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公开(公告)号：US09573131B2
公开(公告)日：2017-02-21
申请号：US14530857
申请日：2014-11-03
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Thorsten Brueckner , Peter Koltay , Norbert Oranth , Juergen Spinke , Laurent Tanguy
CPC classification number: B01L3/52 , B01L1/00 , B01L3/523 , B01L5/00 , B01L2200/0684 , B01L2200/141 , B01L2300/048 , B01L2300/0681 , B01L2400/086 , G01N35/1002 , Y10T436/11
Abstract: A cartridge for dispensing a fluid is presented. The cartridge comprises a reservoir chamber for receiving the fluid and for receiving a ventilation gas. The reservoir chamber comprises an inlet for receiving the ventilation gas and an outlet for dispensing the fluid. At least a portion of the reservoir chamber is filled with the ventilation gas when in an operating position. The inlet is located in the portion being filled with the ventilation gas. The fluid comprises a reagent. The cartridge further comprises a baffle for restricting gas diffusion through the inlet. The reservoir chamber receives the ventilation gas via the baffle. The inlet is maintains a constant gas pressure within the portion of the reservoir chamber that is being filled with the ventilation gas.
Abstract translation: 呈现用于分配流体的盒。 墨盒包括用于接收流体并用于接收通气气体的储存室。 储存室包括用于接收通气气体的入口和用于分配流体的出口。 当处于操作位置时，储存室的至少一部分填充有通气气体。 入口位于填充有通气气体的部分中。 流体包含试剂。 墨盒还包括用于限制通过入口的气体扩散的挡板。 储存室通过挡板接收通气气体。 入口在储存室的被填充有通风气体的部分内保持恒定的气体压力。
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公开(公告)号：US12042795B2
公开(公告)日：2024-07-23
申请号：US17099970
申请日：2020-11-17
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Christoph Boehm , Thorsten Brueckner , Sascha Lutz , Alexander Keuchel
IPC: B01L3/00
CPC classification number: B01L3/523 , B01L2200/026 , B01L2200/04 , B01L2200/0689 , B01L2200/141 , B01L2200/16 , B01L2300/042 , B01L2400/0478
Abstract: A cartridge including a structural part with a hole surrounded at least partially by a recess, so that a wall is formed that separates the hole from the recess. The cartridge includes a liquid pack, wherein the liquid pack comprises a surrounding seal portion and a liquid containing portion. The liquid pack is arranged at least partially in the hole, in that a circumferential outer line of the seal portion protrudes over the hole.
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公开(公告)号：US10416054B2
公开(公告)日：2019-09-17
申请号：US15387007
申请日：2016-12-21
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Christoph Boehm , Thorsten Brueckner , Sascha Lutz , Bruntje Esrom , Michael Herbel
IPC: G01N1/40 , G01N1/10 , G01N1/28 , G01N33/49 , G01N21/07 , G01N21/84 , B01L3/00 , B01D17/02 , A61B5/15 , A61B5/157 , A61B10/00
Abstract: System and method of determining an amount of an analyte in a blood sample using a cartridge and blood collector are disclosed. The blood collector has a mounting surface, a capillary structure with a curved portion, and a capillary inlet. The cartridge has a receiving surface, a cartridge inlet, a microfluidic structure, and a measurement structure. The method includes placing the blood sample into the capillary inlet; attaching the mounting surface to the receiving surface; rotating the cartridge about a rotational axis to transport the blood sample from the capillary structure to the cartridge inlet and into the microfluidic structure; controlling the rotation of the cartridge to process the blood sample into the processed sample using the microfluidic structure; controlling the rotation of the cartridge to transfer the processed sample to the measurement structure; and measuring the amount of the analyte using the measurement structure and a measurement system.
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Patent Agency Ranking
24.发明授权公开(公告)号：US10288609B2
公开(公告)日：2019-05-14
申请号：US15951536
申请日：2018-04-12
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Thorsten Brueckner , Eloisa Lopez-Calle , Norbert Oranth , Josef Roedl
IPC: G01N21/27 , G01N21/63 , G01N33/52 , G06F19/18 , G01N33/543 , G16B20/00 , G01N21/78 , G01N21/82 , G01D18/00 , G01N33/573 , G01N33/68 , G01N33/92 , G16H50/30
Abstract: A method for determining the amount of a specific analyte by photometric assays, wherein the specific analyte in a sample reacts with an analyte specific reaction partner in a reaction mixture. At least two calibration curves are generated, the first calibration curve recorded at a first wavelength is optimized for low concentrations of the specific analyte thereby maximizing the lower detection limit and, the second calibration curve recorded at a second wavelength is optimized for high concentrations of the specific analyte thereby maximizing the upper detection limit. The optimized lower detection limit and the optimized upper detection limit results in an extended dynamic range.
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公开(公告)号：US20180369812A1
公开(公告)日：2018-12-27
申请号：US16116174
申请日：2018-08-29
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Christoph Boehm , Thorsten Brueckner , Sascha Lutz
IPC: B01L3/00 , G01N30/74 , B01J20/281
Abstract: A method of performing an optical measurement of an analyte in a processed biological sample using a cartridge is provided. The cartridge is operable for being spun around a rotational axis. The method comprises: placing the biological sample into a sample inlet; controlling the rotational rate of the cartridge to process a biological sample into the processed biological sample using a fluidic structure; controlling the rotational rate of the cartridge to allow the processed biological sample to flow from the measurement structure inlet to an absorbent structure via a chromatographic membrane, and performing an optical measurement of a detection zone on the chromatographic membrane with an optical instrument. An inlet air baffle reduces evaporation of the processed biological sample from the chromatographic membrane during rotation of the cartridge.
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公开(公告)号：US20180264471A1
公开(公告)日：2018-09-20
申请号：US15982009
申请日：2018-05-17
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Christoph Boehm , Thorsten Brueckner , Thomas Fischer , Eloisa Lopez-Calle , Sascha Lutz , Josef Roedl , Juergen Spinke , Pamela Espindola , Thomas Manuel Keller , Thomas Dolbinow , Sabrina Adler , Erik Beiersdorf , Domenik Wensorra
IPC: B01L3/00
CPC classification number: B01L3/502753 , B01L3/5023 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L2200/0605 , B01L2200/16 , B01L2300/0627 , B01L2300/0803 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2400/0406 , B01L2400/0409 , B01L2400/0688 , B01L2400/084 , G01N35/00069 , G01N2035/1032
Abstract: A medical system for determining an analyte quantity in a blood sample via a cartridge that spins around a rotational axis. The cartridge may include: a separation chamber that separates blood plasma from the sample; a processing chamber containing a reagent with a specific binding partner which binds to the analyte to form an analyte specific binding partner complex; a first valve structure connecting the separation chamber to the processing chamber; a measurement structure to measure the quantity of the analyte, wherein the measurement structure includes a chromatographic membrane with an immobilized binding partner for direct or indirect binding of the analyte or the analyte specific binding partner complex, and an absorbent structure that is nearer to the axis than the membrane; a second valve structure connecting the processing chamber to the measurement structure; and a fluid chamber filled with a washing buffer and fluidically connected to the measurement structure.
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公开(公告)号：US09341641B2
公开(公告)日：2016-05-17
申请号：US14530862
申请日：2014-11-03
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Christoph Boehm , Peter Kupser , Norbert Oranth , Juergen Spinke , Thorsten Brueckner , Timo Klein
CPC classification number: G01N35/1002 , A61M5/14216 , A61M5/16809 , B01L3/0217 , B01L3/0224 , B01L3/502 , B01L2200/025 , B01L2200/0605 , B01L2200/0684 , B01L2200/16 , B01L2300/0627 , B01L2300/0681 , B01L2400/0478 , B01L2400/0644 , B01L2400/065 , G01F11/021 , G01N35/00871 , G01N35/1016 , G01N35/1097 , G01N2035/1025 , Y10T436/119163 , Y10T436/2575
Abstract: A cartridge for dispensing fluid is presented. The cartridge comprises a valve. The valve comprises a pumping chamber for pumping the fluid. The valve positions a pumping chamber conduit. The pumping chamber conduit is connected to the pumping chamber. The cartridge further comprises a plunger for changing the volume of the pumping chamber. The cartridge further comprises a reservoir conduit for connecting the reservoir with the valve. The valve positions the pumping chamber conduit to connect with the reservoir conduit. The cartridge further comprises an outlet conduit for dispensing the fluid. The valve further rotates the pumping chamber conduit to connect with the outlet conduit.
Abstract translation: 提出了用于分配流体的盒。 墨盒包括阀。 阀包括用于泵送流体的泵送室。 阀门定位泵送管道。 泵送室导管连接到泵送室。 墨盒还包括用于改变泵送室的容积的柱塞。 墨盒还包括用于将储存器与阀连接的储存器导管。 阀将泵室导管定位成与储存器导管连接。 墨盒还包括用于分配流体的出口导管。 阀进一步旋转泵送室导管以与出口导管连接。
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公开(公告)号：US20150224500A1
公开(公告)日：2015-08-13
申请号：US14530857
申请日：2014-11-03
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Thorsten Brueckner , Peter Koltay , Norbert Oranth , Juergen Spinke , Laurent Tanguy
CPC classification number: B01L3/52 , B01L1/00 , B01L3/523 , B01L5/00 , B01L2200/0684 , B01L2200/141 , B01L2300/048 , B01L2300/0681 , B01L2400/086 , G01N35/1002 , Y10T436/11
Abstract: A cartridge for dispensing a fluid is presented. The cartridge comprises a reservoir chamber for receiving the fluid and for receiving a ventilation gas. The reservoir chamber comprises an inlet for receiving the ventilation gas and an outlet for dispensing the fluid. At least a portion of the reservoir chamber is filled with the ventilation gas when in an operating position. The inlet is located in the portion being filled with the ventilation gas. The fluid comprises a reagent. The cartridge further comprises a baffle for restricting gas diffusion through the inlet. The reservoir chamber receives the ventilation gas via the baffle. The inlet is maintains a constant gas pressure within the portion of the reservoir chamber that is being filled with the ventilation gas.
Abstract translation: 呈现用于分配流体的盒。 墨盒包括用于接收流体并用于接收通气气体的储存室。 储存室包括用于接收通气气体的入口和用于分配流体的出口。 当处于操作位置时，储存室的至少一部分填充有通气气体。 入口位于填充有通气气体的部分中。 流体包含试剂。 墨盒还包括用于限制通过入口的气体扩散的挡板。 储存室通过挡板接收通气气体。 入口在储存室的被填充有通风气体的部分内保持恒定的气体压力。
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