专利检索 ipc:"C12N5/00" 第 5 页

41.

发明授权
Method of producing cell structure, carrier, and method of producing carrier 有权

公开(公告)号：US12037571B2

公开(公告)日：2024-07-16

申请号：US17252977

申请日：2019-05-09

申请人： YOKOGAWA ELECTRIC CORPORATION

发明人： Takeyuki Mogi

IPC分类号： C12M3/00 , B01L3/00 , C12M1/00 , C12M1/12 , C12M3/06 , C12N5/00 , C12N5/09 , C12N11/02

CPC分类号： C12M23/50 , C12M21/08 , C12M23/06 , C12M23/44 , C12M27/16 , C12N5/0062 , C12N5/0693 , C12N11/02 , C12N2513/00 , C12N2537/00

摘要： A method of producing a cell structure includes applying a magnetic field, in a container (40), to a plurality of culture carriers to arrange the culture carriers. The culture carriers include at least one of a carrier (10) and a cell holding carrier (30), the carrier (10) having a magnetic portion (12), formed only in a part of the carrier (10), and a cell holder (11). The method also includes culturing cells (20) held on the cell holder (11) while maintaining the culture carriers in the arranged state.

42.

发明公开
METHOD FOR PROMOTING PROLIFERATION AND PLURIPOTENCY FACTOR EXPRESSION OF STEM CELLS AND COMPOSITION PRODUCED USING THE SAME 审中-公开

公开(公告)号：US20240228953A1

公开(公告)日：2024-07-11

申请号：US18359053

申请日：2023-07-26

申请人： BUDDHIST TZU CHI MEDICAL FOUNDATION

发明人： WU LI Wei , Shinn-Zong LIN , Tzyy-Wen CHIOU , Horng-Jyh HARN , Peng-Yeong WOON

IPC分类号： C12N5/079 , C12N5/00

CPC分类号： C12N5/0618 , C12N5/0018 , C12N2500/38 , C12N2501/15 , C12N2501/2306 , C12N2501/2308 , C12N2501/998 , C12N2501/999

摘要： A method for promoting proliferation and enhancing expression of pluripotency factors of stem cells and a method for promoting proliferation of cells differentiated from the stem cells are provided in the present disclosure. The methods comprise culturing the stem cells in a medium comprising thrombospondin 1 (TSP1) and left-right determination factor 2 (LEFTY2). The present disclosure also provides a composition comprising a derivative of the stem cells produced by the methods of the present disclosure and a pharmaceutically or cosmetically acceptable carrier.

43.

发明公开
DYNAMIC MONOSACCHARIDE CONTROL PROCESSES 审中-公开

公开(公告)号：US20240228948A9

公开(公告)日：2024-07-11

申请号：US17769373

申请日：2020-10-16

申请人： JANSSEN BIOTECH, INC.

发明人： James Vincent PRICE , Stefanie BERGES-VORSANGER , Amalie LEVY , Steven SAVAGE , Abbey WEITH

IPC分类号： C12N5/00 , C12M1/00 , C12M1/06 , C12M1/34 , C12M1/36

CPC分类号： C12N5/00 , C12M27/06 , C12M29/06 , C12M41/32 , C12M41/36 , C12M41/48

摘要： Materials and methods to control a nutrient feed in a cell culture process is provided. A sample is received from a bioreactor comprising a cell culture. A viable cell density and a residual nutrient measurement are determined from the received sample. A daily nutrient feeding target is calculated based on the viable cell density and the residual nutrient measurement. The nutrient is fed to the bioreactor according to the calculated daily nutrient feeding target.

44.

发明公开
HEMATOPOIETIC STEM CELLS IN COMBINATORIAL THERAPY WITH IMMUNE CHECKPOINT INHIBITORS AGAINST CANCER 审中-公开

公开(公告)号：US20240226290A1

公开(公告)日：2024-07-11

申请号：US18412412

申请日：2024-01-12

申请人： University of Florida Research Foundation, Incorporated

发明人： Duane Mitchell , Catherine Flores

IPC分类号： A61K39/395 , A61K35/28 , A61K39/00 , A61K45/06 , A61P31/12 , A61P35/00 , C07K16/28 , C12N5/00

CPC分类号： A61K39/3955 , A61K35/28 , A61K45/06 , A61P31/12 , A61P35/00 , C07K16/28 , C07K16/2818 , C12N5/00 , A61K2039/5154 , A61K2300/00

摘要： The novel synergistic combination of immune checkpoint blockade and hematopoietic stem cell transplantation and/or hematopoictic stem cell mobilization yield synergistic effects in disease therapy.

45.

发明授权
Methods for reprogramming cells and uses thereof 有权

公开(公告)号：US12024722B2

公开(公告)日：2024-07-02

申请号：US16125528

申请日：2018-09-07

申请人： Genesis Technologies Limited

发明人： Jan-Eric Ahlfors , Rouwayda El-Ayoubi

IPC分类号： C12N5/00 , C12N5/071 , C12N5/074 , C12N5/0775 , C12N5/0789 , C12N5/0797 , C12N15/85

CPC分类号： C12N5/0696 , C12N5/0623 , C12N5/0647 , C12N5/0662 , C12N5/0678 , C12N15/85 , C12N2501/40 , C12N2501/60 , C12N2501/603 , C12N2501/604 , C12N2501/605 , C12N2501/998 , C12N2502/99 , C12N2506/094 , C12N2506/11 , C12N2506/1307 , C12N2506/1384

摘要： Described herein are reprogrammed cells, and methods for cell dedifferentiation, transformation and eukaryotic cell reprogramming. Also described are cells, cell lines, and tissues that can be transplanted in a patient after steps of in vitro dedifferentiation and in vitro reprogramming. In particular embodiments the cells are Stem-Like Cells (SLCs), including Neural Stem-Like Cells (NSLCs), Cardiac Stem-Like Cells (CSLC), Hematopoietic Stem-Like Cells (HSLC), Pancreatic Progenitor-Like Cells, and Mesendoderm-like Cells. Also described are methods for generating these cells from human somatic cells and other types of cells. Also provided are compositions and methods of using of the cells so generated in human therapy and in other areas.

46.

发明授权
Laser processing machine 有权

公开(公告)号：US12018239B2

公开(公告)日：2024-06-25

申请号：US17103539

申请日：2020-11-24

申请人： KATAOKA CORPORATION , NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY

发明人： Masami Suzuki , Norio Nishi , Junichi Matsumoto , Kimio Sumaru , Toshiyuki Kanamori

IPC分类号： C12M1/34 , C12M1/00 , C12M1/12 , C12M1/26 , C12M1/32 , C12M1/42 , C12N1/00 , C12N1/02 , C12N5/00 , C12N13/00

CPC分类号： C12M1/42 , C12M1/005 , C12M1/3446 , C12M23/20 , C12M25/06 , C12M31/02 , C12M33/06 , C12M33/10 , C12M47/04 , C12N1/00 , C12N1/02 , C12N5/0081 , C12N13/00

摘要： A laser processing machine for killing specific cells from a group of cells on a surface of a layer containing an ingredient capable of absorbing laser light, the laser processing machine being configured to: control a laser light source to output laser light at 5W or less and at a wavelength of 380 nm or greater such that the laser light source is applied to a second area on a second surface of the layer opposed to the first surface; and control an actuator to provide a relative movement between the second area where the laser light is applied and the layer at a rate of 2000 mm/sec or less such that the irradiated second area absorbs energy to generate heat that kills unwanted cells on a first area of the first surface and the laser light does not instantly kill the specific cells on the first area upon irradiation.

47.

发明公开
SYSTEM AND METHOD FOR TRANSFERRING TISSUE 审中-公开

公开(公告)号：US20240200011A1

公开(公告)日：2024-06-20

申请号：US18594189

申请日：2024-03-04

申请人： DEKA Products Limited Partnership

发明人： Michael C. Tilley , Richard E. Andrews , Dane C. Fawkes

IPC分类号： C12M1/32 , A61L27/36 , C12M1/26 , C12M3/00 , C12N5/00

CPC分类号： C12M33/06 , A61L27/3608 , A61L27/3633 , C12M21/08 , C12M33/00 , C12N5/0062 , C12N2513/00

摘要： A transfer device designed to extract an amorphous or semi-solid structure, tissue, or construct from supporting media while maintaining the spatial integrity/organizational architecture thereof. The transfer device can include a controller, an actuator assembly, a plunger, and a needle. The controller can move the transfer device and the plunger independently.

48.

发明授权
Method of making induced pluripotent stem cells using p53 inhibitors 有权

公开(公告)号：US12012615B2

公开(公告)日：2024-06-18

申请号：US16195054

申请日：2018-11-19

申请人： Kyoto University

发明人： Shinya Yamanaka , Kazutoshi Takahashi , Keisuke Okita

IPC分类号： C12N5/00 , C12N5/074 , C12N15/85

CPC分类号： C12N5/0696 , C12N15/85 , C12N2501/60 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/606 , C12N2506/11 , C12N2510/00

摘要： The invention provides an in vitro method of improving the efficiency of establishment of induced pluripotent stem (iPS) cells. The method comprises contacting an isolated somatic cell being reprogrammed into an iPS cell with an inhibitor of p53 function. The invention also provides an in vitro method of producing iPS cells. The method comprises bringing (a) nuclear reprogramming substances or nucleic acids encoding the nuclear reprogramming substances and (b) an inhibitor of p53 function into contact with a somatic cell.