公开(公告)号：US09685324B2

公开(公告)日：2017-06-20

申请号：US14610254

申请日：2015-01-30

Applicant: Seung-Chang Lee ,  Steven R. J. Brueck

Inventor： Seung-Chang Lee ,  Steven R. J. Brueck

IPC: H01L21/20 ,  H01L21/02 ,  C30B25/04 ,  C30B25/18 ,  C30B29/40 ,  C30B23/02 ,  C30B29/42 ,  H01L29/06 ,  H01L29/267 ,  C30B7/00

CPC classification number: H01L21/02513 ,  C30B7/005 ,  C30B23/025 ,  C30B25/04 ,  C30B25/18 ,  C30B25/183 ,  C30B29/40 ,  C30B29/42 ,  H01L21/02381 ,  H01L21/02433 ,  H01L21/02455 ,  H01L21/02458 ,  H01L21/02505 ,  H01L21/02538 ,  H01L21/02546 ,  H01L21/02636 ,  H01L21/02642 ,  H01L21/02647 ,  H01L29/0665 ,  H01L29/0688 ,  H01L29/267

Abstract: Exemplary embodiments provide materials and methods of forming high-quality semiconductor devices using lattice-mismatched materials. In one embodiment, a composite film including one or more substantially-single-particle-thick nanoparticle layers can be deposited over a substrate as a nanoscale selective growth mask for epitaxially growing lattice-mismatched materials over the substrate.

公开(公告)号：US09666877B2

公开(公告)日：2017-05-30

申请号：US14381266

申请日：2013-03-11

Applicant: Alexey Serov ,  Ulises A Martinez ,  Plamen B Atanassov

Inventor： Alexey Serov ,  Ulises A Martinez ,  Plamen B Atanassov

IPC: H01M4/86 ,  H01M4/92 ,  H01M4/90 ,  B01J37/06 ,  B01J37/16 ,  B01J37/18 ,  B01J37/34 ,  B01J23/62 ,  B01J23/652 ,  B01J23/89 ,  B01J35/10 ,  B01J23/40 ,  B01J23/56 ,  B01J25/00 ,  B01J37/00 ,  B01J35/00

CPC classification number: H01M4/925 ,  B01J23/40 ,  B01J23/56 ,  B01J23/62 ,  B01J23/626 ,  B01J23/6525 ,  B01J23/8973 ,  B01J25/00 ,  B01J35/0013 ,  B01J35/0033 ,  B01J35/1061 ,  B01J37/0018 ,  B01J37/06 ,  B01J37/16 ,  B01J37/18 ,  B01J37/343 ,  B01J37/349 ,  H01M4/8605 ,  H01M4/8657 ,  H01M4/9016 ,  H01M4/92 ,  H01M4/921

Abstract: A method of preparing catalytic materials comprising depositing platinum or non-platinum group metals, or alloys thereof on a porous oxide support.

公开(公告)号：US09666431B1

公开(公告)日：2017-05-30

申请号：US15161633

申请日：2016-05-23

Applicant: Sang M. Han ,  Talid R. Sinno

Inventor： Sang M. Han ,  Talid R. Sinno

IPC: H01L21/02 ,  H01L51/00 ,  H01L21/8234 ,  H01L21/324 ,  B82Y40/00

CPC classification number: H01L21/02601 ,  B82Y40/00 ,  H01L21/02381 ,  H01L21/02532 ,  H01L21/02546 ,  H01L21/02631 ,  H01L21/02639 ,  H01L21/02658 ,  H01L21/3245 ,  H01L21/823493 ,  Y10S977/774 ,  Y10S977/814 ,  Y10S977/819 ,  Y10S977/891

Abstract: Provided is a method for forming a two-dimensional array of semiconductor quantum confined structures. The method includes providing a layer that has first atoms and second atoms, the first atoms having a different size than the second atoms; providing an indenter template that includes at least one indenter structure extending from a surface of the indenter template; contacting the layer and the at least one indenter structure together with a pressure sufficient to generate an elastic deformation in the layer but without generating plastic deformation of the layer; annealing the layer. The contacting of the layer and the at least one indenter structure includes forming at least one quantum confined structure in the layer.

公开(公告)号：US09655553B2

公开(公告)日：2017-05-23

申请号：US14850221

申请日：2015-09-10

Applicant: STC.UNM

Inventor： John B. Plumley ,  Erin D. Milligan ,  Marek Osinski

IPC: A61B5/1455 ,  G01N33/58 ,  A61B5/1459 ,  A61B5/00 ,  A61B5/1473

CPC classification number: A61B5/1455 ,  A61B5/1459 ,  A61B5/14735 ,  A61B5/4058 ,  A61B5/6852 ,  A61B5/6877 ,  A61B2562/0233 ,  A61B2562/0285 ,  G01N33/588

Abstract: The invention provides a quantum dot (QD) modified optical fiber-based biosensor which characterizes matrix metalloproteinase (MMP) enzyme activity at pain signaling sites in the central nervous system (CNS) in vivo. Related systems and peptide biomarker screening methods are also provided.

公开(公告)号：US09653793B2

公开(公告)日：2017-05-16

申请号：US14373974

申请日：2013-03-15

Applicant: STC.UNM

Inventor： Youssef A Tawk ,  Christos G Christodoulou ,  Joseph Costantine ,  Maria Elizabeth Zamudio Moreno

IPC: H01Q1/50 ,  H01Q15/24 ,  H01Q13/08 ,  H01Q1/24

CPC classification number: H01Q1/50 ,  H01Q1/24 ,  H01Q13/085 ,  H01Q15/24

Abstract: Embodiments relate to systems and methods for a frequency reconfigurable filtenna system. Implementations incorporate a reconfigurable band-pass filter within the feeding line of an antenna structure. The combination of the filter and the antenna may be referred to as a “filtenna”. Implementations integrate both the band-pass filter and the antenna within the same substrate, permitting easier, more efficient and more compact integration in the transceiver hardware. Moreover, by using this configuration, the biasing of the switching elements are not present in the radiating plane of the antenna. This reduces the negative effect of the biasing lines on the antenna radiation performance, as we!! as provides a tunable filtered antenna radiation characteristic.

公开(公告)号：US20170092959A1

公开(公告)日：2017-03-30

申请号：US15310852

申请日：2015-05-14

Applicant: Alexey Serov ,  Plamen Atanassov ,  Carlo Santoro

Inventor： Alexey Serov ,  Plamen Atanassov ,  Carlo Santoro

IPC: H01M4/90 ,  C02F1/461 ,  H01M8/16

CPC classification number: H01M4/9008 ,  C02F1/46104 ,  H01M4/86 ,  H01M4/9041 ,  H01M8/16 ,  H01M2004/8689 ,  Y02E60/527

Abstract: Novel catalysts suitable for use in biological systems and biological systems using these catalysts are described. In particular, the present disclosure provides microbial fuel cells utilizing non-PGM catalysts having a morphology that makes them particularly suitable for use in a microbial fuel cell.

公开(公告)号：US09579381B2

公开(公告)日：2017-02-28

申请号：US14426543

申请日：2013-09-06

Applicant: STC.UNM

Inventor： Graham Timmins ,  Seong Won Choi

IPC: A61K31/4409 ,  A61K41/00

CPC classification number: A61K41/0052 ,  A61K31/4409

Abstract: The invention provides method of treating a subject suffering from, or at risk of developing, a Mycobacterium infection by administering to the subject a therapeutically-effective amount of isotopically labeled isoniazid and/or ethionamide, or an analog, derivative or prodrug thereof, and exposing the subject to a magnetic field.

Abstract translation: 本发明提供了通过向受试者施用治疗有效量的同位素标记的异烟肼和/或乙硫异烟胺或其类似物，衍生物或前药，以及暴露于受试者的方法，治疗患有或有发展为分枝杆菌感染风险的受试者 受到磁场的影响。

公开(公告)号：US09579283B2

公开(公告)日：2017-02-28

申请号：US14113371

申请日：2012-04-27

Applicant: C. Jeffrey Brinker ,  Eric C. Carnes ,  Carlee Erin Ashley ,  Cheryl L. Willman

Inventor： C. Jeffrey Brinker ,  Eric C. Carnes ,  Carlee Erin Ashley ,  Cheryl L. Willman

IPC: A61K9/127 ,  A61K31/704 ,  A61K31/711 ,  A61K45/06 ,  A61K47/48 ,  C07K14/47 ,  C12N15/88 ,  A61K33/24 ,  A61K39/05 ,  C12N15/113 ,  A61K38/00 ,  A61K48/00

CPC classification number: A61K9/1271 ,  A61K31/704 ,  A61K31/711 ,  A61K33/24 ,  A61K38/00 ,  A61K39/05 ,  A61K45/06 ,  A61K47/62 ,  A61K47/6901 ,  A61K48/0016 ,  C07K14/47 ,  C12N15/1135 ,  C12N15/88 ,  C12N2310/14 ,  C12N2320/32 ,  C12N2810/40

Abstract: The present invention is directed to protocells for specific targeting of hepatocellular and other cancer cells which comprise a nanoporous silica core with a supported lipid bilayer; at least one agent which facilitates cancer cell death (such as a traditional small molecule, a macromolecular cargo (e.g. siRNA or a protein toxin such as ricin toxin A-chain or diphtheria toxin A-chain) and/or a histone-packaged plasmid DNA disposed within the nanoporous silica core (preferably supercoiled in order to more efficiently package the DNA into protocells) which is optionally modified with a nuclear localization sequence to assist in localizing protocells within the nucleus of the cancer cell and the ability to express peptides involved in therapy (apoptosis/cell death) of the cancer cell or as a reporter, a targeting peptide which targets cancer cells in tissue to be treated such that binding of the protocell to the targeted cells is specific and enhanced and a fusogenic peptide that promotes endosomal escape of protocells and encapsulated DNA. Protocells according to the present invention may be used to treat cancer, especially including hepatocellular (liver) cancer using novel binding peptides (c-MET peptides) which selectively bind to hepatocellular tissue or to function in diagnosis of cancer, including cancer treatment and drug discovery.

Abstract translation: 本发明涉及用于特异性靶向肝细胞和其它癌细胞的原细胞，其包含具有支持的脂质双层的纳米多孔二氧化硅核心; 至少一种促进癌细胞死亡的药物（例如传统的小分子，大分子货物（例如siRNA或蛋白质毒素如蓖麻毒素A链或白喉毒素A链）和/或组蛋白包装的质粒DNA 设置在纳米多孔硅芯内（优选超螺旋以更有效地将DNA包装到原细胞中），其任选地用核定位序列修饰以帮助定位癌细胞核内的原细胞，以及表达参与治疗的肽的能力 （凋亡/细胞死亡）或作为报告物，靶向肽靶向待治疗的组织中的癌细胞，使得原细胞与靶细胞的结合是特异性和增强的，并且促进内体逃逸的融合肽 原细胞和包封的DNA。根据本发明的原细胞可用于治疗癌症，特别是包括肝细胞（肝）癌症 选择性结合肝细胞组织或在癌症诊断中起作用的新型结合肽（c-MET肽），包括癌症治疗和药物发现。

公开(公告)号：US09549976B1

公开(公告)日：2017-01-24

申请号：US14081629

申请日：2013-11-15

Applicant: David S. Peabody ,  Bryce Chackerian ,  Carlee Ashley ,  Eric Carnes ,  Oscar Negrete

Inventor： David S. Peabody ,  Bryce Chackerian ,  Carlee Ashley ,  Eric Carnes ,  Oscar Negrete

IPC: A61K39/00 ,  A61K39/155 ,  A61K49/00 ,  A61K39/385 ,  C12Q1/70 ,  C12N7/00 ,  G01N33/569

CPC classification number: A61K39/155 ,  A61K39/12 ,  A61K2039/5256 ,  A61K2039/5258 ,  C12N2760/18234 ,  G01N33/56983

Abstract: The invention relates to virus-like particles of bacteriophage MS2 (MS2 VLPs) displaying peptide epitopes or peptide mimics of epitopes of Nipah Virus envelope glycoprotein that elicit an immune response against Nipah Virus upon vaccination of humans or animals. Affinity selection on Nipah Virus-neutralizing monoclonal antibodies using random sequence peptide libraries on MS2 VLPs selected peptides with sequence similarity to peptide sequences found within the envelope glycoprotein of Nipah itself, thus identifying the epitopes the antibodies recognize. The selected peptide sequences themselves are not necessarily identical in all respects to a sequence within Nipah Virus glycoprotein, and therefore may be referred to as epitope mimics VLPs displaying these epitope mimics can serve as vaccine. On the other hand, display of the corresponding wild-type sequence derived from Nipah Virus and corresponding to the epitope mapped by affinity selection, may also be used as a vaccine.

Abstract translation: 本发明涉及噬菌体MS2（MS2 VLP）的病毒样颗粒，其显示了尼泊尔病毒包膜糖蛋白的表位的肽表位或肽模拟物，其在接种人或动物时引起针对尼帕病毒的免疫应答。 在Nipah病毒中和单克隆抗体上的亲和力选择，使用MS2 VLP上的随机序列肽文库，选择与Nipah本身的包膜糖蛋白内发现的肽序列具有序列相似性的肽，从而鉴定抗体识别的表位。 所选择的肽序列本身在所有方面不一定与尼帕病毒糖蛋白内的序列相同，因此可以称为表位模拟物，显示这些表位模拟物的VLP可以用作疫苗。 另一方面，从Nipah Virus得到的相应野生型序列的显示与通过亲和力选择映射的表位对应，也可以用作疫苗。

公开(公告)号：US09461112B1

公开(公告)日：2016-10-04

申请号：US14826925

申请日：2015-08-14

Applicant: Seung-Chang Lee ,  Steven R. J. Brueck

Inventor： Seung-Chang Lee ,  Steven R. J. Brueck

IPC: H01L29/16 ,  H01L29/06 ,  H01L29/04 ,  H01L29/20

CPC classification number: C30B25/04 ,  C30B25/18 ,  C30B25/186 ,  C30B29/406 ,  H01L21/02381 ,  H01L21/0243 ,  H01L21/02433 ,  H01L21/02458 ,  H01L21/0254 ,  H01L21/02609 ,  H01L21/02639 ,  H01L21/02647 ,  H01L27/1222 ,  H01L29/045 ,  H01L29/06 ,  H01L29/0657 ,  H01L29/16 ,  H01L29/2003

Abstract: A method of epitaxially growing nitrogen-based compound semiconductor thin films on a semiconductor substrate, which is periodically patterned with grooves. The method can provide an epitaxial growth of a first crystalline phase epitaxial film on the substrate, and block the growth of an initial crystalline phase with barrier materials prepared at the sides of the grooves. Semiconductor devices employing the epitaxial films are also disclosed.