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    Method and device for transporting or binding-specific separation of electrically charged molecules
    21.
    发明申请
    Method and device for transporting or binding-specific separation of electrically charged molecules 有权
    用于运输或结合特异性分离带电分子的方法和装置

    公开(公告)号：US20060086625A1

    公开(公告)日：2006-04-27

    申请号：US10537248

    申请日：2003-11-28

    申请人： Heike Barlag ,  Walter Gumbrecht ,  Manfred Stanzel

    发明人： Heike Barlag ,  Walter Gumbrecht ,  Manfred Stanzel

    IPC分类号： G01N27/26 ,  G01N33/487 ,  G01F1/64

    CPC分类号： G01N33/5438 ,  G01N27/3277

    摘要： Electrically charged molecules need to be transported in order to create a DNA sensor. The following measures are undertaken: base metals are introduced into a solution as a positive ion; negatively charged molecules are transported in an opposite direction and are enriched in the vicinity of the measuring electrodes. Binding-specific separation of the charged molecules can be achieved by forming metal layers on the measuring electrodes by depositing metal ions from the solution when a suitable potential is selected. Target DNA can more particularly be introduced into the vicinity of the catcher molecules on the measuring electrodes and non-specifically bound DNA can be removed. According to the associated device, the electrode arrangement may be associated with a sacrificial electrode made of more base metal than the material of the measuring electrodes. The measuring electrodes in particular may be made of noble metal, preferably gold, and the sacrificial electrode may be made of cooper.

    摘要翻译： 需要运送电荷分子以产生DNA传感器。 进行以下措施：将碱金属作为正离子引入溶液中; 带负电荷的分子以相反的方向输送并富集在测量电极附近。 带电分子的结合特异性分离可以通过在选择合适的电位时从溶液中沉积金属离子而在测量电极上形成金属层来实现。 目标DNA可以更特别地引入到测量电极上的捕获剂分子附近，并且可以除去非特异性结合的DNA。 根据相关装置，电极装置可以与由比测量电极的材料更多的基底金属制成的牺牲电极相关联。 测量电极特别可以由贵金属制成，优选由金制成，并且牺牲电极可以由铜制成。

    Microstructured biosensor, use of the biosensor and process for the immobilization of biocatalysts
    24.
    发明授权
    Microstructured biosensor, use of the biosensor and process for the immobilization of biocatalysts 有权
    微结构生物传感器，使用生物传感器和固定生物催化剂的方法

    公开(公告)号：US06440296B1

    公开(公告)日：2002-08-27

    申请号：US09536027

    申请日：2000-03-27

    申请人： Manfred Stanzel ,  Walter Gumbrecht

    发明人： Manfred Stanzel ,  Walter Gumbrecht

    IPC分类号： G01N2726

    CPC分类号： C12Q1/002

    摘要： A biosensor is used for measuring principal metabolites in blood and other substances. The biosensor has a special structure formed of a two-layer enzymatic membrane with a considerably increased functionality compared with enzymatic membranes of the prior art.

    摘要翻译： 生物传感器用于测量血液和其他物质中的主要代谢物。 与现有技术的酶膜相比，生物传感器具有由具有显着增加的功能的双层酶膜形成的特殊结构。

    Method for the production of a solution, associated arrangement and uses of the method and arrangement
    25.
    发明授权
    Method for the production of a solution, associated arrangement and uses of the method and arrangement 有权
    解决方案的生产方法，相关安排和使用方法和安排

    公开(公告)号：US08518343B2

    公开(公告)日：2013-08-27

    申请号：US11587572

    申请日：2005-04-26

    申请人： Walter Gumbrecht ,  Peter Paulicka ,  Manfred Stanzel

    发明人： Walter Gumbrecht ,  Peter Paulicka ,  Manfred Stanzel

    IPC分类号： G01N21/75

    CPC分类号： B01F15/0205 ,  B01F1/00 ,  B01F13/0059 ,  B01F15/021 ,  Y10T436/25

    摘要： Solid matter in a cavity is used to produce a solution of at least one solid matter in a solvent. The solid matter which is soluble in the solvent in initially covered and/or surrounded in the cavity by a medium which is insoluble in a solvent, such that dissolving of the solid matter is prevented. Subsequently the solvent is guided to the cavity and the medium which is insoluble in the solvent is treated in such a manner that contact is made between the solvent and the soluble solid matter, enabling the solid matter to dissolve in the solvent. Solutions including two or more solid matter can be produced in an advantageous manner.

    摘要翻译： 空腔中的固体物质用于在溶剂中产生至少一种固体物质的溶液。 首先被溶解在溶剂中的固体物质通过不溶于溶剂的介质在空腔中被包覆和/或包围，从而防止固体物质的溶解。 随后将溶剂引导到空腔中，并且不溶于溶剂的介质以在溶剂和可溶性固体物质之间接触使得固体物质溶解在溶剂中的方式被处理。 可以以有利的方式制备包含两种或更多种固体物质的溶液。

    DEVICE SIMILAR TO AN ELECTROMECHANICAL CAMERA AND METHOD FOR THE PRODUCTION AND USE OF THE DEVICE
    26.
    发明申请
    DEVICE SIMILAR TO AN ELECTROMECHANICAL CAMERA AND METHOD FOR THE PRODUCTION AND USE OF THE DEVICE 有权
    类似于机电相机的装置及其制造和使用的方法

    公开(公告)号：US20120108456A1

    公开(公告)日：2012-05-03

    申请号：US13262578

    申请日：2010-03-02

    申请人： Alexander Frey ,  Walter Gumbrecht ,  Peter Paulicka ,  Meinrad Schienle ,  Manfred Stanzel

    发明人： Alexander Frey ,  Walter Gumbrecht ,  Peter Paulicka ,  Meinrad Schienle ,  Manfred Stanzel

    IPC分类号： C40B30/04 ,  C40B50/18 ,  C40B60/12

    CPC分类号： G01N27/3277 ,  G01N33/5438

    摘要： A device for detecting chemical or biochemical substances in fluids includes a first carrier having a sensor array with a plurality of electrochemical sensors. A second carrier includes a porous layer having at least one functional region, in which specifically binding capturing molecules are immobilized. The at least one functional region is arranged directly adjacent to at least one non-functionalized region. Assigned to the at least one functional region and the at least one non-functionalized region are several sensors of the sensor array, for use as an electrochemical camera.

    摘要翻译： 用于检测流体中的化学或生化物质的装置包括具有传感器阵列的多个电化学传感器的第一载体。 第二载体包括具有至少一个功能区的多孔层，其中固定有特异性结合的捕获分子。 所述至少一个功能区域直接邻近至少一个非功能化区域布置。 分配给至少一个功能区域和至少一个非功能化区域是传感器阵列的几个传感器，用作电化学照相机。

    PROCESS FOR CONCENTRATING NUCLEIC ACID MOLECULES
    29.
    发明申请
    PROCESS FOR CONCENTRATING NUCLEIC ACID MOLECULES 有权
    浓缩核酸分子的方法

    公开(公告)号：US20100248242A1

    公开(公告)日：2010-09-30

    申请号：US12734934

    申请日：2008-11-03

    申请人： Walter Gumbrecht ,  Peter Paulicka ,  Manfred Stanzel

    发明人： Walter Gumbrecht ,  Peter Paulicka ,  Manfred Stanzel

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/6806 ,  C12Q1/6825 ,  C12Q1/6834 ,  C12Q1/6837 ,  Y10T436/143333 ,  C12Q2527/107 ,  C12Q2537/125 ,  C12Q2565/543

    摘要： A process concentrates nucleic acid molecules to be detected of a sample on a surface, with capture molecules that specifically bind the nucleic acid molecules. A support material has a capture probe that can specifically be linked to the nucleic acid molecules to be detected to give complexes. The support material and the nucleic acid molecules of the sample are incubated to form the complexes. The complexes are moved to the surface. At least one portion of the complexes becomes bound to the capture molecules via the capture probe.

    摘要翻译： 一种方法将待检测的样品的核酸分子浓缩在表面上，其中捕获分子特异性结合核酸分子。 载体材料具有捕获探针，其可以特异性地连接到待检测的核酸分子以得到复合物。 将样品的载体材料和核酸分子孵育以形成复合物。 络合物移动到表面。 复合物的至少一部分经由捕获探针与捕获分子结合。

    Method and device for PCR-amplification and detection of nucleotide sequences
    30.
    发明授权
    Method and device for PCR-amplification and detection of nucleotide sequences 有权
    用于PCR扩增和检测核苷酸序列的方法和装置

    公开(公告)号：US07642053B2

    公开(公告)日：2010-01-05

    申请号：US10539437

    申请日：2003-12-15

    申请人： Walter Gumbrecht ,  Manfred Stanzel

    发明人： Walter Gumbrecht ,  Manfred Stanzel

    IPC分类号： C12Q1/68 ,  C12P19/34

    CPC分类号： C12Q1/686 ,  C12Q2565/607 ,  C12Q2565/501

    摘要： A DNA-Chip includes a flat carrier and an array of spots containing probe molecules (oligonucleotides) which are arranged on said carrier. Each spot is associated with a microelectrode arrangement for impedance spectroscopic detection of binding events occurring between the probe molecules and target molecules (DNA fragments) applied by way of an analyte solution. In order to increase the sensitivity or the binding specific measuring effects of the biochip, the electrode arrangement is at least partially embedded in a hydrophilic reaction layer containing probe molecules and which is permeable to target molecules.

    摘要翻译： DNA芯片包括布置在所述载体上的平坦载体和含有探针分子（寡核苷酸）的斑点阵列。 每个点与微电极装置相关联，用于阻抗光谱检测在通过分析物溶液施加的探针分子和靶分子（DNA片段）之间发生的结合事件。 为了增加生物芯片的灵敏度或结合特异性测量效果，电极布置至少部分地嵌入含有探针分子的亲水性反应层，并且其可渗透靶分子。