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公开(公告)号：US11798700B2
公开(公告)日：2023-10-24
申请号：US17040652
申请日：2019-03-26
CPC分类号： G21G1/001 , B01D15/1871 , B01D15/362 , B01D15/363 , C01B15/0475 , C01F17/13 , G21G1/10 , G21G2001/0089 , G21G2001/0094
摘要： A method of separating actinium and/or radium from proton-irradiated thorium metal. The thorium metal is irradiated to produce isotopes including thorium, actinium and/or radium. The resultant product is dissolved in solution and a selective precipitant is used to precipitate a bulk portion of the thorium. The precipitated thorium can be recovered. Chromatography is carried out on the remaining solution to remove residual thorium and to separate the actinium from the radium.
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公开(公告)号：US11779629B2
公开(公告)日：2023-10-10
申请号：US16999849
申请日：2020-08-21
发明人： Neil R. Cashman
IPC分类号： A61K38/00 , A61K38/17 , C07K7/00 , C07K5/12 , A61K38/07 , A61K38/12 , A61K39/385 , A61K47/64 , C07K14/47 , C07K5/117 , C07K7/06 , C07K7/64 , C12N5/16 , G01N33/68 , A61P25/28 , C07K16/18 , C07K5/083 , C07K5/087 , C07K5/09 , C07K5/093 , C07K5/097 , C07K5/113 , A61K39/00 , A61K51/08 , A61K49/18 , A61K45/00 , A61K39/395 , A61K38/05 , A61K51/10 , A61K47/68 , A61K38/08 , A61K39/39 , A61K45/06 , A61K47/69 , A61L31/10 , A61L27/34 , A61L29/16 , A61L31/16 , A61L29/08 , A61L27/22 , G01N33/50 , C07K5/103 , C07K14/435 , C12N5/10 , C07K7/08
CPC分类号： A61K38/07 , A61K38/12 , A61K39/385 , A61K47/643 , A61K47/646 , A61P25/28 , C07K5/081 , C07K5/0808 , C07K5/0812 , C07K5/0815 , C07K5/0819 , C07K5/0821 , C07K5/1021 , C07K5/1024 , C07K7/06 , C07K7/64 , C07K14/4711 , C07K16/18 , C12N5/16 , G01N33/6896 , A61K38/00 , A61K38/05 , A61K38/08 , A61K39/00 , A61K39/39 , A61K39/395 , A61K39/3955 , A61K39/39533 , A61K45/05 , A61K45/06 , A61K47/6803 , A61K47/6921 , A61K49/1818 , A61K49/1866 , A61K51/088 , A61K51/10 , A61K51/1018 , A61K2039/505 , A61K2039/55505 , A61K2039/6081 , A61K2300/00 , A61L27/227 , A61L27/34 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , C07K5/101 , C07K7/08 , C07K14/435 , C07K2317/20 , C07K2317/24 , C07K2317/30 , C07K2317/33 , C07K2317/34 , C07K2317/524 , C07K2317/526 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/569 , C07K2317/624 , C07K2317/626 , C07K2317/70 , C07K2317/76 , C07K2317/92 , C07K2317/94 , C07K2319/00 , C12N5/10 , G01N33/5058 , G01N2333/4709 , G01N2800/28 , G01N2800/2821 , G01N2800/387
摘要： The disclosure pertains to methods of treating or preventing a disease or condition associated with and/or induced by soluble A-beta oligomer such as Alzheimer's disease by administering to a subject in need thereof conformation specific and/or selective antibodies or binding fragments thereof and related products.
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公开(公告)号：US20230270892A1
公开(公告)日：2023-08-31
申请号：US17801777
申请日：2021-02-25
发明人： Hua YANG , Feng GAO , Paul SCHAFFER , Zheliang YUAN , Chengcheng ZHANG , Francois BENARD , Luke WHARTON
IPC分类号： A61K51/04 , C07D273/00 , A61K51/08
CPC分类号： A61K51/044 , A61K51/088 , C07D273/00
摘要： A chelator having the general structure (I) for chelating ra-diometals such as 225Ac under mild conditions is provided. (I) The chelator can be coupled to a biological targeting moiety to facilitate targeted delivery of the chelated radiometal in a mammalian subject.
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公开(公告)号：US20230256436A1
公开(公告)日：2023-08-17
申请号：US18296954
申请日：2023-04-06
发明人： Pieter R. Cullis , Igor V. Jigaltsev , Robert James Taylor , Timothy Leaver , Andre Wild , Nathan Maurice Belliveau
IPC分类号： B01L3/00 , A61K9/107 , A61K9/127 , B01F23/41 , B01F25/431 , B01F25/433 , B01F33/30 , A61K9/14 , A61K31/704 , A61K47/44 , A61K49/00 , A61J3/00
CPC分类号： B01L3/50273 , A61K9/1075 , A61K9/1271 , A61K9/1277 , B01F23/41 , B01F25/431 , B01F25/4331 , B01F33/30 , A61K9/127 , A61K9/14 , A61K31/704 , A61K47/44 , A61K49/0002 , A61J3/00 , B01L3/502715 , Y10T428/2982 , B01F25/431971 , B01L2200/0605 , B01L2200/0647 , B01L2300/06 , B01L2300/0848 , B01L2300/0867 , B01L2300/18
摘要： Limit size lipid nanoparticles, methods for using the lipid nanoparticles, and methods and systems for making limit size lipid nanoparticles.
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公开(公告)号：US20230235359A1
公开(公告)日：2023-07-27
申请号：US18190737
申请日：2023-03-27
IPC分类号： C12N15/88 , A61K9/127 , A61K31/7088 , A61K47/22 , C12N15/11 , A61K9/14 , C12N15/113
CPC分类号： C12N15/88 , A61K9/1272 , A61K31/7088 , A61K47/22 , C12N15/111 , A61K9/145 , A61K9/146 , C12N15/113 , C12N2320/32 , C12N2310/14
摘要： Lipid particles containing a nucleic acid, devices and methods for making the lipid particles, and methods for using the lipid particles.
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公开(公告)号：US20230206102A1
公开(公告)日：2023-06-29
申请号：US17995068
申请日：2021-04-01
摘要： A method of simulating a quantum computation is provided. The method includes determining, by a first system (110) including one r more first processing units (112), a size parameter of a quantum computation. The quantum computation is configured for solving a computational problem. The size parameter is characteristic of an input size of the computational problem. The method includes communicating, by the first system, the size parameter to a second system (120) including one or more second processing units (122). The method includes communicating, by the second system, a computational key to the first system, wherein the computational key is based on the size parameter of the quantum computation. The method includes performing, by the first system, a simulation of the quantum computation based on the computational key.
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公开(公告)号：US20230157708A1
公开(公告)日：2023-05-25
申请号：US18056210
申请日：2022-11-16
发明人： Robert Meek , Qingan Zhu , Timothy Schwab , Robin John Noel Coope , Jared Slobodan , Scott Young
CPC分类号： A61B17/164 , A61B17/7208 , A61B2017/1602
摘要： Devices for treating a bone and methods of inserting such devices into a bone are disclosed. A device for treating a bone may include a flexible tube, a stiffening mechanism and an actuator. The flexible tube has a distal end and a proximal end. The stiffening mechanism within the flexible tube is configured to cause the flexible tube to become rigid. The actuator is configured to cause the stiffening mechanism to cause the flexible tube to become rigid in response to the actuator being actuated.
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28.发明公开公开(公告)号：US20230149875A1
公开(公告)日：2023-05-18
申请号：US18048308
申请日：2022-10-20
发明人： Xiaotao BI , C. Jim LIM , Shahab SOKHANSANJ , Jianghong PENG , Dening JIA , Ruixu WANG
CPC分类号： B01J8/1818 , B01J8/24 , B01J8/42 , C10B19/00 , C10L5/44 , C10L5/363 , C10L5/406 , C10L9/083 , C10L2290/02 , C10L2290/06 , C10L2290/56 , C10L2290/141
摘要： A fluidized bed reactor for biomass treatment comprising a vessel extending in a first direction from a first end to a second end, an inlet at the first end of the vessel for feeding biomass particles into the vessel, an outlet at the second end of the vessel for outputting processed biomass, a first fluid inlet independently activatable to deliver a first volume of a gas in a second direction into a first region of the vessel, and a second fluid inlet spaced apart from the first fluid inlet in the first direction and independently activatable to deliver a second volume of the gas in the second direction into a second region of the vessel, the second region adjacent the first region.
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公开(公告)号：US11649175B2
公开(公告)日：2023-05-16
申请号：US17093092
申请日：2020-11-09
发明人： Fariborz Taghipour
IPC分类号： C02F1/32 , H05K1/02 , H05K1/18 , H05K7/20 , C02F103/02
CPC分类号： C02F1/325 , H05K1/0204 , H05K1/181 , H05K7/20272 , C02F2103/026 , C02F2201/326 , C02F2201/328 , C02F2201/3222 , C02F2201/3227 , C02F2301/028 , C02F2303/04 , C02F2307/10 , H05K2201/10106
摘要： A UV reactor irradiates a flow of fluid with UV radiation. The reactor comprises: a fluid conduit defined by a heat conducting conduit body comprising one or more heat conducting walls for permitting a flow of fluid therethrough; a UV-LED operatively connected to a PCB and oriented for directing radiation into the fluid conduit. The PCB comprises a heat conducting substrate having a first surface. The conduit body is in thermal contact with the first surface of the heat conducting substrate. Heat is dissipated from the UV-LED via the heat conducting substrate, the thermal contact between the first surface of the heat conducting substrate and the heat conducting conduit body, and from the one or more heat conducting walls of the heat conducting conduit body to the fluid flowing through the fluid conduit.
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公开(公告)号：US20230148361A1
公开(公告)日：2023-05-11
申请号：US17969709
申请日：2022-10-20
发明人： Mathew John MITCHELL , Lukas CHROSTOWSKI , Becky LIN , Kashif Masud AWAN , Shangxuan YU , Donald WITT , Seyediman TAGHAVI
IPC分类号： H01S5/0237 , G02B6/136
CPC分类号： H01S5/0237 , G02B6/136 , G02B2006/12121
摘要： Systems and methods for fabricating a semiconductor chip with an integrated laser diode (or other optical component). An example method may comprise fabricating a recess shaped to receive the optical component. The method may also comprise metallizing at least one surface of the recess. The method may also comprise coupling the optical component to the at least one metallized surface of the recess. The component may comprise a laser diode comprising a p-type semiconductor and an n-type semiconductor. The n-type semiconductor may be electrically coupled to the at least one metallized surface of the recess. The method may also comprise optically coupling an optical output of the laser diode (or other optical component) to an optical input of a photonic interface of the chip with a photonic wire bond and/or at least one polymer lens.
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