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    Catalytic antibody components
    11.
    发明授权
    Catalytic antibody components 失效
    催化抗体成分

    公开(公告)号：US5658753A

    公开(公告)日：1997-08-19

    申请号：US402158

    申请日：1995-03-09

    申请人： Sudhir Paul ,  Michael J. Powell ,  Richard J. Massey ,  John H. Kenten

    发明人： Sudhir Paul ,  Michael J. Powell ,  Richard J. Massey ,  John H. Kenten

    IPC分类号： C12N9/00 ,  C12P21/06

    CPC分类号： C12N9/0002

    摘要： Catalytic antibody components, methods for producing catalytic antibody components, methods for using catalytic antibody components, in particular, single chain and smaller components are disclosed. Catalytic antibody components able to promote the cleavage or formation of an amide, peptide, ester or glycosidic bond, and which are prepared from monoclonal catalytic antibodies, catalytic autoantibodies or by site-directed mutagenesis are disclosed. Methods of using catalytic antibody components alone or in combination with other antibody components or other biological moieties are disclosed.

    摘要翻译： 公开了催化抗体组分，用于制备催化抗体组分的方法，使用催化抗体组分的方法，特别是单链和较小组分。 公开了能够促进切割或形成酰胺，肽，酯或糖苷键的催化抗体组分，其由单克隆催化抗体，催化自身抗体或通过定点诱变制备。 公开了单独使用催化抗体组分或与其它抗体组分或其它生物学部分组合的方法。

    Method of catalyzing stereochemical reactions
    13.
    发明授权
    Method of catalyzing stereochemical reactions 失效
    催化立体化学反应的方法

    公开(公告)号：US6057121A

    公开(公告)日：2000-05-02

    申请号：US478954

    申请日：1995-06-07

    申请人： Richard J. Massey ,  Michael J. Powell ,  Richard C. Titmas

    发明人： Richard J. Massey ,  Michael J. Powell ,  Richard C. Titmas

    IPC分类号： C07K16/10 ,  C12N9/00 ,  C12P1/00 ,  C12P13/22 ,  C12P17/10 ,  C12P19/34 ,  C12P21/08 ,  C12P41/00 ,  C12Q1/25

    CPC分类号： B82Y5/00 ,  C07K16/1063 ,  C12N9/0002 ,  C12P1/00 ,  C12P13/227 ,  C12P17/10 ,  C12P19/34 ,  C12P41/004 ,  C12Q1/25 ,  G01N2333/16 ,  G01N2333/96472

    摘要： A method for increasing the rate of a chemical reaction involving conversion of at least one reactant to at least one product which comprises contacting the reactant with at least one appropriate monoclonal antibody to the reactant under suitable conditions permitting formation of a complex between the monoclonal antibody and the reactant, conversion of the reactant to the product and release of the product from the complex, the monoclonal antibody being characterized by a K>1, where K=k.sub.r /k.sub.p, k.sub.r is the affinity constant of the monoclonal antibody for the reactant and k.sub.p is the affinity constant of the monoclonal antibody for the product, by an r.sub.1 >r.sub.0, where r.sub.1 is the rate of formation of the complex between the antibody and the reactant and where r.sub.0 is the rate of the chemical reaction in the absence of monclonal antibody, by an r.sub.2 >r.sub.0, where r.sub.2 is the rate of the conversion of the complexed reactant to the complexed product and by an r.sub.3 >r.sub.0, where r.sub.3 is the rate of release of the product from the complex.

    摘要翻译： 一种用于增加涉及将至少一种反应物转化为至少一种产物的化学反应速率的方法，该方法包括使反应物与至少一种合适的单克隆抗体在合适的条件下接触，从而允许单克隆抗体和 反应物，反应物向产物的转化和产物从复合物的释放，单克隆抗体的特征在于K> 1，其中K = kr / kp，kr是单克隆抗体对于反应物的亲和常数， kp是单克隆抗体对产物的亲和常数，通过r1> r0，其中r1是抗体和反应物之间复合物的形成速率，其中r0是在没有单克隆的情况下化学反应的速率 抗体，r2> r0，其中r2是复合反应物转化为络合产物的速率和r3> r0，其中r3是产物释放速率 从复杂。