公开(公告)号：US06342359B1

公开(公告)日：2002-01-29

申请号：US09672787

申请日：2000-09-29

申请人： Won Yong Lee ,  Je Kyun Park ,  Su Hyeon Kim ,  Tae Han Kim

发明人： Won Yong Lee ,  Je Kyun Park ,  Su Hyeon Kim ,  Tae Han Kim

IPC分类号： C12Q168

CPC分类号： B82Y30/00 ,  B01J2219/00576 ,  B01J2219/00578 ,  B01J2219/00608 ,  B01J2219/00612 ,  B01J2219/00617 ,  B01J2219/0063 ,  B01J2219/00635 ,  B01J2219/00653 ,  B01J2219/00677 ,  B01J2219/00704 ,  C12Q1/6837 ,  C12Q2565/607 ,  C12Q2563/113

摘要： The present invention provides a nucleic acid detector for detecting a base sequences of a target DNA of interest, which comprises a DNA chip in which probe DNA and electrochemiluminescent material such as tris(2,2′-bipyridyl) metal complex, or derivatives thereof are immobilized on a surface of gold electrode; an electrochemical apparatus for applying a predetermined voltage to the DNA chip with respect to a reference electrode; and an optical measurement apparatus for measuring electrochemiluminescence generated from the DNA chip. The present invention also provides a method for producing the said detector for nucleic acids, and method for detecting nucleic acids using the same in a cost-saving way with high sensitivity.

摘要翻译： 本发明提供了一种用于检测目标DNA的碱基序列的核酸检测器，其包含DNA芯片，其中探针DNA和电化学发光材料如三（2,2'-联吡啶）金属络合物或其衍生物为 固定在金电极的表面上; 用于相对于参考电极向DNA芯片施加预定电压的电化学装置; 以及用于测量从DNA芯片产生的电化学发光的光学测量装置。 本发明还提供了一种用于生产所述核酸检测器的方法，以及以高灵敏度的成本节约方式检测核酸的方法。

公开(公告)号：US06534270B2

公开(公告)日：2003-03-18

申请号：US09832944

申请日：2001-04-12

申请人： Su Hyeon Kim ,  Je Kyun Park ,  Tae Han Kim

发明人： Su Hyeon Kim ,  Je Kyun Park ,  Tae Han Kim

IPC分类号： G01N3353

CPC分类号： C12Q1/6837 ,  B01J19/0046 ,  B01J2219/00515 ,  B01J2219/00524 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00617 ,  B01J2219/00621 ,  B01J2219/00626 ,  B01J2219/0063 ,  B01J2219/00657 ,  B01J2219/00659 ,  B01J2219/00673 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01J2219/00729 ,  B01J2219/0074 ,  C40B40/06 ,  C40B40/10 ,  G01N33/54373 ,  Y10S435/961 ,  Y10S435/969 ,  Y10S436/807 ,  Y10S436/809 ,  Y10S436/823 ,  Y10T436/25

摘要： Disclosed are biochips having a high detecting sensitivity with readiness in fabrication of microarray, and a method for fabricating the same, in which a solid support wound with fibers is immersed in a solution containing biomolecules to immobilize the biomolecules onto the fiber, and the individual fibers with the biomolecules immobilized thereon are straightened and arranged. The arranged fibers are embedded with a defined material and cut in a direction perpendicular to the lengthwise arrangement direction of the fibers to obtain thin chips. The chips are placed on a substrate to remove the material used for embedding and thereby remain fibers with the immobilized biomolecules on the substrate. This biochip fabrication method immobilizes a great number of biomolecules onto the fibers having a large surface area to enhance the detection sensitivity and allows production of a great number of substrates with an array of biomolecules immobilized simultaneously.

摘要翻译： 公开了具有高检测灵敏度的生物芯片，其准备好在微阵列的制造中，以及其制造方法，其中用纤维缠绕的固体支持体浸入含有生物分子的溶液中以将生物分子固定在纤维上，并且各纤维 固定在其上的生物分子被矫直和布置。 布置的纤维被嵌入限定的材料并且沿着与纤维的纵向排列方向垂直的方向切割以获得薄的碎片。 将芯片放置在基材上以除去用于包埋的材料，从而在基材上保留具有固定的生物分子的纤维。 这种生物芯片制造方法将大量生物分子固定在具有大表面积的纤维上，以增强检测灵敏度，并允许生产具有同时固定的生物分子阵列的大量底物。

公开(公告)号：US07943369B2

公开(公告)日：2011-05-17

申请号：US11517090

申请日：2006-09-07

申请人： In Ho Lee ,  Jun Hong Min ,  Su Hyeon Kim ,  Chin Sung Park ,  Ah gi Kim ,  Kui Hyun Kim

发明人： In Ho Lee ,  Jun Hong Min ,  Su Hyeon Kim ,  Chin Sung Park ,  Ah gi Kim ,  Kui Hyun Kim

IPC分类号： C12M1/34

CPC分类号： G01N33/5308

摘要： A DNA (Deoxyribo Nucleic Acid) detection device and a manufacturing method thereof detects DNA by an electrical method without a separate process for detection by using semiconductor microfabrication techniques. The DNA detection device includes a pair of chambers formed on a semiconductor substrate for accommodating a detection sample, a channel connecting the pair of chambers and a lid covering the pair of chambers. According to the present invention, it is possible to attain a DNA detection device, which can be mass-produced from a silicon substrate by using semiconductor manufacturing technology with improved microfabrication techniques, and a manufacturing method thereof.

摘要翻译： DNA（脱氧核糖核酸）检测装置及其制造方法，通过使用半导体微细加工技术，不用单独的检测方法，通过电气方式检测DNA。 DNA检测装置包括形成在用于容纳检测样品的半导体基板上的一对室，连接该对室的通道和覆盖该对室的盖。 根据本发明，可以通过使用具有改进的微细加工技术的半导体制造技术来获得可以从硅基板批量生产的DNA检测装置及其制造方法。

公开(公告)号：US06716738B2

公开(公告)日：2004-04-06

申请号：US10232471

申请日：2002-08-30

申请人： Su Hyeon Kim ,  Jong Yeon Kim ,  Jin Yu

发明人： Su Hyeon Kim ,  Jong Yeon Kim ,  Jin Yu

IPC分类号： H01L2144

CPC分类号： C25D5/18 ,  C25D5/12 ,  C25D7/123 ,  H01L21/2885 ,  H01L24/05 ,  H01L24/11 ,  H01L24/13 ,  H01L2224/0401 ,  H01L2224/05147 ,  H01L2224/05155 ,  H01L2224/05647 ,  H01L2224/05655 ,  H01L2224/11462 ,  H01L2224/1147 ,  H01L2224/13099 ,  H01L2224/131 ,  H01L2924/0001 ,  H01L2924/01006 ,  H01L2924/01011 ,  H01L2924/01013 ,  H01L2924/01015 ,  H01L2924/01022 ,  H01L2924/01023 ,  H01L2924/01024 ,  H01L2924/01028 ,  H01L2924/01029 ,  H01L2924/01033 ,  H01L2924/01047 ,  H01L2924/0105 ,  H01L2924/01074 ,  H01L2924/01078 ,  H01L2924/01079 ,  H01L2924/01082 ,  H01L2924/01327 ,  H01L2924/014 ,  H01L2924/14 ,  H01L2924/00014

摘要： Disclosed is a fabrication method of UBM for flip chip interconnections of a semiconductor device, consisting of dipping a patterned wafer into a plating solution containing materials supplying nickel and copper ions, forming a copper layer at a predetermined current density for connection between a chip pad and a solder bump and for residual stress-buffering, and forming a nickel-copper alloy layer at an increased current density for prevention of diffusion between the solder and the pad. The method is advantageous in terms of low fabrication cost due to not requiring an etching process, while meeting the conditions of wettability, diffusion-barrier function and small residual stress required to form UBM on the patterned wafer.

摘要翻译： 公开了一种用于半导体器件的倒装芯片互连的UBM的制造方法，其包括将图案化晶片浸入含有供应镍和铜离子的材料的镀液中，形成预定电流密度的铜层，用于连接芯片焊盘和 焊料凸块和残余应力缓冲，并以增加的电流密度形成镍 - 铜合金层，以防止焊料和焊盘之间的扩散。 该方法由于不需要蚀刻工艺而在低制造成本方面是有利的，同时满足在图案化晶片上形成UBM所需的润湿性，扩散阻挡功能和小的残余应力条件。

公开(公告)号：US09670568B2

公开(公告)日：2017-06-06

申请号：US14004824

申请日：2012-03-16

申请人： Jung Moo Lee ,  Su Hyeon Kim ,  Suk Bong Kang ,  Young Hee Cho

发明人： Jung Moo Lee ,  Su Hyeon Kim ,  Suk Bong Kang ,  Young Hee Cho

IPC分类号： B22D21/04 ,  C22C32/00 ,  B22D19/14 ,  C22C1/03 ,  C22C29/00 ,  C22C29/12 ,  C22C21/00 ,  C22C21/02 ,  C22C21/06

CPC分类号： C22C32/00 ,  B22D19/14 ,  B22D21/04 ,  C22C1/03 ,  C22C21/00 ,  C22C21/02 ,  C22C21/06 ,  C22C29/005 ,  C22C29/12

摘要： A method of stably preparing an aluminum composite with excellent mechanical properties while the temperature of molten aluminum is maintained at 950° C. or less, includes mixing aluminum powder, a source material for titanium, a source material for a nonmetallic element that is able to be combined with titanium to form a compound, and an active material to prepare a precursor; adding the precursor to molten aluminum; and casting the molten aluminum.

公开(公告)号：US20140037494A1

公开(公告)日：2014-02-06

申请号：US14004824

申请日：2012-03-16

申请人： Jung Moo Lee ,  Su Hyeon Kim ,  Suk Bong Kang ,  Young Hee Cho

发明人： Jung Moo Lee ,  Su Hyeon Kim ,  Suk Bong Kang ,  Young Hee Cho

IPC分类号： C22C32/00 ,  B22D19/14

CPC分类号： C22C32/00 ,  B22D19/14 ,  B22D21/04 ,  C22C1/03 ,  C22C21/00 ,  C22C21/02 ,  C22C21/06 ,  C22C29/005 ,  C22C29/12

摘要： A method of stably preparing an aluminum composite with excellent mechanical properties while the temperature of molten aluminum is maintained at 950° C. or less, includes mixing aluminum powder, a source material for titanium, a source material for a nonmetallic element that is able to be combined with titanium to form a compound, and an active material to prepare a precursor; adding the precursor to molten aluminum; and casting the molten aluminum.

摘要翻译： 在熔融铝的温度保持在950℃以下的状态下稳定地制备具有优异的机械性能的铝复合体的方法包括：将铝粉末，钛原料混合，将非金属元素的原料 与钛组合以形成化合物，以及制备前体的活性材料; 将前体添加到熔融铝中; 并铸造熔融铝。

公开(公告)号：US07892491B2

公开(公告)日：2011-02-22

申请号：US11533961

申请日：2006-09-21

申请人： Su Hyeon Kim ,  Jeong Gun Lee ,  Seung Yeon Yang

发明人： Su Hyeon Kim ,  Jeong Gun Lee ,  Seung Yeon Yang

IPC分类号： G01N15/06

CPC分类号： C12N13/00 ,  C12M47/06 ,  C12N1/066

摘要： An apparatus for disruption of cells or viruses using a laser and magnetic beads includes a cell lysis chip including a sample inlet hole into which a sample and the magnetic beads are introduced, a vibrator fixing the cell lysis chip and transferring vibrations in a prescribed direction, a laser generator supplying the laser to the cell lysis chip and a controller controlling operations of the vibrator and the laser generator.

摘要翻译： 使用激光和磁珠对细胞或病毒进行破坏的装置包括细胞裂解芯片，其包括样品入口孔和样品入口孔，样品和磁珠被引入其中，振动器固定细胞裂解芯片并沿规定方向传递振动， 将激光器提供给细胞裂解芯片的激光发生器和控制振动器和激光发生器的操作的控制器。