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    Rigid disposable flow path
    52.
    发明授权
    Rigid disposable flow path 有权
    刚性一次性流路

    公开(公告)号：US09494259B2

    公开(公告)日：2016-11-15

    申请号：US14074815

    申请日：2013-11-08

    Applicant: EMD Millipore Corporation

    Inventor： Martin Morrissey ,  Neil Schauer

    IPC: F16L9/127 ,  F16L9/00 ,  F16L9/133 ,  F16L9/22 ,  B01L3/00 ,  B01J19/00

    CPC classification number: F16L9/00 ,  B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00808 ,  B01J2219/00813 ,  B01J2219/00833 ,  B01J2219/00968 ,  B01L3/502707 ,  B01L3/502715 ,  B01L3/561 ,  B01L2200/027 ,  B01L2200/0689 ,  B01L2300/0887 ,  F16L9/127 ,  F16L9/133 ,  F16L9/22 ,  Y10T137/87153

    Abstract: A disposable flow path having a manifold system that provides pressure resistance for the disposable device. The disposable device is comprised of a first rigid plastic sheet and a second rigid plastic sheet. Each sheet has two major surfaces and a thickness between them. At least one sheet surface has flow channels formed in it. The flow channels extend away from a first major surface and beyond the normal plane of a second major surface of the sheet. The sheets are liquid tightly sealed to each other at their adjoining first major surfaces. When each sheet contains a flow channel, the flow channels are aligned and in register with each other. One or more fittings can be secured in the flow channel(s) at an edge of the two liquid tightly sealed sheets. Alternatively, tubing is placed in the channels before the sheets are secured to one another.

    Abstract translation: 一次性流路，其具有为一次性装置提供耐压性的歧管系统。 一次性装置包括第一刚性塑料片和第二刚性塑料片。 每片具有两个主表面和它们之间的厚度。 至少一个片材表面上形成有流动通道。 流动通道远离第一主表面并超过板的第二主表面的法线平面。 片材在相邻的第一主要表面彼此液体密封。 当每个纸张包含流动通道时，流动通道对齐并彼此对准。 一个或多个配件可以固定在两个液密封片的边缘处的流动通道中。 或者，在片彼此固定之前，将管道放置在通道中。

    Holding needle comprising gripping cheeks
    53.
    发明授权
    Holding needle comprising gripping cheeks 有权
    保持针包括抓握的脸颊

    公开(公告)号：US09475157B2

    公开(公告)日：2016-10-25

    申请号：US14162823

    申请日：2014-01-24

    Applicant: EMD Millipore Corporation

    Inventor： Stephane Olivier ,  Jerome Geyer ,  Gerard Muller

    IPC: B23P19/00 ,  B23P19/04 ,  A61M5/162 ,  A61M5/158 ,  A61B17/34 ,  A61M25/06

    CPC classification number: B23P19/04 ,  A61B17/3417 ,  A61B17/3421 ,  A61M5/158 ,  A61M5/162 ,  A61M25/06 ,  A61M25/065 ,  A61M2005/1623 ,  Y10T29/49826 ,  Y10T29/49892 ,  Y10T29/49895 ,  Y10T29/49897 ,  Y10T29/49899 ,  Y10T29/49947

    Abstract: A take-off needle comprises a hollow lance having a distal end adapted to perform a insertion operation, said hollow lance being connected to at least one pipe provided with a spigot for it to be connected to a tube, and comprising a body for holding the hollow lance and pipe relative to each other such that the spigot projects from the holding body, said needle timber comprising two flanges held on respective sides of and spaced from the holding body by virtue of a spacer disposed between each flange and the holding body, said flanges extending in a longitudinal direction from the spigot to the vicinity of the proximal end of the hollow lance, the width of each flange being greater than the width of the portion of the holding body facing the flanges.

    Abstract translation: 起飞针包括具有适于执行插入操作的远端的中空喷枪，所述中空喷枪连接到至少一个设置有插口的管子，以将其连接到管，并且包括用于保持 空心枪和管相对于彼此，使得插口从保持体突出，所述针木由包括设置在每个凸缘和保持体之间的间隔件而保持在保持体的相应侧面并与保持体间隔开的两个凸缘， 凸缘从纵向方向延伸到中空喷枪的近端附近，每个凸缘的宽度大于保持体面对凸缘的部分的宽度。

    Purification of proteins
    56.
    发明授权
    Purification of proteins 有权

    公开(公告)号：US09376464B2

    公开(公告)日：2016-06-28

    申请号：US13747495

    申请日：2013-01-23

    Applicant: EMD Millipore Corporation

    Inventor： Wilson Moya ,  Jad Jaber

    IPC: C07K1/30 ,  C07K1/32

    CPC classification number: C07K1/32 ,  C07K1/30

    Abstract: The present invention relates to a selectively soluble polymer capable of binding to a desired biomolecules in a mixture containing various biological materials and the methods of using such a polymer to purify a biomolecule from such a mixture. The polymer is soluble in the mixture under a certain set of process conditions such as pH or temperature and/or salt concentration and is rendered insoluble and precipitates out of solution upon a change in the process conditions. The polymer is capable of binding to the desired biomolecule (protein, polypeptide, etc) and remains capable of binding to that biomolecule even after the polymer is precipitated out of solution. The precipitate can then be filtered out from the remainder of the stream and the desired biomolecule is recovered such as by elution and further processed.

    Layered Flask Cell Culture System
    57.
    发明申请
    Layered Flask Cell Culture System 有权
    分层烧瓶细胞培养系统

    公开(公告)号：US20160137961A2

    公开(公告)日：2016-05-19

    申请号：US12460265

    申请日：2009-07-16

    Applicant: Phillip Clark ,  Kurt Greenizen ,  Christopher A. Scott ,  Marc Emerick

    Inventor： Phillip Clark ,  Kurt Greenizen ,  Christopher A. Scott ,  Marc Emerick

    IPC: C12M1/24 ,  C12M3/00 ,  C12M1/12

    CPC classification number: C12M23/08 ,  C12M21/08 ,  C12M23/04 ,  C12M23/22 ,  C12M23/34 ,  C12M23/38 ,  C12M23/58 ,  C12M25/06 ,  C12M37/02

    Abstract: The present invention is a cell cultivating vessel or device, such as a single or multitier flask, including a cover having a top plate, a side wall and a resealable port; an intermediate tray for receiving cells and cell culture media, having a bottom plate, a side wall, and a gap region formed between an interior upwardly angled lip located on an interior portion of the intermediate tray bottom plate and an adjacent outwardly angled side wall portion of the intermediate tray bottom plate, wherein the lip has a outwardly swooping curvilinear edge feature; and a base tray for receiving the cells and cell culture media, including a bottom plate and a side wall. The intermediate tray is positioned between the cover and the base tray, such that the gap region of the intermediate tray bottom plate is in alignment with the port located on the cover, resulting in the port, the intermediate tray and the base tray in fluid communication with one another which provides direct access, such as by a user to remove and/or add cells, cell media, and nutrients located on each of the intermediate and/or the base trays. Alternatively, the cell cultivating flask includes a plurality of intermediate trays stacked on top of one another and the gap regions of each intermediate tray are in alignment with each other and with the port on the cover.

    Abstract translation: 本发明是一种细胞培养容器或装置，例如单个或多个烧瓶，包括具有顶板，侧壁和可再密封端口的盖; 用于接收细胞和细胞培养基的中间托盘，具有底板，侧壁和形成在位于中间托盘底板的内部部分上的内部向上倾斜的唇缘和相邻的向外成角度的侧壁部分之间的间隙区域 的中间托盘底板，其中所述唇部具有向外的转动曲线边缘特征; 以及用于接纳细胞和细胞培养基的底盘，包括底板和侧壁。 中间托盘定位在盖和基托之间，使得中间托盘底板的间隙区域与位于盖上的端口对准，导致端口，中间托盘和底盘处于流体连通 彼此之间提供直接访问，诸如由用户去除和/或添加位于中间和/或底盘中的每一个上的细胞，细胞培养基和营养物质。 或者，细胞培养瓶包括堆叠在彼此顶部的多个中间托盘，并且每个中间托盘的间隙区域彼此对准并且与盖上的端口对齐。

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