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    Optical detection cell for micro-fluidics
    3.
    发明申请
    Optical detection cell for micro-fluidics 审中-公开
    用于微流体学的光学检测单元

    公开(公告)号：US20070218454A1

    公开(公告)日：2007-09-20

    申请号：US11378760

    申请日：2006-03-16

    申请人： Reid Brennen ,  Timothy Beerling ,  Hongfeng Yin ,  Kevin Killeen

    发明人： Reid Brennen ,  Timothy Beerling ,  Hongfeng Yin ,  Kevin Killeen

    IPC分类号： C12Q1/00

    CPC分类号： G01N21/0303 ,  G01N2021/036 ,  G01N2201/0245

    摘要： The present invention relates to an optical detection cell for micro-fluidics. The detection cell provides a first layer, a detection cell layer contacting the first layer, a third layer contacting the detection cell layer and a detection channel defined through the detection cell to serve as a light path for receiving light for detecting a molecule Methods of detecting molecules and making the detection cell are also disclosed

    摘要翻译： 本发明涉及一种用于微流体学的光学检测单元。 检测单元提供第一层，接触第一层的检测单元层，接触检测单元层的第三层和通过检测单元定义的检测通道，用作接收用于检测分子的光的光路。检测方法 分子和制备检测电池也被公开

    Microfluidic Device for Sample Analysis
    4.
    发明申请
    Microfluidic Device for Sample Analysis 有权
    用于样品分析的微流体装置

    公开(公告)号：US20090188868A1

    公开(公告)日：2009-07-30

    申请号：US12022684

    申请日：2008-01-30

    申请人： Hongfeng Yin ,  Reid Brennen ,  Kevin Killeen

    发明人： Hongfeng Yin ,  Reid Brennen ,  Kevin Killeen

    IPC分类号： B01D15/08 ,  B01D15/22

    CPC分类号： G01N30/20 ,  B01D15/22 ,  B01D15/305 ,  B01D15/325 ,  B01L3/502738 ,  B01L2200/0605 ,  B01L2200/10 ,  B01L2200/14 ,  B01L2300/0816 ,  B01L2300/087 ,  B01L2300/0874 ,  B01L2400/0622 ,  B01L2400/0644 ,  G01N30/08 ,  G01N2030/085 ,  G01N2030/202 ,  G01N30/6095

    摘要： A device for sample analysis includes a microfluidic device for separating analytes of a sample comprising a liquid, the microfluidic device comprising a substrate having a first surface and a second surface opposite the first surface, the substrate defining features that collectively occupy an area of the substrate of about 0.1 to 10 cm2, the features comprising a sample input port located at the first surface; a drying agent input port located at the first surface; an enrichment column; a separation column; switching ports located at the second surface; and fluid-conducting passages extending through the substrate from the switching ports to the sample input port, the drying agent input port, the enrichment column and the separation column. Also provided are methods and systems for separating analytes from a sample.

    摘要翻译： 用于样品分析的装置包括用于分离包含液体的样品的分析物的微流体装置，所述微流体装置包括具有第一表面和与所述第一表面相对的第二表面的基底，所述基底限定了共同占据所述基底的区域的特征 约0.1至10cm 2，其特征包括位于第一表面处的样品输入端口; 位于第一表面的干燥剂输入口; 浓缩柱 分离柱; 位于第二表面的切换端口; 以及从所述基板从所述切换口延伸到所述样品输入口，所述干燥剂输入口，所述浓缩塔和所述分离塔的流体导通通路。 还提供了用于从样品中分离分析物的方法和系统。

    Fluidic device having contiguous conductive layer over interior and exterior surfaces thereof
    5.
    发明申请
    Fluidic device having contiguous conductive layer over interior and exterior surfaces thereof 审中-公开
    流体装置在其内表面和外表面上具有相邻的导电层

    公开(公告)号：US20070151856A1

    公开(公告)日：2007-07-05

    申请号：US11321302

    申请日：2005-12-29

    申请人： R. Fazzio ,  Kevin Killeen ,  Atul Goel ,  Reid Brennen ,  Hongfeng Yin

    发明人： R. Fazzio ,  Kevin Killeen ,  Atul Goel ,  Reid Brennen ,  Hongfeng Yin

    IPC分类号： G01N27/00

    CPC分类号： G01N27/44791 ,  B01L3/5027 ,  B01L9/527 ,  B01L2200/027 ,  B01L2300/069 ,  B01L2300/0887 ,  B01L2400/0421

    摘要： A fluidic device is provided that includes a body and a contiguous electrically conductive layer. The body has interior and exterior surfaces. The interior surface defines at least a well and a fluid-transporting feature, e.g., a microfeature in fluid-communication with the well. The well has a sidewall and an exterior opening terminating at the exterior surface. The contiguous electrically conductive layer is located on at least the sidewall of the well and selected regions of the interior and exterior surfaces so as to form a contact pad region on the exterior surface in electrical communication with any fluid within the fluid-transporting feature. Also provided is a method for forming a fluidic device.

    摘要翻译： 提供了一种流体装置，其包括主体和相邻的导电层。 身体内部和外部表面。 内表面至少限定了井和流体输送特征，例如与井流体连通的微特征。 该井具有侧壁和外部开口，终止于外表面。 连续的导电层位于孔的至少侧壁和内表面和外表面的选定区域之间，以在外表面上形成与流体输送特征内的任何流体电连通的接触垫区域。 还提供了一种用于形成流体装置的方法。

    Devices and methods using fluid-transporting features of differing dwell times
    7.
    发明申请
    Devices and methods using fluid-transporting features of differing dwell times 审中-公开
    使用不同停留时间的流体输送特征的装置和方法

    公开(公告)号：US20070113907A1

    公开(公告)日：2007-05-24

    申请号：US11283363

    申请日：2005-11-18

    申请人： Reid Brennen ,  Hongfeng Yin ,  Kevin Killeen ,  Arthur Schleifer

    发明人： Reid Brennen ,  Hongfeng Yin ,  Kevin Killeen ,  Arthur Schleifer

    IPC分类号： F15C1/06

    CPC分类号： G01N30/34 ,  B01F13/0059 ,  B01F13/0094 ,  B01L3/502746 ,  B01L2300/0867 ,  B01L2400/0418 ,  B01L2400/0487 ,  B01L2400/084 ,  Y10T137/2224

    摘要： A fluidic device is provided that includes a plurality of fluid-transporting features extending from a common inlet to a common outlet and a means for effecting fluid flow through the fluid-transporting features. The features are associated with differing fluid dwell times. The means for effecting fluid flow cooperates with the fluid-transporting features to merge fluids from the fluid-transporting features in a manner effective to produce an output stream from the common outlet that exhibits at least one desired characteristic generated as a result of the differing dwell times. Also provided is a method for producing a fluid stream exhibiting at least one desired characteristic. Optionally, the device and/or method are used in microfluidic applications.

    摘要翻译： 提供了一种流体装置，其包括从公共入口延伸到公共出口的多个流体输送特征以及用于使流体流过流体输送特征的装置。 这些特征与不同的流体停留时间有关。 用于实现流体流动的装置与流体输送特征协作，以有效地产生来自公共出口的输出流的方式合并来自流体输送特征的流体，其显示由于不同驻留而产生的至少一个期望特性 次 还提供了一种产生表现出至少一种期望特性的流体流的方法。 可选地，该装置和/或方法用于微流体应用中。

    Apparatus and method for gas flow management
    8.
    发明申请
    Apparatus and method for gas flow management 有权
    气流管理装置及方法

    公开(公告)号：US20070045532A1

    公开(公告)日：2007-03-01

    申请号：US11216884

    申请日：2005-08-30

    申请人： Reid Brennen ,  Tom van de Goor ,  Gangqiang Li ,  Kevin Killeen

    发明人： Reid Brennen ,  Tom van de Goor ,  Gangqiang Li ,  Kevin Killeen

    IPC分类号： H01J49/10

    CPC分类号： H01J49/10

    摘要： The invention described herein provides a mass spectrometry system, having an ion source including an ionization device for producing ions, a collection conduit adjacent to the ionization device for collecting ions produced by the ionization device, a first gas source for supplying gas to desolvate ions produced by the ionization device, a second gas source for supplying gas at a defined flow to the ionization region, and a detector downstream from the ion source for detecting ions produced by the ion source. The invention also provides an ion source including an ionization device for producing ions, a collection conduit adjacent to the ionization device for collecting ions produced by the ionization device, a first gas source for supplying gas to desolvate ions produced by the ionization device, and a second gas source for supplying gas at a defined flow to the ionization region. A method for producing analyte ions is also disclosed. The method includes producing analyte ions from an ionization device, directing a first heated gas toward the analyte ions to desolvate the analyte ions, and directing a second gas toward the analyte ions at a defined and continual flow rate.

    摘要翻译： 本发明提供了一种质谱系统，其具有离子源，该离子源包括用于产生离子的离子化装置，与电离装置相邻的收集管，用于收集由离子化装置产生的离子;第一气体源，用于向产生的脱溶质离子供应气体 通过电离装置将用于以规定的流量供给到电离区域的气体的第二气体源和离子源下游的检测器，用于检测由离子源产生的离子。 本发明还提供一种离子源，其包括用于产生离子的离子化装置，与离子化装置相邻的收集管道，用于收集由离子化装置产生的离子，用于向离子化装置产生的脱溶质离子供给气体的第一气体源， 用于以限定的流量供应气体至电离区的第二气体源。 还公开了一种生产分析物离子的方法。 该方法包括从电离装置产生分析物离子，将第一加热气体引向分析物离子以使分析物离子脱溶质，并以限定和持续的流速将第二气体引向分析物离子。

    Fluidic separation devices and methods with reduced sample broadening
    10.
    发明申请
    Fluidic separation devices and methods with reduced sample broadening 审中-公开
    流体分离装置和减少样品扩增的方法

    公开(公告)号：US20070140918A1

    公开(公告)日：2007-06-21

    申请号：US11311960

    申请日：2005-12-19

    申请人： Hongfeng Yin ,  Kevin Killeen ,  Reid Brennen

    发明人： Hongfeng Yin ,  Kevin Killeen ,  Reid Brennen

    IPC分类号： B01L11/00

    CPC分类号： G01N30/20 ,  G01N30/02 ,  G01N30/6095 ,  G01N30/7266 ,  G01N2030/202 ,  Y10T436/25 ,  B01D15/14

    摘要： Fluidic separation devices and methods with reduced sample broadening are provided. A column is located downstream from a holding chamber, and a flow providing means provides fluid flow effective to convey a sample along a flow path that extends from the holding chamber into the separation column. The sample is typically focused in the flow path upstream from the separation column. Optionally, the invention may be employed with electrospray mass spectrometry and in microfluidic applications.

    摘要翻译： 提供了流体分离装置和减少样品加宽的方法。 柱位于保持室的下游，并且流动提供装置提供有效地沿着沿着从保持室延伸到分离柱的流动路径输送样品的流体流。 样品通常聚焦在分离柱上游的流路中。 任选地，本发明可以与电喷雾质谱法和微流体应用一起使用。