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    Primers for exons of variants of RHCE and RHD genes
    33.
    发明授权
    Primers for exons of variants of RHCE and RHD genes 有权
    RHCE和RHD基因变体外显子的引物

    公开(公告)号：US07612193B2

    公开(公告)日：2009-11-03

    申请号：US12206859

    申请日：2008-09-09

    Applicant: Ghazala Hashmi ,  Michael Seul ,  Marion E. Reid ,  Michael Pierce

    Inventor： Ghazala Hashmi ,  Michael Seul ,  Marion E. Reid ,  Michael Pierce

    IPC: C07H21/04 ,  C12N15/12

    CPC classification number: C12Q1/6881 ,  C12Q2600/156 ,  C12Q2600/16

    Abstract: Disclosed are a method and an algorithm for genetic cross-matching based on the comparison of recipient and donor genotypes—and the underlying combinations of alleles and haplotypes. The method of the invention, rather than focusing on phenotype prediction, instead relies on a comparison of genetic variants identified in the recipient and available donors, whose information preferably will be compiled in a widely available donor registry, to maximize molecular compatibility. The genotypes can be matched based on the weighted clinical significance of a genotypic difference between donor and recipient, such that certain mismatches are more acceptable than others.

    Abstract translation: 公开了基于接受者和供体基因型的比较以及等位基因和单体型的潜在组合的遗传交叉匹配的方法和算法。 本发明的方法而不是侧重于表型预测，而是依赖于在接受者和可用供体中鉴定的遗传变异体的比较，其信息优选地将在广泛可用的供体登记册中编译，以最大化分子相容性。 可以基于供体和受体之间的基因型差异的加权临床意义来匹配基因型，使得某些错配比其他错配更可接受。

    Analysis, secure access to, and transmission of array images
    34.
    发明授权
    Analysis, secure access to, and transmission of array images 有权
    分析，安全访问和传输阵列图像

    公开(公告)号：US07526114B2

    公开(公告)日：2009-04-28

    申请号：US10714203

    申请日：2003-11-14

    Applicant: Xiongwu Xia ,  Michael Seul ,  Chiu Chau ,  Scott Determan

    Inventor： Xiongwu Xia ,  Michael Seul ,  Chiu Chau ,  Scott Determan

    IPC: G06K9/00

    CPC classification number: G06T7/0012 ,  G01N33/566 ,  G06K9/00 ,  G06K9/00147 ,  G06K2209/07 ,  G06T7/11 ,  G06T7/155 ,  G06T7/33 ,  G06T2207/10064 ,  G06T2207/20152 ,  G06T2207/30072

    Abstract: Systems and methods are provided the autocentering, autofocusing, acquiring, decoding, aligning, analyzing and exchanging among various parties, images, where the images are of arrays of signals associated with ligand-receptor interactions, and more particularly, ligand-receptor interactions where a multitude of receptors are associated with microparticles or microbeads. The beads are encoded to indicate the identity of the receptor attached, and therefore, an assay image and a decoding image are aligned to effect the decoding. The images or data extracted from such images can be exchanged between de-centralized assay locations and a centralized location where the data are analyzed to indicate assay results. Access to data can be restricted to authorized parties in possession of certain coding information, so as to preserve confidentiality.

    Abstract translation: 系统和方法提供了各方之间的自动对中，自动聚焦，获取，解码，对齐，分析和交换，其中图像是与配体 - 受体相互作用相关联的信号阵列，更具体地，配体 - 受体相互作用，其中 许多受体与微粒或微珠相关。 编码珠子以指示所连接的受体的身份，因此，分析图像和解码图像被对准以实现解码。 从这样的图像提取的图像或数据可以在非集中测定位置和数据被分析以指示测定结果的集中位置之间交换。 访问数据可以限于拥有某些编码信息的授权方，以保护机密性。

    Primers for Exons of Variants of RhCE and RhD Genes
    35.
    发明申请
    Primers for Exons of Variants of RhCE and RhD Genes 有权
    RhCE和RhD基因变异外显子的引物

    公开(公告)号：US20090054636A1

    公开(公告)日：2009-02-26

    申请号：US12206859

    申请日：2008-09-09

    Applicant: Ghazala Hashmi ,  Michael Seul ,  Marion E. Reid ,  Michael Pierce

    Inventor： Ghazala Hashmi ,  Michael Seul ,  Marion E. Reid ,  Michael Pierce

    IPC: C07H21/04

    CPC classification number: C12Q1/6881 ,  C12Q2600/156 ,  C12Q2600/16

    Abstract: Disclosed are a method and an algorithm for genetic cross-matching based on the comparison of recipient and donor genotypes—and the underlying combinations of alleles and haplotypes. The method of the invention, rather than focusing on phenotype prediction, instead relies on a comparison of genetic variants identified in the recipient and available donors, whose information preferably will be compiled in a widely available donor registry, to maximize molecular compatibility. The genotypes can be matched based on the weighted clinical significance of a genotypic difference between donor and recipient, such that certain mismatches are more acceptable than others.

    Abstract translation: 公开了基于接受者和供体基因型的比较以及等位基因和单体型的潜在组合的遗传交叉匹配的方法和算法。 本发明的方法而不是侧重于表型预测，而是依赖于在接受者和可用供体中鉴定的遗传变异体的比较，其信息优选地将在广泛可用的供体登记册中编译，以最大化分子相容性。 可以基于供体和受体之间的基因型差异的加权临床意义来匹配基因型，使得某些错配比其他错配更可接受。

    Method for Selecting Desired level of Dye Loading and Controlling Loading of Polymer Microparticles
    37.
    发明申请
    Method for Selecting Desired level of Dye Loading and Controlling Loading of Polymer Microparticles 审中-公开
    选择染料加载和控制聚合物微粒负载水平的方法

    公开(公告)号：US20080282483A1

    公开(公告)日：2008-11-20

    申请号：US11685875

    申请日：2007-03-14

    Applicant: Sukanta Banerjee ,  Cecilia Georgescu ,  Michael Seul

    Inventor： Sukanta Banerjee ,  Cecilia Georgescu ,  Michael Seul

    IPC: D06P3/79 ,  D06P3/04 ,  D06P3/00

    CPC classification number: C08J3/212 ,  C08J3/215 ,  C08J3/22 ,  C08J2325/08

    Abstract: Solute-loaded polymer microparticles are obtained by immersing microparticles in a bath comprising a selected solute dissolved in a ternary solvent system. A first solvent of the ternary system is a strong solvent for both the solute and the polymer from which the microparticle was formed. A second solvent is a weak solvent or non-solvent for the solute and the polymer (tuning solvent). A third solvent is a weak solvent or non-solvent for the solute and polymer, but serves as a co-solvent with respect to the first and second solvents in that it is miscible with both the first and second solvents. The amount of solute incorporated into the microparticles is controlled by adjusting the ratio of solute with respect to the microparticle polymer, and by adjusting the composition of the ternary solvent system, principally the amount of tuning solvent. The method is particularly useful for providing libraries of combinatorially encoded microparticles containing distinguishable dye loadings, particularly distinguishable fluorescent dye loadings.

    Abstract translation: 通过将微粒浸入包含溶解在三元溶剂系统中的选定溶质的浴中来获得溶质负载的聚合物微粒。 三元体系的第一溶剂是溶质和形成微粒的聚合物的强溶剂。 第二溶剂是用于溶质和聚合物（调谐溶剂）的弱溶剂或非溶剂。 第三溶剂是用于溶质和聚合物的弱溶剂或非溶剂，但是作为相对于第一和第二溶剂的共溶剂，因为其可与第一溶剂和第二溶剂混溶。 通过调节溶质相对于微粒聚合物的比例，调节三元溶剂体系的组成，主要是调谐溶剂的量来控制掺入微粒的溶质量。 该方法对于提供包含可区分的染料负载，特别是可区分的荧光染料负载的组合编码的微粒的文库是特别有用的。

    Multiplexed analysis of polymorphic loci by concurrent interrogation and enzyme-mediated detection
    40.
    发明申请
    Multiplexed analysis of polymorphic loci by concurrent interrogation and enzyme-mediated detection 审中-公开
    通过同时询问和酶介导检测多态位点的多重分析

    公开(公告)号：US20070264641A1

    公开(公告)日：2007-11-15

    申请号：US11438723

    申请日：2006-05-22

    Applicant: Alice Li ,  Ghazala Hashmi ,  Michael Seul

    Inventor： Alice Li ,  Ghazala Hashmi ,  Michael Seul

    IPC: C12Q1/68

    CPC classification number: C12Q1/6827

    Abstract: The invention provides methods and processes for the identification of polymorphisms at one or more designated sites, without interference from non-designated sites located within proximity of such designated sites. Probes are provided capable of interrogation of such designated sites in order to determine the composition of each such designated site. By the methods of this invention, one or more mutations within the CFTR gene and the HLA gene complex can be can be identified.

    Abstract translation: 本发明提供用于在一个或多个指定位点识别多态性的方法和过程，而不受位于该指定位点附近的非指定位点的干扰。 提供能够询问这些指定地点的探测器，以确定每个这样的指定地点的组成。 通过本发明的方法，可以鉴定CFTR基因和HLA基因复合体内的一个或多个突变。

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