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97 条记录 (耗时 0.055 秒)

    Western blot by incorporating an affinity purification zone
    54.
    发明授权
    Western blot by incorporating an affinity purification zone 有权
    通过掺入亲和纯化区的蛋白质印迹

    公开(公告)号：US08592141B2

    公开(公告)日：2013-11-26

    申请号：US13216441

    申请日：2011-08-24

    申请人： Matthew B Murphy ,  Robert S. Dubrow

    发明人： Matthew B Murphy ,  Robert S. Dubrow

    IPC分类号： C12Q1/00

    CPC分类号： G01N33/54366

    摘要： A mixture of components is flowed through a binding channel region comprising a component-binding moiety, thereby binding at least a portion of a component of interest. The mixture is then flowed through a separation channel region that includes a buffer comprising a detergent, resulting in separated components. Diluent is mixed with the separated components, diluting the detergent, and the separated components are detected. The component of interest is released from the component-binding moiety and flowed through the separation channel region. Diluent is mixed with the released component of interest, diluting the detergent, and the released component of interest is detected.

    摘要翻译： 组分的混合物流过包含组分结合部分的结合通道区，从而结合目的组分的至少一部分。 然后将混合物流过包括包含洗涤剂的缓冲液的分离通道区域，得到分离的组分。 将稀释剂与分离的组分混合，稀释洗涤剂，并检测分离的组分。 感兴趣的组分从组分结合部分释放并流过分离通道区。 将稀释液与所释放的感兴趣组分混合，稀释洗涤剂，并检测释放的感兴趣组分。

    Nanostructured Thin Films and Their Uses
    59.
    发明申请
    Nanostructured Thin Films and Their Uses 失效
    纳米结构薄膜及其用途

    公开(公告)号：US20090124034A1

    公开(公告)日：2009-05-14

    申请号：US12121008

    申请日：2008-05-15

    申请人： Chunming Niu ,  R. Hugh Daniels ,  Robert S. Dubrow ,  Jay L. Goldman

    发明人： Chunming Niu ,  R. Hugh Daniels ,  Robert S. Dubrow ,  Jay L. Goldman

    IPC分类号： H01L21/30

    CPC分类号： A61L27/303 ,  A61L31/122 ,  H01J49/0418 ,  Y10S977/701 ,  Y10T428/12736 ,  Y10T428/12743

    摘要： The present invention generally discloses the use of a nanostructured non-silicon thin film (such as an alumina or aluminum thin film) on a supporting substrate which is subsequently coated with an active layer of a material such as silicon or tungsten. The base, underlying non-silicon material generates enhanced surface area while the active layer assists in incorporating and transferring energy to one or more analytes adsorbed on the active layer when irradiated with a laser during laser desorption of the analyte(s). The present invention provides substrate surfaces that can be produced by relatively straightforward and inexpensive manufacturing processes and which can be used for a variety of applications such as mass spectrometry, hydrophobic or hydrophilic coatings, medical device applications, electronics, catalysis, protection, data storage, optics, and sensors.

    摘要翻译： 本发明一般公开了在支撑衬底上使用纳米结构非硅薄膜（例如氧化铝或铝薄膜），随后用诸如硅或钨的材料的活性层涂覆。 底层的非硅材料产生增强的表面积，而活性层有助于在分析物的激光解吸附中用激光照射时，将能量并入和转移到吸附在活性层上的一种或多种分析物。 本发明提供了可以通过相对直接和廉价的制造方法制造的衬底表面，其可用于各种应用，例如质谱，疏水或亲水涂层，医疗器械应用，电子学，催化，保护，数据存储， 光学和传感器。

    Methods, systems and apparatus for separation and isolation of one or more sample components of a sample biological material
    60.
    发明授权
    Methods, systems and apparatus for separation and isolation of one or more sample components of a sample biological material 有权
    用于分离和分离样品生物材料的一种或多种样品组分的方法，系统和装置

    公开(公告)号：US07419784B2

    公开(公告)日：2008-09-02

    申请号：US10401110

    申请日：2003-03-27

    申请人： Robert S. Dubrow ,  Luc J. Bousse ,  Huan L. Phan

    发明人： Robert S. Dubrow ,  Luc J. Bousse ,  Huan L. Phan

    IPC分类号： G01N33/53

    CPC分类号： B01L3/50273 ,  B01L3/502715 ,  B01L3/502753 ,  B01L3/502784 ,  B01L2200/0605 ,  B01L2200/0631 ,  B01L2200/10 ,  B01L2300/0816 ,  B01L2400/0421 ,  B01L2400/0487 ,  G01N27/44791 ,  Y10T436/25

    摘要： Devices, systems and methods for use in separating sample materials into different sample components and then isolating one or more of the sample components for further processing or analysis are disclosed. Devices employ configurations that optionally allow a sample material to be electrophoretically separated into sample components in a separation matrix within a separation conduit. The sample components may then be detected in a detection zone in the separation conduit, and then selected components shunted to a component collection conduit within the device downstream of the detection zone for further processing or analysis based on information received at the detection zone. Methods of using these devices, and systems that incorporate these devices are also envisioned.

    摘要翻译： 公开了用于将样品材料分离成不同样品组分，然后分离一个或多个样品组分用于进一步处理或分析的装置，系统和方法。 设备采用可选地允许样品材料在分离管道内的分离基质中电泳分离成样品组分的构型。 然后可以在分离管道中的检测区域中检测样品组分，然后根据在检测区域接收的信息，将选定的组分分流到检测区域下游装置内的组件收集管道进一步处理或分析。 也可以设想使用这些装置的方法以及包含这些装置的系统。