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公开(公告)号：US20190186987A1
公开(公告)日：2019-06-20
申请号：US16219715
申请日：2018-12-13
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Itay BARAK
CPC classification number: G01J1/0403 , G01J1/0407 , G01N21/6428 , G01N21/76 , G01N33/5302 , G01N2021/6439
Abstract: A combination imaging system includes a housing having a base and a lid, the lid having a closed position against the base and having an open position. The imaging device further includes a contact area image sensor. The lid shields the contact area image sensor from ambient light when the lid is in the closed position. The imaging device also includes a camera. The camera includes a lens, and the field of view of the camera encompasses at least a portion of an imaging area of the contact area image sensor when the lid is in the open position. The device may be especially useful for capturing a chemiluminescent image of an electrophoretic assay result, and capturing a colorimetric image of the same result, so that non-chemiluminescent protein standards may be located with respect to chemiluminescent analytes of interest.
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公开(公告)号：US20190145881A1
公开(公告)日：2019-05-16
申请号：US16247424
申请日：2019-01-14
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Daniel Nelson Fox , Susan Hunter
CPC classification number: G01N15/1012 , G01J3/0218 , G01J3/027 , G01J3/10 , G01J3/36 , G01J2003/104 , G01N15/1434 , G01N15/1459 , G01N2015/0065 , G01N2015/1006
Abstract: Disclosed is a system and method for characterizing optical filters in a flow cytometer and optionally checking the operation of detectors in the flow cytometer. In some embodiments, the system may utilize an LED board having an opening through which the fluorescence and side scatter beams, rays, or images pass and light emitting diodes around the opening that emit light having different spectral profiles. The different spectral profiles allow the system to identify the optical filters that are placed in the flow cytometer, to verify detector operation, to assist in instrumentation troubleshooting, and to provide a quantitative reference for detector comparison.
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公开(公告)号：US20190134581A1
公开(公告)日：2019-05-09
申请号：US16181256
申请日：2018-11-05
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Yevgeny Yurkovetsky , Darren Roy Link , Jonathan William Larson
Abstract: The invention generally relates to methods for forming mixed droplets. In certain embodiments, methods of the invention involve forming a droplet, and contacting the droplet with a fluid stream, wherein a portion of the fluid stream integrates with the droplet to form a mixed droplet.
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公开(公告)号：US10284756B2
公开(公告)日：2019-05-07
申请号：US15449786
申请日：2017-03-03
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Evelio Perez , Evan P. Thrush , Stephen L. R. Swihart , Brian D. Hall
Abstract: Techniques and systems for implementing fast, fixed-focal-length lens imaging systems for molecular biology or genetics applications are provided. In particular, techniques and structures are provided for allowing for precise alignment of the optical and imaging components of such imaging systems during assembly with a minimal amount of adjustment.
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公开(公告)号：US10279350B2
公开(公告)日：2019-05-07
申请号：US15365894
申请日：2016-11-30
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Benjamin J. Hindson , Kevin D. Ness , Billy W. Colston, Jr. , Fred P. Milanovich , Donald A. Masquelier
IPC: B01L3/00 , B01F13/00 , B01F15/00 , B01L3/02 , B01L7/00 , B29C45/00 , C12Q1/686 , G01N21/3563 , G01N21/49 , G01N21/64 , B01F3/08 , B29L31/00
CPC classification number: B01L3/502784 , B01F3/0807 , B01F13/0062 , B01F15/00922 , B01F2003/0834 , B01F2003/0842 , B01F2215/0037 , B01L3/0241 , B01L3/502715 , B01L7/52 , B01L7/525 , B01L2200/0673 , B01L2200/0689 , B01L2200/10 , B01L2200/12 , B01L2300/041 , B01L2300/0654 , B01L2300/0816 , B01L2300/0819 , B01L2300/0858 , B01L2300/0867 , B01L2300/1822 , B01L2400/0478 , B01L2400/0487 , B01L2400/049 , B01L2400/0622 , B29C45/0053 , B29C45/006 , B29C2045/0079 , B29L2031/752 , C12Q1/686 , G01N21/3563 , G01N21/49 , G01N21/6428 , G01N21/6486 , G01N2021/6439 , Y02A90/26
Abstract: Methods of generating droplets. In an exemplary method, a device including a sample well, a carrier well, a droplet well, and a plurality of microfluidic channels is selected. The microfluidic channels include a first channel, a second channel, and a third channel. A discrete volume of sample-containing fluid is placed into the sample well, and a discrete volume of carrier fluid is placed into the carrier well. A pressure differential is created after placing the discrete volumes, to cause fluid flow. Sample-containing fluid flows from the sample well to a droplet-generation region of the device via the first channel. Carrier fluid flows from the carrier well to the droplet-generation region via the second channel. Sample-containing droplets and carrier fluid flow from the droplet-generation region to the droplet well via the third channel.
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Patent Agency Ranking
公开(公告)号：US20190127792A1
公开(公告)日：2019-05-02
申请号：US16178313
申请日：2018-11-01
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Ronald Lebofsky , Jennifer Chew
IPC: C12Q1/6869 , C12Q1/6855 , C12Q1/6862 , C12Q1/6876 , C12Q1/6848 , C12Q1/6806 , C12Q1/686 , C12N15/10 , C12N9/12
Abstract: The methods and reagents are provided for barcoding and analysis of DNA samples using partition (e.g., droplet) technology while avoiding performing amplification in droplets.
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公开(公告)号：US10261058B2
公开(公告)日：2019-04-16
申请号：US14592308
申请日：2015-01-08
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Jeff Habel
Abstract: One embodiment of the invention is directed to a method of analyzing liquid chromatography data. The method comprises collecting, by a data processing system, first volume fractions data from a first liquid chromatography column for a first absorbance wavelength of light λ1 from a first run of a liquid chromatography process on a mixture, wherein the first liquid chromatography column screens for a first characteristic of the mixture. The method further comprising, normalizing a first relative peak area for a first volume of a component of interest in the mixture for the first absorbance wavelength λ1 to obtain a first set of purity quotient values PQ1, collecting second volume fractions data from a second liquid chromatography column for a second absorbance wavelength of light λ2 from a second run of a liquid chromatography process on the mixture, wherein the second liquid chromatography column screens for a second characteristic of the mixture, normalizing a second relative peak area for the second volume of the component of interest in the mixture for the second absorbance wavelength λ2 to obtain a second set of purity quotient values PQ2, storing the values PQ1 and PQ2 in a memory, calculating a difference between values PQ1 and PQ2 for each volume fraction location of the first and second volumes to obtain a first set of purity quotient difference (“PQD”) values, displaying in a graphical display the first set of PQD values, and determining which volume fractions to pool together based on the display of the first set of PQD values.
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公开(公告)号：US10258989B2
公开(公告)日：2019-04-16
申请号：US15365888
申请日：2016-11-30
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Kevin D. Ness , Benjamin J. Hindson , Billy W. Colston, Jr. , Donald A. Masquelier
IPC: B01L3/00 , B01F3/08 , B01F13/00 , B01L3/02 , B01L7/00 , G01N21/3563 , C12Q1/686 , G01N21/64 , B01F15/00 , B29C45/00 , G01N21/49 , B29L31/00
Abstract: Methods of making a droplet-generating device. In an exemplary method, an upper member is injection molded. The upper member includes a bottom surface and also includes a first microfluidic channel, a second microfluidic channel, and a third microfluidic channel each formed in the bottom surface. The upper member has a plurality of openings each extending completely through the upper member from the bottom surface and creating a side wall region of a sample well, a carrier well, and a droplet well. A cover layer is attached to the bottom surface of the upper member, such that the cover layer seals a bottom side of each microfluidic channel. The microfluidic channels meet one another to create a droplet-generation region. The sample well, the carrier well, and the droplet well are connected to the droplet-generation region via the first, second, and third microfluidic channels, respectively.
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公开(公告)号：US20190107484A1
公开(公告)日：2019-04-11
申请号：US16151732
申请日：2018-10-04
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Evan Thrush , Steven Swihart , William Strong , Trey Marlowe
IPC: G01N21/31 , G01N21/3577 , G01N21/3563
Abstract: Systems for protein quantitation using a Fabry-Perot interferometer. In one arrangement, a quantitation device includes an infrared source, a sample holder, and a Fabry-Perot interferometer positioned to receive infrared radiation from the source passing through a sample on the sample holder. A band pass optical filter sets the working range of the interferometer, and radiation exiting the interferometer falls on a detector that produces a signal indicating the intensity of the received radiation. A controller causes the interferometer to be tuned to a number of different resonance wavelengths and receives the intensity signals, for determination of an absorbance spectrum.
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公开(公告)号：US20190094214A1
公开(公告)日：2019-03-28
申请号：US16141069
申请日：2018-09-25
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Boaz Gildor , Dalia Shezifi
IPC: G01N33/543 , G01N33/541
Abstract: Methods of detecting a target in a sample are provided. Kits for performing the methods described herein are also provided.
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