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    Droplet actuator with improved top substrate
    43.
    发明授权
    Droplet actuator with improved top substrate 有权
    具有改进的顶部基板的液滴致动器

    公开(公告)号：US09511369B2

    公开(公告)日：2016-12-06

    申请号：US14248884

    申请日：2014-04-09

    Applicant: Advanced Liquid Logic, Inc.

    Inventor： Vijay Srinivasan ,  Michael G. Pollack ,  Alexander Shenderov ,  Zhishan Hua ,  Arjun Sudarsan

    IPC: B01L3/00

    CPC classification number: B01L3/502792 ,  B01L2200/12 ,  B01L2300/0819 ,  B01L2300/089 ,  B01L2400/0415 ,  B01L2400/0421 ,  B01L2400/0427 ,  Y10T29/49826

    Abstract: The invention provides a droplet actuator. The droplet actuator may include a base substrate and a top substrate separated to form a gap. The base substrate may include electrodes configured for conducting droplet operations in the gap; and the top substrate may include a glass substrate portion coupled to a non-glass portion, where the non-glass portion may include one or more openings establishing a fluid path extending from an exterior of the droplet actuator and into the gap. The invention also provides related methods of manufacturing the droplet actuator, methods of using the droplet actuator, and methods of loading the droplet actuator.

    Abstract translation: 本发明提供一种液滴致动器。 液滴致动器可以包括分离以形成间隙的基底基板和顶基板。 基底基板可以包括被配置用于在间隙中进行液滴操作的电极; 并且顶部衬底可以包括联接到非玻璃部分的玻璃衬底部分，其中非玻璃部分可以包括建立从液滴致动器的外部延伸到间隙中的流体路径的一个或多个开口。 本发明还提供了制造液滴致动器的相关方法，使用液滴致动器的方法以及装载液滴致动器的方法。

    Methods of Improving Accuracy and Precision of Droplet Metering Using an On-Actuator Reservoir as the Fluid Input
    46.
    发明申请
    Methods of Improving Accuracy and Precision of Droplet Metering Using an On-Actuator Reservoir as the Fluid Input 审中-公开
    使用致动器水库作为流体输入提高液滴计量精度和精度的方法

    公开(公告)号：US20160175859A1

    公开(公告)日：2016-06-23

    申请号：US14911191

    申请日：2014-08-13

    Applicant: ADVANCED LIQUID LOGIC, INC.

    Inventor： Uichong B. Yi ,  Vijay Srinivasan

    IPC: B05B5/025 ,  B05B12/08

    CPC classification number: B05B5/0255 ,  B05B12/082 ,  G01F23/22 ,  G01F23/24 ,  G01F23/26

    Abstract: The present invention is directed to methods of improving accuracy of droplet metering using at least one on-actuator reservoir as the fluid input. In some embodiments, the on-actuator reservoir that is used for metering droplets includes a loading port, a liquid storage zone, a droplet metering zone, and a droplet dispensing zone. The on-actuator reservoirs are designed to prevent liquid flow-back into the loading port and to prevent liquid from flooding into the droplet operations gap in the dispensing zone.

    Abstract translation: 本发明涉及使用至少一个致动器容器作为流体输入来提高液滴计量精度的方法。 在一些实施例中，用于计量液滴的致动器储存器包括装载端口，液体存储区域，液滴计量区域和液滴分配区域。 致动器容器被设计成防止液体回流到装载口中并防止液体溢出到分配区域中的液滴操作间隙中。

    Integrated Droplet Actuator for Gel Electrophoresis and Molecular Analysis
    47.
    发明申请
    Integrated Droplet Actuator for Gel Electrophoresis and Molecular Analysis 有权
    用于凝胶电泳和分子分析的集成滴液致动器

    公开(公告)号：US20150323496A1

    公开(公告)日：2015-11-12

    申请号：US14795304

    申请日：2015-07-09

    Applicant: Advanced Liquid Logic, Inc. ,  Duke University

    Inventor： Michael G. Pollack ,  Vijay Srinivasan ,  Zhishan Hua ,  Hon Lung Chu ,  Michael Hauser ,  Allen Eckhardt

    IPC: G01N27/447 ,  B01L3/00

    CPC classification number: G01N27/44743 ,  B01L3/502715 ,  B01L3/502792 ,  B01L7/525 ,  B01L2200/025 ,  B01L2200/027 ,  B01L2300/088 ,  B01L2300/0887 ,  B01L2300/089 ,  B01L2300/161 ,  B01L2400/0406 ,  B01L2400/043 ,  B01L2400/0457 ,  B01L2400/046 ,  G01N27/44791

    Abstract: The invention is directed to a droplet actuator device and methods for integrating gel electrophoresis analysis with pre or post-analytical sample handling as well as other molecular analysis processes. Using digital microfluidics technology, the droplet actuator device and methods of the invention provide the ability to perform gel electrophoresis and liquid handling operations on a single integrated device. The integrated liquid handling operations may be used to prepare and deliver samples to the electrophoresis gel, capture and subsequently process products of the electrophoresis gel or perform additional assays on the same sample materials which are analyzed by gel electrophoresis. In one embodiment, one or more molecular assays, such as nucleic acid (e.g., DNA) quantification by real-time PCR, and one or more sample processing operations such as sample dilution is performed on a droplet actuator integrated with an electrophoresis gel. In one embodiment, an electrophoresis gel may be integrated on the top substrate of the droplet actuator.

    Abstract translation: 本发明涉及液滴致动器装置以及用于将凝胶电泳分析与分析前样品或分析后处理以及其它分子分析方法相集成的方法。 使用数字微流体技术，液滴致动器装置和本发明的方法提供了在单个集成装置上执行凝胶电泳和液体处理操作的能力。 集成的液体处理操作可以用于制备并将样品递送到电泳凝胶，捕获并随后处理电泳凝胶的产物，或在通过凝胶电泳分析的相同样品材料上进行附加测定。 在一个实施方案中，在与电泳凝胶结合的液滴致动器上进行一个或多个分子测定，例如通过实时PCR的核酸（例如DNA）定量和一个或多个样品处理操作，例如样品稀释。 在一个实施方案中，电泳凝胶可以集成在液滴致动器的顶部基底上。

    Droplet Dispensing Device and Methods
    48.
    发明申请
    Droplet Dispensing Device and Methods 审中-公开
    滴液分配装置及方法

    公开(公告)号：US20150075985A1

    公开(公告)日：2015-03-19

    申请号：US14541825

    申请日：2014-11-14

    Applicant: ADVANCED LIQUID LOGIC, INC.

    Inventor： Michael G. Pollack ,  Vamsee K. Pamula ,  Vijay Srinivasan

    IPC: B01L3/00 ,  G01N27/447

    CPC classification number: B01L3/502761 ,  B01F13/0071 ,  B01F13/0076 ,  B01L3/502792 ,  B01L2200/0605 ,  B01L2200/0647 ,  B01L2200/0668 ,  B01L2200/16 ,  B01L2300/0819 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/088 ,  B01L2300/089 ,  B01L2400/0427 ,  B01L2400/043 ,  G01N27/447

    Abstract: The invention provides nonlimiting examples of structures for and methods of dispensing droplets in a droplet actuator. The droplet actuator structures and methods of the invention exhibit numerous advantages over droplet actuators of the prior art. In various embodiments, the structures and methods of the invention provide, among other things, improved efficiency, throughput, scalability, and/or droplet uniformity, as compared with existing droplet actuators. Further, in some embodiments, the droplet actuators provide configurations for improved methods of loading and/or unloading fluid and/or droplets. In yet other embodiments, the droplet actuators provide fluid loading configurations for loading numerous fluid reservoirs in a substantially simultaneous and/or substantially sequential manner.

    Abstract translation: 本发明提供了用于在液滴致动器中分配液滴的结构的方法和方法的非限制性实例。 本发明的液滴致动器结构和方法与现有技术的液滴致动器相比表现出许多优点。 在各种实施例中，与现有的液滴致动器相比，本发明的结构和方法尤其提供了改进的效率，吞吐量，可扩展性和/或液滴均匀性。 此外，在一些实施例中，液滴致动器提供用于加载和/或卸载流体和/或液滴的改进方法的构造。 在其他实施例中，液滴致动器提供用于以基本上同时和/或基本顺序的方式装载多个流体储存器的流体加载构造。

    Droplet Actuator with Improved Top Substrate
    50.
    发明申请
    Droplet Actuator with Improved Top Substrate 有权
    具有改进的顶部基材的液滴致动器

    公开(公告)号：US20140216932A1

    公开(公告)日：2014-08-07

    申请号：US14248884

    申请日：2014-04-09

    Applicant: Advanced Liquid Logic, Inc.

    Inventor： Vijay Srinivasan ,  Michael G. Pollack ,  Alexander Shenderov ,  Zhishan Hua ,  Arjun Sudarsan

    IPC: B01L3/00

    CPC classification number: B01L3/502792 ,  B01L2200/12 ,  B01L2300/0819 ,  B01L2300/089 ,  B01L2400/0415 ,  B01L2400/0421 ,  B01L2400/0427 ,  Y10T29/49826

    Abstract: The invention provides a droplet actuator. The droplet actuator may include a base substrate and a top substrate separated to form a gap. The base substrate may include electrodes configured for conducting droplet operations in the gap; and the top substrate may include a glass substrate portion coupled to a non-glass portion, where the non-glass portion may include one or more openings establishing a fluid path extending from an exterior of the droplet actuator and into the gap. The invention also provides related methods of manufacturing the droplet actuator, methods of using the droplet actuator, and methods of loading the droplet actuator.

    Abstract translation: 本发明提供一种液滴致动器。 液滴致动器可以包括分离以形成间隙的基底基板和顶基板。 基底基板可以包括被配置用于在间隙中进行液滴操作的电极; 并且顶部衬底可以包括联接到非玻璃部分的玻璃衬底部分，其中非玻璃部分可以包括建立从液滴致动器的外部延伸到间隙中的流体路径的一个或多个开口。 本发明还提供了制造液滴致动器的相关方法，使用液滴致动器的方法以及装载液滴致动器的方法。

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