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    PHOTOSTABLE UV ABSORBENT CONTAINING alpha -CYANO CINNAMYL MOIETY
    6.
    发明申请
    PHOTOSTABLE UV ABSORBENT CONTAINING alpha -CYANO CINNAMYL MOIETY 审中-公开
    含有α-YANO CINNAMYL MOIETY的可吸收紫外线吸收剂

    公开(公告)号：WO99036049A1

    公开(公告)日：1999-07-22

    申请号：PCT/US1999/000739

    申请日：1999-01-13

    IPC分类号： A61K8/40 ,  A61K8/42 ,  A61K8/49 ,  A61Q17/04 ,  C07C255/37 ,  C07C255/40 ,  C07C255/41 ,  C07C255/43 ,  A61K7/42 ,  A61K31/275

    CPC分类号： C07C255/43 ,  A61K8/40 ,  A61K8/42 ,  A61K8/4973 ,  A61K2800/52 ,  A61Q17/04 ,  C07C255/37 ,  C07C255/40 ,  C07C255/41

    摘要： A photostable UV absorbent with maximum absorption above 340 nm having formula (I), wherein R is -CO(R2) or phenyl optionally substituted with lower alkyl and/or lower alkoxy; R2 is -alkyl, -O(C2+ alkyl), (1) or (2); n has a value of from 2 to 8; S and T each independently are hydroxy, lower alkyl, lower alkoxy or, when R2 is alkyl or alkoxy, S can also be phenyl and when R2 is alkoxy, T is alkoxy, or S + T taken with the phenyl ring form a naphthyl radical or a fused benzodioxol-5-yl heterocyclic radical; k + 1 has a value of from 0 to 3 with the proviso that, when R2 is -O(alkyl), T is -O(lower alkyl) and the value of 1 is 2 or 3; R3 is hydrogen or lower alkylene; R4, R5, and R6 are each independently C1 to C18 alkyl or one of R4, R5 and R6 can be phenyl and A is an anion.

    摘要翻译： 具有式（I）的340nm以上最大吸收的光稳定型UV吸收剂，其中R是-CO（R 2）或任选被低级烷基和/或低级烷氧基取代的苯基; R2是 - 烷基，-O（C2 +烷基），（1）或（2）; n的值为2到8; S和T各自独立地是羟基，低级烷基，低级烷氧基，或当R 2是烷基或烷氧基时，S也可以是苯基，当R 2是烷氧基时，T是烷氧基，或与苯基取代的S + T形成萘基 或稠合苯并间二氧杂环戊烯-5-基杂环基; 如果R 2为-O（烷基），则T为-O（低级烷基），并且其1' u>是2或3; R3是氢或低级亚烷基; R4，R5和R6各自独立地为C1至C18烷基，R4，R5和R6之一可为苯基，A为阴离子。

    CRYSTALLINE FORMS OF METYROSINE
    7.
    发明申请
    CRYSTALLINE FORMS OF METYROSINE 审中-公开

    公开(公告)号：WO2022006366A1

    公开(公告)日：2022-01-06

    申请号：PCT/US2021/040035

    申请日：2021-07-01

    申请人： TYME, INC.

    发明人： ZUCARO, John

    IPC分类号： C07C227/18 ,  C07C237/20 ,  C07C255/43 ,  C07B2200/13 ,  C07C227/42 ,  C07C229/36

    摘要： The disclosure provides crystalline compositions comprising D-metyrosine and L- metyrosine, pharmaceutical formulation comprising one or more crystalline composition described herein and a pharmaceutically acceptable excipient, methods for treating cancer in a patient in need thereof, the method comprising administering to the patient one or more composition described herein, and methods for preparing the compositions described herein.