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    Transparent bacterial cellulose nanocomposite hydrogels
    1.
    发明授权
    Transparent bacterial cellulose nanocomposite hydrogels 有权
    透明细菌纤维素纳米复合水凝胶

    公开(公告)号：US08940337B2

    公开(公告)日：2015-01-27

    申请号：US13520076

    申请日：2010-12-23

    申请人： Xinsheng Li ,  Wankei Wan ,  Chandrakant J. Panchal

    发明人： Xinsheng Li ,  Wankei Wan ,  Chandrakant J. Panchal

    IPC分类号： A61K9/50 ,  C08J3/24 ,  C08F2/00 ,  C08F2/44 ,  C08J3/075 ,  C08L1/02 ,  C08L33/06

    CPC分类号： C08J3/24 ,  C08F2/00 ,  C08F2/44 ,  C08J3/075 ,  C08J2333/04 ,  C08L1/02 ,  C08L33/066 ,  Y10S977/773 ,  Y10S977/906 ,  Y10T428/31935

    摘要： A transparent polymeric nanocomposite hydrogel is provided, wherein the polymeric nanocomposite hydrogel is made from a water insoluble polymer, i.e. poly(2-hydroxyethyl methacrylate) (PHEMA) or/and crosslinked PHEMA and a water insoluble nanofiber, i.e., bacterial cellulose (BC). Disclosed is a synthetic route for polymeric nanocomposites hydrogels. The preferred polymeric nanocompositions are produced through free radical polymerization of HEMA monomer in the presence of bacterial cellulose with an assistance of ultrasound to enhance the mixing of bacterial cellulose, initiator, and the monomers. The polymeric nanocomposite hydrogel is then formed by immersion of the dry polymeric nanocomposite in water. Disclosed is a high transmittance polymer nanocomposite hydrogel with a preferred BC loading less than 0.1%, water content of about 40% in weight, good mechanical integrity and strength. The disclosed polymer nanocomposite hydrogel and compositions pertain to hydrogel applications, particularly contact lenses and optic components for biosensor.

    摘要翻译： 提供了一种透明聚合物纳米复合材料水凝胶，其中聚合纳米复合材料水凝胶由水不溶性聚合物制成，即聚（甲基丙烯酸2-羟乙酯）（PHEMA）或/和交联的PHEMA和水不溶性纳米纤维，即细菌纤维素（BC） 。 公开了聚合物纳米复合材料水凝胶的合成路线。 优选的聚合物纳米组合物通过在细菌纤维素存在下在超声波辅助下的HEMA单体的自由基聚合来生产，以增强细菌纤维素，引发剂和单体的混合。 然后通过将干燥聚合物纳米复合物浸入水中形成聚合物纳米复合材料水凝胶。 公开了一种高透光率聚合物纳米复合水凝胶，其优选BC载量小于0.1％，水含量为约40重量％，良好的机械完整性和强度。 所公开的聚合物纳米复合材料水凝胶和组合物涉及水凝胶应用，特别是用于生物传感器的隐形眼镜和光学部件。

    TRANSPARENT BACTERIAL CELLULOSE NANOCOMPOSITE HYDROGELS
    2.
    发明申请
    TRANSPARENT BACTERIAL CELLULOSE NANOCOMPOSITE HYDROGELS 有权
    透明细菌纤维素纳米复合物水凝胶

    公开(公告)号：US20130011385A1

    公开(公告)日：2013-01-10

    申请号：US13520076

    申请日：2010-12-23

    申请人： Xinsheng Li ,  Wankei Wan ,  Chandrakant J. Panchal

    发明人： Xinsheng Li ,  Wankei Wan ,  Chandrakant J. Panchal

    IPC分类号： C08L33/14 ,  A61K38/02 ,  A61K31/715 ,  A61K39/395 ,  B32B27/30 ,  A61K47/32 ,  A61K48/00 ,  B82Y30/00

    CPC分类号： C08J3/24 ,  C08F2/00 ,  C08F2/44 ,  C08J3/075 ,  C08J2333/04 ,  C08L1/02 ,  C08L33/066 ,  Y10S977/773 ,  Y10S977/906 ,  Y10T428/31935

    摘要： A transparent polymeric nanocomposite hydrogel is provided, wherein the polymeric nanocomposite hydrogel is made from a water insoluble polymer, i.e. poly(2-hydroxyethyl methacrylate) (PHEMA) or/and crosslinked PHEMA and a water insoluble nanofiber, i.e., bacterial cellulose (BC). Disclosed is a synthetic route for polymeric nanocomposites hydrogels. The preferred polymeric nanocompositions are produced through free radical polymerization of HEMA monomer in the presence of bacterial cellulose with an assistance of ultrasound to enhance the mixing of bacterial cellulose, initiator, and the monomers. The polymeric nanocomposite hydrogel is then formed by immersion of the dry polymeric nanocomposite in water. Disclosed is a high transmittance polymer nanocomposite hydrogel with a preferred BC loading less than 0.1%, water content of about 40% in weight, good mechanical integrity and strength. The disclosed polymer nanocomposite hydrogel and compositions pertain to hydrogel applications, particularly contact lenses and optic components for biosensor.

    摘要翻译： 提供了一种透明聚合物纳米复合材料水凝胶，其中聚合纳米复合材料水凝胶由水不溶性聚合物制成，即聚（甲基丙烯酸2-羟乙酯）（PHEMA）或/和交联的PHEMA和水不溶性纳米纤维，即细菌纤维素（BC） 。 公开了聚合物纳米复合材料水凝胶的合成路线。 优选的聚合物纳米组合物通过在细菌纤维素存在下在超声波辅助下的HEMA单体的自由基聚合来生产，以增强细菌纤维素，引发剂和单体的混合。 然后通过将干燥聚合物纳米复合物浸入水中形成聚合物纳米复合材料水凝胶。 公开了一种高透光率聚合物纳米复合水凝胶，其优选BC载量小于0.1％，水含量为约40重量％，良好的机械完整性和强度。 所公开的聚合物纳米复合材料水凝胶和组合物涉及水凝胶应用，特别是用于生物传感器的隐形眼镜和光学部件。

    BIOCOMPATIBLE POLY (AMIC ACID) AND METHOD OF PREPARATION THEREOF
    3.
    发明申请
    BIOCOMPATIBLE POLY (AMIC ACID) AND METHOD OF PREPARATION THEREOF 有权
    生物成分（AMIC酸）及其制备方法

    公开(公告)号：US20130143325A1

    公开(公告)日：2013-06-06

    申请号：US13639826

    申请日：2011-04-08

    申请人： Wankei Wan ,  Donna Padavan

    发明人： Wankei Wan ,  Donna Padavan

    IPC分类号： A61L27/34

    CPC分类号： A61L27/34 ,  A61K47/34 ,  A61L27/18 ,  A61L27/54 ,  A61L31/06 ,  A61L31/10 ,  A61L31/16 ,  C12N5/069 ,  C12N11/08 ,  C08L77/00

    摘要： A method is provided for the preparation of a poly(amic acid) in which ring opening polymerization is employed to react the monomers ethylenediaminetetraacetic dianhydride and paraphenylenediamine in an aprotic solvent. The resulting poly(amic acid) composition is suitable as a biocompatible material, such as a biomedical implant, implant coating material, tissue scaffold material, controlled release drug delivery vehicle, and cellular growth substrate.

    摘要翻译： 提供了一种用于制备聚（酰胺酸）的方法，其中使用开环聚合反应单体乙二胺四乙酸二酐和对苯二胺在非质子溶剂中。 所得聚（酰胺酸）组合物适合作为生物相容性材料，例如生物医学植入物，植入物涂层材料，组织支架材料，控释药物递送载体和细胞生长底物。

    SURGICAL TRAINING AIDS AND METHODS OF FABRICATION THEREOF
    4.
    发明申请
    SURGICAL TRAINING AIDS AND METHODS OF FABRICATION THEREOF 有权
    手术训练艾滋病及其制作方法

    公开(公告)号：US20120282584A1

    公开(公告)日：2012-11-08

    申请号：US13497670

    申请日：2010-09-22

    申请人： Leonardo Millon ,  Wankei Wan ,  Mackenzie Quantz

    发明人： Leonardo Millon ,  Wankei Wan ,  Mackenzie Quantz

    IPC分类号： G09B23/28 ,  B29C35/16

    CPC分类号： B29C39/025 ,  B29C39/003 ,  B29C39/42 ,  B29K2029/04 ,  B29K2105/0061 ,  B29L2031/7532 ,  C08J3/075 ,  C08J2329/04 ,  G06F19/00 ,  G09B23/28 ,  G09B23/306

    摘要： The present invention provides surgical training aids formed from hydrogels and adapted to exhibit realistic mechanical properties mimicking those of real organs. Surgical training aids are preferably fabricated by subjecting a concentration of polyvinyl alcohol to freeze-thaw cycles in a mold designed to approximate the shape of an organ, and process parameters are selected to tailor the mechanical properties of the formed hydrogel to those of the organ simulated by the surgical aid. The mechanical properties of the hydrogel forming the surgical training aid may be tailored by incorporating bacterial cellulose and by applying strain during hydrogel formation, thereby producing controlled anisotropy.

    摘要翻译： 本发明提供由水凝胶形成并适于显示模拟真实器官的机械特性的现实机械特性的外科训练辅助装置。 手术训练辅助剂优选通过使聚乙烯醇的浓度在设计成接近器官形状的模具中进行冻融循环来制造，并且选择工艺参数以将所形成的水凝胶的机械性能与模拟的器官的机械性质 通过手术辅助。 形成外科训练辅助剂的水凝胶的机械性能可以通过掺入细菌纤维素并通过在水凝胶形成期间施加应变来调整，从而产生受控的各向异性。

    Modified regenerated cellulose membrane for non-aqueous separations
    9.
    发明授权
    Modified regenerated cellulose membrane for non-aqueous separations 失效
    改性再生纤维素膜用于非水分离

    公开(公告)号：US4853129A

    公开(公告)日：1989-08-01

    申请号：US50771

    申请日：1987-05-18

    申请人： Wankei Wan

    发明人： Wankei Wan

    IPC分类号： C10G73/00

    CPC分类号： C10G73/00 ,  B01D61/10 ,  B01D67/0093 ,  B01D71/10 ,  B01D2323/30 ,  B01D2323/36 ,  B01D2325/20

    摘要： Regenerated cellulose membranes used for the separation of organic liquids, for example, ketone dewaxing solvents from dewaxed oil or NMP extraction solvents from extract, have their solute rejection capability enhanced by chemical modification by contacting said membrane with a bifunctional reagent that is reactive with the hydroxy groups in the anhydroglucose units of the regenerated cellulose polymer. The reaction of the bifunctional reagent with the hydroxy groups in the polymer results in the crosslinking of the polymer which, in turn, results in the improvement of the membrane's selectivity in organic liquid separations applications.

    摘要翻译： 用于分离有机液体的再生纤维素膜，例如脱蜡油的酮脱蜡溶剂或萃取液中的NMP提取溶剂，通过使所述膜与与羟基反应的双官能试剂接触，通过化学改性增强其溶质排除能力 在再生纤维素聚合物的脱水葡萄糖单元中的基团。 双官能试剂与聚合物中的羟基的反应导致聚合物的交联，其又导致膜在有机液体分离应用中的选择性的改善。

    Surgical training aids and methods of fabrication thereof
    10.
    发明授权
    Surgical training aids and methods of fabrication thereof 有权
    外科手术训练器具及其制造方法

    公开(公告)号：US08870576B2

    公开(公告)日：2014-10-28

    申请号：US13497670

    申请日：2010-09-22

    申请人： Leonardo Millon ,  Wankei Wan ,  Mackenzie Quantz

    发明人： Leonardo Millon ,  Wankei Wan ,  Mackenzie Quantz

    IPC分类号： G09B23/28 ,  C08J3/075 ,  B29C39/42 ,  B29C39/00 ,  B29C39/02 ,  G09B23/30 ,  B29L31/00 ,  B29K105/00 ,  B29K29/00

    CPC分类号： B29C39/025 ,  B29C39/003 ,  B29C39/42 ,  B29K2029/04 ,  B29K2105/0061 ,  B29L2031/7532 ,  C08J3/075 ,  C08J2329/04 ,  G06F19/00 ,  G09B23/28 ,  G09B23/306

    摘要： The present invention provides surgical training aids formed from hydrogels and adapted to exhibit realistic mechanical properties mimicking those of real organs. Surgical training aids are preferably fabricated by subjecting a concentration of polyvinyl alcohol to freeze-thaw cycles in a mold designed to approximate the shape of an organ, and process parameters are selected to tailor the mechanical properties of the formed hydrogel to those of the organ simulated by the surgical aid. The mechanical properties of the hydrogel forming the surgical training aid may be tailored by incorporating bacterial cellulose and by applying strain during hydrogel formation, thereby producing controlled anisotropy.

    摘要翻译： 本发明提供由水凝胶形成并适于显示模拟真实器官的机械特性的现实机械特性的外科训练辅助装置。 手术训练辅助剂优选通过使聚乙烯醇的浓度在设计成接近器官形状的模具中进行冻融循环来制造，并且选择工艺参数以将所形成的水凝胶的机械性能与模拟的器官的机械性质 通过手术辅助。 形成外科训练辅助剂的水凝胶的机械性能可以通过掺入细菌纤维素并通过在水凝胶形成期间施加应变来调整，从而产生受控的各向异性。