公开(公告)号：US11841376B2

公开(公告)日：2023-12-12

申请号：US17301063

申请日：2021-03-23

Applicant: Illumina, Inc.

Inventor： Bradley Kent Drews ,  Kevin James Cappa

IPC: G01N35/10 ,  B01L3/00 ,  B01L3/02

CPC classification number: G01N35/1016 ,  B01L3/0293 ,  B01L3/50273 ,  B01L3/502715 ,  B01L3/502738 ,  G01N35/1002 ,  G01N35/1009 ,  G01N35/1097 ,  B01L2200/027 ,  B01L2200/143 ,  B01L2200/16 ,  B01L2300/024 ,  B01L2300/0877 ,  B01L2400/0478 ,  B01L2400/0622 ,  G01N2035/1025

Abstract: A system includes a reagent selector valve controllable to select a reagent flow path from a plurality of reagent flow paths, and a pump coupled to the reagent flow path to draw a liquid through the reagent flow path in accordance with a prescribed test protocol. The system includes a discharge flow path to expel the drawn liquid, and a flow meter to measure liquid displaced by the pump and that outputs data representative of the measured flow. The system also includes a processor to access the data and to determine a volume of the liquid displaced by the pump.

公开(公告)号：US11815523B2

公开(公告)日：2023-11-14

申请号：US18248127

申请日：2021-10-06

Applicant: Siemens Healthcare Diagnostics Inc.

Inventor： William D. Dunfee ,  Mark H. Sprenkle ,  Colin Ingersoll

IPC: G01N35/10 ,  G01N35/00

CPC classification number: G01N35/1009 ,  G01N35/0099 ,  G01N35/1002 ,  G01N2035/1025

Abstract: A method of detecting a level of a liquid in a well of a container. The method includes looking up an expected liquid level of the liquid in the well of a container; measuring and recording a measured liquid level of the liquid in the well; changing a level of the liquid in the well based upon an expected amount of the liquid to be added or removed; and calculating a next expected liquid level at least in part based on multi-point filtering. Apparatus for carrying out the method are provided, as are other aspects.

公开(公告)号：US11767549B2

公开(公告)日：2023-09-26

申请号：US17137807

申请日：2020-12-30

Applicant: AKONNI BIOSYSTEMS, INC.

Inventor： Christopher G. Cooney ,  Rebecca Holmberg ,  Phillip Belgrader ,  Peter Qiang Qu

IPC: C12Q1/68 ,  C12Q1/6806 ,  G01N35/10 ,  B01L3/00 ,  B01L9/06 ,  G01N35/00 ,  C12N1/06 ,  C12N13/00 ,  C12Q1/689

CPC classification number: C12Q1/6806 ,  B01L3/5082 ,  B01L3/52 ,  B01L9/06 ,  C12N1/066 ,  C12N13/00 ,  C12Q1/689 ,  G01N35/0099 ,  G01N35/1002 ,  B01L2300/0609 ,  B01L2300/0832

Abstract: An integrated sample purification system includes a housing, a sample container rack, a filter holder, and a cylindrical magnet. The sample container rack and the filter device holder are disposed in the housing. The sample container rack is configured to hold one or more sample containers, the filter device holder is configured to hold one or more filter devices. The cylindrical magnet is adjacent to and external to the sample container rack, and is rotated about a central, longitudinal axis of the magnet by an electric motor disposed in the housing to lyse cells. Molecules of interest in the lysed cells are purified using filters that bind specifically to the molecules of interest. The system is readily amenable to automation and rapid purification and analysis of molecules of interest, such as nucleic acids and proteins.

公开(公告)号：US11754554B2

公开(公告)日：2023-09-12

申请号：US15403553

申请日：2017-01-11

Applicant: Labrador Diagnostics LLC

Inventor： Shaunak Roy ,  Melissa Takahashi ,  Ian Gibbons ,  Edmond Ku ,  Thanh Dang ,  Tammy Burd ,  Adam Vollmer ,  Elizabeth A. Holmes

IPC: G01N33/53 ,  G01N35/10 ,  G01N33/49 ,  G01N27/07 ,  G01N33/86 ,  G01N27/06

CPC classification number: G01N33/5304 ,  G01N27/07 ,  G01N33/49 ,  G01N33/5302 ,  G01N33/86 ,  G01N35/1002 ,  G01N27/06 ,  G01N2201/12746 ,  G01N2800/52 ,  Y10S435/973 ,  Y10S436/809 ,  Y10T436/106664

Abstract: The present invention provides fluidic devices and systems that allow detection of analytes from a biological fluid. The methods and devices are particularly useful for providing point-of-care testing for a variety of medical applications.

公开(公告)号：US20230184801A1

公开(公告)日：2023-06-15

申请号：US17915957

申请日：2021-01-15

Applicant: Hitachi High-Tech Corporation

Inventor： Ruochi HSU ,  Nobuhiro TSUKADA ,  Kazuhiro NODA ,  Shinya MATSUOKA

IPC: G01N35/10

CPC classification number: G01N35/1009 ,  G01N35/1002

Abstract: [Problem to be solved]
There is provided a dispensing control method and a dispenser that suppress the division of an air layer and that obtain high dispensing accuracy.
[Solution]
An automatic analyzer includes: a nozzle 20 that dispenses a dispensed liquid 23; a syringe motor 209 that generates a pressure fluctuation for controlling a flow velocity on aspiration or discharge of the dispensed liquid 23 in the nozzle 20; a piping 210 that connects the nozzle 20 to the syringe motor 209; and a controller 102 that controls operations of the nozzle 20 and the syringe motor 209. The controller 102 calculates positions of interfaces 31 to 34 in the piping 210, and the controller 102 controls the flow velocity based on the positions of the interface 31 to 34 and orientations of the interfaces 31 to 34 that move.

公开(公告)号：US20230160917A1

公开(公告)日：2023-05-25

申请号：US17919355

申请日：2021-02-03

Applicant: HITACHI HIGH-TECH CORPORATION

Inventor： Shunsuke MIYAMOTO ,  Hiroyuki MISHIMA ,  Hajime YAMAZAKI ,  Takeshi SETOMARU ,  Akihiro YASUI

IPC: G01N35/10 ,  G01N35/00

CPC classification number: G01N35/1002 ,  G01N35/00732 ,  G01N2035/00891

Abstract: An automatic analyzer includes: a plurality of dispensing units; and a plurality of pump units connected to the respective dispensing units. Each of the plurality of pump units includes: a syringe tube that has a liquid port at one end and an opening at another end; a syringe base that is attached to the opening at the other end of the syringe tube; a plunger that penetrates the syringe base and whose tip end is inserted inside the syringe tube; a seal piece that is configured to seal a gap between the plunger and the syringe base; an actuator; and a power transmission mechanism that connects the actuator and the plunger. Each plunger of the plurality of pump units has an individually set diameter and a different thickness. At least one of the syringe base and the syringe tube represents the diameter of the corresponding plunger in appearance.

公开(公告)号：US20190232291A1

公开(公告)日：2019-08-01

申请号：US16309665

申请日：2017-06-14

Applicant: Diatron MI Zrt.

Inventor： Dániel Gergely Isztli ,  Barna Reskó ,  Bence Salló

IPC: B01L3/00 ,  B05B9/047 ,  G01N35/10

CPC classification number: B01L3/527 ,  B01L3/523 ,  B01L2200/0684 ,  B01L2200/16 ,  B01L2300/048 ,  B01L2300/049 ,  B01L2300/123 ,  B01L2400/0481 ,  B05B9/047 ,  B05B12/1418 ,  G01N35/1002

Abstract: A reagent pack includes a first reservoir having a continuous rigid wall defining a constant inner space that opens to the ambient environment. An air-tight second reservoir has a flexible wall that defines a variable inner space with one or more second openings. The second reservoir is arranged within the first reservoir and stores fluid reagent. A closure element completely fills the first opening of the first reservoir and includes a first fluid passage fluidly connecting the inner space of the first reservoir, as the waste reservoir, to receive waste liquid. Second fluid passages fluidly connect the second openings of said second reservoirs with respective reagent inlets to supply fluid reagent to the sample analyzer. The inner space of the first reservoir further includes an air passage to allow gaseous communication with the ambient environment to maintain a controlled pressure within said inner space while receiving waste liquid.

公开(公告)号：US20190232285A1

公开(公告)日：2019-08-01

申请号：US16378940

申请日：2019-04-09

Applicant: Research & Business Foundation Sungkyunkwan University ,  CDgene Inc

Inventor： Jae Chern YOO

IPC: B01L3/00 ,  G01J1/02 ,  G01N35/00 ,  F16K99/00 ,  G01N35/10

CPC classification number: B01L3/502738 ,  B01L2200/143 ,  B01L2300/0803 ,  B01L2300/087 ,  B01L2300/0874 ,  B01L2300/0887 ,  B01L2300/12 ,  B01L2300/1827 ,  B01L2300/1861 ,  B01L2400/0409 ,  B01L2400/0683 ,  F16K99/003 ,  F16K99/004 ,  F16K2099/008 ,  F16K2099/0084 ,  G01J1/0204 ,  G01N35/00069 ,  G01N35/1002 ,  G01N35/1097 ,  G01N2035/00247 ,  G01N2035/00267

Abstract: A thin film valve includes at least one chamber for storing a fluid required for biological/chemical analysis, a plurality of chamber for performing a biological/biochemical reaction, or connecting, at least one chamber performing the biological or biochemical reaction to enable a movement of the fluid flow, a flow path arranged to communicate with the hole on the flow path, a thin film closing membrane for closing the fluid hole, a thin film valve including the hole and the fluid hole closing membrane, a multilayered plurality of substrates forming the fluid path, the fluid hole and the chamber, a rotatable disk forming the fluid path, fluid hole, the plurality of chambers, a heat generator, laser beam generator heating the thin film valves, a light detector for detecting amount of light passing through the membrane and closing the fluid hole, and a feedback controller for controlling the focusing actuator.

公开(公告)号：US20190204347A1

公开(公告)日：2019-07-04

申请号：US16234910

申请日：2018-12-28

Applicant: JEOL Ltd.

Inventor： Shinichi Tomii

IPC: G01N35/00 ,  G01N35/10 ,  G01N35/02

CPC classification number: G01N35/00732 ,  G01N35/025 ,  G01N35/1002 ,  G01N2035/00891

Abstract: A biochemical analyzer has a control section which outputs the results of analysis of measurement values from a reactant measured by a multi-wavelength photometer to a host device through a communication section. The control section causes both analyte identification information for identifying the analyte instructed to be retested through the communication section from the host device and analyte receptacle positional information indicative of the position of a sample receptacle receiving the analyte instructed to be retested from the host device on a sample turntable to be displayed on a display unit.

公开(公告)号：US20190203252A1

公开(公告)日：2019-07-04

申请号：US16297356

申请日：2019-03-08

Applicant: Accelerate Diagnostics, Inc.

Inventor： Austin Ashby ,  Wayne Showalter ,  Jasmin Cote

IPC: C12Q1/02 ,  G01N21/64 ,  G01N35/10 ,  G01N35/02 ,  H04N5/232 ,  C12Q1/04 ,  G01N1/38 ,  G02B7/28 ,  G01N15/06 ,  B01L3/00

CPC classification number: C12Q1/025 ,  B01L3/527 ,  B01L2300/0893 ,  C12Q1/04 ,  G01N1/38 ,  G01N15/06 ,  G01N21/6458 ,  G01N35/025 ,  G01N35/1002 ,  G01N2015/0693 ,  G01N2021/6419 ,  G01N2035/00346 ,  G01N2035/0443 ,  G01N2035/0444 ,  G01N2035/0446 ,  G01N2035/0455 ,  G01N2035/1032 ,  G02B7/28 ,  H04N5/23212

Abstract: A system for automated microorganism identification and antibiotic susceptibility testing comprising a reagent cartridge, a reagent stage, a cassette, a cassette, stage, a pipettor assembly, an optical detection system, and a controller is disclosed. The system is designed to dynamically adjust motor idle torque to control heat load and employs a fast focus process for determining the true focus position of an individual microorganism. The system also may quantify the relative abundance of viable microorganisms in a sample using dynamic dilution, and facilitate growth of microorganisms in customized media for rapid, accurate antimicrobial susceptibility testing.