公开(公告)号：US12109519B2

公开(公告)日：2024-10-08

申请号：US16900682

申请日：2020-06-12

申请人： Utah Valley University

发明人： Timothy Edwin Doyle

IPC分类号： B01L3/00 ,  A61B5/00 ,  A61B5/08 ,  A61B5/1468 ,  A61B5/1477 ,  A61M15/00 ,  A61M15/02 ,  A61M16/10 ,  A62B23/02 ,  B01D39/16 ,  B01F23/00 ,  B01F23/41 ,  B01F101/23 ,  B23Q17/24 ,  C07K14/705 ,  C12M1/34 ,  C12Q1/04 ,  C12Q1/18 ,  C12Q1/686 ,  G01N21/3577 ,  G01N21/359 ,  G01N21/39 ,  G01N21/45 ,  G01N21/64 ,  G01N27/414 ,  G01N30/12 ,  G01N30/68 ,  G01N30/70 ,  G01N30/72 ,  G01N30/88 ,  G01N33/00 ,  G01N33/18 ,  G01N33/50 ,  G01N33/53 ,  G01N33/543 ,  G01N33/68 ,  G01N33/74 ,  H10K10/46 ,  H10K85/00 ,  H10K85/20

CPC分类号： B01D39/1623 ,  A61B5/1468 ,  A61B5/1477 ,  A61B5/6803 ,  A61M15/0001 ,  A61M15/02 ,  A61M16/105 ,  A62B23/025 ,  A61B5/082 ,  A61M2205/0244 ,  A61M2205/0294 ,  A61M2205/18 ,  A61M2205/3303 ,  A61M2205/7536 ,  B01D2239/0414

摘要： Disclosed herein is a molecular imprinted protective face mask comprising a supportive structure, a surface material that receives and retains a molecular imprint and that is positioned to contact airborne molecules during use, a molecular imprint of a bioactive molecule wherein an imprinted cavity is at least one of a bioactive molecule with a molecular configuration that captures a specific airborne and/or microdroplet-borne molecule and a protein with a binding site that captures a specific molecule.

公开(公告)号：US12102999B2

公开(公告)日：2024-10-01

申请号：US17417537

申请日：2019-12-27

申请人： ASTRAVEUS

发明人： Jérémie Laurent ,  Vincent Thisse

IPC分类号： B01L3/00 ,  B01F23/00 ,  B01F23/41 ,  B01F101/23 ,  B01L3/02 ,  B23Q17/24 ,  C12M1/34 ,  C12Q1/04 ,  C12Q1/18 ,  C12Q1/686 ,  G01N21/3577 ,  G01N21/359 ,  G01N21/39 ,  G01N21/45 ,  G01N21/64 ,  G01N30/12 ,  G01N30/68 ,  G01N30/70 ,  G01N30/72 ,  G01N30/88 ,  G01N33/00 ,  G01N33/18 ,  G01N33/50 ,  G01N33/543 ,  G01N33/68 ,  G01N35/04 ,  G01N35/10

CPC分类号： B01L3/502715 ,  B01L3/0289 ,  B01L3/50273 ,  B01L2200/0673 ,  B01L2200/0689 ,  B01L2200/141 ,  B01L2300/028 ,  B01L2300/0681 ,  B01L2300/0883 ,  B01L2300/14 ,  B01L2300/1883

摘要： A device for handling a particle suspension, in particular a cell suspension, which includes at least one channel for flowing the particle suspension, a pumping unit configured to move a driving fluid and control element for controlling the pumping unit. Also, a method for handling a particle suspension, which includes flowing the particle suspension in or out of at least one channel using a driving fluid for driving the particle suspension in the channel.

公开(公告)号：US20240319090A1

公开(公告)日：2024-09-26

申请号：US18733911

申请日：2024-06-05

申请人： Nirrin Technologies, Inc.

发明人： Bryan A. Hassell ,  Walid A. Atia ,  David P. Marchessault

IPC分类号： G01N21/39 ,  C12M1/34 ,  G01N21/3577 ,  G01N21/359 ,  G01N21/45 ,  G01N33/68

CPC分类号： G01N21/39 ,  C12M41/32 ,  G01N21/3577 ,  G01N21/359 ,  G01N21/45 ,  G01N33/6854 ,  G01N2201/06113

摘要： A method for studying cell viability and protein aggregation involves establishing a Fabry Perot etalon signal within an optical spectroscopic feature, e.g., in the near infrared region. Protein aggregation and cell viability can be reflected by changes observed in the magnitude of the Fourier Transform peaks observed in the frequency or space domain associated with the contrast of the etalon. In short, the presence of viable cells and protein aggregates can degrade the etalon contrast of an etalon window. In some cases, the concentration of cells and monomeric protein can be measured as well.

公开(公告)号：US12097499B2

公开(公告)日：2024-09-24

申请号：US18151011

申请日：2023-01-06

申请人： Tokitae LLC

发明人： Toan Huynh ,  Bernhard Hans Weigl ,  Samantha A. Byrnes ,  Kevin Paul Flood Nichols

IPC分类号： B01L3/00 ,  B01F23/00 ,  B01F23/41 ,  B01F101/23 ,  B23Q17/24 ,  C12M1/34 ,  C12Q1/04 ,  C12Q1/18 ,  C12Q1/6816 ,  C12Q1/686 ,  C23C2/00 ,  G01N21/3577 ,  G01N21/359 ,  G01N21/39 ,  G01N21/45 ,  G01N21/64 ,  G01N30/12 ,  G01N30/68 ,  G01N30/70 ,  G01N30/72 ,  G01N30/88 ,  G01N33/00 ,  G01N33/18 ,  G01N33/50 ,  G01N33/543 ,  G01N33/68 ,  G01N35/04 ,  G01N35/10

CPC分类号： B01L3/5082 ,  C12Q1/6816 ,  C23C2/51 ,  B01L2200/18 ,  B01L2300/0663 ,  B01L2300/0832 ,  B01L2400/0433 ,  G01N33/18

摘要： An embodiment of a system includes a compartment-generating device, a compartment detector, and electronic computing circuitry. The device is configured to generate compartments of a digital assay, at least one of the compartments having a respective volume that is different from a respective volume of each of at least another one of the compartments. The detector is configured to determine a number of the compartments each having a respective number of a target that is greater than a threshold number of the target. And the electronic circuitry is configured to determine a bulk concentration of the target in a source of the sample in response to the determined number of compartments. Because such a system can be configured to estimate a bulk concentration of a target in a source from a polydisperse digital assay, the system can be portable, and lower-cost and faster, than conventional systems.

公开(公告)号：US20240275128A1

公开(公告)日：2024-08-15

申请号：US18642630

申请日：2024-04-22

申请人： PILOT PHOTONICS LIMITED

发明人： Jules BRADDELL ,  Frank SMYTH

IPC分类号： H01S5/065 ,  G01J3/10 ,  G01J3/42 ,  G01N21/31 ,  G01N21/3504 ,  G01N21/39 ,  G01N21/45 ,  H01S5/00 ,  H01S5/042 ,  H01S5/10 ,  H01S5/40

CPC分类号： H01S5/0656 ,  G01J3/10 ,  G01J3/42 ,  G01N21/3504 ,  H01S5/0064 ,  H01S5/0085 ,  H01S5/0427 ,  H01S5/1096 ,  H01S5/4006 ,  G01N2021/3133 ,  G01N2021/3148 ,  G01N2021/399 ,  G01N2021/451 ,  G01N2201/0612

摘要： A method of performing spectroscopic measurements provides an optical frequency comb, and directs the comb through or at a sample. The optical frequency comb is generated by gain switching a laser diode constructed from Gallium Nitride and related materials. Various techniques are described for manipulating the comb source to achieve desired benefits for spectroscopy.

公开(公告)号：US12030048B2

公开(公告)日：2024-07-09

申请号：US17292716

申请日：2019-03-06

申请人： SHENZHEN BIORAIN TECHNOLOGY CO., LTD.

发明人： Linfen Yu ,  Wei Yang

IPC分类号： B01L3/00 ,  B01F23/00 ,  B01F23/41 ,  B01F101/23 ,  B23Q17/24 ,  C12M1/34 ,  C12Q1/04 ,  C12Q1/18 ,  C12Q1/686 ,  G01N21/3577 ,  G01N21/359 ,  G01N21/39 ,  G01N21/45 ,  G01N21/64 ,  G01N30/12 ,  G01N30/68 ,  G01N30/70 ,  G01N30/72 ,  G01N30/88 ,  G01N33/00 ,  G01N33/18 ,  G01N33/50 ,  G01N33/68

CPC分类号： B01L3/50273 ,  B01L3/502715 ,  B01L3/502753 ,  B01L3/502784 ,  B01L2200/0684 ,  B01L2200/0689 ,  B01L2300/04 ,  B01L2300/0627 ,  B01L2300/0681 ,  C12Q1/686

摘要： Disclosed is a microfluidic chip, including a chip upper cover, a chip lower layer, a membrane, a sealing gasket and a sealing ring. The microfluidic chip is provided with a sample storage zone, a droplet formation zone, a droplet storage zone, a droplet detection zone and a waste liquid storage zone. The sample storage zone, the droplet formation zone, the droplet storage zone, the droplet detection zone and the waste liquid storage zone communicate by means of a micropore or a micro-channel. The droplet formation zone is used to transform the sample phase into tens of thousands to millions of droplets, the droplets undergo the PCR reaction in the droplet storage zone, the droplet detection zone is used to perform optical detection on the droplets after PCR reaction, and the waste liquid storage zone is used to collect and store the detected droplets and continuous phase.

公开(公告)号：US12011117B2

公开(公告)日：2024-06-18

申请号：US17600869

申请日：2020-03-30

申请人： Aurora Life Science GmbH

发明人： Philo Boras ,  Jonathan Oberthür

IPC分类号： A47J47/00 ,  A47J47/16 ,  G01G19/52 ,  G01N21/45 ,  G01N33/02

CPC分类号： A47J47/005 ,  A47J47/16 ,  G01G19/52 ,  G01N21/45 ,  G01N33/02

摘要： A chopping board for foodstuffs has a base and an upper part which can be arranged detachably on the base. A cutting surface on which foodstuff to be chopped can be arranged and cut is formed on an upper-part upper side. The upper part has connecting elements, by which the upper part is located on the base. The base of the chopping board has at least one bearing surface by which the chopping board sits on a supporting surface. The upper part has an optical element, by which electromagnetic radiation emitted and/or reflected by the cut foodstuff, in particular near-IR light, is propagated. At least one radiation sensor for detecting electromagnetic radiation, more particularly an interferometer, is arranged in a sensor area of the base assigned to the optical element, by which sensor the electromagnetic radiation is detected, so that characteristics of the foodstuff to be chopped can be determined.

公开(公告)号：US20240167929A1

公开(公告)日：2024-05-23

申请号：US18234047

申请日：2023-08-15

申请人： The Government of the United States of America, as represented by the Secretary of Homeland Security

发明人： Jeffrey Barber ,  James C. Weatherall ,  Duane Karns ,  Barry T. Smith

IPC分类号： G01N11/00 ,  G01N21/45 ,  G01N27/06

CPC分类号： G01N11/00 ,  G01N21/45 ,  G01N27/06

摘要： A device to determine density includes a housing, a first transducer disposed in the housing at a first position, and a second transducer disposed in the housing at a second position. The second transducer is located a distance from the first transducer. The device also includes a controller that reads a first output from the first transducer, and reads a second output from the second transducer. The controller determines a density of a liquid based on the first output, the second output, and the distance.

公开(公告)号：US20240142373A1

公开(公告)日：2024-05-02

申请号：US18385106

申请日：2023-10-30

申请人： Georgia Tech Research Corporation

发明人： Jie XU ,  Walker Thomas Byrnes

IPC分类号： G01N21/45 ,  G01N33/53

CPC分类号： G01N21/45 ,  G01N33/5308

摘要： A sensing layer composition is provided. The sensing layer composition is particularly suited to be adhered to at least one side of one or more waveguide channels in/on a waveguide chip of an interferometric system. The sensing layer composition is particularly suited to bind or be selectively disturbed by peracetic acid via optical interferometric analysis.

公开(公告)号：US11927483B2

公开(公告)日：2024-03-12

申请号：US17771517

申请日：2020-10-27

申请人： Yokogawa Electric Corporation

发明人： Yasuyuki Suzuki ,  Yukihiro Nakamura ,  Tetsushi Namatame

IPC分类号： G01J3/453 ,  G01J3/02 ,  G01N21/27 ,  G01N21/45

CPC分类号： G01J3/453 ,  G01J3/0208 ,  G01J3/027 ,  G01N21/274 ,  G01N21/45 ,  G01N2021/458

摘要： A Fourier spectrophotometer includes: a light source; an interferometer configured to obtain first and second interferograms whose intensity distributions are inverted from each other from the light emitted from light source; a multiplexing optical system configured to multiplex the first and second interferograms to irradiate the sample with a resultant interferogram; a demultiplexing optical system configured to demultiplex the first and second interferograms contained in the light passing through the sample; a light receiver configured to output a first light reception signal obtained by receiving the demultiplexed first interferogram and a second light reception signal obtained by receiving the demultiplexed second interferogram; and a signal processing device configured to perform processing for obtaining a noise-removed spectrum of the wavelength component in the analysis wavelength band by using the first and second light reception signals.