公开(公告)号：US20230236112A1

公开(公告)日：2023-07-27

申请号：US18162385

申请日：2023-01-31

Applicant: Photothermal Spectroscopy Corp

Inventor： Craig Prater ,  Kevin Kjoller ,  Roshan Shetty

IPC: G01N21/17 ,  G01J3/28 ,  G01J3/427 ,  G01J3/44 ,  G01N21/64 ,  G01N21/65

CPC classification number: G01N21/171 ,  G01J3/2823 ,  G01J3/427 ,  G01J3/4406 ,  G01J3/4412 ,  G01N21/6458 ,  G01N21/65 ,  G01N2021/1714

Abstract: System for performing chemical spectroscopy on samples from the scale of nanometers to millimeters or more with a multifunctional platform combining analytical and imaging techniques including dual beam photo-thermal spectroscopy with confocal microscopy, Raman spectroscopy, fluorescence detection, various vacuum analytical techniques and/or mass spectrometry. In embodiments described herein, the light beams of a dual-beam system are used for heating and sensing.

公开(公告)号：US20230194345A1

公开(公告)日：2023-06-22

申请号：US17994391

申请日：2022-11-28

Applicant: Shimadzu Corporation

Inventor： Naoya FUJIWARA ,  Yuri ITO

IPC: G01J3/28 ,  G01J3/44 ,  G01J3/02 ,  G01J3/10

CPC classification number: G01J3/2823 ,  G01J3/4412 ,  G01J3/0237 ,  G01J3/108 ,  G01J2003/106

Abstract: In a Raman microscope, a depth measurement processor performs depth measurement by changing a focal position of laser light along a depth direction of a sample which is an irradiation direction of the laser light with respect to the sample, and meanwhile, acquiring a Raman spectrum of the sample at a plurality of points in the depth direction. The display processor causes Raman spectra obtained at the plurality of points by the depth measurement to be displayed. The display processor can display a surface image of the sample on the stage and a depth image representing a plurality of points in the depth direction and causes, in a case where at least one point of the plurality of points in the depth image is selected, the Raman spectrum corresponding to the at least one point to be displayed.

公开(公告)号：US20190242751A1

公开(公告)日：2019-08-08

申请号：US16126998

申请日：2018-09-10

Applicant: MKS TECHNOLOGY (D/B/A SNOWY RANGE INSTRUMENTS)

Inventor： Keith T. Carron ,  Shane A. Buller ,  Mark A. Watson ,  Sean Patrick Woodward

IPC: G01J3/44 ,  G01J3/02 ,  G01N21/65 ,  G01J3/10

CPC classification number: G01J3/4412 ,  G01J3/0208 ,  G01J3/021 ,  G01J3/027 ,  G01J3/0297 ,  G01J3/10 ,  G01J3/44 ,  G01N21/65 ,  G01N2021/4711 ,  G01N2201/0612 ,  G01N2201/068 ,  G01N2201/12

Abstract: Spectrometers and methods for determining the presence or absence of a material in proximity to and/or combined with another material are provided. In one particular example, a spectrometer is provided that includes a light source, a detector and an optical system. In this implementation, the light source is configured to provide an excitation incident beam. The detector is configured to detect a spectroscopy signal. The optical system is configured to direct the excitation incident beam toward a sample at a non-zero angle from a zero-angle reference. The optical system is further configured to receive a spectroscopy signal from the sample and provide the spectroscopy signal to the detector. The detector is configured to remove a spectral interference component of the spectroscopy signal.

公开(公告)号：US20190203255A1

公开(公告)日：2019-07-04

申请号：US16284050

申请日：2019-02-25

Applicant: Seraph Biosciences, Inc. ,  Wayne State University

Inventor： Gregory William Auner ,  Charles Shanley ,  Michelle Brusatori ,  Tara Twomey ,  David Sant

IPC: C12Q1/04 ,  G01J3/02 ,  G01J3/44 ,  C12Q1/14 ,  A61B5/00 ,  G01N21/65

CPC classification number: C12Q1/04 ,  A61B5/0075 ,  A61B5/445 ,  A61B5/6815 ,  A61B5/6819 ,  A61B5/682 ,  A61B5/6846 ,  C12Q1/14 ,  G01J3/0208 ,  G01J3/0264 ,  G01J3/0272 ,  G01J3/0291 ,  G01J3/44 ,  G01J3/4406 ,  G01J3/4412 ,  G01N21/65 ,  G01N2201/0221 ,  G01N2333/11 ,  G01N2333/31 ,  G01N2333/34

Abstract: A Raman spectroscopy based system and method for examination and interrogation provides a method for rapid and cost effective screening of various protein-based compounds such as bacteria, virus, drugs, and tissue abnormalities. A hand-held spectroscope includes a laser and optical train for generating a Raman-shifting sample signal, signal processing and identification algorithms for signal conditioning and target detection with combinations of ultra-high resolution micro-filters and an imaging detector array to provide specific analysis of target spectral peaks within discrete spectral bands associated with a target pathogen.

公开(公告)号：US10060794B2

公开(公告)日：2018-08-28

申请号：US15190771

申请日：2016-06-23

Applicant: SAMSUNG ELECTRONICS CO., LTD.

Inventor： June Young Lee

IPC: G01J3/44 ,  G01J3/02 ,  G01J3/10 ,  A61B5/00

CPC classification number: G01J3/0297 ,  A61B5/0075 ,  A61B5/441 ,  A61B2560/0406 ,  G01J3/0202 ,  G01J3/0262 ,  G01J3/0291 ,  G01J3/10 ,  G01J3/4412

Abstract: The spectrometer includes a spectrometer body; a shield including a layer on an exterior of the spectrometer body to prevent light from entering and escaping through an area other than a contact surface between the spectrometer body and an object; an internal light source placed within the shield and configured to emit light to the object; a spectroscope mounted in the spectrometer body and configured to allow the light that passes therethrough to be casted into a spectrum; a detector configured to have one surface that is in full contact with the spectroscope and to detect external light entering from outside of the shield; and a processor configured to, in response to the detector detecting the external light, perform a certain processing.

公开(公告)号：US20180002398A1

公开(公告)日：2018-01-04

申请号：US15690403

申请日：2017-08-30

Applicant: The General Hospital Corporation

Inventor： Seok-Hyun Yun

IPC: C07K14/705 ,  G01N21/47 ,  A61B5/00 ,  G01J3/44 ,  G01N21/63

CPC classification number: C07K14/70503 ,  A61B3/102 ,  A61B3/117 ,  A61B5/0059 ,  A61B5/0066 ,  A61B5/0073 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/0086 ,  A61B5/0095 ,  A61B5/0097 ,  A61B5/4088 ,  A61B5/412 ,  A61B5/413 ,  C07K2319/30 ,  C07K2319/32 ,  C07K2319/70 ,  G01B9/02091 ,  G01J3/4412 ,  G01N21/1717 ,  G01N21/4795 ,  G01N21/636 ,  G01N2021/1725 ,  G01N2021/638 ,  G01N2201/06 ,  G01N2201/0612 ,  G01N2800/042 ,  G01N2800/387 ,  G01N2800/7023 ,  G01N2800/7028 ,  G02B21/0052

Abstract: Arrangements and methods are provided for obtaining information associated with an anatomical sample. For example, at least one first electro-magnetic radiation can be provided to the anatomical sample so as to generate at least one acoustic wave in the anatomical sample. At least one second electro-magnetic radiation can be produced based on the acoustic wave. At least one portion of at least one second electro-magnetic radiation can be provided so as to determine information associated with at least one portion of the anatomical sample. In addition, the information based on data associated with the second electro-magnetic radiation can be analyzed. The first electro-magnetic radiation may include at least one first magnitude and at least one first frequency. The second electro-magnetic radiation can include at least one second magnitude and at least one second frequency. The data may relate to a first difference between the first and second magnitudes and/or a second difference between the first and second frequencies. The second difference may be approximately between −100 GHz and 100 GHz, excluding zero.

公开(公告)号：US09791375B2

公开(公告)日：2017-10-17

申请号：US14668500

申请日：2015-03-25

Applicant: FUJIFILM Corporation

Inventor： Shogo Yamazoe ,  Masayuki Naya ,  Megumi Shiota

IPC: G01J3/44 ,  G01N21/00 ,  G01N21/65 ,  G01B11/14 ,  G01J3/02

CPC classification number: G01N21/658 ,  G01B11/14 ,  G01J3/0227 ,  G01J3/4412 ,  G01N2201/0612

Abstract: Using an optical electric field enhancing device including a fine uneven structure made of gold formed on the front surface of a transparent substrate, illumination light of a wavelength in the range from 400 to 530 nm is applied at least to an analyte, positional information of the analyte is detected by a position detection unit disposed on the rear surface side of the optical electric field enhancing device, and excitation light is applied to the detected position by an excitation light application unit. Signal light emitted from the analyte when the excitation light is applied is detected from the rear surface side of the transparent substrate.

公开(公告)号：US09778105B2

公开(公告)日：2017-10-03

申请号：US14518588

申请日：2014-10-20

Applicant: WAYNE STATE UNIVERSITY

Inventor： Gregory W. Auner ,  Changhe Huang ,  Christopher M. Thrush ,  Michelle Brusatori

IPC: G01J3/28 ,  G01J3/02 ,  G02B5/18 ,  G01J3/18 ,  G01J3/44 ,  G01J3/453 ,  G01J3/45

CPC classification number: G01J3/021 ,  G01J3/18 ,  G01J3/44 ,  G01J3/4412 ,  G01J3/45 ,  G01J3/4531 ,  G01J3/4532 ,  G02B5/1861

Abstract: An apparatus for performing Raman spectral analysis of a sample is described, comprising a coherent light source, an first optical chain to direct the coherent light to impinge on the sample, a second optical chain to direct the scattered light onto a diffraction grating, and a third optical chain to direct the diffracted light onto detection array. The diffraction grating is a stairstep with a metalized surface, and a plurality of metalized stripes on a flat surface is disposed in a direction orthogonal to the long dimension of the stairsteps. The region between the flat surface and the stairstep is transparent. The zeroth-order fringe is selected by a slit and directed onto camera. The resultant interferogram is Fourier transformed to produce a representation of the Raman spectrum.

公开(公告)号：US20170191938A1

公开(公告)日：2017-07-06

申请号：US15394045

申请日：2016-12-29

Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE ,  NATIONAL TSING HUA UNIVERSITY

Inventor： Ding-Zheng LIN ,  Ta-Jen YEN ,  Bi-Shen LEE ,  Chih-Hao HUANG

IPC: G01N21/65 ,  G01N30/92

CPC classification number: G01J3/4412 ,  B82Y35/00 ,  G01N15/0211 ,  G01N21/65 ,  G01N21/658 ,  G01N30/92 ,  G01N30/95

Abstract: A Raman detecting chip for thin layer chromatography and a method for separating and detecting an analyte are provided. The Raman detecting chip for thin layer chromatography includes a silicon substrate. The silicon substrate includes a flat portion and a plurality of silicon nanowires disposed on the flat portion, wherein each silicon nanowire has a top surface and a sidewall. A metal layer covers the top surface and at least a part of the sidewall. The silicon nanowire has a length from 5 μm to 15 μm.

公开(公告)号：US09664561B2

公开(公告)日：2017-05-30

申请号：US14896556

申请日：2014-06-04

Applicant: The Board of Regents of The University of Texas System

Inventor： Philip Varghese ,  Manfred Fink

IPC: G01J3/44 ,  G01J3/02 ,  G01J3/12

CPC classification number: G01J3/0205 ,  G01J3/0208 ,  G01J3/0264 ,  G01J3/4412 ,  G01J2003/1213

Abstract: Raman scattering, while a powerful and versatile technique, relies of the detection of weak signals. Detecting the signal can be difficult if there is interference, especially if the interference comes from scattered stray light of the laser used to generate the Raman signal. Described here is a frequency modulation technique in combination with heterodyne detection that simultaneously rejects interference from ambient light as well as from scattered stray laser light. This provides a means to detect Raman signal and discriminate against scattered light without using an expensive and bulky spectrometer.