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公开(公告)号:US06365368B1
公开(公告)日:2002-04-02
申请号:US07987233
申请日:1992-12-07
IPC分类号: G01N33543
CPC分类号: C12Q1/10 , C12Q1/06 , G01N33/569 , G01N33/56916 , Y10S435/848 , Y10S435/849 , Y10S436/809 , Y10T436/25375 , Y10T436/255
摘要: The present invention concerns methods of testing water for microbe contamination. The methods of the invention comprise supplementing existing methods with assays using specific reagents such as monoclonal antibodies. The invention also concerns a device for use in the methods of the invention.
摘要翻译: 本发明涉及测试微生物污染水的方法。 本发明的方法包括使用特异性试剂例如单克隆抗体用测定法补充现有方法。 本发明还涉及用于本发明方法的装置。
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公开(公告)号:US20050106652A1
公开(公告)日:2005-05-19
申请号:US10274079
申请日:2002-10-18
申请人: Richard Massey , Michael Powell , Paul Mied , Peter Feng , Leopoldo Della Ciana , Walter Dressick , Mohindar Poonian
发明人: Richard Massey , Michael Powell , Paul Mied , Peter Feng , Leopoldo Della Ciana , Walter Dressick , Mohindar Poonian
IPC分类号: C07D473/08 , C07F15/00 , C07H21/00 , C12Q1/04 , C12Q1/68 , G01N33/533 , G01N33/569 , G01N33/58 , G01N33/76 , C12Q1/70 , C12Q1/26 , C12Q1/37 , C12Q1/48
CPC分类号: G01N33/76 , C07D473/08 , C07F15/0026 , C07F15/0053 , C07H21/00 , C12Q1/04 , G01N33/533 , G01N33/569 , G01N33/582
摘要: Qualitative and quantitative electrochemiluminescent assays for analytes of interest present in multicomponent liquids are provided. These methods comprise contacting a sample with a reagent labeled with an electrochemiluminescent chemical moiety and capable of combining with the analyte of interest, exposing the resulting sample to electrochemical energy and detecting electromagnetic radiation emitted by the electrochemiluminescent chemical moiety. Further provided are methods for detecting and identifying the presence of a multiplicity of analytes in a liquid food or food homogenate. These methods comprise immersing a diagnostic reagent holder, provided with a multiplicity of reagents, into the food or food homogenate, removing the diagnostic reagent holder from the liquid food or food homogenate, and detecting and identifying the presence of a multiplicity of analytes of interest bound to the diagnostic reagent holder, thereby detecting and identifying the presence of a multiplicity of analytes of interest in the food or food homogenate. The invention further provides an enzyme immunoassay for coliform bacteria. This assay comprises inoculating a sample into a suitable medium for coliform reproduction, immobilizing coliforms present in the medium to a suitable surface, treating the surface with an antibody directed to the immobilized coliforms and detecting the presence of the immobilized coliforms immobilized to a suitable surface.
摘要翻译: 提供了对多组分液体中存在感兴趣分析物的定性和定量的电化学发光测定。 这些方法包括使样品与标示有电化学发光化学部分的试剂接触,并能够与感兴趣的分析物结合,将所得样品暴露于电化学能并检测由电化学发光化学部分发射的电磁辐射。 还提供了用于检测和鉴定液体食物或食物匀浆中多种分析物的存在的方法。 这些方法包括将设置有多种试剂的诊断试剂保持器浸入食物或食物匀浆中,从液体食物或食物匀浆中除去诊断试剂载体,以及检测和鉴定多种感兴趣分析物的存在 到诊断试剂保持器,从而检测和鉴定食物或食物匀浆中感兴趣的多种分析物的存在。 本发明还提供了大肠杆菌的酶免疫测定法。 该测定包括将样品接种到用于大肠杆菌繁殖的合适的培养基中,将存在于培养基中的大肠杆菌固定在合适的表面上,用针对固定的大肠菌群的抗体处理该表面并检测固定在合适的表面上的固定的大肠杆菌的存在。
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公开(公告)号:US20060160246A1
公开(公告)日:2006-07-20
申请号:US11385277
申请日:2006-03-20
申请人: Richard Massey , Mark Martin , Liwen Dong , Ming Lu , Alan Fischer , Fabian Jameison , Pam Liang , Robert Hoch , Jonathan Leland
发明人: Richard Massey , Mark Martin , Liwen Dong , Ming Lu , Alan Fischer , Fabian Jameison , Pam Liang , Robert Hoch , Jonathan Leland
IPC分类号: G01N33/543 , C12M1/34
CPC分类号: C01B31/0213 , B82Y30/00 , B82Y40/00 , C01B32/152 , C01B32/174 , C01B2202/34 , C01B2202/36 , C07K17/06 , D01F9/12 , D01F11/14 , G01N21/69 , G01N21/76 , G01N33/54373 , G01N33/5438 , G01N33/582 , G01N2030/8863 , G11C13/025 , H01M4/60 , Y10S435/968 , Y10S436/805 , Y10S436/806 , Y10S977/737 , Y10S977/742
摘要: Graphitic nanotubes, which include tubular fullerenes (commonly called “buckytubes”) and fibrils, which are functionalized by chemical substitution, are used as solid supports in electrogenerated chemiluminescence assays. The graphitic nanotubes are chemically modified with functional group biomolecules prior to use in an assay. Association of electrochemiluminescent ruthenium complexes with the functional group biomolecule-modified nanotubes permits detection of molecules including nucleic acids, antigens, enzymes, and enzyme substrates by multiple formats.
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公开(公告)号:US20130110546A1
公开(公告)日:2013-05-02
申请号:US13288006
申请日:2011-11-02
申请人: Tom Steinhauer , Willis Lam , Jerrod Ullah , David Hernandez , Richard Massey
发明人: Tom Steinhauer , Willis Lam , Jerrod Ullah , David Hernandez , Richard Massey
IPC分类号: G06Q50/24
CPC分类号: G06Q50/24 , G06F19/3418 , G06Q10/10 , G16H40/20 , G16H40/63
摘要: A method for assisting ventilator documentation at a point of care. The method includes accessing ventilator data of a ventilator associated with a patient; displaying the ventilator data at a point of care of the patient; and confirming the ventilator data is correct at the point of care to assist in the ventilator documentation.
摘要翻译: 一种在护理点辅助呼吸机文件的方法。 该方法包括:访问与患者相关联的呼吸机的呼吸机数据; 在患者的护理点显示呼吸机数据; 并且在小心点确认呼吸机数据是正确的,以协助呼吸机文档。
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公开(公告)号:US20050164410A1
公开(公告)日:2005-07-28
申请号:US10912574
申请日:2004-08-06
申请人: John Leland , Haresh Shah , John Kenten , Jack Goodman , George Lowke , Yuzaburo Namba , Gary Blackburn , Richard Massey
发明人: John Leland , Haresh Shah , John Kenten , Jack Goodman , George Lowke , Yuzaburo Namba , Gary Blackburn , Richard Massey
CPC分类号: G01N33/582 , C07H21/00 , G01N1/40 , G01N21/66 , G01N21/76 , G01N33/54313 , G01N33/54326 , G01N33/54366 , G01N33/5438
摘要: An apparatus for performing a binding assay for an analyte of interest present in a sample based upon measurement of electrochemiluminescence at an electrode surface comprising a cell defining a sample containing volume intersecting with inlet and outlet means, an electrode having a substantially horizontally positioned surface exposed to and positioned below a portion of the sample containing volume, means for impressing electrochemical energy upon said electrode sufficient to generate luminescence, means for magnetically collecting particles along said surface and means for measuring the luminescence generated at said electrode.
摘要翻译: 基于在包括限定与入口和出口装置相交的体积的样品的细胞的电极表面上测量电化学发光,对样品中存在的感兴趣分析物进行结合测定的装置,具有暴露于 并且位于所述样品容纳体积的一部分下方,用于在所述电极上施加足以产生发光的电化学能量的装置,用于沿着所述表面磁性收集颗粒的装置和用于测量在所述电极处产生的发光的装置。
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公开(公告)号:US20070135965A1
公开(公告)日:2007-06-14
申请号:US11298813
申请日:2005-12-09
申请人: Thuy Nguyen , Richard Massey
发明人: Thuy Nguyen , Richard Massey
IPC分类号: G06F17/00
CPC分类号: G07F11/62 , A61B50/10 , A61B50/13 , A61B90/96 , A61B90/98 , A61G12/001 , A61G2205/10 , G06F19/00 , G06F19/3462 , G06Q10/087 , G06Q50/22 , G07F9/026 , G07F11/00 , G07F17/0092
摘要: A system and method for storing items and tracking usage of items in a user configurable medication dispensing cabinet is disclosed. Items are stored in a tray or drawer having user-adjustable storage spaces. A graphical user interface comprising a touch screen enables users to rapidly customize the layout of storage spaces, which allows a wide variety of shapes and sizes of items to be stored in the tray. A kit of items that are identified in advance may be removed more efficiently by ordering removal based on the location of the storage spaces in which the items are stored. Items not identified in advance may be removed and tracked more efficiently through the use of the graphical user interface or a scanner for reading machine-readable identification tags on the items or the storage spaces. Bar codes and RFID devices are contemplated for use as identification tags.
摘要翻译: 公开了一种用于存储项目并跟踪用户可配置药物分配柜中的物品的使用的系统和方法。 物品存放在具有用户可调整存储空间的托盘或抽屉中。 包括触摸屏的图形用户界面使得用户能够快速地定制存储空间的布局,这允许存储在托盘中的各种形状和尺寸的物品。 可以通过根据存储物品的存储空间的位置排序移除来更有效地移除事先标识的一组物品。 通过使用图形用户界面或用于读取物品或存储空间上的机器可读识别标签的扫描仪,可以将事先未识别的物品移除和跟踪更有效。 条形码和RFID装置被设想用作识别标签。
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公开(公告)号:US20050123533A1
公开(公告)日:2005-06-09
申请号:US10699966
申请日:2003-11-03
申请人: John Kenten , Reid Borstel , Jan Casadei , Balreddy Kamireddy , Mark Martin , Richard Massey , Andrew Napper , David Simpson , Rodger Smith , Richard Titmas , Richard Williams
发明人: John Kenten , Reid Borstel , Jan Casadei , Balreddy Kamireddy , Mark Martin , Richard Massey , Andrew Napper , David Simpson , Rodger Smith , Richard Titmas , Richard Williams
IPC分类号: A61K31/195 , A61K31/425 , A61K31/505 , A61K31/70 , A61K31/7028 , A61K31/7034 , A61K31/704 , A61K31/7042 , A61K31/7052 , A61K31/7064 , A61K31/7068 , A61K31/7072 , A61K39/385 , A61K39/395 , A61K47/48 , A61P31/12 , A61P43/00 , C07C311/19 , C07D227/02 , C07D233/64 , C07D233/88 , C07D405/04 , C07D417/12 , C07D417/14 , C07F9/24 , C07F9/26 , C07F9/40 , C07F9/6509 , C07F9/6571 , C07F9/6574 , C07H15/252 , C07H19/04 , C07H19/067 , C07H19/09 , C07H19/10 , C07H19/11 , C07K16/46 , C12N15/09 , C12P21/08 , C12R1/92 , G01N33/50 , G01N33/53 , C07H15/24 , C07K16/18
CPC分类号: G01N33/5011 , C07C311/19 , C07F9/2408 , C07F9/2458 , C07F9/4006 , C07F9/4075 , C07F9/650952 , C07F9/657181 , C07H15/252 , C07H19/04 , C07K16/468 , G01N33/5008 , G01N33/5014 , G01N33/5088 , G01N33/5094 , G01N2500/00
摘要: Disclosed and claimed are prodrugs activated by catalytic proteins, such as enzymes and catalytic antibodies. The invention comprehends such prodrugs, as well as haptens, to elicit catalytic antibodies to activate the prodrugs. The prodrugs are useful as cytotoxic chemotherapeutic agents; e.g., as antitumor agents.
摘要翻译: 披露和要求的是由催化蛋白如酶和催化抗体活化的前药。 本发明包括这些前药以及半抗原以引发催化抗体以活化前药。 前药可用作细胞毒性化学治疗剂; 例如作为抗肿瘤剂。
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