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公开(公告)号：US20050170340A9
公开(公告)日：2005-08-04
申请号：US10102915
申请日：2002-03-22
申请人： Stephen Fodor , Dennis Solas , William Dower
发明人： Stephen Fodor , Dennis Solas , William Dower
IPC分类号： B01J19/00 , C07B61/00 , C07H19/10 , C07H21/00 , C07K1/04 , C07K17/06 , C07K17/14 , C12Q1/68 , C40B40/06 , C40B40/10 , C40B60/14 , G01N15/14 , G03F7/00 , G03F7/26 , G03F7/38 , G11C13/02 , C12M1/34 , G01N33/53 , G01N33/542
CPC分类号： G03F7/00 , B01J19/0046 , B01J2219/00315 , B01J2219/00432 , B01J2219/00434 , B01J2219/00436 , B01J2219/00459 , B01J2219/00468 , B01J2219/00475 , B01J2219/005 , B01J2219/00527 , B01J2219/00529 , B01J2219/00531 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00617 , B01J2219/00626 , B01J2219/0063 , B01J2219/00637 , B01J2219/00641 , B01J2219/00648 , B01J2219/00659 , B01J2219/00689 , B01J2219/00695 , B01J2219/00711 , B01J2219/00722 , B01J2219/00725 , B82Y10/00 , B82Y30/00 , C07B2200/11 , C07H19/10 , C07H21/00 , C07K1/042 , C07K1/045 , C07K17/06 , C07K17/14 , C12Q1/6804 , C12Q1/6809 , C12Q1/6816 , C12Q1/6827 , C12Q1/6834 , C12Q1/6837 , C12Q1/6874 , C40B40/06 , C40B40/10 , C40B60/14 , G01N15/1475 , G03F7/265 , G03F7/38 , G11C13/0014 , G11C13/0019 , C12Q2565/513 , C12Q2565/507 , C12Q2545/101 , C12Q2525/185 , C12Q2565/514 , C12Q2563/173 , C12Q2563/119 , C12Q2563/149 , C12Q2525/151 , C12Q2525/179 , C12Q2525/204
摘要： The present invention provides methods and apparatus for sequencing, fingerprinting and mapping biological macromolecules, typically biological polymers. The methods make use of a plurality of sequence specific recognition reagents which can also be used for classification of biological samples, and to characterize their sources.
摘要翻译： 本发明提供了用于测序，指纹和绘制生物大分子（通常为生物聚合物）的方法和装置。 该方法利用多种序列特异性识别试剂，其也可用于生物样品的分类和表征其来源。
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公开(公告)号：US20050164249A1
公开(公告)日：2005-07-28
申请号：US10992772
申请日：2004-11-22
申请人： Stephen Fodor , Dennis Solas , William Dower
发明人： Stephen Fodor , Dennis Solas , William Dower
IPC分类号： B01J19/00 , C07B61/00 , C07H19/10 , C07H21/00 , C07K1/04 , C07K17/06 , C07K17/14 , C12Q1/68 , C40B40/06 , C40B40/10 , C40B60/14 , G01N15/14 , G03F7/00 , G03F7/26 , G03F7/38 , G11C13/02 , C12M1/34 , G01N33/53
CPC分类号： G03F7/00 , B01J19/0046 , B01J2219/00315 , B01J2219/00432 , B01J2219/00434 , B01J2219/00436 , B01J2219/00459 , B01J2219/00468 , B01J2219/00475 , B01J2219/005 , B01J2219/00527 , B01J2219/00529 , B01J2219/00531 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00617 , B01J2219/00626 , B01J2219/0063 , B01J2219/00637 , B01J2219/00641 , B01J2219/00648 , B01J2219/00659 , B01J2219/00689 , B01J2219/00695 , B01J2219/00711 , B01J2219/00722 , B01J2219/00725 , B82Y10/00 , B82Y30/00 , C07B2200/11 , C07H19/10 , C07H21/00 , C07K1/042 , C07K1/045 , C07K17/06 , C07K17/14 , C12Q1/6804 , C12Q1/6809 , C12Q1/6816 , C12Q1/6827 , C12Q1/6834 , C12Q1/6837 , C12Q1/6874 , C40B40/06 , C40B40/10 , C40B60/14 , G01N15/1475 , G03F7/265 , G03F7/38 , G11C13/0014 , G11C13/0019 , C12Q2565/513 , C12Q2565/507 , C12Q2545/101 , C12Q2525/185 , C12Q2565/514 , C12Q2563/173 , C12Q2563/119 , C12Q2563/149 , C12Q2525/151 , C12Q2525/179 , C12Q2525/204
摘要： The present invention provides methods and apparatus for sequencing, fingerprinting and mapping biological macromolecules, typically biological polymers. The methods make use of a plurality of sequence specific recognition reagents which can also be used for classification of biological samples, and to characterize their sources.
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公开(公告)号：US20050158743A1
公开(公告)日：2005-07-21
申请号：US10992782
申请日：2004-11-22
申请人： Stephen Fodor , Dennis Solas , William Dower
发明人： Stephen Fodor , Dennis Solas , William Dower
IPC分类号： B01J19/00 , C07B61/00 , C07H19/10 , C07H21/00 , C07K1/04 , C07K17/06 , C07K17/14 , C12Q1/68 , C40B40/06 , C40B40/10 , C40B60/14 , G01N15/14 , G03F7/00 , G03F7/26 , G03F7/38 , G11C13/02 , C12M1/34 , G01N33/53
CPC分类号： G03F7/00 , B01J19/0046 , B01J2219/00315 , B01J2219/00432 , B01J2219/00434 , B01J2219/00436 , B01J2219/00459 , B01J2219/00468 , B01J2219/00475 , B01J2219/005 , B01J2219/00527 , B01J2219/00529 , B01J2219/00531 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00617 , B01J2219/00626 , B01J2219/0063 , B01J2219/00637 , B01J2219/00641 , B01J2219/00648 , B01J2219/00659 , B01J2219/00689 , B01J2219/00695 , B01J2219/00711 , B01J2219/00722 , B01J2219/00725 , B82Y10/00 , B82Y30/00 , C07B2200/11 , C07H19/10 , C07H21/00 , C07K1/042 , C07K1/045 , C07K17/06 , C07K17/14 , C12Q1/6804 , C12Q1/6809 , C12Q1/6816 , C12Q1/6827 , C12Q1/6834 , C12Q1/6837 , C12Q1/6874 , C40B40/06 , C40B40/10 , C40B60/14 , G01N15/1475 , G03F7/265 , G03F7/38 , G11C13/0014 , G11C13/0019 , C12Q2565/513 , C12Q2565/507 , C12Q2545/101 , C12Q2525/185 , C12Q2565/514 , C12Q2563/173 , C12Q2563/119 , C12Q2563/149 , C12Q2525/151 , C12Q2525/179 , C12Q2525/204
摘要： The present invention provides methods and apparatus for sequencing, fingerprinting and mapping biological macromolecules, typically biological polymers. The methods make use of a plurality of sequence specific recognition reagents which can also be used for classification of biological samples, and to characterize their sources.
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公开(公告)号：US20050112676A1
公开(公告)日：2005-05-26
申请号：US10993432
申请日：2004-11-22
申请人： Stephen Fodor , Dennis Solas , William Dower
发明人： Stephen Fodor , Dennis Solas , William Dower
IPC分类号： B01J19/00 , C07B61/00 , C07H19/10 , C07H21/00 , C07K1/04 , C07K17/06 , C07K17/14 , C12Q1/68 , C40B40/06 , C40B40/10 , C40B60/14 , G01N15/14 , G03F7/00 , G03F7/26 , G03F7/38 , G11C13/02 , G01N33/53 , G01N33/542
CPC分类号： G03F7/00 , B01J19/0046 , B01J2219/00315 , B01J2219/00432 , B01J2219/00434 , B01J2219/00436 , B01J2219/00459 , B01J2219/00468 , B01J2219/00475 , B01J2219/005 , B01J2219/00527 , B01J2219/00529 , B01J2219/00531 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00617 , B01J2219/00626 , B01J2219/0063 , B01J2219/00637 , B01J2219/00641 , B01J2219/00648 , B01J2219/00659 , B01J2219/00689 , B01J2219/00695 , B01J2219/00711 , B01J2219/00722 , B01J2219/00725 , B82Y10/00 , B82Y30/00 , C07B2200/11 , C07H19/10 , C07H21/00 , C07K1/042 , C07K1/045 , C07K17/06 , C07K17/14 , C12Q1/6804 , C12Q1/6809 , C12Q1/6816 , C12Q1/6827 , C12Q1/6834 , C12Q1/6837 , C12Q1/6874 , C40B40/06 , C40B40/10 , C40B60/14 , G01N15/1475 , G03F7/265 , G03F7/38 , G11C13/0014 , G11C13/0019 , C12Q2565/513 , C12Q2565/507 , C12Q2545/101 , C12Q2525/185 , C12Q2565/514 , C12Q2563/173 , C12Q2563/119 , C12Q2563/149 , C12Q2525/151 , C12Q2525/179 , C12Q2525/204
摘要： The present invention provides methods and apparatus for sequencing, fingerprinting and mapping biological macromolecules, typically biological polymers. The methods make use of a plurality of sequence specific recognition reagents which can also be used for classification of biological samples, and to characterize their sources.
摘要翻译： 本发明提供了用于测序，指纹和绘制生物大分子（通常为生物聚合物）的方法和装置。 该方法利用多种序列特异性识别试剂，其也可用于生物样品的分类和表征其来源。
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公开(公告)号：US20050053928A9
公开(公告)日：2005-03-10
申请号：US10125530
申请日：2002-04-19
申请人： Stephen Fodor , Dennis Solas , William Dower
发明人： Stephen Fodor , Dennis Solas , William Dower
IPC分类号： B01J19/00 , C07B61/00 , C07H19/10 , C07H21/00 , C07K1/04 , C07K17/06 , C07K17/14 , C12Q1/68 , C40B40/06 , C40B40/10 , C40B60/14 , G01N15/14 , G03F7/00 , G03F7/26 , G03F7/38 , G11C13/02 , C12M1/34 , G01N33/53 , G01N33/542
CPC分类号： G03F7/00 , B01J19/0046 , B01J2219/00315 , B01J2219/00432 , B01J2219/00434 , B01J2219/00436 , B01J2219/00459 , B01J2219/00468 , B01J2219/00475 , B01J2219/005 , B01J2219/00527 , B01J2219/00529 , B01J2219/00531 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00617 , B01J2219/00626 , B01J2219/0063 , B01J2219/00637 , B01J2219/00641 , B01J2219/00648 , B01J2219/00659 , B01J2219/00689 , B01J2219/00695 , B01J2219/00711 , B01J2219/00722 , B01J2219/00725 , B82Y10/00 , B82Y30/00 , C07B2200/11 , C07H19/10 , C07H21/00 , C07K1/042 , C07K1/045 , C07K17/06 , C07K17/14 , C12Q1/6804 , C12Q1/6809 , C12Q1/6816 , C12Q1/6827 , C12Q1/6834 , C12Q1/6837 , C12Q1/6874 , C40B40/06 , C40B40/10 , C40B60/14 , G01N15/1475 , G03F7/265 , G03F7/38 , G11C13/0014 , G11C13/0019 , C12Q2565/513 , C12Q2565/507 , C12Q2545/101 , C12Q2525/185 , C12Q2565/514 , C12Q2563/173 , C12Q2563/119 , C12Q2563/149 , C12Q2525/151 , C12Q2525/179 , C12Q2525/204
摘要： The present invention provides methods and apparatus for sequencing, fingerprinting and mapping biological macromolecules, typically biological polymers. The methods make use of a plurality of sequence specific recognition reagents which can also be used for classification of biological samples, and to characterize their sources.
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公开(公告)号：US20050009014A9
公开(公告)日：2005-01-13
申请号：US10102774
申请日：2002-03-22
申请人： Stephen Fodor , Dennis Solas , William Dower
发明人： Stephen Fodor , Dennis Solas , William Dower
IPC分类号： B01J19/00 , C07B61/00 , C07H19/10 , C07H21/00 , C07K1/04 , C07K17/06 , C07K17/14 , C12Q1/68 , C40B40/06 , C40B40/10 , C40B60/14 , G01N15/14 , G03F7/00 , G03F7/26 , G03F7/38 , G11C13/02 , C12M1/34 , G01N33/53 , G01N33/542
CPC分类号： G03F7/00 , B01J19/0046 , B01J2219/00315 , B01J2219/00432 , B01J2219/00434 , B01J2219/00436 , B01J2219/00459 , B01J2219/00468 , B01J2219/00475 , B01J2219/005 , B01J2219/00527 , B01J2219/00529 , B01J2219/00531 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00617 , B01J2219/00626 , B01J2219/0063 , B01J2219/00637 , B01J2219/00641 , B01J2219/00648 , B01J2219/00659 , B01J2219/00689 , B01J2219/00695 , B01J2219/00711 , B01J2219/00722 , B01J2219/00725 , B82Y10/00 , B82Y30/00 , C07B2200/11 , C07H19/10 , C07H21/00 , C07K1/042 , C07K1/045 , C07K17/06 , C07K17/14 , C12Q1/6804 , C12Q1/6809 , C12Q1/6816 , C12Q1/6827 , C12Q1/6834 , C12Q1/6837 , C12Q1/6874 , C40B40/06 , C40B40/10 , C40B60/14 , G01N15/1475 , G03F7/265 , G03F7/38 , G11C13/0014 , G11C13/0019 , C12Q2565/513 , C12Q2565/507 , C12Q2545/101 , C12Q2525/185 , C12Q2565/514 , C12Q2563/173 , C12Q2563/119 , C12Q2563/149 , C12Q2525/151 , C12Q2525/179 , C12Q2525/204
摘要： The present invention provides methods and apparatus for sequencing, fingerprinting and mapping biological macromolecules, typically biological polymers. The methods make use of a plurality of sequence specific recognition reagents which can also be used for classification of biological samples, and to characterize their sources.
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公开(公告)号：US20060210452A1
公开(公告)日：2006-09-21
申请号：US11212551
申请日：2005-08-25
IPC分类号： B01J19/00
CPC分类号： C08G69/00 , B01J19/0046 , B01J2219/00315 , B01J2219/00432 , B01J2219/00434 , B01J2219/00436 , B01J2219/00459 , B01J2219/00468 , B01J2219/00475 , B01J2219/005 , B01J2219/00527 , B01J2219/00529 , B01J2219/00531 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00617 , B01J2219/00619 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00639 , B01J2219/00648 , B01J2219/00659 , B01J2219/00689 , B01J2219/00695 , B01J2219/00711 , B01J2219/00722 , B01J2219/00725 , B01L7/52 , B82Y10/00 , B82Y30/00 , C07B2200/11 , C07C229/14 , C07C229/16 , C07D263/44 , C07D317/62 , C07H19/04 , C07H19/10 , C07H21/00 , C07K1/04 , C07K1/042 , C07K1/045 , C07K1/047 , C07K1/062 , C07K7/06 , C07K17/06 , C07K17/14 , C12Q1/6809 , C12Q1/6816 , C12Q1/6837 , C12Q1/6874 , C40B40/06 , C40B40/10 , C40B60/14 , C40B80/00 , G01N15/1475 , G01N21/253 , G01N21/6428 , G01N21/6452 , G03F7/00 , G03F7/26 , G03F7/265 , G03F7/38 , G11C13/0014 , G11C13/0019 , H01L25/50 , H01L2924/0002 , Y02P20/55 , Y10S435/961 , Y10S435/968 , Y10S435/969 , Y10S435/973 , Y10S436/807 , Y10S436/809 , Y10T428/31971 , Y10T436/2575 , H01L2924/00
摘要： A synthetic strategy for the creation of large scale chemical diversity. Solid-phase chemistry, photolabile protecting groups, and photolithography are used to achieve light-directed spatially-addressable parallel chemical synthesis. Binary masking techniques are utilized in one embodiment. A reactor system, photoremovable protective groups, and improved data collection and handling techniques are also disclosed. A technique for screening linker molecules is also provided.
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公开(公告)号：US20070028916A1
公开(公告)日：2007-02-08
申请号：US10633876
申请日：2003-08-04
申请人： Ron Hale , Peter Lloyd , Amy Lu , Daniel Myers , Reynaldo Quintana , Joshua Rabinowitz , Dennis Solas , Soonho Song , Curtis Tom , Martin Wensley
发明人： Ron Hale , Peter Lloyd , Amy Lu , Daniel Myers , Reynaldo Quintana , Joshua Rabinowitz , Dennis Solas , Soonho Song , Curtis Tom , Martin Wensley
IPC分类号： A61M11/00
CPC分类号： A61M11/041 , A61K9/007 , A61K9/0073 , A61M11/042 , A61M11/047 , A61M15/002 , A61M15/0028 , A61M2016/0039 , A61M2205/3606 , A61M2205/3653 , A61M2205/368 , A61M2205/50 , B05B7/1686 , B05B17/04 , Y10S514/958
摘要： A device, method, and system for producing a condensation aerosol are disclosed. The device includes a chamber having an upstream opening and a downstream opening which allow gas to flow through the chamber, and a heat-conductive substrate located at a position between the upstream and downstream openings. Formed on the substrate is a drug composition film containing a therapeutically effective dose of a drug when the drug is administered in aerosol form. A heat source in the device is operable to supply heat to the substrate to produce a substrate temperature greater than 300° C., and to substantially volatilize the drug composition film from the substrate in a period of 2 seconds or less. The device produces an aerosol containing less than about 10% by weight drug composition degradation products and at least 50% of the drug composition of said film.
摘要翻译： 公开了一种用于生产冷凝气雾剂的装置，方法和系统。 该装置包括具有允许气体流过腔室的上游开口和下游开口的腔室，以及位于上游和下游开口之间位置的导热基底。 在基质上形成药物组合物膜，当药物以气溶胶形式施用时，其含有治疗有效剂量的药物。 装置中的热源可操作以向衬底供应热量以产生大于300℃的衬底温度，并且在2秒或更短的时间内使药物组合物膜从衬底基本挥发。 该装置产生含有小于约10重量％的药物组合物降解产物和所述膜的药物组合物的至少50％的气溶胶。
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公开(公告)号：US5607691A
公开(公告)日：1997-03-04
申请号：US449188
申请日：1995-05-24
申请人： Ron L. Hale , Amy Lu , Dennis Solas , Harold E. Selick , Kevin R. Oldenburg , Alejandro C. Zaffaroni
发明人： Ron L. Hale , Amy Lu , Dennis Solas , Harold E. Selick , Kevin R. Oldenburg , Alejandro C. Zaffaroni
CPC分类号： A61K31/70 , A61K31/568 , A61K47/4803 , A61K47/48992 , A61K9/0009 , A61K9/1272
摘要： The present invention relates to methods of delivering pharmaceutical agents across membranes, including the skin layer or mucosal membranes of a patient. A pharmaceutical agent is covalently bonded to a chemical modifier, via a physiologically cleavable bond, such that the membrane transport and delivery of the agent is enhanced.
摘要翻译： 本发明涉及通过膜（包括患者的皮肤层或粘膜）递送药剂的方法。 药剂通过生理上可切割的键共价结合到化学改性剂上，使得药物的膜输送和递送得到增强。
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公开(公告)号：US20060233717A1
公开(公告)日：2006-10-19
申请号：US11385992
申请日：2006-03-21
申请人： Ron Hale , Joshua Rabinowitz , Dennis Solas , Alejandro Zaffaroni
发明人： Ron Hale , Joshua Rabinowitz , Dennis Solas , Alejandro Zaffaroni
IPC分类号： A61K9/14 , A61L9/04 , B29B9/00 , A61K31/405
CPC分类号： A61K9/007 , A61K9/0073 , A61K31/405 , Y10S514/958
摘要： The present invention relates to the delivery of migraine headache drugs through an inhalation route. Specifically, it relates to aerosols containing migraine headache drugs that are used in inhalation therapy.
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