公开(公告)号：US20060263264A1

公开(公告)日：2006-11-23

申请号：US11486186

申请日：2006-07-13

申请人： Sebastian Bohm ,  John Gilbert

发明人： Sebastian Bohm ,  John Gilbert

IPC分类号： B01L3/02

CPC分类号： B01F13/0059 ,  B01D57/02 ,  B01J19/0093 ,  B01J2219/00371 ,  B01J2219/00378 ,  B01J2219/00783 ,  B01J2219/00831 ,  B01J2219/00837 ,  B01J2219/00869 ,  B01J2219/00889 ,  B01J2219/00891 ,  B01J2219/00905 ,  B01L3/0244 ,  B01L3/0268 ,  B01L3/502715 ,  B01L3/502792 ,  B01L2200/027 ,  B01L2200/143 ,  B01L2200/147 ,  B01L2300/089 ,  B01L2400/0421 ,  B01L2400/0439 ,  C12Q1/00 ,  G01N27/447 ,  G01N27/44743 ,  G01N27/44782 ,  G01N27/44791 ,  G01N2035/1037 ,  Y10T436/11 ,  Y10T436/117497 ,  Y10T436/118339 ,  Y10T436/2575

摘要： A fluid interface port in a microfluidic system and a method of forming the fluid interface port is provided. The fluid interface port comprises an opening formed in the side wall of a microchannel sized and dimensioned to form a virtual wall when the microchannel is filled with a first liquid. The fluid interface port is utilized to fill the microchannel with a first liquid, to introduce a second liquid into the first liquid and to eject fluid from the microchannel.

公开(公告)号：US20070298171A1

公开(公告)日：2007-12-27

申请号：US11811021

申请日：2007-06-08

申请人： John Gilbert ,  Sebastian Bohm

发明人： John Gilbert ,  Sebastian Bohm

IPC分类号： B05D3/10 ,  B23P17/04

CPC分类号： B01L3/0248 ,  B01L3/0244 ,  B01L3/5088 ,  B01L9/543 ,  B01L2200/12 ,  B01L2200/142 ,  B01L2200/143 ,  B01L2200/147 ,  B01L2300/161 ,  B01L2300/1822 ,  B01L2400/0439 ,  G01N2035/1037 ,  Y10S977/888 ,  Y10T29/49 ,  Y10T436/2575

摘要： A cooled liquid sample dispensing system comprises a pair of pins for holding a droplet of liquid therebetween and a cooling element. Each pin includes a tip spaced predetermined distance from the other pin to define a sample acquisition region. The pins acquire and hold a droplet of the liquid sample in the sample acquisition region formed in the space between the tips and apply the droplet to a selected sample handing system. The cooling element, when activated, cools the droplet of liquid to reduce evaporation.

摘要翻译： 冷却的液体样品分配系统包括用于在其间保持液滴的一对销和冷却元件。 每个引脚包括与另一个引脚间隔预定距离的尖端以限定采样区域。 这些销钉在液体样品的液滴中形成在尖端之间的空间中形成的样品采集区域，并将液滴施加到选定的样品处理系统上。 冷却元件在启动时会冷却液滴以减少蒸发。

公开(公告)号：US10231653B2

公开(公告)日：2019-03-19

申请号：US13247856

申请日：2011-09-28

申请人： Sebastian Bohm ,  Mark Dervaes ,  Eric Johnson ,  Apurv Ullas Kamath ,  Shawn Larvenz ,  Jacob S. Leach ,  Phong Lieu ,  Aarthi Mahalingam ,  Tom Miller ,  Paul V. Neale ,  Jack Pryor ,  Thomas A. Peyser ,  Daiting Rong ,  Kenneth San Vicente ,  Mohammad Ali Shariati ,  Peter C. Simpson ,  Matthew Wightlin

发明人： Sebastian Bohm ,  Mark Dervaes ,  Eric Johnson ,  Apurv Ullas Kamath ,  Shawn Larvenz ,  Jacob S. Leach ,  Phong Lieu ,  Aarthi Mahalingam ,  Tom Miller ,  Paul V. Neale ,  Jack Pryor ,  Thomas A. Peyser ,  Daiting Rong ,  Kenneth San Vicente ,  Mohammad Ali Shariati ,  Peter C. Simpson ,  Matthew Wightlin

IPC分类号： G06F1/32 ,  A61B5/145 ,  G06F1/3203

摘要： Systems and methods for processing, transmitting, and displaying data received from a continuous analyte (e.g., glucose) sensor are provided. A sensor system can comprise a sensor electronics module that includes power saving features, e.g., a low power measurement circuit that can be switched between a measurement mode and a low power mode, wherein charging circuitry continues to apply power to electrodes of a sensor during the low power mode. The sensor electronics module can be switched between a low power storage mode and a higher power operational mode via a switch, e.g., a reed switch or optical switch. A validation routine can be implemented to ensure an interrupt signal sent from the switch is valid. The sensor can be physically connected to the sensor electronics module in direct wireless communication with a plurality of different display devices.

公开(公告)号：US20120265037A1

公开(公告)日：2012-10-18

申请号：US13446983

申请日：2012-04-13

申请人： Sebastian Bohm ,  Daiting Rong ,  Peter C. Simpson

发明人： Sebastian Bohm ,  Daiting Rong ,  Peter C. Simpson

IPC分类号： A61B5/145

CPC分类号： A61B5/1495 ,  A61B5/14503 ,  A61B5/1451 ,  A61B5/14517 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1473 ,  A61B5/1486 ,  A61B5/7257 ,  A61B5/7267 ,  A61B2560/0276 ,  G01D18/00 ,  G01N27/026 ,  G01N27/3274 ,  G01N33/49

摘要： Systems and methods for processing sensor data and self-calibration are provided. In some embodiments, systems and methods are provided which are capable of calibrating a continuous analyte sensor based on an initial sensitivity, and then continuously performing self-calibration without using, or with reduced use of, reference measurements. In certain embodiments, a sensitivity of the analyte sensor is determined by applying an estimative algorithm that is a function of certain parameters. Also described herein are systems and methods for determining a property of an analyte sensor using a stimulus signal. The sensor property can be used to compensate sensor data for sensitivity drift, or determine another property associated with the sensor, such as temperature, sensor membrane damage, moisture ingress in sensor electronics, and scaling factors.

公开(公告)号：US20120262298A1

公开(公告)日：2012-10-18

申请号：US13446977

申请日：2012-04-13

申请人： Sebastian Bohm ,  Daiting Rong ,  Peter C. Simpson

发明人： Sebastian Bohm ,  Daiting Rong ,  Peter C. Simpson

IPC分类号： G01R27/02 ,  G08B21/18 ,  G01N25/00 ,  G08B21/20 ,  G01R31/00 ,  G06F19/00

CPC分类号： A61B5/1495 ,  A61B5/14503 ,  A61B5/1451 ,  A61B5/14517 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1473 ,  A61B5/1486 ,  A61B5/7257 ,  A61B5/7267 ,  A61B2560/0276 ,  G01D18/00 ,  G01N27/026 ,  G01N27/3274 ,  G01N33/49

摘要： Systems and methods for processing sensor data and self-calibration are provided. In some embodiments, systems and methods are provided which are capable of calibrating a continuous analyte sensor based on an initial sensitivity, and then continuously performing self-calibration without using, or with reduced use of, reference measurements. In certain embodiments, a sensitivity of the analyte sensor is determined by applying an estimative algorithm that is a function of certain parameters. Also described herein are systems and methods for determining a property of an analyte sensor using a stimulus signal. The sensor property can be used to compensate sensor data for sensitivity drift, or determine another property associated with the sensor, such as temperature, sensor membrane damage, moisture ingress in sensor electronics, and scaling factors.

公开(公告)号：US20080154187A1

公开(公告)日：2008-06-26

申请号：US11614211

申请日：2006-12-21

申请人： Peter Krulevitch ,  Mingqi Zhao ,  Sebastian Bohm ,  Deon Anex ,  Michael Gearhart

发明人： Peter Krulevitch ,  Mingqi Zhao ,  Sebastian Bohm ,  Deon Anex ,  Michael Gearhart

IPC分类号： A61M1/00

CPC分类号： A61M5/14526 ,  A61M5/14244 ,  A61M5/14566 ,  A61M5/16831 ,  A61M2005/14513 ,  A61M2205/3317

摘要： The present application is directed to systems and methods associated with infusion pumps, which can optionally utilize an electrokinetic driving mechanism. Infusion pumps, including electrokinetically-driven pumps, are discussed, along with schemes for controlling their operation. As well, systems and methods of detecting malfunctions in infusion pumps are discussed. Any number of malfunctions can be detected including the presence of occlusions and/or leaks. In some instances, a measurement associated with some aspect of electrokinetic phenomena (e.g., an electrode measurement such as voltage or current) is compared with one or more sample values, the comparison allowing an indication of pump malfunction to be determined. A variety of such measurements and comparison techniques are discussed in the present disclosure.

摘要翻译： 本申请涉及与输注泵相关联的系统和方法，其可以可选地使用电动驱动机构。 讨论了输液泵，包括电动泵，以及控制其操作的方案。 此外，还讨论了检测输液泵故障的系统和方法。 可以检测到任何数量的故障，包括堵塞和/或泄漏的存在。 在一些情况下，将与动电现象的一些方面（例如，诸如电压或电流的电极测量）相关联的测量与一个或多个样本值进行比较，所述比较允许确定泵故障的指示。 在本公开中讨论了各种这样的测量和比较技术。

公开(公告)号：US20060000709A1

公开(公告)日：2006-01-05

申请号：US10882647

申请日：2004-06-30

申请人： Sebastian Bohm ,  Alan McNeilage

发明人： Sebastian Bohm ,  Alan McNeilage

IPC分类号： C12M1/00 ,  G01N21/00 ,  G01N15/06

CPC分类号： F16K99/0017 ,  B01L3/502738 ,  B01L2300/0645 ,  B01L2400/0406 ,  B01L2400/0487 ,  B01L2400/0688 ,  F16K99/0001 ,  F16K2099/0074 ,  F16K2099/0078 ,  F16K2099/0084 ,  F16K2099/0086

摘要： Methods for modulating the flow of a liquid are provided.

摘要翻译： 提供了调节液体流动的方法。

公开(公告)号：US20050220629A1

公开(公告)日：2005-10-06

申请号：US11095636

申请日：2005-03-30

申请人： Sebastian Bohm ,  Alan McNeilage

发明人： Sebastian Bohm ,  Alan McNeilage

IPC分类号： B01L3/00 ,  F04B1/00 ,  F04B7/00 ,  G01N33/487 ,  G01N35/10

CPC分类号： B01L3/502784 ,  B01L2200/0605 ,  B01L2200/0673 ,  B01L2200/143 ,  B01L2400/0406 ,  B01L2400/0409 ,  B01L2400/0442 ,  B01L2400/0487 ,  B01L2400/0694 ,  G01N27/3271 ,  G01N35/1095

摘要： The invention described is a method of segregating a bolus of fluid using a pneumatic actuator in a fluid handling circuit. The described invention further includes a method of segregating a bolus of fluid using a pneumatic actuator in a fluid handling circuit wherein the method includes the step of injecting an air pocket into the fluid stream to create the bolus. In addition, the described invention includes a method of measuring the analyte concentration in a bolus of fluid using a pneumatic actuator in a fluid handling circuit. The described invention further includes a method of measuring the analyte concentration in a bolus of fluid using a pneumatic actuator in a fluid handling circuit wherein the method includes the step of injecting an air pocket into the fluid stream to create the bolus.

摘要翻译： 本发明描述了一种在流体处理电路中使用气动致动器分离流体的方法。 所描述的发明还包括在流体处理电路中使用气动致动器分离流体的方法，其中所述方法包括将空气袋注入流体流以产生推注的步骤。 此外，所描述的发明包括使用流体处理电路中的气动致动器测量流体中的分析物浓度的方法。 所描述的发明还包括使用流体处理电路中的气动致动器来测量流体中的分析物浓度的方法，其中所述方法包括将空气袋注入流体流中以产生推注的步骤。

公开(公告)号：US20120265035A1

公开(公告)日：2012-10-18

申请号：US13446848

申请日：2012-04-13

申请人： Sebastian Bohm ,  Daiting Rong ,  Peter C. Simpson

发明人： Sebastian Bohm ,  Daiting Rong ,  Peter C. Simpson

IPC分类号： A61B5/1495 ,  G01N37/00

CPC分类号： A61B5/1495 ,  A61B5/14503 ,  A61B5/1451 ,  A61B5/14517 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1473 ,  A61B5/1486 ,  A61B5/7257 ,  A61B5/7267 ,  A61B2560/0276 ,  G01D18/00 ,  G01N27/026 ,  G01N27/3274 ,  G01N33/49

摘要： Systems and methods for processing sensor data and self-calibration are provided. In some embodiments, systems and methods are provided which are capable of calibrating a continuous analyte sensor based on an initial sensitivity, and then continuously performing self-calibration without using, or with reduced use of, reference measurements. In certain embodiments, a sensitivity of the analyte sensor is determined by applying an estimative algorithm that is a function of certain parameters. Also described herein are systems and methods for determining a property of an analyte sensor using a stimulus signal. The sensor property can be used to compensate sensor data for sensitivity drift, or determine another property associated with the sensor, such as temperature, sensor membrane damage, moisture ingress in sensor electronics, and scaling factors.

公开(公告)号：US20120078071A1

公开(公告)日：2012-03-29

申请号：US13247856

申请日：2011-09-28

申请人： Sebastian Bohm ,  Mark Dervaes ,  Eric Johnson ,  Apurv Ullas Kamath ,  Shawn Larvenz ,  Jacob S. Leach ,  Phong Lieu ,  Aarthi Mahalingam ,  Tom Miller ,  Paul V. Neale ,  Jack Pryor ,  Thomas A. Peyser ,  Daiting Rong ,  Kenneth San Vicente ,  Mohammad Ali Shariati ,  Peter C. Simpson ,  Matthew Wightlin

发明人： Sebastian Bohm ,  Mark Dervaes ,  Eric Johnson ,  Apurv Ullas Kamath ,  Shawn Larvenz ,  Jacob S. Leach ,  Phong Lieu ,  Aarthi Mahalingam ,  Tom Miller ,  Paul V. Neale ,  Jack Pryor ,  Thomas A. Peyser ,  Daiting Rong ,  Kenneth San Vicente ,  Mohammad Ali Shariati ,  Peter C. Simpson ,  Matthew Wightlin

IPC分类号： A61B5/145

CPC分类号： A61B5/14532 ,  A61B5/14507 ,  A61B5/1451 ,  A61B2560/0209 ,  A61B2560/0214 ,  A61B2562/02 ,  G06F1/3203

摘要： Systems and methods for processing, transmitting, and displaying data received from a continuous analyte (e.g., glucose) sensor are provided. A sensor system can comprise a sensor electronics module that includes power saving features, e.g., a low power measurement circuit that can be switched between a measurement mode and a low power mode, wherein charging circuitry continues to apply power to electrodes of a sensor during the low power mode. The sensor electronics module can be switched between a low power storage mode and a higher power operational mode via a switch, e.g., a reed switch or optical switch. A validation routine can be implemented to ensure an interrupt signal sent from the switch is valid. The sensor can be physically connected to the sensor electronics module in direct wireless communication with a plurality of different display devices.

摘要翻译： 提供了用于处理，传输和显示从连续分析物（例如，葡萄糖）传感器接收的数据的系统和方法。 传感器系统可以包括传感器电子模块，其包括省电功能，例如可以在测量模式和低功率模式之间切换的低功率测量电路，其中充电电路在该期间继续向传感器的电极施加功率 低功耗模式。 传感器电子模块可以通过诸如簧片开关或光开关的开关在低功率存储模式和较高功率操作模式之间切换。 可以实现验证程序，以确保从交换机发送的中断信号有效。 传感器可以与多个不同的显示设备直接无线通信，物理地连接到传感器电子模块。