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187 条记录 (耗时 0.019 秒)

    Multifaceted endovascular stent coating for preventing restenosis
    62.
    发明申请
    Multifaceted endovascular stent coating for preventing restenosis 有权
    用于预防再狭窄的多层血管内支架涂层

    公开(公告)号：US20050158363A1

    公开(公告)日：2005-07-21

    申请号：US10510125

    申请日：2003-04-23

    申请人： Shalaby Shalaby

    发明人： Shalaby Shalaby

    IPC分类号： A61L31/10 ,  A61L31/16 ,  A61F2/00

    CPC分类号： A61L31/16 ,  A61L31/10 ,  A61L2300/41 ,  A61L2300/416 ,  A61L2300/42 ,  A61L2300/45 ,  C08L67/04 ,  C08L71/02 ,  C08L101/02

    摘要： This invention deals with a carboxyl-bearing, amphiphilic, solid copolyester stent coating composition for multifaceted prevention of vascular restenosis through a plurality of physicopharmacological modes. The composition includes one or more bioactive compounds and a copolymerization product of polyalkylene glycol, end-grafted with one or more cyclic monomer and treated further to introduce carboxyl-bearing end- or side-groups. The invention also deals with bioactive agents in an ionically conjugated form. The present coating may be applied to a metallic or an absorbable polymeric stent for use in preventing vascular restenosis.

    摘要翻译： 本发明涉及通过多种物理药理学模式多元预防血管再狭窄的含羧基的两亲性固体共聚酯支架涂层组合物。 该组合物包括一种或多种生物活性化合物和与一种或多种环状单体端接的聚亚烷基二醇的共聚产物，并进一步处理以引入含羧基的端基或侧基。 本发明还涉及离子共轭形式的生物活性剂。 本发明的涂层可以应用于金属或可吸收聚合物支架，用于预防血管再狭窄。

    Modulated molecularly bonded inherently conductive polymers on substrates with conjugated multiple lamellae and shaped articles thereof
    63.
    发明授权
    Modulated molecularly bonded inherently conductive polymers on substrates with conjugated multiple lamellae and shaped articles thereof 失效
    在具有共轭多层片及其成型制品的基底上调制分子结合的固有导电聚合物

    公开(公告)号：US6117554A

    公开(公告)日：2000-09-12

    申请号：US862945

    申请日：1997-05-30

    申请人： Shalaby W. Shalaby ,  Jacqueline M. Allan

    发明人： Shalaby W. Shalaby ,  Jacqueline M. Allan

    IPC分类号： C08G61/12 ,  C08J7/12 ,  C08J7/16 ,  C23C28/00 ,  B32B31/06 ,  B05D3/00 ,  B05D3/04 ,  B32B15/04

    CPC分类号： C23C28/00 ,  C08G61/122 ,  C08G61/124 ,  C08J7/12 ,  C08J7/16

    摘要： Organic inherently conductive polymers, such as those based on polyaniline, polypyrrole and polythiophene, are sequentially formed in-situ onto polymeric surfaces that are chemically functionalized to molecularly bond the conductive polymers to the substrates. The polymeric substrate is preferably a preshaped or preformed thermoplastic film, fabric, or tube, although other forms of thermoplastic and thermoset polymers can be used as the substrates for functionalization using, most preferably, phosphonylation-based processes followed by exposure to an oxidatively polymerizable compound capable of forming an electrically conductive polymer. It has been found that the degree of electrical conductivity may be modulated by bonding further electrically conductive layers to the article. That is, each underlying conductive layer is functionalized prior to bonding of a subsequent conductive layer thereto until the degree of conductivity is achieved. In an alternative embodiment, metals such as gold or platinum may be bonded to one of the functionalized surfaces.

    摘要翻译： 有机固有导电聚合物，例如基于聚苯胺，聚吡咯和聚噻吩的固体导电聚合物，原位地依次形成在化学官能化以将导电聚合物分子结合到基底上的聚合物表面上。 聚合物基材优选为预成型或预成型的热塑性薄膜，织物或管，尽管其它形式的热塑性和热固性聚合物可用作官能化底物，最优选使用基于膦酰基化的方法，随后暴露于氧化可聚合化合物 能够形成导电聚合物。 已经发现，可以通过将另外的导电层粘合到制品上来调节导电性的程度。 也就是说，每个下面的导电层在其后面的导电层结合之前被功能化，直到达到导电度。 在替代实施例中，诸如金或铂的金属可以结合到功能化表面之一。

    Peracylated proteins and synthetic polypeptides and process for making the same
    64.
    发明授权
    Peracylated proteins and synthetic polypeptides and process for making the same 失效
    过酰化蛋白质和合成多肽及其制备方法

    公开(公告)号：US5986050A

    公开(公告)日：1999-11-16

    申请号：US996366

    申请日：1997-12-22

    申请人： Shalaby W. Shalaby ,  Jacqueline M. Allan ,  Joel T. Corbett

    发明人： Shalaby W. Shalaby ,  Jacqueline M. Allan ,  Joel T. Corbett

    IPC分类号： C07K1/113 ,  C07K14/415 ,  C07K1/00 ,  A61K35/78

    CPC分类号： C07K14/415 ,  C07K1/113 ,  Y10T428/29 ,  Y10T428/2913 ,  Y10T428/2915

    摘要： A method for modifying a protein or polypeptide is disclosed which includes the steps of dispersing a protein or polypeptide in an essentially non-aqueous medium and peracylating the protein or polypeptide with a cyclic anhydride having a carbon chain substituent selected from the group consisting of alkyl and alkenyl groups. Most preferably, the cyclic anhydride is succinic anhydride, although glutaric anhydride may also be employed. Preferably, the step of peracylating the protein or polypeptide is performed in the presence of an acid catalyst, most preferably .rho.-toluene sulfonic acid. The resultant modified protein or polypeptide may be employed in numerous applications including drug delivery, absorbable sutures, and thermoplastic films and molded articles.

    摘要翻译： 公开了一种修饰蛋白质或多肽的方法，其包括以下步骤：将蛋白质或多肽分散在基本上非水性的培养基中，并将所述蛋白质或多肽与具有选自以下的碳链取代基的环酸酐进行过酰化：烷基和 烯基。 最优选地，环状酸酐是琥珀酸酐，尽管也可以使用戊二酸酐。 优选地，在酰基化蛋白质或多肽的步骤在酸催化剂，最优选Rho-甲苯磺酸的存在下进行。 所得到的修饰的蛋白质或多肽可用于许多应用，包括药物递送，可吸收缝合线，以及热塑性薄膜和模塑制品。