Patent search cpc:"C07C45/59" Page 5

41.

发明授权
Retroviral protease inhibiting compounds 失效
Title translation: 逆转录病毒蛋白酶抑制化合物

公开(公告)号：US5659045A

公开(公告)日：1997-08-19

申请号：US417295

申请日：1995-04-05

Applicant: Dale J. Kempf , Daniel W. Norbeck , Chen Zhao , Thomas J. Sowin

Inventor： Dale J. Kempf , Daniel W. Norbeck , Chen Zhao , Thomas J. Sowin

IPC: A61K31/425 , A61K31/427 , A61K38/00 , A61K45/06 , C07C33/46 , C07C43/164 , C07C43/174 , C07C43/205 , C07C43/215 , C07C43/23 , C07C43/30 , C07C43/315 , C07C45/00 , C07C45/29 , C07C45/56 , C07C45/59 , C07C45/62 , C07C45/67 , C07C45/74 , C07C53/134 , C07C69/34 , C07C69/65 , C07C69/732 , C07C211/27 , C07C215/18 , C07C215/20 , C07C215/28 , C07C229/08 , C07C229/26 , C07C229/34 , C07C233/36 , C07C233/40 , C07C235/10 , C07C235/12 , C07C235/34 , C07C235/78 , C07C237/10 , C07C237/20 , C07C237/22 , C07C239/10 , C07C239/18 , C07C239/20 , C07C247/10 , C07C251/40 , C07C271/20 , C07C271/22 , C07C271/34 , C07C275/16 , C07C275/24 , C07C311/03 , C07C311/13 , C07C311/18 , C07C317/10 , C07C317/28 , C07C317/44 , C07C323/12 , C07C323/25 , C07C381/00 , C07D207/08 , C07D207/24 , C07D209/42 , C07D211/62 , C07D213/26 , C07D213/30 , C07D213/34 , C07D213/40 , C07D213/54 , C07D213/56 , C07D213/61 , C07D213/75 , C07D233/54 , C07D233/84 , C07D235/14 , C07D235/16 , C07D239/26 , C07D241/12 , C07D261/08 , C07D263/32 , C07D277/24 , C07D277/28 , C07D277/30 , C07D277/34 , C07D277/36 , C07D277/40 , C07D277/42 , C07D277/56 , C07D295/13 , C07D295/205 , C07D295/215 , C07D303/36 , C07D307/42 , C07D333/16 , C07D401/12 , C07D413/12 , C07D417/12 , C07D521/00 , C07K5/06 , C07K5/065

CPC classification number: C07D207/08 , A61K31/425 , A61K31/427 , A61K45/06 , C07C211/27 , C07C215/18 , C07C215/20 , C07C215/28 , C07C229/08 , C07C229/26 , C07C229/34 , C07C233/36 , C07C233/40 , C07C235/10 , C07C235/12 , C07C235/34 , C07C235/78 , C07C237/10 , C07C237/20 , C07C237/22 , C07C239/10 , C07C239/18 , C07C239/20 , C07C247/10 , C07C251/40 , C07C271/20 , C07C271/22 , C07C271/34 , C07C275/16 , C07C275/24 , C07C311/03 , C07C311/13 , C07C311/18 , C07C317/10 , C07C317/28 , C07C317/44 , C07C323/12 , C07C323/25 , C07C33/46 , C07C381/00 , C07C43/164 , C07C43/1742 , C07C43/2055 , C07C43/215 , C07C43/23 , C07C43/30 , C07C43/315 , C07C45/004 , C07C45/29 , C07C45/567 , C07C45/59 , C07C45/62 , C07C45/673 , C07C45/74 , C07C53/134 , C07C69/34 , C07C69/65 , C07C69/732 , C07D207/24 , C07D209/42 , C07D211/62 , C07D213/26 , C07D213/30 , C07D213/34 , C07D213/40 , C07D213/54 , C07D213/56 , C07D213/61 , C07D213/75 , C07D231/12 , C07D233/56 , C07D233/64 , C07D233/84 , C07D235/14 , C07D235/16 , C07D239/26 , C07D241/12 , C07D249/08 , C07D261/08 , C07D263/32 , C07D277/24 , C07D277/28 , C07D277/30 , C07D277/34 , C07D277/36 , C07D277/40 , C07D277/42 , C07D277/56 , C07D295/13 , C07D295/205 , C07D295/215 , C07D303/36 , C07D307/42 , C07D333/16 , C07D401/12 , C07D413/12 , C07D417/12 , C07K5/06026 , C07K5/06078 , A61K38/00

Abstract: A retroviral protease inhibiting compound of the formula: ##STR1## is disclosed.

Abstract translation: 公开了下式的逆转录病毒蛋白酶抑制化合物：。

42.

发明授权
Retroviral protease inhibiting compounds 失效

公开(公告)号：US5659044A

公开(公告)日：1997-08-19

申请号：US417165

申请日：1995-04-05

Applicant: Dale J. Kempf , Daniel W. Norbeck , Chen Zhao , Thomas J. Sowin

Inventor： Dale J. Kempf , Daniel W. Norbeck , Chen Zhao , Thomas J. Sowin

IPC: A61K31/425 , A61K31/427 , A61K38/00 , A61K45/06 , C07C33/46 , C07C43/164 , C07C43/174 , C07C43/205 , C07C43/215 , C07C43/23 , C07C43/30 , C07C43/315 , C07C45/00 , C07C45/29 , C07C45/56 , C07C45/59 , C07C45/62 , C07C45/67 , C07C45/74 , C07C53/134 , C07C69/34 , C07C69/65 , C07C69/732 , C07C211/27 , C07C215/18 , C07C215/20 , C07C215/28 , C07C229/08 , C07C229/26 , C07C229/34 , C07C233/36 , C07C233/40 , C07C235/10 , C07C235/12 , C07C235/34 , C07C235/78 , C07C237/10 , C07C237/20 , C07C237/22 , C07C239/10 , C07C239/18 , C07C239/20 , C07C247/10 , C07C251/40 , C07C271/20 , C07C271/22 , C07C271/34 , C07C275/16 , C07C275/24 , C07C311/03 , C07C311/13 , C07C311/18 , C07C317/10 , C07C317/28 , C07C317/44 , C07C323/12 , C07C323/25 , C07C381/00 , C07D207/08 , C07D207/24 , C07D209/42 , C07D211/62 , C07D213/26 , C07D213/30 , C07D213/34 , C07D213/40 , C07D213/54 , C07D213/56 , C07D213/61 , C07D213/75 , C07D233/54 , C07D233/84 , C07D235/14 , C07D235/16 , C07D239/26 , C07D241/12 , C07D261/08 , C07D263/32 , C07D277/24 , C07D277/28 , C07D277/30 , C07D277/34 , C07D277/36 , C07D277/40 , C07D277/42 , C07D277/56 , C07D295/13 , C07D295/205 , C07D295/215 , C07D303/36 , C07D307/42 , C07D333/16 , C07D401/12 , C07D413/12 , C07D417/12 , C07D521/00 , C07K5/06 , C07K5/065

CPC classification number: C07D207/08 , A61K31/425 , A61K31/427 , A61K45/06 , C07C211/27 , C07C215/18 , C07C215/20 , C07C215/28 , C07C229/08 , C07C229/26 , C07C229/34 , C07C233/36 , C07C233/40 , C07C235/10 , C07C235/12 , C07C235/34 , C07C235/78 , C07C237/10 , C07C237/20 , C07C237/22 , C07C239/10 , C07C239/18 , C07C239/20 , C07C247/10 , C07C251/40 , C07C271/20 , C07C271/22 , C07C271/34 , C07C275/16 , C07C275/24 , C07C311/03 , C07C311/13 , C07C311/18 , C07C317/10 , C07C317/28 , C07C317/44 , C07C323/12 , C07C323/25 , C07C33/46 , C07C381/00 , C07C43/164 , C07C43/1742 , C07C43/2055 , C07C43/215 , C07C43/23 , C07C43/30 , C07C43/315 , C07C45/004 , C07C45/29 , C07C45/567 , C07C45/59 , C07C45/62 , C07C45/673 , C07C45/74 , C07C53/134 , C07C69/34 , C07C69/65 , C07C69/732 , C07D207/24 , C07D209/42 , C07D211/62 , C07D213/26 , C07D213/30 , C07D213/34 , C07D213/40 , C07D213/54 , C07D213/56 , C07D213/61 , C07D213/75 , C07D231/12 , C07D233/56 , C07D233/64 , C07D233/84 , C07D235/14 , C07D235/16 , C07D239/26 , C07D241/12 , C07D249/08 , C07D261/08 , C07D263/32 , C07D277/24 , C07D277/28 , C07D277/30 , C07D277/34 , C07D277/36 , C07D277/40 , C07D277/42 , C07D277/56 , C07D295/13 , C07D295/205 , C07D295/215 , C07D303/36 , C07D307/42 , C07D333/16 , C07D401/12 , C07D413/12 , C07D417/12 , C07K5/06026 , C07K5/06078 , A61K38/00

Abstract: A retroviral protease inhibiting compound of the formula: ##STR1## is disclosed.

43.

发明授权
Process for the conversion of 2,3-dihydrofuran to cyclopropanecarboxaldehyde 失效
Title translation: 2,3-二氢呋喃转化为环丙烷甲醛的方法

公开(公告)号：US5633410A

公开(公告)日：1997-05-27

申请号：US706157

申请日：1996-08-30

Applicant: Shaowo Liang , Timothy W. Price

Inventor： Shaowo Liang , Timothy W. Price

IPC: C07B61/00 , C07C45/59 , C07C47/293

CPC classification number: C07C45/59

Abstract: Disclosed is a process for the preparation of cyclopropanecarboxaldehyde by the isomerization of 2,3-dihydrofuran wherein 2,3-dihydrofuran is contacted with a catalyst selected from alumina, silica-alumina, silica, zirconia, titania and mixtures thereof having a nitrogen BET surface area of about 10 to 350 square meters per gram at elevated temperature.

Abstract translation: 公开了通过2,3-二氢呋喃的异构化制备环丙烷甲醛的方法，其中2,3-二氢呋喃与选自氧化铝，二氧化硅 - 氧化铝，二氧化硅，氧化锆，二氧化钛及其混合物的催化剂接触，其具有氮BET表面面积约10〜350平方米/克，升高温度。

44.

发明授权
Retinoid-like compounds 失效
Title translation: 类视黄醇样化合物

公开(公告)号：US5618839A

公开(公告)日：1997-04-08

申请号：US643142

申请日：1996-05-02

Applicant: John E. Starrett, Jr. , Kuo-Long Yu , Muzammil M. Mansuri , David R. Tortolani , Peter R. Reczek

Inventor： John E. Starrett, Jr. , Kuo-Long Yu , Muzammil M. Mansuri , David R. Tortolani , Peter R. Reczek

IPC: A61K31/695 , A61K31/165 , A61K31/19 , A61K31/195 , A61K31/235 , A61K31/24 , A61K31/245 , A61K31/255 , A61P17/00 , A61P35/00 , A61P43/00 , C07C17/16 , C07C45/41 , C07C45/45 , C07C45/59 , C07C45/63 , C07C45/64 , C07C45/67 , C07C47/548 , C07C49/67 , C07C49/683 , C07C49/697 , C07C49/747 , C07C49/798 , C07C51/09 , C07C63/331 , C07C63/49 , C07C63/66 , C07C63/74 , C07C65/26 , C07C65/28 , C07C65/36 , C07C67/14 , C07C67/317 , C07C67/333 , C07C67/343 , C07C69/00 , C07C69/618 , C07C69/76 , C07C69/773 , C07C69/78 , C07C69/82 , C07C69/83 , C07C69/90 , C07C69/92 , C07C69/94 , C07C205/06 , C07C205/45 , C07C205/58 , C07C227/18 , C07C229/38 , C07C229/60 , C07C231/02 , C07C231/12 , C07C233/15 , C07C233/54 , C07C233/65 , C07C233/66 , C07C233/76 , C07C233/81 , C07C233/87 , C07C309/71 , C07C309/75 , C07C319/14 , C07C323/56 , C07C323/62 , C07C327/26 , C07C327/28 , C07C327/32 , C07C327/48 , C07F7/10 , A61K31/21 , A61K31/185 , C07C229/34

CPC classification number: C07C69/00 , C07C17/16 , C07C205/06 , C07C205/45 , C07C205/58 , C07C229/38 , C07C229/60 , C07C233/65 , C07C233/76 , C07C233/81 , C07C323/56 , C07C323/62 , C07C327/26 , C07C327/28 , C07C327/32 , C07C327/48 , C07C45/41 , C07C45/45 , C07C45/59 , C07C45/63 , C07C45/64 , C07C45/673 , C07C47/548 , C07C49/67 , C07C49/683 , C07C49/697 , C07C49/747 , C07C49/798 , C07C63/49 , C07C63/66 , C07C63/74 , C07C65/26 , C07C65/36 , C07C69/618 , C07C69/76 , C07C69/82 , C07C69/90 , C07C69/92 , C07C2102/08 , C07C2102/10 , C07C2103/00 , C07C2103/24 , Y10S514/825

Abstract: The present invention relates to a compound of formula I ##STR1## or a nontoxic pharmaceutically acceptable salt, physiologically hydrolyzable ester or solvate thereof, in whichX is --O--CO--, --NH--CO--, --CS--NH--, --CO--O--, --CO--NH--, --COS--, --SCO--, --SCH.sub.2 --, --CH.sub.2 --CH.sub.2 --, --C.tbd.C--, --CH.sub.2 --NH--, --COCH.sub.2 --, --NHCS--, --CH.sub.2 S--, --CH.sub.2 O--, --OCH.sub.2 --, --NHCH.sub.2 -- or --CR.sup.5 .dbd.CR.sup.6 --;R.sup.m and R.sup.k are independently hydrogen, halogen, C.sub.1-6 alkyl, hydroxy, C.sub.1-6 alkyloxy or nitro;n is zero or one;R.sup.4 is --(CH.sub.2).sub.t --Y, C.sub.1-6 alkyl, or C.sub.3-6 cycloalkyl;R.sup.1 is --CO.sub.2 Z, C.sub.1-6 alkyl, CH.sub.2 OH, --CONHR.sup.y, or CHO;R.sup.2 and R.sup.3 are independently hydrogen or C.sub.1-6 alkyl;R.sup.a and R.sup.b are independently hydrogen or C.sub.1-6 alkyl; but when n is one, R.sup.a and R.sup.b together can form a radical of the formula ##STR2## Y is naphthyl or phenyl, both radicals can be optionally substituted with one to three same or different C.sub.1-6 alkyl or halogen;Z is hydrogen or C.sub.1-6 alkyl;R.sup.5, R.sup.6 and R.sup.y are independently hydrogen or C.sub.1-6 alkyl; andt is zero to six.

Abstract translation: 本发明涉及式I的化合物或其无毒的药学上可接受的盐，生理上可水解的酯或其溶剂合物，其中X是-O-CO-，-NH-CO-，-CS-NH-， -CO-O-，-CO-NH-，-COS-，-SCO-，-SCH 2 - ， - CH 2 -CH 2 - ， - C 3BOND C - ， - CH 2 -NH-，-COCH 2 - ， - NHCS-， -CH 2 S - ， - CH 2 O - ， - OCH 2 - ， - NHCH 2 - 或-CR 5 = CR 6 - ; R m和R k独立地是氢，卤素，C 1-6烷基，羟基，C 1-6烷氧基或硝基; n为零或一; R4是 - （CH2）t-Y，C1-6烷基或C3-6环烷基; R1是-CO2Z，C1-6烷基，CH2OH，-CONHRy或CHO; R2和R3独立地是氢或C1-6烷基; R a和R b独立地是氢或C 1-6烷基; 但是当n为1时，R a和R b可以一起形成下式的基团：Y是萘基或苯基，两个基团可任选地被一至三个相同或不同的C 1-6烷基或卤素取代; Z是氢或C 1-6烷基; R5，R6和Ry独立地是氢或C1-6烷基; t为0〜6。