利索-全球专利检索

  1. Login
  2. Sign Up

Search Results

151 records (took 0.022 seconds)

    NITROSATED AND NITROSYLATED CARDIOVASCULAR COMPOUNDS, COMPOSITIONS AND METHODS OF USE
    91.
    发明申请
    NITROSATED AND NITROSYLATED CARDIOVASCULAR COMPOUNDS, COMPOSITIONS AND METHODS OF USE 审中-公开
    硝酸和硝基化血管化合物，组合物和使用方法

    公开(公告)号：WO2005023182A3

    公开(公告)日：2006-10-19

    申请号：PCT/US2004026910

    申请日：2004-08-20

    Applicant: NITROMED INC ,  GARVEY DAVID S ,  LETTS GORDON L ,  WORCEL MANUEL

    Inventor： GARVEY DAVID S ,  LETTS GORDON L ,  WORCEL MANUEL

    IPC: A61K31/4523 ,  A61K20060101 ,  A61K31/517 ,  A61K31/5415 ,  A61K31/549 ,  C07D211/00 ,  C07D285/22 ,  C07D295/00 ,  C07D307/00 ,  C07D417/12 ,  C07D417/14

    CPC classification number: C07D403/10 ,  C07C205/40 ,  C07D233/68 ,  C07D235/18 ,  C07D257/04 ,  C07D307/52 ,  C07D401/12 ,  C07D401/14 ,  C07D405/06 ,  C07D405/12 ,  C07D405/14 ,  C07D409/04 ,  C07D409/06 ,  C07D409/14 ,  C07D413/10 ,  C07D471/04 ,  C07D487/04 ,  C07D495/04 ,  C07D498/04

    Abstract: The invention describes novel nitrosated and/or nitrosylated cardiovascular compounds or pharmaceutically acceptable salts thereof, and novel compositions comprising at least one nitrosated and/or nitrosylated cardiovascular compound, and, optionally, at least one nitric oxide donor and/or at least one therapeutic agent. The invention also provides novel compositions and kits comprising at least one cardiovascular compound of the invention, that is optionally nitrosated and/or nitrosylated, and, optionally, at least one nitric oxide donor compound and/or at least one therapeutic agent. The invention also provides methods for (a) treating cardiovascular diseases; (b) treating renovascular diseases; (c) treating diabetes; (d) treating diseases resulting from oxidative stress; (e) treating endothelial dysfunctions; (f) treating diseases caused by endothelial dysfunctions; (g) treating cirrhosis; (h) treating pre-eclampsia; (j) treating osteoporosis; and (k) treating nephropathy. The nitrosated and/or nitrosylated cardiovascular compounds are preferably nitrosated and/or nitrosylated aldosterone antagonists, nitrosated and/or nitrosylated angiotensin II antagonists, nitrosated and/or nitrosylated calcium channel blockers, nitrosated and/or nitrosylated endothelin antagonists, nitrosated and/or nitrosylated hydralazine compounds, nitrosated and/or nitrosylated neutral endopeptidase inhibitors and nitrosated and/or nitrosylated renin inhibitors.

    Abstract translation: 本发明描述了新的亚硝化和/或亚硝基化的心血管化合物或其药学上可接受的盐，以及包含至少一种亚硝化和/或亚硝基化的心血管化合物和任选的至少一种一氧化氮供体和/或至少一种治疗剂的新组合物 。 本发明还提供了包含至少一种本发明的心血管化合物，其任选被亚硝化和/或亚硝基化的新组合物和试剂盒，以及任选的至少一种一氧化氮供体化合物和/或至少一种治疗剂。 本发明还提供了（a）治疗心血管疾病的方法; （b）治疗血管性疾病; （c）治疗糖尿病; （d）治疗由氧化应激引起的疾病; （e）治疗内皮功能障碍; （f）治疗由内皮功能障碍引起的疾病; （g）治疗肝硬化; （h）治疗先兆子痫; （j）治疗骨质疏松症; 和（k）治疗肾病。 亚硝化和/或亚硝基化的心血管化合物优选为亚硝化和/或亚硝基化的醛固酮拮抗剂，亚硝化和/或亚硝酰化的血管紧张素II拮抗剂，亚硝化和/或亚硝酰化的钙通道阻断剂，亚硝化和/或亚硝基化的内皮素拮抗剂，亚硝化和/ 化合物，亚硝化和/或亚硝基化的中性内肽酶抑制剂和亚硝化和/或亚硝基化的肾素抑制剂。

    SUBSTITUTED IMIDAZOLES AS SELECTIVE MODULATORS OF BRADYKININ B2 RECEPTORS
    98.
    发明申请
    SUBSTITUTED IMIDAZOLES AS SELECTIVE MODULATORS OF BRADYKININ B2 RECEPTORS 审中-公开
    取代的咪唑啉作为选择性调节剂的BRADYKININ B2受体

    公开(公告)号：WO01056995A1

    公开(公告)日：2001-08-09

    申请号：PCT/US2001/001618

    申请日：2001-01-17

    IPC: A61P29/00 ,  C07D233/54 ,  C07D233/68 ,  C07D401/06 ,  A61K31/4174 ,  C07D403/10

    CPC classification number: C07D233/64 ,  C07D233/68 ,  C07D401/06

    Abstract: Disclosed are compounds of formula (I): or the pharmaceutically acceptable non-toxic salts thereof wherein Y, R1, R2, R3, R4, R5, R6, R7 R7' are variables defined herein, which compounds are modulators of Bradykinin B2 receptors. These compounds are therefore useful in the diagnosis and treatment of renal diseases, heart failure, hypertension, Meniere's disease, vaginal inflammation and pain, peripheral circulatory disorders, climacteric disturbance, retinochoroidal circulatory disorders, myocardial ischemia, myocardial infarction, postmyocardial infarction syndrome, angina pectoris, restenosis after percutaneous transluminal coronary angioplasty, hepatitis, liver cirrhosis, pancreatitis, ileus, diabetes, diabetic complications, male infertility, glaucoma, pain, asthma, and rhinitis, and for the increase of permeability of the blood-brain barrier or the blood-brain-tumor barrier.

    Abstract translation: 公开了式（I）化合物或其药学上可接受的无毒盐，其中Y，R 1，R 2，R 3，R 4，R 5，R 6，R 7 R 7'为本文定义的变量，该化合物是缓激肽B2受体的调节剂。 因此，这些化合物可用于诊断和治疗肾脏疾病，心力衰竭，高血压，梅尼埃病，阴道炎症和疼痛，外周循环障碍，更年期障碍，视网膜循环障碍，心肌缺血，心肌梗塞，心肌梗死后综合征，心绞痛 经皮腔内冠状动脉血管成形术，肝炎，肝硬化，胰腺炎，肠梗阻，糖尿病，糖尿病并发症，男性不育症，青光眼，疼痛，哮喘和鼻炎的再狭窄，以及增加血脑屏障或血液 - 脑肿瘤屏障。

    4-ARYL-1-DIFLUOROMETHOXYIMIDAZOLE
    99.
    发明申请
    4-ARYL-1-DIFLUOROMETHOXYIMIDAZOLE 审中-公开
    4-芳基-1- DIFLUORMETHOXYIMIDAZOLE

    公开(公告)号：WO01049668A2

    公开(公告)日：2001-07-12

    申请号：PCT/EP2001/000077

    申请日：2001-01-05

    IPC: C07D233/64 ,  A01N43/50 ,  A01N43/76 ,  A01N43/78 ,  A01N43/84 ,  A01N57/16 ,  C07D233/54 ,  C07D233/68 ,  C07D401/04 ,  C07D233/00

    CPC classification number: C07D233/64 ,  C07D233/68

    Abstract: 4-Aryl-1-difluoromethoxyimidazoles of formula (I) are disclosed, where the substituents R and R have the meanings given in the description. Compounds of formula (I) are effective herbicides and can be used for the treatment of undesired plant growth. Furthermore, compounds of formula (I) are suitable for the desiccation and/or defoliation of plants, in particular, of cotton. The invention further relates to herbicidal agents and agents for desiccation and/or defoliation of plants.

    Abstract translation: 中描述了式（I）的4-芳基-1- difluormethoxyimidazole其中变量R <1>，R <2>和R <3>具有说明书中所提及的含义。 式（I）的化合物是有效的除草剂，可用于防治不希望的植物生长。 此外，式I化合物用于干燥和/或植物的落叶，尤其是棉花，是合适的。 本发明还涉及组合物用于防治有害植物和组合物用于植物干燥和/或脱叶。

Patent Agency Ranking