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公开(公告)号：US10739349B2
公开(公告)日：2020-08-11
申请号：US15167513
申请日：2016-05-27
Inventor： Daniel T. Chiu , Changfeng Wu , Xuanjun Zhang , Jiangbo Yu , Fangmao Ye
IPC: C09K11/06 , G01N33/58 , B82Y30/00 , B82Y40/00 , B82Y15/00 , H01L51/00 , C08G61/12 , C08J3/11 , C09K11/02
Abstract: The present invention provides, among other aspects, stabilized chromophoric nanoparticles. In certain embodiments, the chromophoric nanoparticles provided herein are rationally functionalized with a pre-determined number of functional groups. In certain embodiments, the stable chromophoric nanoparticles provided herein are modified with a low density of functional groups. In yet other embodiments, the chromophoric nanoparticles provided herein are conjugated to one or more molecules. Also provided herein are methods for making rationally functionalized chromophoric nanoparticles.
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公开(公告)号：US10000797B2
公开(公告)日：2018-06-19
申请号：US15230162
申请日：2016-08-05
Inventor： Daniel T. Chiu , Bryant S. Fujimoto , Alexander R. Gansen , Gloria S. Yen , Robert M. Lorenz
IPC: C12Q1/68
CPC classification number: C12Q1/6851 , C12Q1/6806 , C12Q2527/146 , C12Q2531/113 , C12Q2545/114
Abstract: Methods, devices and systems for performing digital measurements are provided.
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公开(公告)号：US09997344B2
公开(公告)日：2018-06-12
申请号：US14891620
申请日：2014-05-30
Inventor： Daniel T. Chiu , Dingsheng Liu
CPC classification number: H01J49/165 , B05B5/025 , B05B5/03 , H01J49/0445
Abstract: The present disclosure describes devices and methods capable of generating multi-phase emulsions, including double emulsion droplets in a gas phase. The present disclosure also describes interfaces for coupling a multi-phase emulsion droplet source to an analytical instrument such as a mass spectrometer. The present disclosure further describes methods, systems, and apparatuses for using the devices and interfaces described to perform analysis, including mass spectrometry. The present disclosure also describes methods, systems, and apparatuses for generating and using multi-phase emulsions to perform analysis.
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公开(公告)号：US09797840B2
公开(公告)日：2017-10-24
申请号：US13687813
申请日：2012-11-28
Inventor： Daniel T. Chiu , Changfeng Wu , Fangmao Ye
CPC classification number: G01N21/6486 , B82Y15/00 , G01N33/588 , Y10T428/2982
Abstract: Fluorescent nanoparticles are provided. The nanoparticles are formed from poly[2-methoxy-5-(2-ethylhexyloxy)-1,4-(1-cyanovinylene-1,4-phenylene)]. Also provided are methods for imaging a target to which the nanoparticles are bound.
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公开(公告)号：US20130266957A1
公开(公告)日：2013-10-10
申请号：US13687813
申请日：2012-11-28
Inventor： Daniel T. Chiu , Changfeng Wu , Fangmao Ye
IPC: G01N21/64
CPC classification number: G01N21/6486 , B82Y15/00 , G01N33/588 , Y10T428/2982
Abstract: Fluorescent nanoparticles are provided. The nanoparticles are formed from poly[2-methoxy-5-(2-ethylhexyloxy)-1,4-(1-cyanovinylene-1,4-phenylene)]. Also provided are methods for imaging a target to which the nanoparticles are bound.
Abstract translation: 提供荧光纳米粒子。 纳米颗粒由聚[2-甲氧基-5-（2-乙基己氧基）-1,4-（1-氰基亚乙烯基-1,4-亚苯基）]形成。 还提供了用于对纳米颗粒结合的靶进行成像的方法。
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Patent Agency Ranking
公开(公告)号：US11808767B2
公开(公告)日：2023-11-07
申请号：US17932687
申请日：2022-09-16
Inventor： Daniel T. Chiu , Mengxia Zhao , Wyatt Nelson , Perry G. Schiro
IPC: G01N33/574 , B01L3/00 , G01N15/06 , G01N15/14 , G01N33/49 , G01N21/64 , G01N33/53 , G01N35/10 , G01N35/00 , G01N15/10
CPC classification number: G01N33/57492 , B01L3/502761 , B01L3/561 , B01L3/567 , G01N15/0612 , G01N15/0656 , G01N15/1456 , G01N15/1484 , G01N21/6428 , G01N21/6456 , G01N33/49 , G01N33/5304 , B01L3/502738 , B01L3/502776 , B01L2200/0652 , B01L2200/0668 , B01L2200/0673 , B01L2200/10 , B01L2300/0636 , B01L2300/0681 , B01L2300/0816 , B01L2300/0832 , B01L2300/0864 , B01L2300/0883 , B01L2400/0406 , B01L2400/0415 , B01L2400/0487 , B01L2400/06 , B01L2400/0633 , B01L2400/086 , G01N15/0618 , G01N35/0098 , G01N2015/0681 , G01N2015/0693 , G01N2015/1006 , G01N2015/149 , G01N2035/00237 , G01N2035/00356 , G01N2035/1034
Abstract: Provided herein, among other aspects, are methods and apparatuses for analyzing particles in a sample. In some aspects, the particles can be analytes, cells, nucleic acids, or proteins and contacted with a tag, partitioned into aliquots, detected by a ranking device, and isolated. The methods and apparatuses provided herein may include a microfluidic chip. In some aspects, the methods and apparatuses may be used to quantify rare particles in a sample, such as cancer cells and other rare cells for disease diagnosis, prognosis, or treatment.
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公开(公告)号：US10768180B2
公开(公告)日：2020-09-08
申请号：US16041569
申请日：2018-07-20
Inventor： Daniel T. Chiu , Yuhui Jin , Fangmao Ye , Changfeng Wu , Yang-Hsiang Chan
Abstract: Polymer nanoparticles and related methods are provided. The polymer particles can include polymer dots having a coating including a polyelectrolyte polymer. Methods of making and using the polymer nanoparticles are also provided.
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公开(公告)号：US10514381B2
公开(公告)日：2019-12-24
申请号：US14774971
申请日：2014-03-14
Inventor： Daniel T. Chiu , Wei Sun , Jiangbo Yu , Changfeng Wu , Fangmao Ye
IPC: G01N33/58 , C09K11/02 , G01N33/543 , C08G61/02 , C08G73/00 , C08G75/32 , G01N33/533
Abstract: Lyophilized chromophoric polymer dot compositions are provided. Also disclosed are methods of making and using the lyophilized compositions, methods of dispersing the lyophilized compositions in aqueous solutions and kits supplying the compositions.
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公开(公告)号：US10236170B2
公开(公告)日：2019-03-19
申请号：US15454558
申请日：2017-03-09
Inventor： Daniel T. Chiu , Dingsheng Liu
Abstract: The present disclosure describes devices and methods capable of generating multi¬phase emulsions, including double emulsion droplets in a gas phase. The present disclosure also describes interfaces for coupling a multi-phase emulsion droplet source to an analytical instrument such as a mass spectrometer. The present disclosure further describes methods, systems, and apparatuses for using the devices and interfaces described to perform analysis, including mass spectrometry. The present disclosure also describes methods, systems, and apparatuses for generating and using multi-phase emulsions to perform analysis.
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公开(公告)号：US09810693B2
公开(公告)日：2017-11-07
申请号：US13865942
申请日：2013-04-18
Inventor： Daniel T. Chiu , Changfeng Wu , Xuanjun Zhang , Jiangbo Yu , Fangmao Ye
IPC: G01N33/58 , C09K11/06 , B82Y30/00 , B82Y40/00 , H01L51/00 , B82Y15/00 , C08G61/12 , C08J3/11 , C09K11/02
CPC classification number: G01N33/588 , B82Y15/00 , B82Y30/00 , B82Y40/00 , C08G61/126 , C08G2261/12 , C08G2261/1426 , C08G2261/228 , C08G2261/3142 , C08G2261/3246 , C08G2261/522 , C08G2261/54 , C08G2261/72 , C08G2261/94 , C08J3/11 , C08J2327/22 , C09K11/025 , C09K11/06 , C09K2211/1425 , H01L51/0039
Abstract: The present invention provides, among other aspects, stabilized chromophoric nanoparticles. In certain embodiments, the chromophoric nanoparticles provided herein are rationally functionalized with a pre-determined number of functional groups. In certain embodiments, the stable chromophoric nanoparticles provided herein are modified with a low density of functional groups. In yet other embodiments, the chromophoric nanoparticles provided herein are conjugated to one or more molecules. Also provided herein are methods for making rationally functionalized chromophoric nanoparticles.
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