-
公开(公告)号：US11884912B2
公开(公告)日：2024-01-30
申请号：US16727057
申请日：2019-12-26
Applicant: Industrial Technology Research Institute
Inventor： Kuo-Hsing Wen , Ting-Hsuan Chen , Cheng-Tai Chen , Chien-An Chen , Su-Fung Chiu , Yung-Chi Chang , Nien-Jen Chou , Ping-Jung Wu , Shaw-Hwa Parng , Pei-Shin Jiang
Abstract: A cell culture device includes a culture unit, a gas supply unit, a first pressure unit, at least one inspecting unit and a control unit. The culture unit contains a cell culture liquid. The gas supply unit, connected with the culture unit, is used for transmitting a culture gas into the culture unit. The first pressure unit, connected with the culture unit, is used for applying a pressure to the cell culture liquid in the culture unit. The at least one inspecting unit, connected with the culture unit, is used for receiving the cell culture liquid for inspection. The control unit, electrically coupled with the culture unit, the first pressure unit, the gas supply unit and the at least one inspecting unit, is used for monitoring corresponding condition parameters to determine respective operations. In addition, a cell culture method for the cell culture device is also provided.
-
公开(公告)号：US20180104696A1
公开(公告)日：2018-04-19
申请号：US15588043
申请日：2017-05-05
Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
Inventor： Tseng-Huang Liu , Kuo-Hsing Wen , Pei-Shin Jiang , Jie-Len Huang , Ting-Hsuan CHEN
CPC classification number: B01L7/52 , B01L7/525 , B01L2300/0654 , B01L2300/0681 , B01L2300/0832 , B01L2300/18 , B01L2400/0445 , C12Q1/686 , G01N21/00
Abstract: A convective polymerase chain reaction apparatus includes a tube, a temperature control unit, at least one light source and a sensor. The tube includes a cavity used to contain a reaction solution. The reaction solution has a liquid level measured from a bottom of the cavity to a top surface of the reaction solution. The temperature control unit is disposed adjacent to the tube for controlling the temperature of the reaction solution. The at least one light source provides a light beam passing through an incident portion of the tube to excite the reaction solution emitting a fluorescent light. The incident portion is located at a height greater than ½ of a liquid level. The sensor is adjacent to the tube for detecting the excited fluorescence. The light beam has an incident direction forming a non-straight angle with a long axis of the tube.
-
公开(公告)号：US11920190B2
公开(公告)日：2024-03-05
申请号：US17134502
申请日：2020-12-28
Applicant: Industrial Technology Research Institute
Inventor： Pei-Shin Jiang , Jenn-Yeh Fann , Hung-Chi Chien , Yu-Yu Lin , Chih-Lung Lin
IPC: C12Q1/6855 , C12Q1/6869
CPC classification number: C12Q1/6855 , C12Q1/6869
Abstract: Methods of amplifying and determining a target nucleotide sequence are provided. The method of amplifying the target nucleotide sequence includes the following steps. A first adaptor and a second adaptor are linked to two ends of a double-stranded nucleic acid molecule with a target nucleotide sequence respectively to form a nucleic acid template, in which the first adaptor includes a Y-form adaptor or a hairpin adaptor and the second adaptor is a hairpin adaptor. Then, a PCR amplification cycle is performed on the nucleic acid template to obtain a PCR amplicon of the target nucleotide sequence.
-
公开(公告)号：US20230245808A1
公开(公告)日：2023-08-03
申请号：US18185346
申请日：2023-03-16
Applicant: Industrial Technology Research Institute
Inventor： Chien-An Chen , Cheng-Tai Chen , Pei-Shin Jiang
CPC classification number: H01F1/26 , H01F1/0054 , H01F1/37 , G01N2446/10 , G01N33/5434
Abstract: Described herein is a manufacturing method of a magnetic particle. First, deionized water, an organic solvent, a hydrophilic polymer, a lipid-soluble initiator, and at least two monomers are placed in a reactor and then stirred for polymerizing the at least two monomers into a copolymer to form a knobby copolymer core. Next, a polymer layer is formed to cover the knobby copolymer core, wherein the polymer layer has at least one functional group. Thereafter, a magnetic substance precursor is adsorbed by the knobby copolymer core covered with the polymer layer to form a magnetic substance layer. Further, a silicon-based layer may be additionally formed to cover the magnetic substance layer.
-
公开(公告)号：US11613755B2
公开(公告)日：2023-03-28
申请号：US17132793
申请日：2020-12-23
Applicant: Industrial Technology Research Institute
Inventor： Ping-Fu Cheng , Ya-Ling Chiu , Kang-Li Wang , Po-Yen Lin , Shih-Ta Chen , Tseng-Huang Liu , Pei-Shin Jiang
IPC: C12N15/115 , A61K47/54 , A61P35/00 , A61K9/00 , C12N15/113
Abstract: A nucleic acid-drug complex is provided in the present disclosure, which includes a nucleic acid sequence of an anti-PD-L1 aptamer and a CpG oligonucleotide sequence capable of activating TLR9, in which the CpG oligonucleotide sequence consists of a first fragment and a second fragment, and the nucleic acid sequence of the anti-PD-L1 aptamer is inserted between the first fragment and the second fragment.
-
Patent Agency Ranking
公开(公告)号：US20220169985A1
公开(公告)日：2022-06-02
申请号：US17535694
申请日：2021-11-26
Applicant: Industrial Technology Research Institute
Inventor： Ting-Hsuan Chen , Kuo-Hsing Wen , Ya-Hui Chiu , Nien-Tzu Chou , Ching-Fang Lu , Cheng-Tai Chen , Ting-Shuo Chen , Pei-Shin Jiang
IPC: C12N5/0783 , C12M1/00 , C12M1/42 , C12M1/06
Abstract: A cell activation reactor and a cell activation method are provided. The cell activation reactor includes a body, a rotating part, an upper cover, a microporous film, and multiple baffles. The body has an accommodating space, which is suitable for accommodating multiple cells and multiple magnetic beads. The rotating part is disposed in the accommodating space and includes multiple impellers. The microporous film is disposed in the accommodating space and covers multiple holes of the accommodating space. The baffles are disposed in the body. When the rotating part is driven to rotate, the interaction between the baffles and the impellers separates the cells and the magnetic beads.
-
公开(公告)号：US10183295B2
公开(公告)日：2019-01-22
申请号：US15588043
申请日：2017-05-05
Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
Inventor： Tseng-Huang Liu , Kuo-Hsing Wen , Pei-Shin Jiang , Jie-Len Huang , Ting-Hsuan Chen
Abstract: A convective polymerase chain reaction apparatus includes a tube, a temperature control unit, at least one light source and a sensor. The tube includes a cavity used to contain a reaction solution. The reaction solution has a liquid level measured from a bottom of the cavity to a top surface of the reaction solution. The temperature control unit is disposed adjacent to the tube for controlling the temperature of the reaction solution. The at least one light source provides a light beam passing through an incident portion of the tube to excite the reaction solution emitting a fluorescent light. The incident portion is located at a height greater than ½ of a liquid level. The sensor is adjacent to the tube for detecting the excited fluorescence. The light beam has an incident direction forming a non-straight angle with a long axis of the tube.
-
公开(公告)号：US20180164196A1
公开(公告)日：2018-06-14
申请号：US15381116
申请日：2016-12-16
Applicant: Industrial Technology Research Institute
Inventor： Chien-An Chen , Wen-Ching Lee , Tzu-Hui Wu , Pei-Shin Jiang , Ping-Jung Wu , Ruey-Shyan Hong , Hsiao-Jou Chang , Chun-Chieh Huang , Ting-Hsuan Chen , Chih-Lung Lin
CPC classification number: G01N1/36 , B01L3/508 , B01L7/52 , B01L2200/025 , B01L2200/0605 , B01L2200/0621 , B01L2200/0631 , B01L2300/0681 , B01L2300/0832 , B01L2300/0867 , B01L2400/0478 , B01L2400/0622 , B01L2400/0644 , C12M1/42 , C12N15/10 , G01N33/48
Abstract: A biological sample processing device includes a base, a purification unit, a metering unit and a first tube. The purification unit is disposed on the base and is configured to purify a sample. The metering unit is disposed on the base and has an inlet, at least one metering trough and an overflow trough. The inlet is connected to the purification unit via the first tube, and the metering trough is connected between the inlet and the overflow trough. The sample from the purification unit is configured to enter the metering unit through the inlet to be moved toward the metering trough, and to be moved toward the overflow trough after the metering trough is filled with the sample.
-
公开(公告)号：US09506864B2
公开(公告)日：2016-11-29
申请号：US14582428
申请日：2014-12-24
Applicant: Industrial Technology Research Institute
Inventor： Cheng-Tai Chen , Pei-Shin Jiang , Ting-Shou Chen , Jane S-C Tsai
CPC classification number: C09K11/06 , B82Y15/00 , B82Y20/00 , B82Y35/00 , C09K11/00 , C09K2211/10 , G01N21/6428 , G01N2021/6439 , Y10S977/774 , Y10S977/896 , Y10S977/95
Abstract: A gold nanocluster composition and method for preparing the same are provided. The method includes providing a gold ion-containing solution. Next, the method entails mixing the gold ion-containing solution and a reducing agent solution to obtain a first mixture liquid, and heating the first mixture liquid to obtain a second mixture liquid, wherein the second mixture liquid contains the gold nanoclusters, which are partially capped by reducing agent.
Abstract translation: 提供了一种金纳米簇组合物及其制备方法。 该方法包括提供含金离子的溶液。 接着，将含金离子的溶液和还原剂溶液混合，得到第一混合液，加热第一混合液，得到第二混合液，其中第二混合液含有金纳米团簇， 由还原剂加盖。
-
公开(公告)号：US09309501B2
公开(公告)日：2016-04-12
申请号：US14138155
申请日：2013-12-23
Applicant: Industrial Technology Research Institute
Inventor： Tseng-Huang Liu , Pei-Shin Jiang , Chih-Lung Lin , Su-Jan Lee , Chao-Hung Kao
IPC: C12N9/12
CPC classification number: C12N9/1252
Abstract: Isolated DNA polymerase and the mutant DNA polymerases thereof are provided. The DNA polymerases have good thermostability.
Abstract translation: 提供了分离的DNA聚合酶及其突变型DNA聚合酶。 DNA聚合酶具有良好的热稳定性。
-
-
-
-
-
-
-
-
-
Search Results
20
records
(took 0.02 seconds)
