述宏观孔和所述宏观区域的壁一起限定宏观尺寸， 好。
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6.发明授权公开(公告)号：US06803205B2
公开(公告)日：2004-10-12
申请号：US10206534
申请日：2002-07-29
IPC分类号： C12Q148
CPC分类号： G01N33/54366 , B01D2325/08 , B01J2219/00274 , B01J2219/00317 , B01J2219/00662 , B01J2219/00722 , B01J2219/00725 , B01J2219/00743 , B01L3/5025 , B01L3/5027 , B01L3/5085 , B01L2200/021 , B01L2200/025 , B01L2200/0647 , B01L2200/12 , B01L2300/0636 , B01L2300/0829 , B01L2300/0848 , B01L2300/0887 , B01L2300/123 , B82Y5/00 , B82Y30/00 , C12M23/12 , C12Q1/025 , C40B40/06 , C40B40/10 , C40B60/14 , G01N15/1468 , G01N2015/1497 , G06T7/0012 , G06T7/70 , G06T2207/10008 , G06T2207/10064 , G06T2207/30072
摘要： Devices and methods for performing assays on materials, particularly biological materials, are provided. The devices and methods make use of self-sealing members, which can be applied to a flat surface to form wells to facilitate immobilization of materials on the flat surface, then removed to yield a flat surface that facilitates the performance of processes on and/or detection of the immobilized material.
摘要翻译： 提供了用于对材料，特别是生物材料进行测定的装置和方法。 这些装置和方法利用自密封构件，其可以应用于平坦表面以形成井，以便于材料在平坦表面上的固定，然后移除以产生平坦表面，其有助于在和/或 检测固定化材料。
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7.发明授权公开(公告)号：US08705027B2
公开(公告)日：2014-04-22
申请号：US13384330
申请日：2010-07-15
IPC分类号： G01N21/00
CPC分类号： G01N21/95607 , Y10T428/24521 , Y10T428/31504
摘要： A method for wafer defect inspection may include, but is not limited to: providing an inspection target; applying at least one defect inspection enhancement to the inspection target; illuminating the inspection target including the at least one inspection enhancement to generate one or more inspection signals associated with one or more features of the inspection target; detecting the inspection signals; and generating one or more inspection parameters from the inspection signals. An inspection target may include, but is not limited to: at least one inspection layer; and at least one inspection enhancement layer.
摘要翻译： 晶片缺陷检查的方法可以包括但不限于：提供检查目标; 对检查对象应用至少一个缺陷检查增强; 照亮包括所述至少一个检查增强的所述检查目标以产生与所述检查对象的一个或多个特征相关联的一个或多个检查信号; 检测检测信号; 以及从所述检查信号生成一个或多个检查参数。 检查对象可以包括但不限于：至少一个检查层; 和至少一个检查增强层。
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8.发明申请公开(公告)号：US20120113416A1
公开(公告)日：2012-05-10
申请号：US13384330
申请日：2010-07-15
CPC分类号： G01N21/95607 , Y10T428/24521 , Y10T428/31504
摘要： A method for wafer defect inspection may include, but is not limited to: providing an inspection target; applying at least one defect inspection enhancement to the inspection target; illuminating the inspection target including the at least one inspection enhancement to generate one or more inspection signals associated with one or more features of the inspection target; detecting the inspection signals; and generating one or more inspection parameters from the inspection signals. An inspection target may include, but is not limited to: at least one inspection layer; and at least one inspection enhancement layer.
摘要翻译： 晶片缺陷检查的方法可以包括但不限于：提供检查目标; 对检查对象应用至少一个缺陷检查增强; 照亮包括所述至少一个检查增强的所述检查目标以产生与所述检查对象的一个或多个特征相关联的一个或多个检查信号; 检测检测信号; 以及从所述检查信号生成一个或多个检查参数。 检查对象可以包括但不限于：至少一个检查层; 和至少一个检查增强层。
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公开(公告)号：US06468787B1
公开(公告)日：2002-10-22
申请号：US09294169
申请日：1999-04-19
申请人： Rhett L. Affleck , Doug Hobbs , Ilya Feygin , Gregory L. Kirk , James A. Connelly , Ning Zhao , James P. Mueller , Peter Kieselbach
发明人： Rhett L. Affleck , Doug Hobbs , Ilya Feygin , Gregory L. Kirk , James A. Connelly , Ning Zhao , James P. Mueller , Peter Kieselbach
IPC分类号： C12M100
CPC分类号： B82Y30/00 , B01J19/0046 , B01J2219/00283 , B01J2219/00306 , B01J2219/00308 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00659 , B01J2219/00711 , B01J2219/00713 , B01J2219/0072 , C07K1/04 , C07K1/12 , C40B60/14 , G01N33/54353
摘要： A method for photoeluting photocleavable linker-attached chemical compounds, and an apparatus suitable for implementing the method, are disclosed. According to the method, photocleavable linker-attached library compounds are photoeluted from solid support media under conditions of controlled light exposure and controlled temperature. An apparatus suitable for carrying out the present photoelution method includes means for substantially evenly illuminating the photocleavable linker, means for controlling illumination time and intensity, and means for controlling sample temperature.
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10.再颁专利High throughput solid phase chemical synthesis utilizing thin cylindrical reaction vessels useable for biological assay 失效使用可用于生物测定的薄的圆柱形反应容器的高通量固相化学合成公开(公告)号：USRE37194E1
公开(公告)日：2001-05-29
申请号：US09567618
申请日：2000-05-09
申请人： Gregory L. Kirk , Robert H. Grubbs
发明人： Gregory L. Kirk , Robert H. Grubbs
IPC分类号： C25B1502
CPC分类号： G01N30/466 , B01J19/0046 , B01J2219/00286 , B01J2219/00306 , B01J2219/00308 , B01J2219/00315 , B01J2219/00355 , B01J2219/00389 , B01J2219/00418 , B01J2219/00463 , B01J2219/00495 , B01J2219/005 , B01J2219/00511 , B01J2219/0052 , B01J2219/00547 , B01J2219/00585 , B01J2219/0059 , B01J2219/00592 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00621 , B01J2219/00637 , B01J2219/00641 , B01J2219/00644 , B01J2219/00659 , B01J2219/00689 , B01J2219/00702 , B01J2219/00711 , B82Y30/00 , C07K1/045 , C40B60/14 , C40B70/00 , G01N30/46 , G01N30/60 , G01N30/6043 , G01N2030/524 , Y10T436/113332 , Y10T436/114165 , Y10T436/114998 , Y10T436/117497 , Y10T436/12
摘要： A high throughput chemical synthesis system utilizing cylindrical reaction vessels is disclosed. Reaction vessels are utilized which include a tubular member adapted for placement of electronically readable identifying indicia thereon. The identifying indicia are representative of reaction conditions within the tubular member and of one or more reagents utilized in a reaction within the tubular members. A method of performing chemical synthesis on solid phase reactive material within a plurality of reaction vessels using a plurality of reaction stages resulting in final products and employing identifying indicia representing the reaction stages is also disclosed. The method includes reading the identifying indicia located on the reaction vessels, reacting one or more reagents within the reaction vessels under particular reaction conditions which may be determined by reading the identifying indicia, thereby synthesizing chemical compounds within the reaction vessels. The method allows chemical synthesis to occur according to a predetermined set of reactions and also allows for combinatorial chemistry to be performed utilizing random mix and split techniques. The final synthesized products may be tested for chemical or biological activity. The chemical structures of desired end products may be obtained by reading recorded information wherein the reaction conditions and reagents of reaction steps have been recorded, preferably in conjunction with the identifying indicia.
摘要翻译： 公开了一种利用圆柱形反应容器的高通量化学合成系统。 使用反应容器，其包括适于在其上放置电子可读识别标记的管状构件。 识别标记是管状构件内的反应条件以及在管状构件内的反应中使用的一种或多种试剂的代表。 还公开了使用多个反应阶段在多个反应容器内对固相反应性材料进行化学合成的方法，所述反应阶段产生最终产物并采用代表反应级的识别标记。 该方法包括读取位于反应容器上的识别标记，在特定反应条件下在反应容器内反应一种或多种试剂，该反应条件可通过读取识别标记确定，由此合成反应容器内的化合物。 该方法允许根据预定的一组反应进行化学合成，并且还允许使用随机混合和分离技术进行组合化学。 最终的合成产物可以测试化学或生物活性。 期望的最终产物的化学结构可以通过阅读记录的信息来获得，其中已经记录了反应步骤的反应条件和试剂，优选结合识别标记。
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