公开(公告)号：US20130178536A1

公开(公告)日：2013-07-11

申请号：US13744719

申请日：2013-01-18

Applicant: STC. UNM

Inventor： David L. Vander Jagt ,  Lorraine M. Deck ,  Robert E. Royer ,  John E. Heidrich ,  Laurel O. Sillerud

IPC: A61K31/136 ,  A61K31/05 ,  A61K31/085

CPC classification number: A61K31/136 ,  A61K31/05 ,  A61K31/085 ,  A61K31/381 ,  A61K31/44 ,  A61K31/525 ,  A61K31/66 ,  C07D213/30 ,  C07D333/16

Abstract: The present invention relates to method(s) of treating a subject afflicted with cancer or a precancerous condition, an inflammatory disease or condition, and/or stroke or other ischemic disease or condition, the method comprising administering to the subject or patient in need a composition comprising a therapeutically effective amount of a substituted cis or trans-stilbene. A method of treating or reducing the likelihood of Alzheimer's disease in a patient is an additional embodiment of the present invention.

Abstract translation: 本发明涉及治疗患有癌症或癌前病症，炎性疾病或病症，和/或中风或其他缺血性疾病或病症的受试者的方法，所述方法包括对需要的受试者或患者施用 组合物，其包含治疗有效量的取代的顺式或反式二苯乙烯。 治疗或降低患者中阿尔茨海默氏病的可能性的方法是本发明的另外的实施方案。

公开(公告)号：US20130175501A1

公开(公告)日：2013-07-11

申请号：US13783219

申请日：2013-03-01

Applicant: STC.UNM

Inventor： Stephen D. Hersee ,  Xin Wang ,  Xinyu Sun

IPC: H01L21/02 ,  H01L29/20 ,  H01L29/04

CPC classification number: H01L29/413 ,  B82Y10/00 ,  B82Y20/00 ,  B82Y30/00 ,  C30B29/60 ,  H01L21/0237 ,  H01L21/02458 ,  H01L21/0254 ,  H01L21/02573 ,  H01L21/02603 ,  H01L21/02609 ,  H01L21/02612 ,  H01L21/0262 ,  H01L21/02636 ,  H01L21/02639 ,  H01L21/02642 ,  H01L29/045 ,  H01L29/0676 ,  H01L29/2003 ,  H01L29/775 ,  H01L31/0304 ,  H01L31/035236 ,  H01L31/184 ,  H01L33/18 ,  H01L33/24 ,  H01L2221/1094 ,  H01L2924/0002 ,  H01S5/1042 ,  H01S5/1835 ,  H01S5/18369 ,  H01S5/3428 ,  Y02E10/544 ,  Y02P70/521 ,  Y10S977/762 ,  Y10S977/816 ,  Y10T428/24612 ,  H01L2924/00

Abstract: Exemplary embodiments provide semiconductor devices including high-quality (i.e., defect free) group III-N nanowires and uniform group III-N nanowire arrays as well as their scalable processes for manufacturing, where the position, orientation, cross-sectional features, length and the crystallinity of each nanowire can be precisely controlled. A pulsed growth mode can be used to fabricate the disclosed group III-N nanowires and/or nanowire arrays providing a uniform length of about 10 nm to about 1000 microns with constant cross-sectional features including an exemplary diameter of about 10-1000 nm. In addition, high-quality GaN substrate structures can be formed by coalescing the plurality of GaN nanowires and/or nanowire arrays to facilitate the fabrication of visible LEDs and lasers. Furthermore, core-shell nanowire/MQW active structures can be formed by a core-shell growth on the nonpolar sidewalls of each nanowire.

Abstract translation: 示例性实施例提供包括高质量（即，无缺陷）III-N族纳米线和均匀III-N纳米线阵列的半导体器件及其可制造的可扩展工艺，其中位置，取向，横截面特征，长度和 可以精确地控制每个纳米线的结晶度。 可以使用脉冲生长模式来制造公开的提供约10nm至约1000微米的均匀长度的III-N族纳米线和/或纳米线阵列，其具有恒定的横截面特征，包括约10-1000nm的示例性直径。 此外，可以通过聚结多个GaN纳米线和/或纳米线阵列来形成高质量的GaN衬底结构，以便制造可见的LED和激光器。 此外，核 - 壳纳米线/ MQW活性结构可以通过在每个纳米线的非极性侧壁上的核 - 壳生长形成。

公开(公告)号：US20130146995A1

公开(公告)日：2013-06-13

申请号：US13764558

申请日：2013-02-11

Applicant: STC.UNM

Inventor： Jingkuang Chen

IPC: B06B1/06

CPC classification number: B06B1/06 ,  A61B1/041 ,  A61B8/12 ,  A61B8/4472 ,  A61B8/4488 ,  A61B8/4494 ,  B06B1/0292 ,  B81B2201/0271 ,  B81C1/00095 ,  B81C3/008 ,  G01S15/8929 ,  Y10T29/42

Abstract: Systems, apparatus, and associated methods of forming the systems and/or apparatus may include imaging devices that may comprise multiple arrays of ultrasonic transducer elements for use in a variety of applications. These multiple arrays of ultrasonic transducer elements can be arranged to form a three-dimensional imaging device. Non-coplanar arrays of ultrasonic transducer elements can be coupled together. These imaging devices may be used as medical imaging devices. Additional apparatus, systems, and methods are disclosed.

Abstract translation: 形成系统和/或装置的系统，装置和相关联的方法可以包括可以包括用于各种应用的超声换能器元件的多个阵列的成像装置。 这些多个超声波换能器阵列阵列可被布置成形成三维成像装置。 非共面阵列的超声换能器元件可以耦合在一起。 这些成像装置可以用作医疗成像装置。 公开了附加装置，系统和方法。

公开(公告)号：US08455265B2

公开(公告)日：2013-06-04

申请号：US12529390

申请日：2008-02-29

Applicant: David G. Whitten ,  Sireesha Chemburu ,  Thomas Corbitt ,  Linnea Ista ,  Gabriel Lopez ,  Kirk S. Schanze ,  Motokatsu Ogawa ,  Eunkyung Ji

Inventor： David G. Whitten ,  Sireesha Chemburu ,  Thomas Corbitt ,  Linnea Ista ,  Gabriel Lopez ,  Kirk S. Schanze ,  Motokatsu Ogawa ,  Eunkyung Ji

IPC: G01N33/552 ,  G01N33/543

CPC classification number: C07K17/08 ,  C07K1/1077 ,  G01N33/542 ,  G01N33/54313 ,  Y10T436/14 ,  Y10T436/141111 ,  Y10T436/142222 ,  Y10T436/143333 ,  Y10T436/144444 ,  Y10T436/145555 ,  Y10T436/146666 ,  Y10T436/147777

Abstract: A surface grafted conjugated polyelectrolyte (CPE) is formed by coupling a CPE by a coupling moiety to the surface of a substrate. The substrate can be of any shape and size, and for many uses of the surface grafted CPE, it is advantageous that the substrate is a nanoparticle or microparticle. Surface grafted CPEs are presented that use silica particles as the substrate, where a modified silane coupling agent connects the surface to the CPE by a series of covalent bonds. Two methods of preparing the surface grafted CPEs are presented. One method involves the inclusion of the surface being modified by the coupling agent and condensed with monomers that form the CPE in a grafted state to the substrate. A second method involves the formation of a CPE with terminal groups that are complimentary to functionality that has been placed on the surface of the substrate by reaction with a coupling agent. The surface grafted CPEs are also described for use as biosensors and biocides.

Abstract translation: 表面接枝共轭聚电解质（CPE）通过将CPE通过偶联部分偶联到基材的表面而形成。 衬底可以是任何形状和尺寸，并且对于表面接枝CPE的许多用途，衬底是纳米颗粒或微粒是有利的。 提出了使用二氧化硅颗粒作为底物的表面接枝CPE，其中改性的硅烷偶联剂通过一系列共价键将表面连接到CPE。 提出了两种制备表面接枝CPE的方法。 一种方法包括包含被偶联剂改性的表面，并与接枝状态的形成CPE的单体冷凝。 第二种方法包括形成具有末端基团的CPE，其与通过与偶联剂反应放置在基底表面上的官能度互补。 表面接枝的CPE也被描述为用作生物传感器和杀生物剂。

公开(公告)号：US20130127464A1

公开(公告)日：2013-05-23

申请号：US13717412

申请日：2012-12-17

Applicant: STC.UNM

Inventor： Laurel Sillerud ,  Todd M. Alam ,  Andrew F. McDowell

IPC: G01R33/465

CPC classification number: G01R33/32 ,  B82Y15/00 ,  G01N24/08 ,  G01N33/54326 ,  G01N33/553 ,  G01R33/281 ,  G01R33/302 ,  G01R33/34007 ,  G01R33/34046 ,  G01R33/34092 ,  G01R33/341 ,  G01R33/465 ,  G01R33/5601

Abstract: A biological detector includes a conduit for receiving a fluid containing one or more magnetic nanoparticle-labeled, biological objects to be detected and one or more permanent magnets or electromagnet for establishing a low magnetic field in which the conduit is disposed. A microcoil is disposed proximate the conduit for energization at a frequency that permits detection by NMR spectroscopy of whether the one or more magnetically-labeled biological objects is/are present in the fluid.

公开(公告)号：US08446592B1

公开(公告)日：2013-05-21

申请号：US12535509

申请日：2009-08-04

Applicant: Ladan Arissian ,  Jean-Claude Diels

Inventor： Ladan Arissian ,  Jean-Claude Diels

IPC: G01B9/02 ,  G01B11/02

CPC classification number: G01B9/02003 ,  B82Y35/00 ,  G01B9/02014 ,  G01B9/02092 ,  G01B2290/35

Abstract: A Scanning Phase Intracavity Nanoscope as a measurement system can be realized with a reference laser cavity and a sample laser cavity superimposed upon each other to operatively propagate two laser beams. The sample laser cavity is operatively formed by the sample to be measured. A measurement of the sample is based on differences in the reference laser cavity and the sample laser cavity determined from difference in the two laser beams.

Abstract translation: 作为测量系统的扫描相位腔内纳米镜可以通过相互叠加的参考激光腔和样品激光腔实现，以可操作地传播两个激光束。 样品激光腔由待测样品可操作地形成。 样品的测量基于参考激光腔和由两个激光束的差异确定的样品激光腔的差异。

公开(公告)号：US08394839B2

公开(公告)日：2013-03-12

申请号：US12674188

申请日：2008-08-20

Applicant: Graham Timmins ,  Vojo P Deretic

Inventor： Graham Timmins ,  Vojo P Deretic

IPC: A61K31/4409 ,  C07D213/86

CPC classification number: C07D213/81 ,  A61K9/0019 ,  A61K9/0073 ,  A61K31/44 ,  A61K31/4409 ,  C07D213/83 ,  C07D213/86

Abstract: The present invention relates to the use of isotopically labeled derivatives of isoniazid, ethionamide and related compounds as effective therapy for the treatment of mycobacterial diseases, including Mycobacterium tuberculosis.

Abstract translation: 本发明涉及异烟肼，乙硫异烟胺和相关化合物的同位素标记衍生物在治疗分枝杆菌疾病（包括结核分枝杆菌）中的有效疗法。

公开(公告)号：US20130054670A1

公开(公告)日：2013-02-28

申请号：US13643844

申请日：2011-04-28

Applicant: Roy William Keyes ,  Christian Romano ,  Shuang Luan ,  Dorian C. Arnold

Inventor： Roy William Keyes ,  Christian Romano ,  Shuang Luan ,  Dorian C. Arnold

IPC: G06F19/00 ,  G06F15/16

CPC classification number: G06F19/3481 ,  G06F9/5083 ,  G06F19/00 ,  G16H50/50

Abstract: A method of calculating radiation fluence and energy deposition distributions on a networked virtual computational cluster is presented. With this method, complex Monte Carlo simulations that require expansive equipment, personnel, and financial resources can be done efficiently and inexpensively by hospitals and clinics requiring radiation therapy dose calculations.

Abstract translation: 提出了一种在网络虚拟计算群上计算辐射能量密度和能量沉积分布的方法。 通过这种方法，复杂的蒙特卡洛模拟需要广泛的设备，人员和财务资源，可以由需要放射治疗剂量计算的医院和诊所进行有效和低成本的处理。

公开(公告)号：US08378296B1

公开(公告)日：2013-02-19

申请号：US13080392

申请日：2011-04-05

Applicant: Christie Enke

Inventor： Christie Enke

IPC: B01D59/44 ,  H01J49/00

CPC classification number: H01J49/40 ,  H01J49/025

Abstract: Methods and instruments for high dynamic range analysis of sample components are described. A sample is subjected to time-dependent separation, ionized, and the ions dispersed with a constant integration time across an array of detectors according to the ions m/z values. Each of the detectors in the array has a dynamically adjustable gain or a logarithmic response function, producing an instrument capable of detecting a ratio of responses or 4 or more orders of magnitude.

Abstract translation: 描述了样品组分高动态范围分析的方法和仪器。 根据离子m / z值，将样品经受时间依赖性分离，电离和离子以恒定积分时间分布在检测器阵列上。 阵列中的每个检测器具有可动态调节的增益或对数响应函数，产生能够检测响应比例或4个或更多个数量级的仪器。

公开(公告)号：US20130017210A1

公开(公告)日：2013-01-17

申请号：US13583047

申请日：2011-03-17

Applicant: David S. Peabody ,  Bryce Chackerian

Inventor： David S. Peabody ,  Bryce Chackerian

IPC: A61K39/395 ,  A61P31/12 ,  A61P35/02 ,  C12N1/21 ,  C12N15/63 ,  C12N15/11 ,  C40B50/06 ,  C40B30/04 ,  A61P35/00 ,  G01N33/574

CPC classification number: C12N15/1037 ,  C07K16/005 ,  C07K2317/622 ,  C07K2319/00 ,  C12N7/00 ,  C12N2795/16023 ,  C12N2795/16061 ,  C12N2795/18023 ,  C12N2795/18061

Abstract: The invention enables the display of antibody single-chain variable fragments (scFv's on virus-like particles (VLPs) of bacteriophages such as MS2. The VLPs encapsidate mRNA encoding the coat protein from which it assembles, enabling the recovery by reverse transcription and PGR of affinity-selected sequences from scFv libraries. Related virus-like particles, method for constructing a library of scFv-VLPs, drug delivery vehicles comprising one or more pharmaceutically-active ingredients, biomedical imaging agents, assays, and kits are also provided.

Abstract translation: 本发明使得能够显示抗体单链可变片段（scFv在噬菌体如MS2的病毒样颗粒（VLP）上），VLP包裹编码其组装的外壳蛋白的mRNA，使得能够通过逆转录和PGR 还提供了相关病毒样颗粒，用于构建scFv-VLPs文库的方法，包含一种或多种药物活性成分的药物递送载体，生物医学成像剂，测定法和试剂盒。