公开(公告)号：US20180194877A1

公开(公告)日：2018-07-12

申请号：US15915184

申请日：2018-03-08

申请人： Ascensia Diabetes Care Holdings AG

发明人： Jiangfeng Fei ,  William Chiang ,  Frank Kerrigan ,  Stuart Green ,  Craig Robson ,  Howard Easterfield

IPC分类号： C08F8/34 ,  G01N27/327 ,  C07D417/14 ,  C08G73/02 ,  C07D279/20 ,  A61K49/00 ,  C07D279/08 ,  C12Q1/00 ,  C08G59/40 ,  C08F8/30 ,  C08G75/24

CPC分类号： C08F8/34 ,  A61K49/0004 ,  C07D279/08 ,  C07D279/20 ,  C07D417/14 ,  C08F8/30 ,  C08G59/4007 ,  C08G59/4064 ,  C08G73/024 ,  C08G75/24 ,  C12Q1/004 ,  G01N27/3272

摘要： A non-leaching mediator may include a polymer having a polymeric backbone, and a plurality of phenothiazine groups bonded to the polymeric backbone. The plurality of phenothiazine groups may include at least one of a phenothiazine group having the general formula (IV): and salts thereof, where n is about 9 and “R” represents the polymeric backbone to which the phenothiazine group is bonded, and a phenothiazine group having the general formula (V): and salts thereof, where n is about 9 and “R” represents the polymeric backbone to which the phenothiazine group is bonded.

公开(公告)号：US09907804B2

公开(公告)日：2018-03-06

申请号：US15056610

申请日：2016-02-29

申请人： WisTa Laboratories Ltd.

发明人： Colin Marshall ,  Scott Clunas ,  John Mervyn David Storey ,  James Peter Sinclair ,  Thomas Craven Baddeley ,  Ahtsham Ishaq ,  Michael Simpson ,  Craig Williamson ,  Barry Alan Wood ,  Claude Michel Wischik ,  Charles Robert Harrington ,  Janet Elizabeth Rickard ,  David Horsley ,  Yin Sze Loh ,  Karrar Ahmad Khan ,  Christopher Paul Larch

IPC分类号： A61K31/5415 ,  A61K9/00 ,  A61K9/20 ,  A61L2/00 ,  C07D279/20 ,  A61K9/28 ,  C07C309/04 ,  C07C309/05 ,  C07C309/30 ,  C07C309/35 ,  C07C303/32

CPC分类号： A61K31/5415 ,  A61K9/0053 ,  A61K9/2095 ,  A61K9/2893 ,  A61L2/0052 ,  C07C303/32 ,  C07C309/04 ,  C07C309/05 ,  C07C309/30 ,  C07C309/35 ,  C07D279/20 ,  Y02A50/393 ,  Y02A50/411

摘要： Disclosed are compounds of general formula (I): and pharmaceutically acceptable salts thereof, formulations, methods and uses in, for example, the treatment of disease.

公开(公告)号：US20170351177A1

公开(公告)日：2017-12-07

申请号：US15598428

申请日：2017-05-18

申请人： Shin-Etsu Chemical Co., Ltd.

发明人： Jun Hatakeyama ,  Masaki Ohashi

IPC分类号： G03F7/038 ,  G03F7/32 ,  C07C57/58 ,  C07C63/70 ,  C07C65/03 ,  G03F7/20 ,  G03F7/16 ,  G03F7/039 ,  G03F7/004 ,  C07D333/76 ,  C07D327/08 ,  C07D279/20 ,  C07C381/12 ,  C07C309/66 ,  C07C271/28 ,  C07C233/54 ,  G03F7/38 ,  C07C2603/68 ,  C07C2601/18 ,  C07C2602/28 ,  C07C2603/74

CPC分类号： G03F7/0382 ,  C07C57/58 ,  C07C63/70 ,  C07C65/03 ,  C07C65/05 ,  C07C233/54 ,  C07C271/28 ,  C07C309/65 ,  C07C309/66 ,  C07C381/12 ,  C07C2601/14 ,  C07C2601/18 ,  C07C2602/28 ,  C07C2603/68 ,  C07C2603/74 ,  C07D279/20 ,  C07D327/08 ,  C07D333/76 ,  G03F7/0045 ,  G03F7/0046 ,  G03F7/0048 ,  G03F7/0392 ,  G03F7/0397 ,  G03F7/162 ,  G03F7/168 ,  G03F7/2004 ,  G03F7/2006 ,  G03F7/2037 ,  G03F7/322 ,  G03F7/325 ,  G03F7/38

摘要： A resist composition comprising a base polymer and a sulfonium salt of iodized benzoic acid offers a high sensitivity and minimal LWR independent of whether it is of positive or negative tone.

公开(公告)号：US09796693B2

公开(公告)日：2017-10-24

申请号：US15079967

申请日：2016-03-24

申请人： Nitto Europe N.V.

发明人： Greet Bossaert ,  Monica Gomes ,  Bart Forier

IPC分类号： C07D279/20 ,  C07C67/62 ,  C09B49/06 ,  C07D279/18 ,  C08F220/18 ,  C08L33/08 ,  C07C67/03

CPC分类号： C07D279/20 ,  C07C67/03 ,  C07C67/62 ,  C07D279/18 ,  C08F220/18 ,  C08G2261/58 ,  C08L33/08 ,  C09B17/00 ,  C09B19/00 ,  C09B21/00 ,  C09B49/06 ,  C07C69/54

摘要： The present invention relates to a method for prevention of premature polymerization during the preparation, purification, transportation and storage of a polymerizable compound with at least one conjugated unsaturated group in the presence of an azine dye-based compound as inhibitor. Further the present invention relates to methods of preparing such inhibitors as well as to the inhibitors itself, as well as to methods of improving solubility and stability of dissolved inhibitors.

公开(公告)号：US20170275591A1

公开(公告)日：2017-09-28

申请号：US15475518

申请日：2017-03-31

申请人： Eastern Virginia Medical School

发明人： David TAYLOR-FISHWICK

IPC分类号： C12N5/071 ,  A61K31/444 ,  A01N1/02 ,  C12N15/113 ,  A61K31/713 ,  A61K45/06 ,  C07D279/20 ,  C07D471/04 ,  A61K31/437 ,  A61K31/5415

CPC分类号： C12N5/0676 ,  A01N1/0226 ,  A61K31/437 ,  A61K31/444 ,  A61K31/5415 ,  A61K31/713 ,  A61K45/06 ,  C07D279/20 ,  C07D471/04 ,  C12N15/1137 ,  C12N2310/14 ,  C12N2320/30 ,  C12N2501/999 ,  A61K2300/00

摘要： Methods of preserving and/or protecting pancreatic beta cells by inhibiting NOX-1. In a further aspect, NOX-1 inhibitors are administered to a subject in order to preserve and/or protect beta cells in the prevention or treatment of diabetes. NOX-1 inhibitors are also disclosed.

公开(公告)号：US09688960B2

公开(公告)日：2017-06-27

申请号：US14776132

申请日：2014-03-14

申请人： Eastern Viriginia Medical School

发明人： David Taylor-Fishwick

IPC分类号： A61K31/54 ,  C12N5/071 ,  C07D471/04 ,  A61K45/06 ,  A61K31/444 ,  A61K31/5415 ,  A61K31/713 ,  C07D279/20 ,  A01N1/02 ,  A61K31/437 ,  C12N15/113

CPC分类号： C12N5/0676 ,  A01N1/0226 ,  A61K31/437 ,  A61K31/444 ,  A61K31/5415 ,  A61K31/713 ,  A61K45/06 ,  C07D279/20 ,  C07D471/04 ,  C12N15/1137 ,  C12N2310/14 ,  C12N2320/30 ,  C12N2501/999 ,  A61K2300/00

摘要： Methods to preserve and/or protect beta cell function by contacting a population or preparation of pancreatic cells, beta cells and/or islets with an inhibitor of NADPH oxidase-1 (NOX-1). Methods of treating a subject for diabetes by administering a therapeutically effective amount of a NOX-1 inhibitor to the subject.

公开(公告)号：US20170162916A1

公开(公告)日：2017-06-08

申请号：US15327197

申请日：2015-07-17

申请人： Board of Trustees of Michigan State University

发明人： Thomas F. Guarr ,  Matthew M. Gregory ,  Nicholas Robert Boersma ,  Robert Andrew Polik ,  Nicholas Mortimer

IPC分类号： H01M10/42 ,  H01M10/0567 ,  C07D279/20 ,  C07D241/46 ,  C07D279/26 ,  C07D209/88 ,  C07D209/86 ,  H01M10/0525 ,  C07D279/22

CPC分类号： H01M10/4235 ,  C07D209/86 ,  C07D209/88 ,  C07D241/46 ,  C07D279/20 ,  C07D279/22 ,  C07D279/26 ,  H01M10/0525 ,  H01M10/0567 ,  H01M10/0569

摘要： A rechargeable lithium-ion cell has a cell capacity and includes a positive electrode having a recharged potential and a negative electrode. The rechargeable lithium-ion cell also includes a charge-carrying electrolyte. The charge-carrying electrolyte includes a charge-carrying medium and a lithium salt. The rechargeable lithium-ion cell also includes a redox shuttle having the following structure. Formula (I)

公开(公告)号：US09512380B2

公开(公告)日：2016-12-06

申请号：US14296763

申请日：2014-06-05

申请人： CHINA PETROLEUM & CHEMICAL CORPORATION ,  RESEARCH INSTITUTE OF PETROLEUM PROCESSING, SINOPEC

发明人： Shuo Su ,  Jun Long ,  Qinghua Duan ,  Han Zhou ,  Zhiqiang Wu ,  Xinhua Li ,  Yi Zhao ,  Xiaoguang Zhao

IPC分类号： C10M135/36 ,  C10M135/28 ,  C07C319/14 ,  C07D219/08 ,  C07D279/20 ,  C07D513/04 ,  C07C313/04 ,  C07C323/20 ,  C07C323/25 ,  C07C323/32 ,  C07C323/52 ,  C07C323/60

CPC分类号： C10M135/36 ,  C07C313/04 ,  C07C319/14 ,  C07C323/20 ,  C07C323/25 ,  C07C323/32 ,  C07C323/52 ,  C07C323/60 ,  C07D219/08 ,  C07D279/20 ,  C07D513/04 ,  C10M129/10 ,  C10M135/12 ,  C10M135/28 ,  C10M2203/1025 ,  C10M2207/026 ,  C10M2207/289 ,  C10M2215/064 ,  C10M2215/065 ,  C10M2219/06 ,  C10M2219/086 ,  C10M2219/087 ,  C10M2219/104 ,  C10M2219/108 ,  C10N2230/02 ,  C10N2230/04 ,  C10N2230/10 ,  C10N2230/12

摘要： This invention relates to a novel hindered phenol compound of Formula (I) (wherein the groups R and R′ are as defined in the specification), preparation thereof and use thereof as an antioxidant. By using the hindered phenol compound of this invention as an antioxidant, it is possible to produce a lubricant oil composition exhibiting excellent oxidation resistance at elevated temperatures.

公开(公告)号：US09242945B2

公开(公告)日：2016-01-26

申请号：US14090350

申请日：2013-11-26

申请人： E. Premkumar Reddy ,  M. V. Ramana Reddy

发明人： E. Premkumar Reddy ,  M. V. Ramana Reddy

IPC分类号： C07D279/16 ,  C07D417/06 ,  C07D417/10 ,  C07D279/20 ,  A61K47/48

CPC分类号： C07D279/16 ,  A61K47/48384 ,  A61K47/6803 ,  C07D279/20 ,  C07D417/06 ,  C07D417/10

摘要： The present invention relates to compounds according to Formula I: and salts thereof, wherein R1, R2, R3, R4, Ar, and n are as defined herein. Methods for preparing compounds of Formula I are also provided. The present invention further includes methods of treating cellular proliferative disorders, such as cancer, with the compounds of Formula I.

摘要翻译： 本发明涉及式I化合物及其盐，其中R 1，R 2，R 3，R 4，Ar和n如本文所定义。 还提供了制备式I化合物的方法。 本发明还包括用式I化合物治疗细胞增殖性疾病如癌症的方法。

公开(公告)号：US09187439B2

公开(公告)日：2015-11-17

申请号：US14345914

申请日：2012-09-19

申请人： INCEPTION 1, INC.

发明人： Austin Chih-Yu Chen ,  Jill Melissa Baccei ,  Brian Andrew Stearns ,  Nicholas Simon Stock ,  Yen Pham Truong

IPC分类号： C07D279/20 ,  C07D487/10 ,  C07D491/107 ,  C07D279/28

CPC分类号： C07D279/28 ,  C07D487/10 ,  C07D491/107

摘要： The invention disclosed herein is direct to compounds of Formula I and pharmaceutically acceptable salts thereof, which are useful in treating neurodegenerative diseases and promoting the generation or survival of neurons in the mammalian brain. The invention also comprises pharmaceutical compositions comprising a therapeutically effective amount of compound of Formula I or a pharmaceutically acceptable salt thereof. The invention disclosed herein is also directed to a method of promoting the generation or survival of neurons in a patient in need thereof in neurodegenerative and related diseases.

摘要翻译： 本文公开的本发明直接涉及式I化合物及其药学上可接受的盐，其可用于治疗神经变性疾病并促进哺乳动物脑中神经元的产生或存活。 本发明还包括药物组合物，其包含治疗有效量的式I化合物或其药学上可接受的盐。 本文公开的本发明还涉及在神经变性和相关疾病中促进有此需要的患者中神经元的产生或存活的方法。