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公开(公告)号：US20180266889A1
公开(公告)日：2018-09-20
申请号：US15761082
申请日：2016-08-12
Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
Inventor： Jifang TAO , Hong CAI , Yuandong Alex GU , Guoqiang WU
CPC classification number: G01J5/20 , G01J5/0803 , G01J5/0818 , G01J5/10
Abstract: Various aspects of this disclosure provide a bolometer including a substrate and a ring resonator structure over the substrate. The bolometer may also include a silicon oxide layer in thermal contact with the ring resonator structure. The bolometer may further include a first waveguide over the substrate and coupled to the ring resonator structure, the first waveguide configured to couple an infrared light to the ring resonator structure so that the infrared light generates a temperature increase in the silicon oxide layer. The bolometer may additionally include a second waveguide over the substrate and coupled to the ring resonator structure, the second waveguide configured to couple a probe light input to the ring resonator structure so that a probe light output is generated from the probe light input, the probe light output having a change in a characteristic from the probe light input based on the temperature increase.
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公开(公告)号：US20180265512A1
公开(公告)日：2018-09-20
申请号：US15916986
申请日：2018-03-09
Applicant: Agency for Science, Technology and Research
Inventor： Haishan Wang , Dizhong Chen , Chang Kai Soh
IPC: C07D473/34 , A61K31/52 , C07D473/40 , A61K45/06 , A61K31/5377 , C07D473/32 , C07D473/16
CPC classification number: C07D473/34 , A61K31/52 , A61K31/5377 , A61K45/06 , C07D473/16 , C07D473/32 , C07D473/40 , A61K2300/00
Abstract: The present invention relates to fused pyrimidine-based hydroxamate compounds of formula (I), comprising a hydroxamate group, that are inhibitors of hiStone deacetylase (HDAC) and kinases. More particularly, the present invention relates to hydroxamate substituted purine or 5H-pyrrolo[3,2-d]pyrimidine derivatives, methods for their preparation, pharmaceutical compositions containing these compounds and uses of these compounds in the treatment of disorders/conditions/diseases involving, relating to or associated with enzymes having histone deacetylase, non-histone deacetylase and kinase activities/functions and/or via unspecified/multi-targeted mechanisms.
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公开(公告)号：US10077227B2
公开(公告)日：2018-09-18
申请号：US15541925
申请日：2016-04-15
Applicant: Agency for Science, Technology and Research
Inventor： Yugen Zhang , Xiukai Li
IPC: C07C51/25 , C07C29/60 , B01J23/00 , B01J23/28 , B01J23/30 , B01J37/08 , B01J37/00 , B01J23/22 , C07C57/04
CPC classification number: C07C51/25 , B01J23/002 , B01J23/22 , B01J23/28 , B01J23/30 , B01J37/0009 , B01J37/0063 , B01J37/08 , B01J2523/00 , B01J2523/55 , B01J2523/68 , B01J2523/69 , C07C29/60 , C07C51/235 , C07C57/04 , C07C33/03
Abstract: There is provided a method for synthesizing an alkenoic acid, in particular acrylic acid comprising the step of oxidizing an alkenyl alcohol in the presence of a metal oxide catalyst to form the alkenoic acid. The invention further provides a step of deoxydehydrating a polyol, including glycerol to obtain said alkenyl alcohol including an allyl alcohol.
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公开(公告)号：US10071183B2
公开(公告)日：2018-09-11
申请号：US14719674
申请日：2015-05-22
Applicant: Agency for Science, Technology and Research
Inventor： Charlotte A. E. Hauser , Ulung Gondo Kusumo Khoe , Archana Mishra
IPC: A61K9/00 , A01N63/00 , A01N65/00 , A01N25/00 , A61K47/00 , C12N5/00 , C12N5/02 , A61L27/22 , A61K8/04 , A61K8/64 , A61Q19/00 , C07K5/062 , C07K5/072 , C07K5/083 , C07K5/103 , C07K7/06 , A61L27/52 , A61L27/54 , A61K38/00
CPC classification number: A61L27/22 , A61K8/042 , A61K8/64 , A61K38/00 , A61L27/52 , A61L27/54 , A61L2430/00 , A61Q19/00 , C07K5/06026 , C07K5/06043 , C07K5/06052 , C07K5/0606 , C07K5/06069 , C07K5/06104 , C07K5/06113 , C07K5/0806 , C07K5/0808 , C07K5/1008 , C07K5/101 , C07K7/06
Abstract: The present invention provides an amphiphilic linear peptide and/or peptoid as well as a hy-drogel that includes the amphiphilic linear peptide/peptoid. The amphiphilic linear pep-tide/peptoid is capable of forming, a hydrogel. These peptides/peptoids include short amphi-philic sequences with a hydrophobic portion of aliphatic amino acids and at least one acidic, neutral, or basic polar amino acid. The amphiphilic linear peptide/peptoid is build up of non repetitive aliphatic amino acids, which may be in the L- or D-form. A plurality of such pep-tides/peptoids assembles to supramolecular helical fibers and forms peptide hydrogels after assembly: A corresponding hydrogel is formed in aqueous solutions at physiological pH and is thus useful for inter alia cell culture, tissue engineering, and drug release. Such hydrogels which are rigid, biocompatible and entrapping up to 99.9% of water are also well suited for applications utilizing electronic devices.
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公开(公告)号：US10071115B2
公开(公告)日：2018-09-11
申请号：US15389013
申请日：2016-12-22
Applicant: Agency for Science, Technology and Research
Inventor： Prabha Sampath
IPC: C12N15/11 , C07H21/02 , C07H21/04 , A61K48/00 , A61K31/7088 , A61K38/18 , A61K38/17 , C12Q1/6883 , G01N33/68
CPC classification number: A61K31/7088 , A61K38/1709 , A61K38/1841 , C12N15/113 , C12N15/1136 , C12N2310/113 , C12N2310/14 , C12N2310/315 , C12N2310/316 , C12N2310/322 , C12N2310/3231 , C12N2310/3517 , C12N2320/31 , C12Q1/6883 , C12Q2600/158 , C12Q2600/178 , G01N33/6887 , G01N2333/4704 , G01N2800/20 , C12N2310/3525 , A61K2300/00
Abstract: Disclosed is a method of promoting wound healing or wound closure. The method comprises administration of a miR-198 inhibitor and/or a follistatin-like-1 (FSTL1) polypeptide. Also disclosed are method of treating chronic cutaneous wounds, method of identifying a non-healing wound, use and a pharmaceutical composition comprising a miR-198 inhibitor and/or a follistatin-like-1 (FSTL1) polypeptide.
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Patent Agency Ranking
公开(公告)号：US20180243441A1
公开(公告)日：2018-08-30
申请号：US15555482
申请日：2016-03-03
Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
Inventor： Sheng-Hao CHAO
CPC classification number: A61K47/6931 , A61K38/00 , A61K38/04 , A61K39/39558 , A61K45/06 , A61K47/66 , A61K47/6851 , A61K2039/572 , A61K2300/00 , A61P3/04 , A61P35/00 , C07K7/08 , C07K14/00 , C07K14/4703
Abstract: Disclosed are isolated cytotoxic peptides having similar sequences as the basic region (BR) of Hexamethylene Bisacetamide Inducible Protein 1 (HEXIM1). Preferred embodiments include QLGKKKHRRRPSKKKRHW (SEQ ID No: 3). QLGRRRHRRRPSRRRRHW (SEQ ID No: 4) and QLGKKILAARPSKKKRHW (SEQ ID No: 5). Also encompassed are isolated nucleic acid molecules encoding for the claimed peptides, vectors comprising the isolated nucleic acids, compositions comprising peptides conjugated to cell-targeting or penetrating peptides or antibodies, nucleic acid molecules or vectors expressing conjugates thereof; methods of treating or preventing diseases or conditions, including cancers and obesity as well as a method of eliminating undifferentiated stem cells.
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公开(公告)号：US20180236604A1
公开(公告)日：2018-08-23
申请号：US15755536
申请日：2016-08-11
Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
IPC: B23K26/144 , B23K26/21 , E21B17/00
CPC classification number: B23K26/144 , B23K26/21 , B33Y10/00 , B33Y80/00 , E21B17/003
Abstract: A method of forming an elongated body with an embedded channel extending longitudinally beneath a surface along a length of the elongated body, comprising forming the elongated body with an opened channel recessed into the elongated body; the opened channel having an inner and outer portion proximal and distal to and from a channel bottom respectively of the opened channel. The method further comprises placing an elongated cover over the opened channel, and having a base and two slope surfaces extending from the base toward an apex opposite the base to cover the inner portion of the opened channel with the base, and to form two grooves each having a profile defined by a corresponding slope surface of the elongated cover and a corresponding outer portion of the opened channel forming the groove. The method further comprises filling the two grooves to join the elongated cover to the elongated body.
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公开(公告)号：US10052389B2
公开(公告)日：2018-08-21
申请号：US14767784
申请日：2014-02-13
Applicant: Agency for Science, Technology and Research
Inventor： Motoichi Kurisawa , Ki Hyun Bae , Fan Lee
IPC: A61K47/61 , A61K47/69 , A61K47/48 , A61L27/20 , A61L27/22 , A61L27/48 , A61L27/52 , A61L27/54 , A61L31/04 , A61L31/12 , A61L31/14 , A61L31/16 , A61L15/44 , A61L15/60 , A61K9/00 , A61K47/10 , A61K47/36 , A61K38/21 , A61K38/28 , A61K38/38 , C08B37/02 , C08L5/02 , A61K47/60
CPC classification number: A61K47/61 , A61K9/0019 , A61K9/0024 , A61K38/21 , A61K38/212 , A61K38/28 , A61K38/385 , A61K47/10 , A61K47/36 , A61K47/60 , A61K47/6903 , A61L15/44 , A61L15/60 , A61L27/20 , A61L27/22 , A61L27/48 , A61L27/52 , A61L27/54 , A61L31/042 , A61L31/043 , A61L31/129 , A61L31/145 , A61L31/16 , A61L2300/622 , A61L2400/06 , C08B37/0021 , C08L5/02 , C08L89/00 , C08L5/00 , C08L71/02
Abstract: The present disclosure relates to a polymeric system for release of an active agent, comprising a first polymeric phase containing the active agent, the first polymeric phase forming discrete regions of a set size range and being dispersed within a second polymeric phase comprising a cross-linked polymer-phenol conjugate for release of the active agent therein. The present disclosure further provides an injectable hydrogel comprising the disclosed polymeric system, a carrier for delivering a biologically active substance or a drug comprising the injectable hydrogel, and a method for producing the disclosed polymeric system.
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公开(公告)号：US20180229454A1
公开(公告)日：2018-08-16
申请号：US15750050
申请日：2016-06-27
Applicant: Agency for Science, Technology and Research
Inventor： Yau Yen Ooi
CPC classification number: B29C70/745 , B29C33/38 , B29C35/0888 , B29C70/74 , B29C2035/0827 , B81C1/00349
Abstract: In various embodiments, a method of forming a masking layer on at least a portion of an object. The method may include providing a plurality of mould pieces. The method may include forming an assembled mould using the plurality of the mould pieces. The assembled mould may include one or more inner surfaces to define a cavity for holding the portion of the object. The method may include providing a masking fluid in said cavity. The method may include providing electromagnetic waves to cure the masking fluid to form the masking layer on the portion of the object.
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公开(公告)号：US10050557B2
公开(公告)日：2018-08-14
申请号：US14020976
申请日：2013-09-09
Applicant: Agency for Science, Technology and Research
Inventor： Yuan Gao , I Made Darmayuda , San Jeow Cheng , Minkyu Je , Chun Huat Heng
Abstract: In various embodiments of the present disclosure, there is provided an energy harvesting apparatus, including: an energy harvester for generating electric power from an ambient source; a power conditioning circuit coupled to the output of the energy harvester; including: a boost converter module; a buck-boost converter module; and a power modification control module; wherein the power modification control module is configured to initialize the energy harvesting apparatus from inactivity to a normal energy harvesting state by operating the boost converter module, and operating the buck-boost converter when an output voltage of the power conditioning circuit rises to a predetermined value. A corresponding method of operating an energy harvesting apparatus is provided.
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