公开(公告)号：US10066182B2

公开(公告)日：2018-09-04

申请号：US14399192

申请日：2013-05-07

申请人： Becton Dickinson France

发明人： Virginie Santucci-Aribert ,  Emanuela Rossito

IPC分类号： C10M107/50 ,  B05D5/08 ,  B65D39/00 ,  B05D3/06 ,  A61M5/31 ,  A61L29/06 ,  A61L29/14 ,  C09D183/04 ,  C08G77/20

CPC分类号： C10M107/50 ,  A61L29/06 ,  A61L29/14 ,  A61L2400/10 ,  A61M5/3129 ,  A61M2005/3131 ,  B05D3/068 ,  B05D5/08 ,  B65D39/0005 ,  B65D2539/008 ,  C08G77/20 ,  C09D183/04 ,  C10M2229/0415 ,  C10M2229/0435 ,  C10N2220/022 ,  C10N2230/06 ,  C10N2230/10 ,  C10N2230/68 ,  C10N2240/66 ,  C10N2250/10 ,  C10N2250/121 ,  C08L83/00

摘要： The invention relates to a lubricant coating for a medical container comprising a cross-linked lubricant composition comprising a mixture of non-reactive silicone with reactive silicone, characterized in that the reactive silicone comprises a mixture of vinyl-based silicone and acrylate-based silicone. The invention further relates to a lubricant composition usable as an intermediate product in the fabrication of a lubricant coating. The invention further relates to a medical container comprising a barrel and a stopper in gliding engagement within the barrel, comprising such a lubricant coating. The invention also relates to a process of manufacturing a medical container comprising a barrel and a stopper in gliding engagement within the barrel including depositing a lubricant composition on the inner surface of the barrel and/or on the stopper, and irradiating the coated barrel and/or stopper so as to cross-link the lubricant composition to form a lubricant coating.

公开(公告)号：US10052413B2

公开(公告)日：2018-08-21

申请号：US13829913

申请日：2013-03-14

申请人： Medtronic Vascular, Inc.

发明人： Mingfei Chen

IPC分类号： C08L29/06 ,  A61F2/95 ,  C08K5/20 ,  A61L29/06 ,  A61L29/14 ,  C08K5/00

CPC分类号： A61L29/06 ,  A61F2/95 ,  A61L29/141 ,  C08K5/0016 ,  C08K5/20 ,  C08L77/00 ,  C08L77/02

摘要： A medical device, such as a dilatation balloon, including plasticized nylon, and plasticized nylon.

公开(公告)号：US20180214628A1

公开(公告)日：2018-08-02

申请号：US15940196

申请日：2018-03-29

申请人： Patent Wide International Corporation

发明人： Lih-Chiu WU ,  Hui-Shuan LEE ,  Tze-Yu LEE

IPC分类号： A61M3/02 ,  A61L29/06 ,  A61L29/16 ,  A61L29/04

CPC分类号： A61M3/0279 ,  A61B50/31 ,  A61L29/042 ,  A61L29/06 ,  A61L29/16 ,  A61M3/0208 ,  A61M3/022 ,  A61M3/0262 ,  A61M2210/0618 ,  C08L83/04

摘要： A nasal ejecting catheter for home remedy of nasal irrigation treatment comprises a catheter unit and a connecting unit. The catheter unit comprises an open end, a closed end on the opposite side and a plurality of apertures formed near the closed end. The connection unit comprises a connection portion for connecting the open end of the catheter and an assembling portion for connecting an injection unit. The catheter body is made of silicone, latex, thermoplastic elastomer or other soft material to be operated by the patient. The total area of apertures is smaller than the cross section area of inner lumen of the catheter in order to eject substantially even strength multiple thin spouts.

公开(公告)号：US20180208706A1

公开(公告)日：2018-07-26

申请号：US15745540

申请日：2016-07-15

申请人： Lubrizol Advanced Materials, Inc.

发明人： Jennifer Green ,  John M. Cox ,  Joseph J. Vontorcik, JR. ,  Barbara Morgan

IPC分类号： C08G18/40 ,  C08G18/76 ,  C08G18/42 ,  C08G18/48 ,  C08G18/44 ,  C08G18/34 ,  C08G18/66 ,  C08G18/32 ,  A61L31/06 ,  A61L29/06 ,  A61L27/18 ,  A61K47/34 ,  A61L31/14 ,  A61L29/14 ,  A61L27/58 ,  B33Y70/00 ,  B33Y80/00

CPC分类号： C08G18/4018 ,  A61K47/34 ,  A61L27/18 ,  A61L27/58 ,  A61L29/06 ,  A61L29/148 ,  A61L31/06 ,  A61L31/148 ,  B29C64/118 ,  B29C64/153 ,  B29K2075/00 ,  B29L2031/753 ,  B33Y10/00 ,  B33Y70/00 ,  B33Y80/00 ,  C08G18/0895 ,  C08G18/3206 ,  C08G18/348 ,  C08G18/4238 ,  C08G18/4266 ,  C08G18/4277 ,  C08G18/44 ,  C08G18/4845 ,  C08G18/4854 ,  C08G18/664 ,  C08G18/6666 ,  C08G18/6674 ,  C08G18/76 ,  C08G18/7671

摘要： The invention relates to compositions and methods for solid freeform fabrication of medical devices, components and applications in which the composition includes a thermoplastic polyurethane which is particularly suited for such processing. The useful thermoplastic polyurethanes are derived from (a) an aromatic diisocyanate component, (b) a polyol component, and (c) a chain extender component where the molar ratio of (c) to (b) is at least 4.25.

公开(公告)号：US09987478B2

公开(公告)日：2018-06-05

申请号：US14600611

申请日：2015-01-20

申请人： Cardiac Pacemakers, Inc.

发明人： Adegbola O. Adenusi ,  James P. Rohl ,  David R. Wulfman ,  Joseph T. Delaney, Jr. ,  Adeniyi Aremu

IPC分类号： B29C71/02 ,  A61M39/08 ,  A61M39/00 ,  B32B1/08 ,  B32B5/02 ,  B32B27/08 ,  B32B27/12 ,  D01D5/00 ,  D01D5/098 ,  A61L29/04 ,  A61L29/06 ,  A61L29/08 ,  A61L29/14 ,  A61L31/04 ,  A61L31/06 ,  A61L31/10 ,  A61L31/14 ,  A61N1/05

CPC分类号： A61M39/08 ,  A61L29/041 ,  A61L29/06 ,  A61L29/085 ,  A61L29/145 ,  A61L29/146 ,  A61L31/048 ,  A61L31/06 ,  A61L31/10 ,  A61L31/145 ,  A61L31/146 ,  A61M39/00 ,  A61N1/0541 ,  A61N1/056 ,  B32B1/08 ,  B32B5/02 ,  B32B5/022 ,  B32B27/08 ,  B32B27/12 ,  B32B2262/0238 ,  B32B2535/00 ,  D01D5/0023 ,  D01D5/0076 ,  D01D5/0084 ,  D01D5/0985 ,  Y10T428/1372 ,  C08L71/02 ,  C08L39/06 ,  C08L75/04 ,  C08L83/04

摘要： A method for making a tubular medical device having a hybrid polymeric structure includes forming a first layer comprising a non-woven fibrous matrix made of a first polymeric material and forming a second layer comprising a second polymeric material about the first layer such that at least a portion of the second polymeric material of the second layer embeds into at least a portion of the first polymeric material of the first layer.

公开(公告)号：US20180071169A1

公开(公告)日：2018-03-15

申请号：US15815713

申请日：2017-11-17

申请人： NEOMED, INC.

发明人： Benjamin Martin DAVIS ,  Mark M. COSTELLO ,  Mariann CARY ,  Adrian McDERMOTT

IPC分类号： A61J7/00 ,  A61M39/10 ,  A61L29/04 ,  A61L29/06

CPC分类号： A61J7/0053 ,  A61J11/0035 ,  A61J15/0011 ,  A61J15/0076 ,  A61L29/041 ,  A61L29/06 ,  A61M5/142 ,  A61M39/10 ,  A61M2005/3139 ,  A61M2039/1033 ,  A61M2202/0482

摘要： An improved oral administration coupler for delivery of fluids such as medications and nutritional fluids. Example oral administration couplers have a first end with an applicator for oral delivery to an infant, and a second end with a coupling compatible with an enteral fluid delivery syringe. A fluid delivery conduit extends in fluid communication from the first end to the second end, to deliver fluid from the syringe to the infant. In some example embodiments, the coupler is configured for back-of-mouth delivery, and can comprise a generally elongate and at least partially flexible tube or straw.

公开(公告)号：US09913753B2

公开(公告)日：2018-03-13

申请号：US14424882

申请日：2013-07-31

申请人： KANEKA CORPORATION

发明人： Kohei Fukaya ,  Hidekazu Miyauchi ,  Mariko Matsumoto ,  Eiji Ogino ,  Chihiro Koga

IPC分类号： A61M5/00 ,  A61F9/007 ,  A61L29/04 ,  A61L29/06 ,  A61L29/14

CPC分类号： A61F9/00772 ,  A61L29/041 ,  A61L29/049 ,  A61L29/06 ,  A61L29/14 ,  A61L2430/16 ,  C08L23/06 ,  C08L77/00 ,  C08L75/04 ,  C08L53/02

摘要： The present invention provides a lacrimal duct tube that can be preferably used for the treatment of lacrimal duct obstruction, in particular, sheath guided endoscopic probing having been frequently performed in recent years, the lacrimal duct tube being excellent in passage through a lesion in the lacrimal duct, operability in the lacrimal duct, and manipulation of the endoscope inserted into the lumen of the tube, and providing a sufficient viewing field of the endoscope. The present invention relates to a lacrimal duct tube, including: a pair of tubular members that each has an opening at one end and a hole in a side wall communicating with a lumen; and a connection member that connects other ends of the tubular members, wherein the tubular members each include a plurality of resin portions different in Shore hardness, at least one of the resin portions is positioned between the opening and the hole and forms a lumen wall of the tubular member, and the lumen wall has a Shore hardness of 57D or more.

公开(公告)号：US09895468B2

公开(公告)日：2018-02-20

申请号：US15449752

申请日：2017-03-03

申请人： BAXTER INTERNATIONAL INC. ,  BAXTER HEALTHCARE SA ,  NORTHWESTERN UNIVERSITY

发明人： Ton That Hai ,  John-Bruce Devault Green ,  Timothy Michael Fulghum ,  Phillip Byron Messersmith ,  Tadas Stanislovas Sileika

IPC分类号： A61L29/16 ,  A61L29/08 ,  A61L33/06 ,  A61L33/04 ,  A61L33/00 ,  A61L29/06

CPC分类号： A61L33/0017 ,  A61L27/54 ,  A61L29/06 ,  A61L29/085 ,  A61L29/16 ,  A61L31/048 ,  A61L31/06 ,  A61L31/16 ,  A61L33/0011 ,  A61L33/0094 ,  A61L33/04 ,  A61L33/068 ,  A61L33/08 ,  A61L2300/42 ,  A61L2400/18 ,  A61L2420/02

摘要： The invention provides methods of immobilizing an active agent to a substrate surface, including the steps of, depositing a primer compound on a substrate, thereby forming a primed substrate, contacting the primed substrate with a solution of a compound including a trihydroxyphenyl group, thereby forming a trihydroxyphenyl-treated primed substrate, and contacting the trihydroxyphenyl-treated primed substrate with a solution of an active agent, thereby immobilizing the active agent on the substrate. Further provided are methods of immobilizing an active agent on a substrate, including the steps of providing a substrate, combining a solution of a compound including a trihydroxyphenyl group with a solution of an active agent, thereby forming a solution of an active agent-trihydroxyphenyl conjugate, and contacting the primed substrate with the solution of the active agent-trihydroxyphenyl conjugate, thereby immobilizing the active agent on the substrate. The invention further provides substrates and medical device or device components with active agents immobilized on the surface thereof.

公开(公告)号：US09839709B1

公开(公告)日：2017-12-12

申请号：US15155988

申请日：2016-05-16

申请人： Mark Lawrence Kayton ,  Norma Alcantar ,  Daniel Restrepo ,  Nicholas S. Laconi ,  Audrey Lynn Buttice ,  Michael Pierce Ebaugh

发明人： Mark Lawrence Kayton ,  Norma Alcantar ,  Daniel Restrepo ,  Nicholas S. Laconi ,  Audrey Lynn Buttice ,  Michael Pierce Ebaugh

IPC分类号： A61L2/18 ,  A01N65/08 ,  A61L33/00 ,  A61L33/18 ,  A61L29/08 ,  A61L29/06 ,  A61L29/00

CPC分类号： A61L2/18 ,  A01N31/02 ,  A01N65/08 ,  A61L29/005 ,  A61L29/06 ,  A61L29/08 ,  A61L33/0011 ,  A61L33/18 ,  A61L2300/404 ,  A61L2300/42

摘要： Provided herein is a method of reducing a microbial infection of a heparinized surface wherein heparin precipitation is reduced as compared to a control. In some embodiments a composition comprising ethanol and isopropanol is applied to the surface. In other embodiments, two or more ethanol compositions are applied and removed sequentially from the surface prior to contacting the surface with a biological fluid, tissue or vessel, wherein the composition in each successive administration comprises an increased amount of ethanol. Also provided is a method of reducing a microbial infection of a surface comprising applying a mucilage extract from an Opuntia ficus indica species to the surface.

公开(公告)号：US09814805B2

公开(公告)日：2017-11-14

申请号：US14786842

申请日：2014-04-25

申请人： INNOVATIVE SURFACE TECHNOLOGIES, INC.

发明人： Kristin Taton ,  Lawin Laurie ,  Patrick Guire

IPC分类号： A61L29/08 ,  A61L27/54 ,  A61L31/16 ,  A61L31/10 ,  A61L27/34 ,  A61L29/16 ,  A61L29/10 ,  A61L29/06

CPC分类号： A61L29/085 ,  A61L27/34 ,  A61L27/54 ,  A61L29/06 ,  A61L29/106 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/104 ,  A61L2300/206 ,  A61L2300/602 ,  A61L2300/608 ,  A61L2420/02 ,  A61L2420/08 ,  C08L83/04

摘要： The present disclosure relates to multilayer coatings that include a hydrophobic encasing layer and allow controlled release of a water soluble drug. The encasing layer encases water soluble, or hydrophilic, drugs with a flexible layer and comes in good intimate contact with the water soluble drug layer. Thus, the encasing layer conforms to the water soluble drug and can control the release of the drug. Advantageously, major cuts or fissures in the coating do not cause the water soluble drug to leak or burst out; rather, the encasing layer continues to provide modulated release of the drug. The present disclosure also includes methods of making the multilayer coatings, methods of using the multilayer coatings, and articles that include the multilayer coatings.