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11.发明授权Preparation and use of mixed mode solid substrates for chromatography adsorbents and biochip arrays 有权制备和使用色谱吸附剂和生物芯片阵列的混合模式固体底物公开(公告)号：US07144743B2
公开(公告)日：2006-12-05
申请号：US10660738
申请日：2003-09-12
Applicant: Egisto Boschetti , Pierre Girot
Inventor： Egisto Boschetti , Pierre Girot
IPC: G01N33/544 , G01N33/548 , G01N33/545 , G01N30/02 , C07K1/04 , C07K1/14 , C07D277/62 , C07K1/16
CPC classification number: B01J20/3255 , B01D15/1807 , B01J20/286 , B01J20/289 , B01J20/3217 , B01J20/3219 , B01J20/3242 , B01J20/3285 , B01J2219/00527 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00626 , B01J2219/00637 , B01J2219/00702 , B01J2219/00725 , B01J2219/0074 , C07K1/165 , C07K1/22 , C40B40/10 , C40B80/00 , G01N33/54353 , G01N2001/045 , G01N2035/00158 , Y10S530/812 , Y10T436/25
Abstract: For certain mixed mode resins having anionic character, a ligand is joined to a solid support via a linkage that includes a mercapto-, ether- or amino-containing moiety. A suitable ligand comprises an aromatic group, a heteroaromatic group, or a heterocyclic group, optionally fused, that is sulfate-, sulfonate-, phosphonate- or phosphate-substituted and that is linked to such a moiety. These resins possess an anionic character under conditions prescribed for their use. Separation of a biological substance, such as a peptide or protein, can be accomplished with a resin of this type via a change in the pH of eluants, thereby effecting adsorption and desorption.
Abstract translation: 对于具有阴离子特性的某些混合模式树脂，配体通过包含巯基，醚或氨基部分的键连接到固体支持物上。 合适的配体包括芳族基团，杂芳族基团或杂环基团，任选地稠合，其是硫酸酯基，磺酸酯基，膦酸酯基或磷酸酯取代的，并且与该部分连接。 这些树脂在其使用条件下具有阴离子特性。 生物物质如肽或蛋白质的分离可以通过这种类型的树脂通过洗脱液的pH的变化来实现，从而进行吸附和解吸附。
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公开(公告)号：US20060063732A1
公开(公告)日：2006-03-23
申请号：US11253435
申请日：2005-10-18
Applicant: Jean-Marie Vogel , Egisto Boschetti
Inventor： Jean-Marie Vogel , Egisto Boschetti
CPC classification number: A61K9/0019 , A61K9/1635 , A61K48/00 , A61K48/0008 , A61K48/0041
Abstract: The present invention relates to injectable compositions comprising biocompatible, swellable, substantially hydrophilic, non-toxic and substantially spherical polymeric material carriers which are capable of efficiently delivering bioactive therapeutic factor(s) physically linked to a transfection agent for use in embolization gene therapy. The present invention further relates to methods of embolization gene therapy, particularly for the treatment of angiogenic and non-angiogenic-dependent diseases, using the injectable compositions., using the injectable compositions.
Abstract translation: 本发明涉及包含生物相容的，可溶胀的，基本上亲水的，无毒的和基本上为球形的聚合物材料载体的可注射组合物，其能够有效地递送与用于栓塞基因治疗的转染剂物理连接的生物活性治疗因子。 本发明还涉及使用可注射组合物的栓塞基因治疗方法，特别是用于使用可注射组合物治疗血管生成和非血管生成依赖性疾病的方法。
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13.发明申请Small dense microporous solid support materials, their preparation, and use for purification for large macromolecules and bioparticles 审中-公开小型微孔固体支持材料，它们的制备和用于大分子和生物颗粒的纯化公开(公告)号：US20050269257A1
公开(公告)日：2005-12-08
申请号：US11185963
申请日：2005-07-21
Applicant: Nicolas Voute , Egisto Boschetti , Pierre Girot
Inventor： Nicolas Voute , Egisto Boschetti , Pierre Girot
IPC: B01J20/281 , B01D15/02 , B01D15/08 , B01D15/18 , B01J20/02 , B01J20/06 , B01J20/26 , B01J20/28 , B01J20/285 , B01J20/32 , C04B38/00 , G01N30/88
CPC classification number: B01J20/3282 , B01D15/1807 , B01D2215/021 , B01J20/06 , B01J20/28004 , B01J20/28097 , B01J20/286 , B01J20/3028 , B01J20/3042 , B01J20/3078 , B01J20/3204 , B01J20/327 , B01J20/3274 , B01J20/3276 , B01J2220/42 , B01J2220/49 , B01J2220/52 , B01J2220/56 , C04B38/00 , C04B38/009 , C04B20/1029 , C04B38/0074
Abstract: The present invention provides small, dense mineral oxide solid supports or microbeads, comprising dense microporous mineral oxides matrices in which a skin of polymers is rooted, and their use in downstream processing, especially for fluidized bed purification of bioparticles or high molecular weight macromolecules.
Abstract translation: 本发明提供小而致密的矿物氧化物固体支持物或微珠，其包含其中根据聚合物皮肤的致密微孔矿物氧化物基质，以及它们在下游加工中的用途，特别是用于生物颗粒或高分子量大分子的流化床净化。
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公开(公告)号：US06790456B2
公开(公告)日：2004-09-14
申请号：US10222819
申请日：2002-08-19
Applicant: Jean-Marie Vogel , Egisto Boschetti
Inventor： Jean-Marie Vogel , Egisto Boschetti
IPC: A61F1300
Abstract: The present invention relates to injectable compositions comprising biocompatible, swellable, hydrophilic, non-toxic and substantially spherical microspheres microspheres and a biocompatible carrier for use in dermal augmentation. The present invention further relates to methods of dermal augmentation, particularly for the treatment of skin contour deficiencies, using the injectable compositions.
Abstract translation: 本发明涉及可注射组合物，其包含生物相容性，可溶胀，亲水，无毒和基本上为球形的微球微球和用于皮肤增生的生物相容性载体。 本发明还涉及使用可注射组合物的皮肤增强方法，特别是用于治疗皮肤轮廓缺陷的方法。
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公开(公告)号：US5486293A
公开(公告)日：1996-01-23
申请号：US215201
申请日：1994-03-21
Applicant: Egisto Boschetti , Pierre Girot , Luc P. Guerrier
Inventor： Egisto Boschetti , Pierre Girot , Luc P. Guerrier
CPC classification number: B01J20/3282 , B01D15/00 , B01J20/28004 , B01J20/28057 , B01J20/28069 , B01J20/28078 , B01J20/28097
Abstract: Novel sorbents and methods for removing small hydrophobic and amphophilic molecules from biological fluids were disclosed. The methods and materials were particularly useful for removing viral inactivating agents from blood and blood fractions. The novel sorbents comprise a porous mineral oxide matrix having its interior porous volume substantially filled with a crosslinked hydrophobic polymer network.
Abstract translation: 公开了从生物液体中去除小疏水和两性分子的新型吸附剂和方法。 所述方法和材料特别可用于从血液和血液部分中除去病毒灭活剂。 新型吸附剂包括多孔矿物氧化物基质，其基本上填充有交联的疏水性聚合物网络的内部多孔体积。
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Patent Agency Ranking16.发明授权Hydrophilic copolymers based on N-[tris(hydroxymethyl)methyl]-acrylamide, processes for their preparation, aqueous gels of said copolymers and their use as ion exchangers 失效基于N- [三（羟甲基）甲基] - 丙烯酰胺的亲水性共聚物，其制备方法，所述共聚物的水凝胶及其作为离子交换剂的用途
公开(公告)号：US4452916A
公开(公告)日：1984-06-05
申请号：US415961
申请日：1982-09-08
Applicant: Egisto Boschetti
Inventor： Egisto Boschetti
IPC: C08F20/00 , B01J20/281 , B01J20/285 , B01J39/20 , B01J41/14 , C08F12/00 , C08F16/14 , C08F16/38 , C08F20/38 , C08F20/52 , C08F26/00 , C08F28/00 , C08F212/14 , C08F216/12 , C08F216/36 , C08F220/38 , C08F220/58 , C08F220/60 , C08F226/02 , C08F228/02 , G01N30/88 , B01D15/00 , C08L5/00 , C08L89/00
CPC classification number: C08F220/58
Abstract: Tridimensional cross-linked random copolymers, insoluble in water, containing in copolymerized form: (a) 25% to 98% by weight of N-[tris(hydroxymethyl)methyl]acrylamide or N-[tris(hydroxymethyl)methyl]methacrylamide, or a mixture of these two compounds. (b) 2% to 50% by weight of one or more monomers containing two or several polymerizable ethylenic double bonds and free from anionic or cationic functional groups, and (c) 0.1% to 50% by weight of one or more monomers containing a polymerizable ethylenic double bond and one or more mono- or di-substituted amino, pyrimidinyl, guanidyl, purinyl, quaternary ammonium, SO.sub.3 H or SO.sub.3 M groups, M being an alkali metal. These copolymers are utilizable, in the form of aqueous gels, as ion exchangers.
Abstract translation: 含有共聚形式的三维交联无规共聚物（a）25％至98％重量的N- [三（羟甲基）甲基]丙烯酰胺或N- [三（羟甲基）甲基]甲基丙烯酰胺，或 这两种化合物的混合物。 （b）2重量％至50重量％的一种或多种含有两个或几个可聚合的烯属双键并且不含阴离子或阳离子官能团的单体，和（c）0.1重量％至50重量％的一种或多种含有 可聚合的烯属双键和一个或多个单取代或二取代的氨基，嘧啶基，胍基，嘌呤基，季铵，SO 3 H或SO 3 M基团，M为碱金属。 这些共聚物可以以水凝胶的形式用作离子交换剂。
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17.发明授权Hydrophilic copolymers, their preparation and their use in separation techniques 失效亲水共聚物，它们的制备及其在分离技术中的应用
公开(公告)号：US4192784A
公开(公告)日：1980-03-11
申请号：US873026
申请日：1978-01-27
Applicant: Eric Brown , Egisto Boschetti , Monique M. Corgier , Joel Touet
Inventor： Eric Brown , Egisto Boschetti , Monique M. Corgier , Joel Touet
IPC: C08F20/00 , B01D15/08 , C08F20/52 , C08F220/58 , C08L33/24 , C08L33/26 , C12N11/08 , C08L89/00 , C08F20/54 , C08L3/00
CPC classification number: C08F220/58 , C12N11/08 , Y10S524/916 , Y10S526/909 , Y10T428/2998
Abstract: Water-insoluble, tridimensional cross-linked random copolymers, which contain in copolymerized form:(a) 25% to 98% by weight of N-[tris(hydroxymethyl)methyl]acrylamide or N-[tris(hydroxymethyl)methyl]methacrylamide or a mixture of these two compounds;(b) 2% to 50% by weight of one or more monomers having several polymerizable ethylenic double bonds and one or more hydroxy groups, and free from NH.sub.2 or COOH groups; and(c) 0% to 50% by weight of one or more monomers having a polymerizable ethylenic double bond and one or more amino or carboxy groups. These copolymers may be used, in the form of aqueous gels, as supports in techniques of separation such as gell permeation chromatography and in techniques of immobilization of natural substances.
Abstract translation: 含有共聚形式的水不溶性三维交联无规共聚物：（a）25-98重量％的N- [三（羟甲基）甲基]丙烯酰胺或N- [三（羟甲基）甲基]甲基丙烯酰胺或 这两种化合物的混合物; （b）2重量％至50重量％的一种或多种具有几个可聚合的烯属双键和一个或多个羟基并且不含NH 2或COOH基团的单体; 和（c）0重量％至50重量％的一种或多种具有可聚合烯键式双键和一个或多个氨基或羧基的单体。 这些共聚物可以水凝胶的形式用作分离技术中的载体，例如凝胶渗透色谱法和固定天然物质的技术。
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18.发明授权Process for obtaining gels of N-methylol-acrylamide copolymers and application of said gels for the stepped gradient separation of seric lipoproteins 失效获得N-羟甲基丙烯酰胺共聚物凝胶的方法和用于梯度梯度分离线性脂蛋白的所述凝胶的应用
公开(公告)号：US4189370A
公开(公告)日：1980-02-19
申请号：US917549
申请日：1978-06-21
Applicant: Egisto Boschetti
Inventor： Egisto Boschetti
IPC: G01N27/447 , G01N27/26 , G01N27/28
CPC classification number: G01N27/44747
Abstract: A process for preparing plates of a new gel polymer, said plates being adapted to the electrophoresis separation of the seric or plasmatic lipoproteins under a stepped gradient. The gel polymers are prepared by radical polymerization of N-methylol-acrylamide and of a bifunctional allylic or acrylic compound causing cross-linking to yield a tridimensional configuration polymer. The polymerization may optionally be catalyzed by peroxides and/or ultraviolet radiation. Anionic polysaccharides containing only COOH groups may be added to assist migration of lipoproteins in the gel.
Abstract translation: 一种制备新凝胶聚合物的平板的方法，所述板适于在梯度梯度下电泳分离浆液或血浆脂蛋白。 凝胶聚合物通过N-羟甲基丙烯酰胺和双官能烯丙基或丙烯酸化合物的自由基聚合制备，引起交联以产生三维构型聚合物。 聚合可以任选地被过氧化物和/或紫外线辐射催化。 可以加入仅含有COOH基团的阴离子多糖以辅助凝胶中脂蛋白的迁移。
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公开(公告)号：US09803184B2
公开(公告)日：2017-10-31
申请号：US13976557
申请日：2011-12-30
Applicant: Egisto Boschetti , Gérald Perret
Inventor： Egisto Boschetti , Gérald Perret
CPC classification number: C12N9/6437 , B01J20/289 , B01J20/3204 , B01J20/3212 , B01J20/3219 , B01J20/3274 , B01J20/3278 , C07H21/02 , C07H21/04 , C07K1/22
Abstract: The invention relates to a method for immobilizing nucleic ligands including at least one reactive amine function, by grafting on an activated solid substrate, including a step of coupling said nucleic acids on said activated solid substrate having a pH of less than 6.
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公开(公告)号：US09308169B2
公开(公告)日：2016-04-12
申请号：US13462004
申请日：2012-05-02
Applicant: Jean-Marie Vogel , Egisto Boschetti
Inventor： Jean-Marie Vogel , Egisto Boschetti
IPC: A61K9/50 , A61K9/16 , A61K31/715 , A61K45/06
CPC classification number: A61K9/1635 , A61K31/715 , A61K45/06 , A61L2430/36 , Y10T428/2982
Abstract: The present invention relates to injectable compositions comprising biocompatible, swellable, substantially hydrophilic, non-toxic and substantially spherical polymeric material carriers which are capable of efficiently delivering bioactive therapeutic factor(s) for use in embolization drug therapy. The present invention further relates to methods of embolization gene therapy, particularly for the treatment of angiogenic and non-angiogenic-dependent diseases, using the injectable compositions.
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