公开(公告)号：US11413615B2

公开(公告)日：2022-08-16

申请号：US15926992

申请日：2018-03-20

Applicant: The University of Chicago

Inventor： Rustem F. Ismagilov ,  Joshua David Tice ,  Cory John Gerdts ,  Bo Zheng

IPC: B01L3/00 ,  B01J19/00 ,  B82Y30/00 ,  G01N35/08 ,  B01F25/433 ,  B01F33/302 ,  G01N1/28 ,  B01D9/00 ,  C07K14/43 ,  C12N9/36 ,  C30B7/14 ,  C30B29/54 ,  C30B29/58 ,  B01J14/00 ,  C12Q1/6806

Abstract: The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.

公开(公告)号：US11413614B2

公开(公告)日：2022-08-16

申请号：US15087176

申请日：2016-03-31

Applicant: The University of Chicago

Inventor： Rustem F. Ismagilov ,  Joshua David Tice ,  Cory John Gerdts ,  Bo Zheng

IPC: B01L3/00 ,  B01J19/00 ,  B82Y30/00 ,  G01N35/08 ,  B01F25/433 ,  B01F33/302 ,  G01N1/28 ,  B01D9/00 ,  C07K14/43 ,  C12N9/36 ,  C30B7/14 ,  C30B29/54 ,  C30B29/58 ,  B01J14/00 ,  C12Q1/6806

Abstract: The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.

公开(公告)号：US10532358B2

公开(公告)日：2020-01-14

申请号：US16105257

申请日：2018-08-20

Applicant: The University of Chicago

Inventor： Rustem F. Ismagilov ,  Joshua David Tice ,  Cory John Gerdts ,  Bo Zheng

IPC: B01L3/00 ,  B01D9/00 ,  B01F5/06 ,  B01F13/00 ,  B01J19/00 ,  B82Y30/00 ,  G01N35/08 ,  G01N1/28 ,  C07K14/43 ,  C12N9/36 ,  C30B7/14 ,  C30B29/54 ,  C30B29/58 ,  B01J14/00 ,  C12Q1/6806

Abstract: The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.

公开(公告)号：US09889446B2

公开(公告)日：2018-02-13

申请号：US15586896

申请日：2017-05-04

Applicant: The University of Chicago

Inventor： Rustem F. Ismagilov ,  Joshua David Tice ,  Helen Song Baca ,  Lewis Spencer Roach

IPC: B01L3/00 ,  B01F5/06 ,  B01F13/00 ,  B01J19/00 ,  G01N35/08 ,  C12P19/34 ,  C12Q1/44 ,  B01F3/08 ,  B01L7/00 ,  B82Y30/00 ,  G01N15/14

CPC classification number: B01L3/502784 ,  B01F3/0861 ,  B01F5/0403 ,  B01F5/0646 ,  B01F5/0647 ,  B01F13/0071 ,  B01F2215/0037 ,  B01J19/0046 ,  B01J19/0093 ,  B01J2219/00286 ,  B01J2219/00576 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00599 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01J2219/00736 ,  B01J2219/0074 ,  B01J2219/00756 ,  B01J2219/00783 ,  B01J2219/00837 ,  B01J2219/0086 ,  B01J2219/00867 ,  B01J2219/00869 ,  B01J2219/00889 ,  B01J2219/00891 ,  B01J2219/00975 ,  B01J2219/00977 ,  B01L3/502746 ,  B01L3/502761 ,  B01L7/52 ,  B01L2200/0647 ,  B01L2200/0668 ,  B01L2200/0673 ,  B01L2200/10 ,  B01L2300/0867 ,  B01L2300/0883 ,  B01L2400/0424 ,  B01L2400/0448 ,  B01L2400/0454 ,  B01L2400/0487 ,  B82Y30/00 ,  C12P19/34 ,  C12Q1/44 ,  G01N15/1404 ,  G01N15/1484 ,  G01N35/08 ,  G01N35/085 ,  G01N2015/1409 ,  Y02A90/26 ,  Y10T436/118339 ,  Y10T436/12 ,  Y10T436/2575

Abstract: The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.

公开(公告)号：US20170368551A1

公开(公告)日：2017-12-28

申请号：US15673929

申请日：2017-08-10

Applicant: The University of Chicago

Inventor： Rustem F. Ismagilov ,  Joshua David Tice ,  Helen Song Baca ,  Lewis Spencer Roach

IPC: B01L3/00 ,  B01F3/08 ,  B01J19/00 ,  B01L7/00 ,  B01F5/06 ,  B01F13/00

Abstract: The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.

公开(公告)号：US20160215411A1

公开(公告)日：2016-07-28

申请号：US14517602

申请日：2014-10-17

Applicant: The University of Chicago

Inventor： Rustem F. Ismagilov ,  Joshua David Tice ,  Cory John Gerdts ,  Bo Zheng

IPC: C30B7/14 ,  B01D9/00 ,  C30B29/54 ,  C30B29/58 ,  C12N9/36 ,  C07K14/43

CPC classification number: B01L3/502784 ,  B01D9/0072 ,  B01D2009/0086 ,  B01F5/0646 ,  B01F5/0647 ,  B01F13/0071 ,  B01J14/00 ,  B01J19/0046 ,  B01J19/0093 ,  B01J2219/00286 ,  B01J2219/00576 ,  B01J2219/00585 ,  B01J2219/00599 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01J2219/00736 ,  B01J2219/00756 ,  B01J2219/00783 ,  B01J2219/00837 ,  B01J2219/0086 ,  B01J2219/00869 ,  B01J2219/00889 ,  B01J2219/00891 ,  B01J2219/00894 ,  B01J2219/00903 ,  B01J2219/00975 ,  B01J2219/00977 ,  B01L3/502715 ,  B01L3/50273 ,  B01L2200/0673 ,  B01L2200/12 ,  B01L2300/0867 ,  B01L2400/0487 ,  B82Y30/00 ,  C07K14/43 ,  C12N9/2462 ,  C12Q1/6806 ,  C12Y302/01017 ,  C30B7/14 ,  C30B29/54 ,  C30B29/58 ,  G01N1/28 ,  G01N35/08 ,  Y10T117/10 ,  Y10T137/0318 ,  Y10T436/117497 ,  Y10T436/143333 ,  Y10T436/25

Abstract: The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.

公开(公告)号：US20160051960A1

公开(公告)日：2016-02-25

申请号：US14836432

申请日：2015-08-26

Applicant: The University of Chicago

Inventor： Rustem F. Ismagilov ,  Joshua David Tice ,  Helen Song ,  Lewis Spencer Roach

IPC: B01J19/00 ,  C12P19/34 ,  C12Q1/44

CPC classification number: B01L3/502784 ,  B01F3/0861 ,  B01F5/0403 ,  B01F5/0646 ,  B01F5/0647 ,  B01F13/0071 ,  B01F2215/0037 ,  B01J19/0046 ,  B01J19/0093 ,  B01J2219/00286 ,  B01J2219/00576 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00599 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01J2219/00736 ,  B01J2219/0074 ,  B01J2219/00756 ,  B01J2219/00783 ,  B01J2219/00837 ,  B01J2219/0086 ,  B01J2219/00867 ,  B01J2219/00869 ,  B01J2219/00889 ,  B01J2219/00891 ,  B01J2219/00975 ,  B01J2219/00977 ,  B01L3/502746 ,  B01L3/502761 ,  B01L7/52 ,  B01L2200/0647 ,  B01L2200/0668 ,  B01L2200/0673 ,  B01L2200/10 ,  B01L2300/0867 ,  B01L2300/0883 ,  B01L2400/0424 ,  B01L2400/0448 ,  B01L2400/0454 ,  B01L2400/0487 ,  B82Y30/00 ,  C12P19/34 ,  C12Q1/44 ,  G01N15/1404 ,  G01N15/1484 ,  G01N35/08 ,  G01N35/085 ,  G01N2015/1409 ,  Y02A90/26 ,  Y10T436/118339 ,  Y10T436/12 ,  Y10T436/2575

Abstract: The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.

公开(公告)号：US20150099264A1

公开(公告)日：2015-04-09

申请号：US14507938

申请日：2014-10-07

Applicant: The University of Chicago

Inventor： Rustem F. Ismagilov ,  Joshua David Tice ,  Helen Song ,  Lewis Spencer Roach

IPC: G01N15/14 ,  G01N35/08 ,  B01J19/00

CPC classification number: B01L3/502784 ,  B01F3/0861 ,  B01F5/0403 ,  B01F5/0646 ,  B01F5/0647 ,  B01F13/0071 ,  B01F2215/0037 ,  B01J19/0046 ,  B01J19/0093 ,  B01J2219/00286 ,  B01J2219/00576 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00599 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01J2219/00736 ,  B01J2219/0074 ,  B01J2219/00756 ,  B01J2219/00783 ,  B01J2219/00837 ,  B01J2219/0086 ,  B01J2219/00867 ,  B01J2219/00869 ,  B01J2219/00889 ,  B01J2219/00891 ,  B01J2219/00975 ,  B01J2219/00977 ,  B01L3/502746 ,  B01L3/502761 ,  B01L7/52 ,  B01L2200/0647 ,  B01L2200/0668 ,  B01L2200/0673 ,  B01L2200/10 ,  B01L2300/0867 ,  B01L2300/0883 ,  B01L2400/0424 ,  B01L2400/0448 ,  B01L2400/0454 ,  B01L2400/0487 ,  B82Y30/00 ,  C12P19/34 ,  C12Q1/44 ,  G01N15/1404 ,  G01N15/1484 ,  G01N35/08 ,  G01N35/085 ,  G01N2015/1409 ,  Y02A90/26 ,  Y10T436/118339 ,  Y10T436/12 ,  Y10T436/2575

Abstract: The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.

Abstract translation: 本发明提供微制造的底物和在这些底物内进行反应的方法。 反应发生在在载体流体流中输送的塞子中。

公开(公告)号：US20240192707A1

公开(公告)日：2024-06-13

申请号：US18412395

申请日：2024-01-12

Applicant: The University of Chicago

Inventor： Rustem F. Ismagilov ,  Bo Zheng ,  Cory John Gerdts

IPC: G05D7/06 ,  B01F25/314 ,  B01F33/302 ,  B01J19/00 ,  B01L3/00 ,  B01L3/02 ,  G01N1/38 ,  G01N35/08 ,  G01N35/10

CPC classification number: G05D7/0694 ,  B01F25/314 ,  B01F33/3021 ,  B01J19/0046 ,  B01L3/0293 ,  B01L3/502784 ,  G01N1/38 ,  G01N35/08 ,  B01J2219/00522 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00599 ,  B01L3/502746 ,  B01L2200/0673 ,  B01L2300/0816 ,  B01L2300/0838 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2400/0487 ,  G01N2035/1034 ,  Y10T137/0318

Abstract: The present invention provides microfluidic technology enabling rapid and economical manipulation of reactions on the femtoliter to microliter scale.

公开(公告)号：US11853087B2

公开(公告)日：2023-12-26

申请号：US16983270

申请日：2020-08-03

Applicant: The University of Chicago

Inventor： Rustem F. Ismagilov ,  Bo Zheng ,  Cory John Gerdts

IPC: G01N1/38 ,  G01N35/08 ,  G05D7/06 ,  B01J19/00 ,  B01L3/02 ,  B01L3/00 ,  B01F25/314 ,  B01F33/302 ,  G01N35/10

CPC classification number: G05D7/0694 ,  B01F25/314 ,  B01F33/3021 ,  B01J19/0046 ,  B01L3/0293 ,  B01L3/502784 ,  G01N1/38 ,  G01N35/08 ,  B01J2219/0059 ,  B01J2219/00522 ,  B01J2219/00585 ,  B01J2219/00599 ,  B01L3/502746 ,  B01L2200/0673 ,  B01L2300/0816 ,  B01L2300/0838 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2400/0487 ,  G01N2035/1034 ,  Y10T137/0318

Abstract: The present invention provides microfluidic technology enabling rapid and economical manipulation of reactions on the femtoliter to microliter scale.