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公开(公告)号：US5834274A
公开(公告)日：1998-11-10
申请号：US467693
申请日：1995-06-06
申请人： Jeffrey A. Hubbell , Chandrashekhar P. Pathak , Amarpreet S. Sawhney , Neil P. Desai , Jennifer L. Hill , Syed F. A. Hossainy
发明人： Jeffrey A. Hubbell , Chandrashekhar P. Pathak , Amarpreet S. Sawhney , Neil P. Desai , Jennifer L. Hill , Syed F. A. Hossainy
IPC分类号： A61K9/16 , A61K9/50 , A61K35/12 , A61K38/42 , A61K38/44 , A61L24/00 , A61L24/04 , A61L26/00 , A61L27/34 , A61L27/38 , A61L27/52 , A61L29/08 , A61L31/10 , A61L31/14 , C08B37/08 , C08F290/00 , C08F290/02 , C08F290/06 , C08F290/08 , C08F290/10 , C08F291/00 , C09D153/00 , C12N5/00 , C12N5/071 , C12N5/077 , C12N11/04 , C12N11/02 , C08J7/16 , A61K47/32
CPC分类号： C12N11/04 , A61K38/42 , A61K38/44 , A61K47/48315 , A61K47/48784 , A61K47/48876 , A61K9/1635 , A61K9/1647 , A61K9/5026 , A61K9/5031 , A61K9/5073 , A61L24/0031 , A61L24/0042 , A61L24/046 , A61L26/0019 , A61L27/34 , A61L27/3683 , A61L27/38 , A61L27/52 , A61L29/085 , A61L31/10 , A61L31/145 , A61L31/148 , B82Y5/00 , C08B37/003 , C08B37/0072 , C08B37/0084 , C08F290/00 , C08F290/02 , C08F290/06 , C08F290/062 , C08F290/08 , C08F290/10 , C08F291/00 , C09D153/00 , C12N5/0012 , C12N5/0677 , A61K2035/128 , C12N2533/30 , C12N2533/32 , C12N2533/40 , C12N2533/74 , Y10S514/801 , Y10S530/812 , Y10S530/813 , Y10S530/815 , Y10S530/817 , Y10T428/2987 , Y10T428/2989
摘要： Water soluble macromers are modified by addition of free radical polymerizable groups, such as those containing a carbon-carbon double or triple bond, which can be polymerized under mild conditions to encapsulate tissues, cells, or biologically active materials. The polymeric materials are particularly useful as tissue adhesives, coatings for tissue lumens including blood vessels, coatings for cells such as islets of Langerhans, coatings, plugs, supports or substrates for contact with biological materials such as the body, and as drug delivery devices for biologically active molecules.
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92.发明授权Bioabsorbable stent that modulates plaque geometric morphology and chemical composition 有权生物可吸收支架，调节斑块几何形态和化学成分公开(公告)号：US09572692B2
公开(公告)日：2017-02-21
申请号：US12510076
申请日：2009-07-27
CPC分类号： A61F2/915 , A61F2/06 , A61F2/82 , A61F2/91 , A61F2/958 , A61F2002/825 , A61F2002/91566 , A61F2002/91583 , A61F2210/0004 , A61F2210/0076 , A61F2230/0054 , A61F2250/0067 , A61L31/06 , A61L31/148 , A61L31/16 , A61L2300/412 , C08L67/04
摘要： Methods of treating a diseased blood vessel exhibiting stenosis with a bioabsorable stent are disclosed. The implanted stent supports the section of the vessel at an increased diameter for a period of time to allow the vessel to heal. The stent loses radial strength sufficient to support the section of the vessel in less than 6 months after implantation, loses mechanical integrity, and then erodes away from the section. The biodegradable stent results in changes in properties of plaque with time as the stent degrades. The time-dependent properties include the luminal area of the plaque and plaque geometric morphology parameters.
摘要翻译： 公开了用生物可吸收支架治疗显示狭窄的患病血管的方法。 植入的支架在增加的直径的一段时间内支撑血管的部分，以允许血管愈合。 支架在植入后6个月内失去足以支撑血管的部分的径向强度，丧失机械完整性，然后从该部分脱落。 生物降解支架随着支架退化而导致斑块的性质随时间的变化。 时间依赖性质包括斑块和斑块几何形态参数的腔面积。
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公开(公告)号：US09561351B2
公开(公告)日：2017-02-07
申请号：US11445079
申请日：2006-05-31
CPC分类号： A61M31/002 , A61F2/88 , A61F2/885 , A61F2250/0039 , A61F2250/0067
摘要： An implantable medical device is disclosed having a helical construct including a set of spiral coils for local in vivo application of a therapeutic substance in a biological lumen. The helical construct is configured to apply less than 0.75 Bar of pressure to the biological lumen wall. The helical construct can have at least two sets of spiral coils having opposing helical directions. The device can be used for the treatment of vascular disorders such as restenosis and vulnerable plaque.
摘要翻译： 公开了一种植入式医疗装置，其具有螺旋构造，其包括用于在生物腔内局部体内施用治疗物质的一组螺旋线圈。 螺旋结构被配置为向生物腔壁施加小于0.75巴的压力。 螺旋结构可以具有至少两组具有相反螺旋方向的螺旋线圈。 该装置可用于治疗血管疾病如再狭窄和易损斑块。
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94.发明授权Primer coatings for stents with oxide, anionic, or hydroxyl surface moieties 有权用于具有氧化物，阴离子或羟基表面部分的支架的底漆涂层公开(公告)号：US09101689B2
公开(公告)日：2015-08-11
申请号：US12723569
申请日：2010-03-12
申请人： Syed F. A. Hossainy , Stephen D. Pacetti , Keith E. Fong , Vinayak Bhat , Deborra Sanders Millare , Judy A. Guruwaiya , Daryush Mirzaee , Evgenia Mandrusov
发明人： Syed F. A. Hossainy , Stephen D. Pacetti , Keith E. Fong , Vinayak Bhat , Deborra Sanders Millare , Judy A. Guruwaiya , Daryush Mirzaee , Evgenia Mandrusov
IPC分类号： A61L27/34 , A61L27/30 , A61L27/54 , A61L29/08 , A61L29/16 , A61L31/10 , A61L31/16 , A61L33/00
CPC分类号： A61L27/34 , A61L27/306 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L33/0011 , A61L2300/416 , A61L2300/602 , A61L2300/606 , A61L2300/608 , A61L2420/02 , A61L2420/08 , C08L29/04
摘要： Coatings for implantable devices or endoluminal prosthesis, such as stents, are provided, including a method of forming the coatings. The coatings can be used for the delivery of an active ingredient or a combination of active ingredients.
摘要翻译： 提供用于可植入装置或腔内假体（例如支架）的涂层，包括形成涂层的方法。 涂层可用于递送活性成分或活性成分的组合。
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95.发明授权Method of coating a stent with a release polymer for 40-O-(2-hydroxy)ethyl-rapamycin 有权用40-O-（2-羟基）乙基雷帕霉素的释放聚合物涂覆支架的方法公开(公告)号：US08961588B2
公开(公告)日：2015-02-24
申请号：US11527971
申请日：2006-09-26
申请人： Syed F. A. Hossainy , Gordon Stewart , Mark A. Williams , Jeff Royal , Paul M. Consigny , Dorie M. Happ , Kurt Scheinpflug , Ty Hu
发明人： Syed F. A. Hossainy , Gordon Stewart , Mark A. Williams , Jeff Royal , Paul M. Consigny , Dorie M. Happ , Kurt Scheinpflug , Ty Hu
CPC分类号： A61F2/844 , A61F2250/0067 , A61L27/54 , A61L31/16 , A61L2300/416 , A61L2300/602 , A61L2300/606
摘要： A method of coating a stent is presented such that less than 50% of the total amount of 40-O-(2-hydroxyl)ethyl-rapamycin, or an analog or derivative thereof, is released in vivo in a 24 hour period, wherein the method comprises exposing the coating to sufficient temperature to modify the structure of the polymer.
摘要翻译： 提出了一种涂覆支架的方法，使得在24小时内体内释放40-O-（2-羟基）乙基雷帕霉素或其类似物或衍生物的总量的少于50％，其中 该方法包括将涂层暴露于足够的温度以改变聚合物的结构。
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96.发明授权公开(公告)号：US08911766B2
公开(公告)日：2014-12-16
申请号：US12493112
申请日：2009-06-26
IPC分类号： A61K9/14 , A61K9/00 , A61K9/51 , A61K9/16 , A61K9/50 , A61L29/16 , A61L31/16 , A61L27/54 , A61M25/10 , A61M25/00
CPC分类号： A61K9/0009 , A61K9/1641 , A61K9/1647 , A61K9/5031 , A61K9/5146 , A61K9/5153 , A61L27/54 , A61L29/16 , A61L31/16 , A61L2300/45 , A61L2300/602 , A61L2400/12 , A61M25/0045 , A61M2025/0057 , A61M2025/105 , Y10S977/773 , Y10S977/906
摘要： The current invention is directed to compositions comprising a plurality of particles including nanoshells or a medical device with a coating including nanoshells allowing for triggered drug release. Methods of treatment with such compositions are also included.
摘要翻译： 本发明涉及包含多个包括纳米壳的颗粒的组合物或具有包含允许触发的药物释放的纳米壳的涂层的医疗装置。 还包括用这些组合物处理的方法。
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公开(公告)号：US08871883B2
公开(公告)日：2014-10-28
申请号：US12844734
申请日：2010-07-27
IPC分类号： C08F228/02 , C08F220/10 , C08F220/26 , A61L31/10
摘要： A copolymer which includes at least one biologically compatible structural moiety and at least one biologically active moiety is disclosed. The copolymer can be used for fabricating a coating for an implantable medical device such as a stent.
摘要翻译： 公开了包含至少一个生物相容结构部分和至少一个生物活性部分的共聚物。 该共聚物可用于制造可植入医疗装置如支架的涂层。
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98.发明授权Coatings for implantable devices having a chromium oxide layer and a method of forming the same 有权具有氧化铬层的可植入装置的涂层及其形成方法公开(公告)号：US08858975B2
公开(公告)日：2014-10-14
申请号：US12723561
申请日：2010-03-12
申请人： Syed F. A. Hossainy , Stephen D. Pacetti , Keith E. Fong , Vinayak Bhat , Deborra Sanders Millare , Judy A. Guruwaiya , Daryush Mirzaee , Evgenia Mandrusov
发明人： Syed F. A. Hossainy , Stephen D. Pacetti , Keith E. Fong , Vinayak Bhat , Deborra Sanders Millare , Judy A. Guruwaiya , Daryush Mirzaee , Evgenia Mandrusov
IPC分类号： A61F13/00 , A61L27/30 , A61L29/08 , A61L27/54 , A61L27/34 , A61L29/16 , A61L31/16 , A61L31/10 , A61L33/00
CPC分类号： A61L27/34 , A61L27/306 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L33/0011 , A61L2300/416 , A61L2300/602 , A61L2300/606 , A61L2300/608 , A61L2420/02 , A61L2420/08 , C08L29/04
摘要： Coatings for implantable devices or endoluminal prosthesis, such as stents, are provided, including a method of forming the coatings. The coatings can be used for the delivery of an active ingredient or a combination of active ingredients.
摘要翻译： 提供用于可植入装置或腔内假体（例如支架）的涂层，包括形成涂层的方法。 涂层可用于递送活性成分或活性成分的组合。
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公开(公告)号：US08563025B2
公开(公告)日：2013-10-22
申请号：US11338058
申请日：2006-01-23
IPC分类号： A61F2/00 , A61K31/56 , A61K31/44 , A61K31/335 , C08F220/00
CPC分类号： A61L31/10 , A61K31/337 , A61K31/4745 , A61K31/56 , A61L31/16 , A61L2300/416 , A61L2300/43 , A61L2300/606 , C08F8/00 , C08F8/30 , C08F8/32 , C08F2800/10 , C08F2810/50 , C08G18/6212 , C08G18/711 , C09D151/003 , C09D151/06 , C09D151/08 , C09D175/04 , C08L2666/02 , C08L2666/04 , C08L2666/14 , C08F216/06 , C08F8/34 , C08F210/02 , C08F8/14
摘要： The present application teaches a coating having a biologically compatible compound conjugated to, or blended with, a polymer, wherein the polymer includes at least one olefin-derived unit and at least one unit derived from a vinyl alcohol, an allyl alcohol, or derivatives thereof.
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100.发明授权Method of treatment with a bioabsorbable stent with time dependent structure and properties and regio-selective degradation 有权用具有时间依赖性结构和性质和区域选择性降解的生物可吸收支架进行治疗的方法公开(公告)号：US08425587B2
公开(公告)日：2013-04-23
申请号：US12561971
申请日：2009-09-17
申请人： Mikael Trollsas , Dariush Davalian , Michael Huy Ngo , Hao-Ming Hsiao , Boris Anukhin , Syed F. A. Hossainy , David C. Gale
发明人： Mikael Trollsas , Dariush Davalian , Michael Huy Ngo , Hao-Ming Hsiao , Boris Anukhin , Syed F. A. Hossainy , David C. Gale
IPC分类号： A61F2/82
CPC分类号： A61F2/89 , A61F2/91 , A61F2/915 , A61F2002/828 , A61F2210/0004 , A61F2230/0054 , A61F2250/0036 , A61L31/06 , A61L31/10 , A61L31/148 , C08L67/04
摘要： A bioabsorbable polymeric stent with time dependent structure and properties and methods of treating a diseased blood vessel with the bioabsorable polymeric stent are disclosed. The structure and properties of the stent change with time and allow the vessel to be restored to a natural unstented state. The bioabsorbable stent loses mechanical integrity in a controlled manner due to modification of selected structural elements.
摘要翻译： 公开了具有时间依赖性结构的生物可吸收聚合物支架，以及用生物可吸收聚合物支架治疗患病血管的特性和方法。 支架的结构和性质随时间而变化，并允许血管恢复到自然不稳定状态。 由于选择的结构元件的修饰，生物可吸收的支架以受控的方式失去机械完整性。
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