公开(公告)号：US20180078875A1

公开(公告)日：2018-03-22

申请号：US15790946

申请日：2017-10-23

Applicant: Waters Technologies Corporation

Inventor： Kurt D. Joudrey ,  Paul Keenan ,  Richard W. Andrews ,  Peyton C. Beals ,  Joshua A. Shreve

IPC: B01D15/10 ,  G01N30/32 ,  B01D15/40 ,  B01D15/16 ,  G01N30/30

CPC classification number: B01D15/10 ,  B01D15/163 ,  B01D15/40 ,  G01N30/32 ,  G01N2030/3007 ,  G01N2030/324

Abstract: A method for controlling fluid flowing through a chromatographic system includes determining a fluidic parameter related to density at a first fluidic location in the chromatographic system; and in response to the determined fluidic parameter, modifying a volumetric flow rate or a pressure at a second fluidic location in the chromatographic system to produce a selected mass flow rate of the fluid.

公开(公告)号：US09835597B2

公开(公告)日：2017-12-05

申请号：US14381971

申请日：2013-03-07

Applicant: Waters Technologies Corporation

Inventor： Joshua A. Shreve ,  Kurt Joudrey ,  John Angelosanto

IPC: G01N30/02 ,  G01N30/46 ,  B01D15/40 ,  G01N30/36 ,  B01D15/16 ,  F17C1/00 ,  G01N30/32

CPC classification number: G01N30/02 ,  B01D15/163 ,  B01D15/40 ,  F17C1/00 ,  G01N30/32 ,  G01N30/36 ,  G01N30/466 ,  G01N2030/027 ,  Y02P20/544 ,  Y10T137/0396 ,  Y10T137/86027 ,  Y10T137/86035 ,  Y10T137/87314 ,  Y10T137/87507 ,  Y10T137/87917 ,  Y10T137/87925

Abstract: Exemplary embodiments are directed to devices, methods and systems capable of pressurization, generally involving a flow system that includes a pressurized reservoir, at least one pump including a pump control valve, an outlet port, a shut-off valve and a vent valve. The flow system is configured to be pressurized. The shut-off valve is disposed between the pressurized reservoir and the at least one pump. The vent valve is disposed between the at least one pump and the outlet port. The shut-off valve, the vent valve and the pump control valve of the at least one pump are configured to actuate in a coordinated manner to control a pressurization of the flow system. Exemplary embodiments are further directed to devices, methods and systems for column switching, generally including at least a first column, a second column and a column switching valve.

公开(公告)号：US09764251B2

公开(公告)日：2017-09-19

申请号：US14383239

申请日：2013-03-05

Applicant: Waters Technologies Corporation

Inventor： Emily J. Berg ,  Joshua A. Shreve ,  James E. Usowicz ,  Douglas P. Wittmer ,  Aaron Lebeau

IPC: G01N1/00 ,  B01D15/14 ,  B01D15/40 ,  G01N30/20 ,  G01N30/16 ,  G01N30/28

CPC classification number: B01D15/14 ,  B01D15/40 ,  G01N30/16 ,  G01N30/20 ,  G01N30/28 ,  G01N2030/201 ,  G01N2030/202 ,  G01N2030/207 ,  G01N30/32

Abstract: A supercritical fluid chromatography system is provided with an injection valve subsystem for introducing a sample into a flow of mobile phase fluid. The injection valve subsystem includes an auxiliary valve and an inject valve. The operations of the auxiliary and inject valves are coordinated in such a manner as to reduce sample carry-over and system pressure perturbations occurring during sample injection.

公开(公告)号：US20170153212A1

公开(公告)日：2017-06-01

申请号：US15309421

申请日：2014-05-07

Applicant: Waters Technologies Corporation

Inventor： Sylvain Cormier ,  Kurt D. Joudrey ,  Joshua A. Shreve

IPC: G01N30/60 ,  B01D15/22 ,  F16L37/092

CPC classification number: G01N30/6026 ,  B01D15/22 ,  F16L37/092 ,  G01N30/6034 ,  G01N2030/027

Abstract: The invention provides compression fittings and methods of assembling compression fittings. In exemplary embodiments, compression fittings are provided that include a fitting body, a ferrule and a tube. For example, the fitting body can be removably coupled to the ferrule when the tube is disposed therethrough.

公开(公告)号：US20170136389A1

公开(公告)日：2017-05-18

申请号：US15333876

申请日：2016-10-25

Applicant: Waters Technologies Corporation

Inventor： Michael R. Jackson ,  Christopher Seith ,  Senthil Bala ,  Colin Fredette ,  Maruth Sok ,  Carlos Gomez ,  Joshua A. Shreve

IPC: B01D19/00 ,  G01N30/14 ,  B01D15/40

CPC classification number: B01D15/40 ,  B01D19/0031 ,  G01N30/84 ,  G01N2030/8423

Abstract: Methods, systems and apparatus are provided for degassing a supersaturated solution. An example degasser is described having a continuous body of gas-permeable tubing to remove an amount of a gas from the supersaturated solution below the gas's saturation point in the supersaturated solution. The degasser can be connected to at least one of a fraction collector or a detector. The example degasser is sized and/or positioned to cause a change in pressure (ΔP) across the degasser to drive removal of a dissolved gas from a supersaturated solution passing through the degasser. As a result of the reduction of gas, efficiencies in system flow and fraction collection are achieved.

公开(公告)号：US20170074838A1

公开(公告)日：2017-03-16

申请号：US15360558

申请日：2016-11-23

Applicant: Waters Technologies Corporation

Inventor： Joshua A. Shreve ,  John Maillet

IPC: G01N30/30 ,  G01N30/60 ,  G01N30/46

CPC classification number: G01N30/30 ,  G01N30/466 ,  G01N30/54 ,  G01N30/6047 ,  G01N2030/027 ,  G01N2030/303 ,  G01N2030/8881

Abstract: A thermal system for use in a column manager of a liquid chromatography system comprises a plurality of spatially separated individually controlled thermoelectric chips. A column module houses a plurality of thermally conductive troughs. Each trough resides in a separate thermal zone to be thermally conditioned individually by one of the individually controlled thermoelectric chips. Each trough is adapted to hold one or more liquid chromatography columns therein. A plurality of spatially separated thermal bridges includes a first thermal bridge thermally coupling one of the thermoelectric chips to a first one of the plurality of troughs and a second thermal bridge of the plurality of thermal bridges thermally coupling another of the thermoelectric chips to a second one of the plurality of troughs.

Abstract translation: 用于液相色谱系统的柱管理器的热系统包括多个空间分离的独立控制的热电芯片。 列模块容纳多个导热槽。 每个槽位于单独的热区中，由单独控制的热电芯片之一分别进行热调节。 每个槽适于在其中容纳一个或多个液相色谱柱。 多个空间分离的热桥包括将热电芯片中的一个热耦合到多个槽中的第一个槽的第一热桥和多个热桥中的另一个热桥将热耦合到第二热桥的第二热桥 的多个槽。

公开(公告)号：US20170038346A1

公开(公告)日：2017-02-09

申请号：US15303328

申请日：2015-04-10

Applicant: Waters Technologies Corporation

Inventor： Joshua A. Shreve ,  Kurt D. Joudrey

IPC: G01N30/30 ,  F24H9/00 ,  F24H3/08 ,  B01D15/16 ,  B01D53/02

CPC classification number: G01N30/30 ,  B01D15/161 ,  B01D53/025 ,  F24H3/062 ,  F24H3/081 ,  F24H9/0073 ,  F24H9/1863 ,  F24H9/2071 ,  F24H2240/08 ,  F24H2250/06 ,  G01N2030/3007

Abstract: A column-conditioning enclosure includes a column chamber adapted to hold one or more chromatography separation columns. A duct system provides an airflow path around the column chamber such that the one or more chromatography separation columns held within the column chamber are isolated from the airflow path. An air mover disposed in the airflow path generates a flow of air within the duct system. A heat exchanger system disposed in the airflow path near the air to exchange heat with the air as the air flows past the heat exchanger system. The air circulates through the duct system around the column chamber, convectively exchanging heat with the column chamber to produce a thermally conditioned environment for the one or more chromatography separation columns held within the column chamber.

Abstract translation: 柱调节外壳包括适于容纳一个或多个色谱分离柱的柱室。 管道系统提供围绕柱室的气流路径，使得保持在柱室内的一个或多个色谱分离柱与气流路径隔离。 设置在气流路径中的鼓风机在管道系统内产生空气流。 一种热交换器系统，其布置在靠近空气的气流中，随着空气流过热交换器系统而与空气交换热量。 空气循环通过柱室周围的管道系统，与塔室对流地进行热交换，以产生用于保持在塔室内的一个或多个色谱分离柱的热调节环境。

公开(公告)号：US09381447B2

公开(公告)日：2016-07-05

申请号：US14381975

申请日：2013-03-07

Applicant: Waters Technologies Corporation

Inventor： Joshua A. Shreve ,  Paul Linderson ,  John Maillet, Jr. ,  John Angelosanto

IPC: B01D15/10 ,  G01N30/32 ,  B01D15/16 ,  B01D15/40 ,  G05D16/20

CPC classification number: B01D15/163 ,  B01D15/10 ,  B01D15/40 ,  G01N30/32 ,  G01N2030/328 ,  G05D16/2013

Abstract: Exemplary embodiments of the present disclosure relate to systems and methods comprising a dynamic pressure regulator and a force balance needle that regulate pressure changes due to flow or composition changes in a pressurized flow system, such as, for example, a CO2-based chromatography system.

Abstract translation: 本公开的示例性实施例涉及包括动态压力调节器和力平衡针的系统和方法，所述动态压力调节器和力平衡针调节由于加压流系统（例如基于CO 2的色谱系统）中的流动或组成变化引起的压力变化。

公开(公告)号：US20150129494A1

公开(公告)日：2015-05-14

申请号：US14539336

申请日：2014-11-12

Applicant: WATERS TECHNOLOGIES CORPORATION

Inventor： Kurt D. Joudrey ,  Paul Keenan ,  Richard W. Andrews ,  Peyton C. Beals ,  Joshua A. Shreve

IPC: B01D15/10 ,  B01D15/40

CPC classification number: B01D15/10 ,  B01D15/163 ,  B01D15/40 ,  G01N30/32 ,  G01N2030/3007 ,  G01N2030/324

Abstract: A method for controlling fluid flowing through a chromatographic system includes determining a fluidic parameter related to density at a first fluidic location in the chromatographic system; and in response to the determined fluidic parameter, modifying a volumetric flow rate or a pressure at a second fluidic location in the chromatographic system to produce a selected mass flow rate of the fluid.

Abstract translation: 用于控制流过色谱系统的流体的方法包括确定与色谱系统中第一流体位置处的密度有关的流体参数; 并且响应于所确定的流体参数，修改色谱系统中的第二流体位置的体积流量或压力以产生所选流体的质量流量。

公开(公告)号：US20150129057A1

公开(公告)日：2015-05-14

申请号：US14382400

申请日：2013-03-05

Applicant: Waters Technologies Corporation

Inventor： Joshua A. Shreve ,  Charles T. Murphy ,  Paul Keenan ,  Ryan M. Hill ,  Sylvain Cormier

IPC: F16K15/06 ,  F16K1/42 ,  F16K25/04 ,  F16K15/04 ,  F16K25/00 ,  F16K1/38 ,  F16K15/02

CPC classification number: F16K15/063 ,  B01D15/40 ,  F16K1/38 ,  F16K1/42 ,  F16K15/021 ,  F16K15/044 ,  F16K25/005 ,  F16K25/04 ,  G01N30/32 ,  G05D16/103 ,  Y10T137/7925

Abstract: The invention generally provides a static back pressure regulator. In exemplary embodiments, the static back pressure regulator includes a seat that defines part of a fluid pathway, a poppet, a spring arranged to bias the poppet toward the seat to restrict fluid flow through the fluid pathway, and a calibration element configured to adjust a force applied to the poppet by the spring. The calibration element can include a through hole that forms part of the fluid pathway. The poppet can include a first guiding portion that extends into the through hole of the calibration element and inhibits tipping of the poppet relative to the seat.

Abstract translation: 本发明通常提供一种静态背压调节器。 在示例性实施例中，静态背压调节器包括限定流体通道的一部分的座，提升阀，弹簧，其布置成将提升阀朝向座椅偏置以限制流过流体通路的流体流动;以及校准元件， 春天施加在提升阀上的力。 校准元件可以包括形成流体通路的一部分的通孔。 提升阀可以包括延伸到校准元件的通孔中的第一引导部分，并且禁止提升阀相对于座椅的倾翻。