摘要:
Compounds represented by formula (Rf-Q-X)s-Z. Each Rf is independently a partially fluorinated or fully fluorinated group selected from Rfa-(O)r-CHF-(CF2)n-; [Rfb-(O)t-C(L)H-CF2-O]m-W-; CF3CFH-O-(CF2)p-; CF3-(O-CF2)z-; and CF3-O-(CF2)3-O-CF2-. Methods of reducing surface tension of a liquid, making foams, and treating a surface using the compounds are also disclosed.
摘要:
Disclosed are compounds of the formula: where variables Q, Z, X, R15, R2, R3, and Rc are defined herein. Compounds disclosed herein are inhibitors of the beta-secretase enzyme and are therefore useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal.
摘要:
The invention relates to novel Acyl coenzyme-A mimics, compositions comprising ketone compounds, and methods useful for treating and preventing cardiovascular diseases, dyshpidemias, dysproteinemias, and glucose metabolism disorders comprising administering a composition comprising a ketone compound. The Acyl coenzyme-A mimics, compositions, and methods of the invention are also useful for treating and preventing Alzheimer's Disease, Syndrome X, peroxisome proliferator activated receptor-related disorders, septicemia, thrombotic disorders, obesity, pancreatitis, hypertension, renal disease, cancer, inflammation, bacterial infection and impotence. In certain embodiments, the Acyl coenzyme-A mimics, compositions, and methods of the invention are useful in combination therapy with other therapeutics, such as hypocholesterolemic and hypoglycemic agents.
摘要:
Polyamides and process for their preparation comprising either: A) epoxidizing an unsaturated or partially hydrogenated fatty acid glyceride; B) transesterifying the epoxidized glyceride with a C1-4 alkanol to obtain epoxidized fatty acid C1-4 alkyl esters; C) ring opening and dimerizing the epoxidized fatty acid C1-4 alkyl esters; and D) reacting the dimerized fatty acid C1-4 alkyl esters with a polyamine to obtain a polyamide; or: A) transesterifying an unsaturated or partially hydrogenated glyceride with a C1-4 alkanol to obtain olefinically unsaturated fatty acid C1-4 alkyl esters; B) epoxidizing the unsaturated fatty acid C1-4 alkyl esters; C) ring opening and dimerizing the epoxidized fatty acid C1-4 alkyl esters; and D) reacting the dimerized fatty acid C1-4 alkyl esters with a polyamine to obtain a polyamide.
摘要:
Compounds having formula (I) in which n is 1, 2 or 3 and R to R represent, independently, branched or unbranched, substituted or unsubstituted alkyl-, alkenyl-, alkinyl-, cycloalkyl-, cycloalkenyl- or aromatic-radicals or hydrogen wherein these radicals may in addition contain one or more - O - and /or (a) - groups, whereby one or two rings can be built by the combination of the respective R to R and this/these ring(s) can be further substituted by an alkyl-group, in which X is either O and R represents a radical of an alcohol or phenol R OH, or X is N and R represents the radical of an amine R R NH, whereby R and R represent independently, branched or unbranched, substituted or unsubstituted alkyl-, alkenyl-, alkinyl-, cycloalkyl-, cycloalkenyl- or aromatic radicals or either R R may be hydrogen, whereby the amine is a fragrant amine or the amine has more than 9 C atoms, whereby R of the alcohol or phenol and R and/or R of the amine, respectively, may further contain at least one remaining part C(OH)R R -CR R -(CR R )n-CO- of formula (I), are useful as precursors for the delivery of odoriferous and/or antibacterial compounds in cosmetic compositions, cosmetic products, air fresheners, hard surface cleaners or laundry products.
摘要:
An alkanamidoammonium compound, represented by general formula (I), excellent in a trichogenic effect, wherein R represents alkyl or cycloalkyl; R represents alkylene; R represents hydrogen or alkyl; R represents alkylene; R and R may be the same or different from each other and each represents alkyl; R represents alkyl, alkenyl or phenylalkyl; A represents oxygen or -S(O)n-, wherein n represents an integer of 0 to 2; X represents an anion; and m represents an integer corresponding to the number of charges on the anion of X.
摘要翻译:由通式(I)表示的烷酰胺基铵化合物,具有卓越的致毛作用,其中R 1表示烷基或环烷基; R 2表示亚烷基; R 3表示氢或烷基; R 4表示亚烷基; R 5和R 6可以彼此相同或不同,并且各自表示烷基; R 7表示烷基,烯基或苯基烷基; A表示氧或-S(O)n - ,其中n表示0至2的整数; X 表示阴离子; m表示与X的阴离子上的电荷数相对应的整数。
摘要:
There are provided novel 1,4-diamine-2,3-dihydroxybutanes useful as antiviral agents, pharmaceutical compositions containing them and processes for preparing such compounds.
摘要:
According to one embodiment, there is provided a method of producing a gene modification T cell (CAR-T cells) which expresses a chimeric antigen receptor (CAR). This method includes stimulating a cell population containing a T cell with an antibody which activates the T cell, bringing the cell population into contact with a nucleic acid-introducing carrier, wherein the nucleic acid-introducing carrier containing a lipid particle, a first nucleic acid and containing a CAR gene, and a second nucleic acid containing a transposase gene encapsulated in the lipid particle, and culturing the cell population after the contacting.