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公开(公告)号：US09999568B2
公开(公告)日：2018-06-19
申请号：US15005118
申请日：2016-01-25
Applicant: EMD Millipore Corporation
Inventor： James Hobson , James Austin , Boris Pesakovich , Elias G. Noukas , Thomas Janko , Shaun McMahon
CPC classification number: A61J1/10 , B65B69/0091 , B65D88/20 , B65D90/046 , B65D2203/10 , B65D2303/00 , B65F1/06 , Y10T29/49826
Abstract: The present invention is an alignment device for a bag containing one or more ports. The alignment device is attached to either the one or more ports or to the bag adjacent the one or more ports. The plate has an indicator or a unique outer edge shape that is designed to fit into a corresponding unique opening in a holder to ensure proper alignment of the bag and its port(s) in the holder. The plate is has a series of holes equal to and in alignment with the one or more ports of the bag and the port(s) extend through the holes of the plate.
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公开(公告)号：US20180111720A1
公开(公告)日：2018-04-26
申请号：US15848156
申请日：2017-12-20
Applicant: EMD Millipore Corporation
Inventor： Sebastien Cirou , Rene Reinbigler , Virginie Buisson , Jean-Louis Weissenbach
CPC classification number: B65D33/00 , A61M1/36 , A61M2205/125 , A61M2209/088 , B01D61/18 , B01D61/20 , B01D2313/105 , B01D2313/125 , B01D2313/58 , F04B43/08
Abstract: The invention concerns a device comprising a base (2) and a door (20), said device having a closed door position in which a circuit (8) of the device comprises a bag comprising two flexible films and connectors of the conveying network, and a press (9) comprising a first shell (16) disposed on a front face (5) of said base (2) and a second shell (17) disposed in said door (20); and a hinge system hinging said door (20) relative to said base (2), and disposed only on one side of said door (20) so as to form lateral clearances between said door (20) and said base (2) over the rest of a perimeter of said door (20).
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公开(公告)号：US09897520B2
公开(公告)日：2018-02-20
申请号：US14974334
申请日：2015-12-18
Applicant: EMD Millipore Corporation
Inventor： Christopher A. Scott , Timothy K. Nadler , Kurt Greenizen , Louis Bonhomme , Sara D. Gutierrez , Masaharu Mabuchi , David Briggs , Phillip Clark , Ralph T. Scaduto
CPC classification number: G01N1/34 , B01D61/18 , B01D63/06 , B01D63/16 , B01D2315/02 , B01L3/5021 , B01L3/5085 , B01L2300/0618 , B01L2300/0681 , C07K1/16 , C07K1/22 , G01N1/405 , G01N1/4077 , G01N2001/4088 , Y10T436/25375
Abstract: Sample preparation device that allows for a complete bind, wash, elute, buffer-exchange and concentration process to be carried out without sample transfer between multiple devices. The device includes a reservoir, a column for holding chromatography media, a holder region for holding a filtration device, and an outlet. The filtration device plugs into the holder region of the centrifugal device, and the assembly can be placed in an optional holder. The assembly, with or without the optional holder, can be placed in a conventional centrifuge tube for centrifugation. The entire bind, wash, elute, buffer exchange and concentration steps can be carried out with the apparatus without any pipette transfers (and the associated sample losses. The sample preparation device also can be used for binding and washing steps, in which case the filtration device is not needed, and for buffer exchange and concentration steps, in which case the media is not needed.
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公开(公告)号：US20180043322A1
公开(公告)日：2018-02-15
申请号：US15791869
申请日：2017-10-24
Applicant: EMD Millipore Corporation
Inventor： Martin Morrissey , Brian Pereira
CPC classification number: B01F15/0085 , B01F7/00241 , B01F13/0827 , B01F15/00487 , B01F2215/0034 , B01F2215/0073 , C12M23/14 , C12M27/02
Abstract: A disposable container, such as a deformable bag, for a fluid, having one or more inlets and one or more outlets and an impeller assembly within the container to cause mixing, dispersing, homogenizing and/or circulation of one or more ingredients contained or added to the container. The region within the container that can contain liquid is funnel shaped, which allows very low fluid level mixing, dispensing while mixing, and a reduction or elimination of vortex formation.
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公开(公告)号：US20170360971A1
公开(公告)日：2017-12-21
申请号：US15691369
申请日：2017-08-30
Applicant: EMD Millipore Corporation
Inventor： Mikhail Kozlov , Wilson Moya , Gabriel Tkacik
CPC classification number: A61L2/0017 , B01D39/1623 , B01D67/0004 , B01D67/002 , B01D69/00 , B01D2239/025 , B01D2323/39 , C02F1/444 , C02F2303/04
Abstract: A method for removing microorganisms from liquid samples and a nanofiber containing liquid filtration medium that simultaneously exhibits high liquid permeability and high microorganism retention. Microorganisms such as bacteria, particularly B. Diminuta, are removed from a liquid by passing the liquid through a porous nanofiber containing filtration medium having a B. Diminuta LRV greater than about 9, and the nanofiber(s) has a diameter from about 10 nm to about 1,000 nm. Another method for removing microorganisms such as bacteria and Mycloplasma, includes passing the liquid through a porous nanofiber containing filtration medium having a microorganism LRV greater than about 8, and the nanofiber(s) has a diameter from about 10 nm to about 1,000 nm. The filtration medium can be in the form of a fibrous electro spun polymeric nanofiber liquid filtration medium mat.
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Patent Agency Ranking
公开(公告)号：US20170319985A1
公开(公告)日：2017-11-09
申请号：US15608102
申请日：2017-05-30
Applicant: EMD Millipore Corporation
Inventor： Jeremy Perreault , Sean Foley , Kevin Rautio
CPC classification number: B01D19/0031 , A61L2/0017 , B01D61/142 , B01D61/18 , B01D63/084 , B01D2313/16 , B01D2313/44 , B01D2315/08 , B01D2317/025 , B01D2317/06 , B01D2319/02 , B01D2325/36 , B01D2325/38
Abstract: Redundant filtration system that includes at least one barrier filter as a process filter, the barrier filter having both hydrophilic and hydrophobic paths, allowing both fluid and gas permeability. The need for vents is eliminated, as is an intermediate drain filter. The device also can be dried in series. The filtration system includes a network of conduits and receptacles, the network receiving liquid raw and/or starting material at one end, conducting it through the process stream defined thereby, and producing the desired liquid product at another end. The network is provided with one or more inputs for introducing liquid raw material into the fluid process stream, and one or more output ports for discharging fluid out of the fluid process stream. The network is preferably an essentially closed network, and also, preferably sterile and/or aseptic.
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公开(公告)号：US09777847B2
公开(公告)日：2017-10-03
申请号：US14413556
申请日：2013-07-18
Applicant: EMD Millipore Corporation
Inventor： Ronald Tuccelli , Sebastien Cirou , Virginie Buisson , Christine Abouayad El Idrissi , Jim Kelly
CPC classification number: F16K7/06 , B01L3/502753 , B01L3/561 , B01L3/565 , B01L3/567 , B01L99/00 , B01L2200/0689 , B01L2300/0816 , B01L2300/0861 , B01L2300/0887 , B01L2400/0655 , B29C49/0047 , B29L2031/14 , F16K7/123 , Y10T137/85954
Abstract: The invention concerns a circuit comprising a bag (11) comprising two flexible films (45, 46) and a press (10) comprising a first (14) and a second (13) shell clamping the bag to form pipes having a passage and edges (41); the first shell comprising a valve (20) which comprises a movable member (24) and a pad (31), which pad has a resting configuration in which a second face (33) of the pad is concave and locally delimits a channel (18) and a pinching configuration in which the second face (33) is convex; said movable member and said pad being configured so that, when said valve is in closed position and said pad in pinching configuration, said passage is pinched by said movable member against said second shell channel and said edges (41) are pinched flat by said movable member against said second shell (13).
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公开(公告)号：US09739424B2
公开(公告)日：2017-08-22
申请号：US14493858
申请日：2014-09-23
Applicant: EMD Millipore Corporation
Inventor： Sebastien Cirou , Rene Reinbigler , Virginie Buisson , Jean-Louis Weissenbach
IPC: B01D61/20 , B01D61/30 , B30B7/00 , B30B9/22 , C12M1/12 , C12M3/06 , F17D1/00 , B01D61/18 , F04B43/08 , C12M1/00
CPC classification number: F17D1/00 , B01D61/18 , B01D61/20 , B01D61/30 , B01D2313/105 , B01D2313/125 , B01D2313/58 , B30B7/00 , B30B9/22 , C12M47/12 , F04B43/08 , Y10T137/0318 , Y10T137/8593
Abstract: The invention concerns a device comprising: a base (2); a moveable or removable door (20), said device having a closed door position; and in the closed door position, a circuit (8) comprising a bag comprising two flexible films and conveying network connectors, and a press (9) comprising a first shell (16) disposed on said front face (5) of said base (2) and a second shell (17) disposed in said door (20); said bag being clamped between said first shell (16) and said second shell (17) in a state in which conduits of said network for conveying liquid are formed between said films.
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公开(公告)号：US20170173511A1
公开(公告)日：2017-06-22
申请号：US15448248
申请日：2017-03-02
Applicant: EMD Millipore Corporation
Inventor： Onur Y. Kas , Mikhail Kozlov , Wilson Moya , Sherry A. Leon , Philip Goddard , Jibin Hao , Gabriel Tkacik
CPC classification number: B01D39/1607 , A61L2/022 , B01D39/00 , B01D39/04 , B01D39/14 , B01D39/16 , B01D39/1615 , B01D39/1623 , B01D39/18 , B01D61/14 , B01D67/0004 , B01D67/002 , B01D69/02 , B01D69/10 , B01D2239/0208 , B01D2239/0216 , B01D2239/025 , B01D2239/0442 , B01D2239/0631 , B01D2239/10 , B01D2239/1233 , B01D2323/39 , B01D2323/42 , B01D2325/20 , C12N7/00 , C12N2740/16051 , D01D1/02 , D01D5/0092 , D01F6/96 , D10B2505/04
Abstract: A method for removing retroviruses from liquid samples and a nanofiber containing liquid filtration medium that simultaneously exhibits high liquid permeability and high microorganism retention is disclosed. Retroviruses are removed from a liquid by passing the liquid through a porous nanofiber containing filtration medium having a retrovirus LRV greater than about 6, and the nanofiber(s) has a diameter from about 10 nm to about 100 nm. The filtration medium can be in the form of a fibrous electrospun polymeric nanofiber liquid filtration medium mat.
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公开(公告)号：US20170165638A1
公开(公告)日：2017-06-15
申请号：US15323471
申请日：2015-08-19
Applicant: EMD Millipore Corporation
Inventor： John Paul Amara , John Boyle , David Yavorsky , Benjamin Cacace
IPC: B01J20/285 , B01D15/32 , B01D15/38 , B01J47/127 , B01J20/28 , B01J39/19 , B01J41/13 , B01D15/36 , C12N7/00
Abstract: Chromatography media including a high surface area thermoplastic porous nanofiber and an ion-exchange ligand functionality on the surface of the fiber. The porous nanofibers display a convoluted structure that is comprised of discrete bundles of highly entangled nanofibrils that may be fibrillated or ridged. The porous fibers can be prepared through the extraction of a dissolvable mineral or polymeric porogen that is embedded into the fiber during its manufacture in a melt extrusion process.
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