-
公开(公告)号：US09028857B2
公开(公告)日：2015-05-12
申请号：US12681676
申请日：2008-10-10
IPC分类号： A61F13/00 , C07H1/00 , C08B37/02 , A61L27/20 , A61L27/38 , A61L27/50 , A61L27/52 , A61L27/56 , C12N5/00 , C08B37/00 , C08B37/08 , C08H1/06 , C08J9/28
CPC分类号： A61L27/56 , A61L27/20 , A61L27/3804 , A61L27/3826 , A61L27/3834 , A61L27/3847 , A61L27/3852 , A61L27/507 , A61L27/52 , A61L27/54 , A61L2300/21 , A61L2430/02 , A61L2430/06 , C08B37/0018 , C08B37/0021 , C08B37/003 , C08B37/0039 , C08B37/0054 , C08B37/0063 , C08B37/0072 , C08B37/0075 , C08B37/0084 , C08H1/06 , C08J3/24 , C08J9/28 , C08J2201/026 , C08J2201/0484 , C08J2205/04 , C08J2207/10 , C08J2305/00 , C08J2305/02 , C08J2305/08 , C08J2305/12 , C12N5/0068 , C12N11/10 , C12N2533/70 , Y10T436/147777
摘要： The present invention relates to a method for preparing a porous scaffold for tissue engineering. It is another object of the present invention to provide a porous scaffold obtainable by the method as above described, and its use for tissue engineering, cell culture and cell delivery. The method of the invention comprise the steps consisting of a) preparing an alkaline aqueous solution comprising an amount of at least one polysaccharide and one cross-linking agent b) freezing the aqueous solution of step a) c) sublimating the frozen solution of step b). characterized in that step b) is performed before the cross-linking of the polysaccharide occurs in the solution of step a).
摘要翻译： 本发明涉及一种用于组织工程的多孔支架的制备方法。 本发明的另一个目的是提供可通过上述方法获得的多孔支架及其在组织工程，细胞培养和细胞递送中的应用。 本发明的方法包括以下步骤：a）制备含有至少一种多糖和一种交联剂的碱性水溶液b）冷冻步骤a）的水溶液c）升华步骤b的冷冻溶液 ）。 其特征在于步骤b）在多糖的交联发生在步骤a）的溶液中之前进行。
-
32.发明授权公开(公告)号：US09011754B2
公开(公告)日：2015-04-21
申请号：US12517701
申请日：2007-12-05
申请人： Meng Fatt Leong , Tze Chiun Lim , Kerm Sin Chian
发明人： Meng Fatt Leong , Tze Chiun Lim , Kerm Sin Chian
CPC分类号： C08J9/00 , A61L27/3847 , A61L27/56 , A61L27/58 , A61L27/60 , D01D5/0076 , Y10T156/10
摘要： The present invention refers to an apparatus and a method for the manufacture of a three-dimensional scaffold at low temperatures and the respective use of this method and apparatus.
摘要翻译： 本发明涉及一种用于在低温下制造三维支架的装置和方法以及该方法和装置的各自用途。
-
公开(公告)号：US20150050618A1
公开(公告)日：2015-02-19
申请号：US14387442
申请日：2013-03-22
发明人： Morten Foss , Ole Zoffmann Andersen , Michael Brammer Sillassen , Jørgen Bøttiger , Inge Hald Andersen , Klaus Pagh Almtoft , Lars Pleth Nielsen , Christian Schärfe Thomsen
CPC分类号： A61L27/306 , A61C8/0015 , A61L27/30 , A61L27/303 , A61L27/365 , A61L27/3847 , A61L27/3865 , A61L27/56 , A61L2400/12 , A61L2420/02 , A61L2420/06 , A61L2420/08 , A61L2430/02 , A61L2430/12 , C23C14/08 , C23C14/083 , C23C14/34 , Y10T428/24997
摘要： The present invention relates to a coating, a substrate, a method for coating a body and a method for producing the body substrate, such as a dental or a bone implant. The coating has a high degree of mechanical stability and comprises elements, such as Sr based compounds, which optimize the tissue response to the implanted body thus stimulating healing, bone or tissue growth in the vicinity of the implant. An implant coated with this coating has the ability of sustained release of strontium in a non-toxic concentration of strontium in the vicinity of the implant.
摘要翻译： 本发明涉及一种涂层，一种基材，一种用于涂覆身体的方法及其制造方法，例如牙科或骨植入物。 涂层具有高度的机械稳定性，并且包括诸如Sr基化合物的元素，其优化组织对植入体的响应，从而刺激植入物附近的愈合，骨骼或组织生长。 涂有该涂层的植入物具有在植入物附近以无毒浓度的锶持续释放锶的能力。
-
34.发明申请DEMINERALIZED BONE FIBERS HAVING CONTROLLD GEOMETRY AND SHAPES AND METHODS THEREOF 有权具有控制几何和形状的脱脂骨架纤维及其方法公开(公告)号：US20140314822A1
公开(公告)日：2014-10-23
申请号：US14256911
申请日：2014-04-18
申请人： THERACELL, INC.
CPC分类号： A61L27/3847 , A61L27/3608 , A61L27/365 , A61L27/3687 , A61L27/54 , A61L2400/06 , A61L2430/02 , A61L2430/40
摘要： A bone repair composition and methods thereof include elongated bone fibers made from cortical bone in which a plurality of approximately uniform bone fibers is made into various implant shapes conducive for various applications. The bone fiber compositions may be in the form of a cavity, ball, pellet, wrap, strip, cylinder, cone, putty, gel, or injectable slurry.
摘要翻译： 骨修复组合物及其方法包括由皮质骨制成的细长骨纤维，其中将多个近似均匀的骨纤维制成各种有助于各种应用的种植体形状。 骨纤维组合物可以是空腔，球，颗粒，包裹，条，圆筒，圆锥，油灰，凝胶或可注射浆料的形式。
-
公开(公告)号：US08790681B2
公开(公告)日：2014-07-29
申请号：US13378474
申请日：2010-05-23
申请人： Nir Altschuler , Razi Vago
发明人： Nir Altschuler , Razi Vago
IPC分类号： A61F13/00 , A61F2/00 , A61F2/28 , A61F2/02 , A61L27/38 , A61L27/56 , A61L27/36 , A61L27/34 , A61L27/42 , A61F2/30
CPC分类号： A61L27/025 , A61F2/28 , A61F2/30756 , A61F2/3094 , A61F2002/30011 , A61F2002/30224 , A61F2002/30807 , A61F2002/3092 , A61F2230/0069 , A61F2250/0023 , A61F2310/00341 , A61L27/18 , A61L27/20 , A61L27/34 , A61L27/3604 , A61L27/3834 , A61L27/3847 , A61L27/3852 , A61L27/427 , A61L27/52 , A61L27/54 , A61L27/56 , A61L2300/414 , A61L2300/606 , A61L2430/02 , A61L2430/06 , C08L5/08
摘要： This invention provides aragonite- and calcite-based scaffolds for the repair, regeneration, enhancement of formation or a combination thereof of cartilage and/or bone, which scaffolds comprise at least two phases, wherein each phase differs in terms of its chemical content, or structure, kits comprising the same, processes for producing solid aragonite or calcite scaffolds and methods of use thereof.
摘要翻译： 本发明提供了用于修复，再生，增强形成或其组合的软骨和/或骨的文石和方解石的支架，该支架包含至少两个相，其中每个相的化学成分方面不同，或 结构，包含其的试剂盒，用于生产固体霰石或方解石支架的方法及其使用方法。
-
公开(公告)号：US20140112998A1
公开(公告)日：2014-04-24
申请号：US14004992
申请日：2012-04-27
申请人： Scheffer Tseng , Ek Kia Tan , Hua He
发明人： Scheffer Tseng , Ek Kia Tan , Hua He
CPC分类号： A61L27/365 , A61K9/0019 , A61K31/728 , A61K33/06 , A61K35/50 , A61K35/51 , A61K35/54 , A61K38/57 , A61L27/20 , A61L27/26 , A61L27/34 , A61L27/3604 , A61L27/3847 , A61L27/54 , A61L2300/236 , A61L2300/252 , A61L2300/434 , A61L2300/45 , A61L2300/606 , A61L2430/02 , C08L5/08 , C08L89/00
摘要： Disclosed herein, in certain instances, are methods of inhibiting osteoclast differentiation, bone resorption, bone formation, and bone remodeling in an individual in need thereof, comprising administering to the individual a composition comprising substantially fetal support tissue product including amniotic membrane and umbilical cord or an extract thereof, or a composition comprising substantially isolated HC-HA complex.
摘要翻译： 在某些情况下，本文公开的是在有需要的个体中抑制破骨细胞分化，骨吸收，骨形成和骨重塑的方法，包括向个体施用包含基本上胎儿支持组织产品的组合物，包括羊膜和脐带，或 或其包含基本上分离的HC-HA复合物的组合物。
-
公开(公告)号：US08686064B2
公开(公告)日：2014-04-01
申请号：US11856977
申请日：2007-09-18
申请人： Lawrence A. Shimp , David Knaack
发明人： Lawrence A. Shimp , David Knaack
CPC分类号： A61L27/3821 , A61L27/3608 , A61L27/365 , A61L27/3683 , A61L27/3687 , A61L27/3847 , A61L27/44 , A61L27/46 , A61L2430/02
摘要： The invention provides a method for the preparation of bone-polymer composites wherein the mineral portion of the bone is treated with a coupling agent before being incorporated into a biocompatible polymeric matrix. The resulting composites may be used as such or be further processed to form an osteoimplant.
摘要翻译： 本发明提供了一种用于制备骨 - 聚合物复合材料的方法，其中骨的矿物部分在被并入生物相容的聚合物基质之前用偶联剂处理。 所得到的复合物可以原样使用或进一步加工以形成骨样植入物。
-
公开(公告)号：US08642061B2
公开(公告)日：2014-02-04
申请号：US12140062
申请日：2008-06-16
申请人： Lawrence A. Shimp , Guobao Wei , Keyvan Behnam
发明人： Lawrence A. Shimp , Guobao Wei , Keyvan Behnam
IPC分类号： A61K35/32
CPC分类号： A61L27/3691 , A61F2/4644 , A61F2002/4646 , A61L27/30 , A61L27/34 , A61L27/3604 , A61L27/3847 , A61L27/48 , A61L27/50 , A61L2430/40 , C08L67/04
摘要： In one embodiment, the method comprises providing tissue, preparing the tissue, and treating the tissue to improve remodeling characteristics of the tissue. The tissue may be, for example, cortical bone. Treating the tissue to improve remodeling characteristics may comprise heating the tissue, treating the tissue with a chemical, or other. Heating the tissue may be done in the absence of oxygen and may comprise heating the tissue in a vacuum, heating the tissue in an inert atmosphere, heating the tissue in a reducing atmosphere, coating the tissue with a protective coating and heating the tissue, or other. Further embodiments comprise treating the tissue in supercritical fluids, for example, to dry or virally inactivate the tissue.
摘要翻译： 在一个实施方案中，该方法包括提供组织，制备组织和处理组织以改善组织的重塑特征。 组织可以是例如皮质骨。 处理组织以改善重塑特征可以包括加热组织，用化学品或其它物质处理组织。 加热组织可以在没有氧的情况下进行，并且可以包括在真空中加热组织，在惰性气氛中加热组织，在还原性气氛中加热组织，用保护涂层涂覆组织并加热组织，或 其他。 另外的实施方案包括处理超临界流体中的组织，例如干燥或病毒灭活组织。
-
公开(公告)号：US20130345826A1
公开(公告)日：2013-12-26
申请号：US13530297
申请日：2012-06-22
申请人： Shu-Tung Li , Hui-Chen Chen , Debbie Yuen
发明人： Shu-Tung Li , Hui-Chen Chen , Debbie Yuen
IPC分类号： A61F2/28
CPC分类号： A61F2/28 , A61F2/30756 , A61F2002/2839 , A61F2002/30016 , A61F2002/30062 , A61F2002/30293 , A61F2002/3092 , A61F2310/00371 , A61L27/12 , A61L27/24 , A61L27/3847 , A61L27/3852 , A61L27/54 , A61L27/58 , A61L2430/02 , A61L2430/06
摘要： An implant for the repair of bone and cartilage that includes a cell conductive zone that contains biopolymeric fibers and an osteoconductive zone that contains biopolymeric fibers and calcium-containing mineral particles. The biopolymeric fibers from one zone overlaps with the fibers in the other zone forming a stable physical and mechanical integration of the two zones thus conferring in vivo stability to the implant.
摘要翻译： 用于修复骨和软骨的植入物，其包括含有生物聚合纤维的细胞导电区和含有生物聚合纤维和含钙矿物颗粒的骨传导区。 来自一个区域的生物聚合物纤维与另一区域中的纤维重叠形成两个区域的稳定的物理和机械整合，从而赋予植入物体内稳定性。
-
公开(公告)号：US08551170B2
公开(公告)日：2013-10-08
申请号：US12811031
申请日：2009-02-26
申请人： Zsombor Lacza , Miklós Weszl
发明人： Zsombor Lacza , Miklós Weszl
CPC分类号： A61L27/3834 , A61L27/34 , A61L27/36 , A61L27/3608 , A61L27/365 , A61L27/3691 , A61L27/3695 , A61L27/3847 , A61L2430/02 , C08L89/00
摘要： Disclosed are methods for producing implantable bone compositions suitable for attaching stem cells thereto, characterized in that bone particles are contacted with an albumin comprising solution. Said bone particles can be mineralized and/or lyophilized bone particles of animal or human origin. Preferably the non-immunogenic albumin comprising solution is lyophilized onto said bone particles. The invention further concerns bone compositions suitable for use in graft implantation obtainable by said methods.
摘要翻译： 公开了用于生产适于将干细胞附着到其上的可植入骨组合物的方法，其特征在于骨颗粒与含白蛋白的溶液接触。 所述骨颗粒可以是矿物质和/或动物或人来源的冻干骨颗粒。 优选地，将包含非免疫原性白蛋白的溶液冻干在所述骨颗粒上。 本发明还涉及适用于通过所述方法获得的移植物植入物中的骨组合物。
-
-
-
-
-
-
-
-
-
搜索结果
568 条记录 (耗时 0.035 秒)
