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181.发明授权公开(公告)号：US09000399B2
公开(公告)日：2015-04-07
申请号：US13271101
申请日：2011-10-11
Applicant: Kyung-ho Kim , Joon-ho Kim , Kak Namkoong , Won-seok Chung
Inventor： Kyung-ho Kim , Joon-ho Kim , Kak Namkoong , Won-seok Chung
CPC classification number: G01N21/645 , G01J3/0208 , G01J3/0229 , G01J3/0237 , G01J3/4406 , G01N21/05 , G01N2021/0346 , G01N2021/6419 , G01N2021/6421 , G01N2021/6478 , G01N2201/0635
Abstract: A fluorescence detection optical system detects fluorescence beams with two or more different wavelengths and maintains a focal position through an automatic focusing function. A multi-channel fluorescence detection apparatus includes the fluorescence detection optical system. The fluorescence detection optical system includes an automatic focusing unit which receives light reflected off a microfluidic device and determines a focal point by using an astigmatic method or a knife edge method, and an actuator which adjusts a position of an objective lens according to control of the automatic focusing unit. In addition, the fluorescence detection optical system may include a plurality of dual band pass filters, dichroic devices, etc., which provide light beams emitted from at least two light sources and transfer fluorescence generated from the microfluidic device to a photodetector.
Abstract translation: 荧光检测光学系统检测具有两个或更多个不同波长的荧光束并通过自动聚焦功能保持焦点位置。 多通道荧光检测装置包括荧光检测光学系统。 荧光检测光学系统包括自动聚焦单元，其接收从微流体装置反射的光并且通过使用散光方法或刀刃方法确定焦点，以及致动器，其根据控制的方式调整物镜的位置 自动对焦单元 此外，荧光检测光学系统可以包括多个双带通滤波器，二向色装置等，其提供从至少两个光源发射的光束并将从微流体装置产生的荧光转移到光电检测器。
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公开(公告)号：US08836948B2
公开(公告)日：2014-09-16
申请号：US13146550
申请日：2010-01-28
Applicant: Zhaowei Liu
Inventor： Zhaowei Liu
CPC classification number: G02B21/16 , G01B9/04 , G01B11/2441 , G01N21/6458 , G01N21/648 , G01N2201/0635 , G01N2201/0675 , G02B5/008 , G02B27/60
Abstract: Disclosed are systems, apparatus, methods and devices, including a method that includes generating two or more sequential surface plasmon interference patterns, at least one of the two or more sequential surface plasmon interference patterns being different from another of the two or more sequential surface plasmon interference patterns, and capturing respective images of a specimen resulting from the interference patterns. Also disclosed is a method that includes generating two or more sequential optical interference patterns, at least one of the two or more sequential optical interference patterns being different from another of the interference patterns, and removing from each of the generated interference patterns, using a beam stopper, a corresponding zero-order diffraction light component included in the respective generated patterns to obtain resultant corresponding two or more sequential optical interference patterns, directed at a specimen, with missing respective zero-order light components.
Abstract translation: 公开了一种系统，装置，方法和装置，包括一种方法，包括产生两个或多个顺序表面等离子体激元干涉图案，两个或更多个顺序表面等离子体激元干涉图案中的至少一个不同于两个或多个顺序表面等离子体激元 干涉图案，并捕获由干涉图案产生的样本的各个图像。 还公开了一种方法，其包括生成两个或多个顺序光学干涉图案，所述两个或更多个顺序光学干涉图案中的至少一个与干涉图案中的另一个不同，以及使用光束从每个所生成的干涉图案中移除 阻挡器，包括在各个生成的图案中的对应的零级衍射光分量，以获得指向样本的相应的两个或更多个顺序的光学干涉图案，缺少相应的零级光分量。
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公开(公告)号：US20140098368A1
公开(公告)日：2014-04-10
申请号：US14032192
申请日：2013-09-19
Applicant: Seagate Technology LLC
Inventor： Joachim Walter Ahner , Samuel Kah Hean Wong , Maissarath Nassirou , Henry Luis Lott , David M. Tung , Florin Zavaliche , Stephen Keith McLaurin
IPC: G01N21/47
CPC classification number: G01N21/4738 , G01N21/95 , G01N2021/4764 , G01N2021/4792 , G01N2201/0635 , G01N2201/0683
Abstract: Provided herein is an apparatus, including an optical characterization device; a photon detector array configured to sequentially receive a first set of photons scattered from surface features of an article and a second set of photons scattered from surface features of the article and subsequently processed by the optical characterization device; and a chemical characterization means for chemically characterizing the surface features of the article, wherein the chemical characterization means is configured for processing the first set of photons received by the photon detector array and the second set of photons received by the photon detector array.
Abstract translation: 本文提供的装置包括光学表征装置; 光子检测器阵列，其被配置为顺序地接收从制品的表面特征散射并随后由所述光学表征装置处理的物品的表面特征散射的第一组光子和第二组光子; 以及用于化学表征所述制品的表面特征的化学表征装置，其中所述化学表征装置被配置用于处理由所述光子检测器阵列接收的第一组光子和由所述光子检测器阵列接收的所述第二组光子。
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公开(公告)号：US08644590B2
公开(公告)日：2014-02-04
申请号：US13619161
申请日：2012-09-14
Applicant: Joong-Ki Jeong , Min-Young Kim , Hee-Wook You
Inventor： Joong-Ki Jeong , Min-Young Kim , Hee-Wook You
CPC classification number: G06T1/0007 , G01B11/0608 , G01B11/2509 , G01J3/50 , G01N21/8806 , G01N21/95684 , G01N2021/95638 , G01N2021/95646 , G01N2201/0635 , G06T7/0008 , G06T7/521 , G06T2207/10024 , G06T2207/10152 , G06T2207/30152
Abstract: In order to measure a measurement target on a PCB, height information of the PCB is acquired by using a first image photographed by illuminating a grating pattern light onto the PCB. Then, a first area protruding on the PCB by greater than a reference height is determined as the measurement target by using the height information. Thereafter, color information of the PCB is acquired by using a second image photographed by illuminating light onto the PCB. Then, the first color information of the first area determined as the measurement target out of the color information of the PCB is set as reference color information. Thereafter, the reference color information is compared with color information of an area except for the first area to judge whether the measurement target is formed in the area except for the first area. Thus, the measurement target may be accurately measured.
Abstract translation: 为了测量PCB上的测量目标，通过使用通过将光栅图案光照射到PCB上拍摄的第一图像来获取PCB的高度信息。 然后，通过使用高度信息，将在PCB上突出大于参考高度的第一区域确定为测量目标。 此后，通过使用通过将光照射到PCB上拍摄的第二图像来获取PCB的颜色信息。 然后，将作为PCB的颜色信息中的测量对象确定的第一区域的第一颜色信息设置为参考颜色信息。 此后，将参考颜色信息与除了第一区域之外的区域的颜色信息进行比较，以判断在除了第一区域之外的区域中是否形成测量对象。 因此，可以精确地测量测量对象。
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公开(公告)号：US20130223056A1
公开(公告)日：2013-08-29
申请号：US13740590
申请日：2013-01-14
Applicant: Bio-Rad Laboratories, Inc.
Inventor： James W. Hillendahl , Evelio Perez
IPC: F21V21/005 , F21V13/02 , F21V9/08
CPC classification number: F21V21/005 , F21V9/083 , F21V13/02 , G01N21/255 , G01N21/6452 , G01N21/6456 , G01N27/447 , G01N2021/6463 , G01N2021/6471 , G01N2201/06 , G01N2201/0626 , G01N2201/0635
Abstract: A planar sample, particularly of the type used in biological laboratories for detection and sometimes analysis of two-dimensional arrays of proteins, nucleic acids, or other biological species, is illuminated by epi-illumination using optically filtered line lights that are arranged along opposing parallel sides of a rectangle in which the sample array resides, with two coaxial line lights on each side of the rectangle, and the two on any given side being separated by a gap whose optimal width depends on the wavelength band transmitted by the optical filter. Surprisingly, the gap eliminates the peak in intensity at the center of the sample area and the decrease that occurs from the center outward that would otherwise occur with a single continuous filtered line light, producing instead a substantially uniform intensity along the direction parallel to the line lights.
Abstract translation: 平面样品，特别是用于生物实验室中用于检测和有时分析蛋白质，核酸或其他生物物种的二维阵列的类型的样品，通过使用沿着相对的平行排列的光学滤波的线光照射外照射 样品阵列所在的矩形的边，在矩形的每一侧上具有两根同轴线灯，并且任意给定侧上的两根被间隔开，该间隙的最佳宽度取决于由滤光器传输的波长带。 令人惊奇的是，间隙消除了样品区域中心处的强度峰值以及从中心向外发生的减少，否则会出现与单个连续过滤线条光线相反的方向，沿着平行于该线条的方向产生基本均匀的强度 灯光
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Patent Agency Ranking
公开(公告)号：US20130143310A1
公开(公告)日：2013-06-06
申请号：US13748508
申请日：2013-01-23
Applicant: Applied Biosystems, LLC
Inventor： Mark F. Oldham , Eugene F. Young
IPC: G01N21/64
CPC classification number: G01N21/6486 , B01L3/5085 , B01L7/52 , C12Q2545/101 , G01N21/274 , G01N21/6428 , G01N21/645 , G01N21/6452 , G01N2021/6419 , G01N2021/6421 , G01N2021/6439 , G01N2021/6441 , G01N2021/6463 , G01N2021/6482 , G01N2201/0245 , G01N2201/0628 , G01N2201/0635 , Y10S435/808 , Y10S435/809
Abstract: An instrument is provided that can monitor nucleic acid sequence amplification reactions, for example, PCR amplification of DNA and DNA fragments. The instrument includes a multi-notch filter disposed along one or both of an excitation beam path and an emission beam path. Methods are also provided for monitoring nucleic acid sequence amplifications using an instrument that includes a multi-notch filter disposed along a beam path.
Abstract translation: 提供了可以监测核酸序列扩增反应的仪器，例如DNA和DNA片段的PCR扩增。 仪器包括沿激发光束路径和发射光束路径中的一个或两个设置的多陷波滤波器。 还提供了使用包括沿着光束路径设置的多陷波滤波器的仪器来监测核酸序列扩增的方法。
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公开(公告)号：US20130050686A1
公开(公告)日：2013-02-28
申请号：US13217859
申请日：2011-08-25
Applicant: Thomas Wunderer , Christopher L. Chua , Brent S. Krusor , Noble M. Johnson
Inventor： Thomas Wunderer , Christopher L. Chua , Brent S. Krusor , Noble M. Johnson
CPC classification number: H01S5/18363 , B82Y20/00 , G01N21/17 , G01N21/41 , G01N2201/0635 , G01N2201/08 , G02B5/0816 , G02B5/085 , H01S5/18308 , H01S5/18341 , H01S5/18369 , H01S5/18377 , H01S5/34333 , H01S2304/04
Abstract: A device includes one or more reflector components. Each reflector component comprises layer pairs of epitaxially grown reflective layers and layers of a non-epitaxial material, such as air. Vias extend through at least some of the layers of the reflector components. The device may include a light emitting layer.
Abstract translation: 装置包括一个或多个反射器部件。 每个反射器组件包括外延生长反射层的层对和非外延材料（例如空气）的层。 通孔延伸穿过反射器部件的至少一些层。 该装置可以包括发光层。
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公开(公告)号：US08383369B2
公开(公告)日：2013-02-26
申请号：US12561221
申请日：2009-09-16
Applicant: Kenneth Mark Maxham , Jon Sorenson , John Eid , Patrick Marks , Kevin Travers , Donald Gray , Robin Emig , Mark Chaisson , Benjamin Flusberg
Inventor： Kenneth Mark Maxham , Jon Sorenson , John Eid , Patrick Marks , Kevin Travers , Donald Gray , Robin Emig , Mark Chaisson , Benjamin Flusberg
CPC classification number: G01N21/6452 , C12Q1/6869 , G01N21/6428 , G01N2201/0635 , Y10T436/143333 , C12Q2525/119 , C12Q2521/125 , C12Q2537/149
Abstract: Methods, devices, and systems for performing intermittent detection during analytical reactions are provided. Such methods facilitate collection of reaction data from disparate reaction times. Further, such methods are useful for reducing photo-induced damage of one or more reactants in an illuminated analytical reaction at a given reaction time. In preferred embodiments, the reaction mixture is subjected to at least one illuminated and non-illuminated period and allowed to proceed such that the time in which the reaction mixture is illuminated is less than a photo-induced damage threshold period.
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公开(公告)号：US20130011848A1
公开(公告)日：2013-01-10
申请号：US13611462
申请日：2012-09-12
Applicant: Steven J. Boege , Howard G. King , Eugene F. Young , Johannes P. Sluis , Mark F. Oldham
Inventor： Steven J. Boege , Howard G. King , Eugene F. Young , Johannes P. Sluis , Mark F. Oldham
CPC classification number: G01N21/6486 , B01L7/52 , C12Q2545/101 , G01N21/6452 , G01N2021/6419 , G01N2021/6421 , G01N2021/6439 , G01N2021/6441 , G01N2021/6463 , G01N2021/6482 , G01N2201/0245 , G01N2201/0628 , G01N2201/0635 , Y10S435/808 , Y10S435/809
Abstract: An optical instrument is provided for simultaneously illuminating two or more spaced-apart reaction regions with excitation beams generated by a light source. The light source can include an area light array of light emitting diodes, one or more solid state lasers, one or more micro-wire lasers, or a combination thereof. According to various embodiments, a Fresnel lens can be disposed along a beam bath between the light source and the reaction regions. Methods of analysis using the optical instrument are also provided.
Abstract translation: 提供了一种光学仪器，用于同时用由光源产生的激发光束照射两个或更多个间隔开的反应区域。 光源可以包括发光二极管的区域光阵列，一个或多个固态激光器，一个或多个微线激光器，或其组合。 根据各种实施例，菲涅耳透镜可以沿着光源和反应区域之间的光束槽设置。 还提供了使用光学仪器的分析方法。
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190.发明申请FLUORESCENCE DETECTING OPTICAL SYSTEM AND MULTI-CHANNEL FLUORESCENCE DETECTION APPARATUS INCLUDING THE SAME 有权检测光学系统和多通道荧光检测装置的荧光检测装置公开(公告)号：US20120280143A1
公开(公告)日：2012-11-08
申请号：US13271101
申请日：2011-10-11
Applicant: Kyung-ho KIM , Joon-ho KIM , Kak NAMKOONG , Won-seok CHUNG
Inventor： Kyung-ho KIM , Joon-ho KIM , Kak NAMKOONG , Won-seok CHUNG
IPC: G01N21/64
CPC classification number: G01N21/645 , G01J3/0208 , G01J3/0229 , G01J3/0237 , G01J3/4406 , G01N21/05 , G01N2021/0346 , G01N2021/6419 , G01N2021/6421 , G01N2021/6478 , G01N2201/0635
Abstract: A fluorescence detection optical system detects fluorescence beams with two or more different wavelengths and maintains a focal position through an automatic focusing function. A multi-channel fluorescence detection apparatus includes the fluorescence detection optical system. The fluorescence detection optical system includes an automatic focusing unit which receives light reflected off a microfluidic device and determines a focal point by using an astigmatic method or a knife edge method, and an actuator which adjusts a position of an objective lens according to control of the automatic focusing unit. In addition, the fluorescence detection optical system may include a plurality of dual band pass filters, dichroic devices, etc., which provide light beams emitted from at least two light sources and transfer fluorescence generated from the microfluidic device to a photodetector.
Abstract translation: 荧光检测光学系统检测具有两个或更多个不同波长的荧光束并通过自动聚焦功能保持焦点位置。 多通道荧光检测装置包括荧光检测光学系统。 荧光检测光学系统包括自动聚焦单元，其接收从微流体装置反射的光并且通过使用散光方法或刀刃方法确定焦点，以及致动器，其根据控制的方式调整物镜的位置 自动对焦单元 此外，荧光检测光学系统可以包括多个双带通滤波器，二向色装置等，其提供从至少两个光源发射的光束并将从微流体装置产生的荧光转移到光电检测器。
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